|
2015 Journal Article Histone deacetylase enzymes as drug targets for the control of the sheep blowfly, Lucilia cuprinaKotze, Andrew C., Hines, Barney M., Bagnall, Neil H., Anstead, Clare A., Gupta, Praveer, Reid, Robert C., Ruffell, Angela P. and Fairlie, David P. (2015). Histone deacetylase enzymes as drug targets for the control of the sheep blowfly, Lucilia cuprina. International Journal for Parasitology: Drugs and Drug Resistance, 5 (3), 201-208. doi: 10.1016/j.ijpddr.2015.09.003 |
|
2015 Journal Article Simultaneous uncoupled expression and purification of the Dengue virus NS3 protease and NS2B co-factor domain.Shannon, A. E, Chappell, K. J., Stoermer, M. J., Chow, S. Y., Kok, W. M., Fairlie, D. P. and Young, P. R. (2015). Simultaneous uncoupled expression and purification of the Dengue virus NS3 protease and NS2B co-factor domain.. Protein Expression and Purification, 119, 124-129. doi: 10.1016/j.pep.2015.11.022 |
|
2015 Journal Article Flexibility versus rigidity for orally bioavailable cyclic hexapeptidesNielsen, Daniel S., Lohman, Rink-Jan, Hoang, Huy Ngoc, Hill, Timothy A., Jones, Alun, Lucke, Andrew J. and Fairlie, David P. (2015). Flexibility versus rigidity for orally bioavailable cyclic hexapeptides. Chembiochem, 16 (16), 2289-2293. doi: 10.1002/cbic.201500441 |
|
2015 Journal Article Repurposing Registered Drugs as Antagonists for Protease-Activated Receptor 2Xu, Weijun, Lim, Junxian, Goh, Chai-Yeen, Suen, Jacky Y., Jiang, Yuhong, Yau, Mei-Kwan, Wu, Kai-Chen, Liu, Ligong and Fairlie, David P. (2015). Repurposing Registered Drugs as Antagonists for Protease-Activated Receptor 2. Journal of Chemical Information and Modeling, 55 (10), 2079-2084. doi: 10.1021/acs.jcim.5b00500 |
|
2015 Journal Article Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonistsSwedberg, Joakim E., Schroeder, Christina I., Mitchell, Justin M., Durek, Thomas, Fairlie, David P., Edmonds, David J., Griffith, David A., Ruggeri, Roger B., Derksen, David R., Loria, Paula M., Liras, Spiros, Price, David A. and Craik, David J. (2015). Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists. European Journal of Medicinal Chemistry, 103, 175-184. doi: 10.1016/j.ejmech.2015.08.046 |
|
2015 Journal Article Virtual Screening of Peptide and Peptidomimetic Fragments Targeted to Inhibit Bacterial Dithiol Oxidase DsbADuprez, Wilko, Bachu, Prabhakar, Stoermer, Martin J, Tay, Stephanie, McMahon, Roisin M, Fairlie, David P and Martin, Jennifer L (2015). Virtual Screening of Peptide and Peptidomimetic Fragments Targeted to Inhibit Bacterial Dithiol Oxidase DsbA. Plos One, 10 (7) e0133805, e0133805. doi: 10.1371/journal.pone.0133805 |
|
2015 Journal Article Nutrient and immune sensing are obligate pathways in metabolism, immunity and diseaseIyer, Abishek, Brown, Lindsay, Whitehead, Jonathan P., Prins, Johannes B. and Fairlie, David P. (2015). Nutrient and immune sensing are obligate pathways in metabolism, immunity and disease. The FASEB Journal. doi: 10.1096/fj.15-271155 |
|
2015 Journal Article Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin MetabolitesSakala, Isaac G., Kjer-Nielsen, Lars, Eickhoff, Christopher S., Wang, Xiaoli, Blazevic, Azra, Liu, Ligong, Fairlie, David P., Rossjohn, Jamie, McCluskey, James, Fremont, David H., Hansen, Ted H. and Hoft, Daniel F. (2015). Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites. The Journal of Immunology, 195 (2), 587-601. doi: 10.4049/jimmunol.1402545 |
|
2015 Journal Article Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramersRahimpour, Azad, Koay, Hui Fern, Enders, Anselm, Clanchy, Rhiannon, Eckle, Sidonia B. G., Meehan, Bronwyn, Chen, Zhenjun, Whittle, Belinda, Liu, Ligong, Fairlie, David P., Goodnow, Chris C., McCluskey, James, Rossjohn, Jamie, Uldrich, Adam P., Pellicci, Daniel G. and Godfrey, Dale I. (2015). Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers. Journal of Experimental Medicine, 212 (7), 1095-1108. doi: 10.1084/jem.20142110 |
|
2015 Journal Article Three homology models for PAR2 derived from different templates: Application to antagonist discoveryPerry, Samuel R., Xu, Weijun, Wirija, Anna, Lim, Junxian, Yau, Mei-Kwan, Stoermer, Martin J., Lucke, Andrew J. and Fairlie, David P. (2015). Three homology models for PAR2 derived from different templates: Application to antagonist discovery. Journal of Chemical Information And Modeling, 55 (6), 1181-1191. doi: 10.1021/acs.jcim.5b00087 |
|
2015 Journal Article Antigen-specific MAIT cell subsets involved in TB immunity (INC2P.420)Sakala, Isaac, Kjer-Nielsen, Lars, Eickhoff, Christopher, Wang, Xiaoli, Blazevic, Azra, Liu, Ligong, Fairlie, David, Rossjohn, Jamie, McCluskey, James, Fremont, Daved, Hansen, Ted and Hoft, Daniel (2015). Antigen-specific MAIT cell subsets involved in TB immunity (INC2P.420). The Journal of Immunology, 194 (1_Supplement), 55.14-55.14. doi: 10.4049/jimmunol.194.supp.55.14 |
|
2015 Journal Article Short hydrophobic peptides with cyclic constraints are potent glucagon-like peptide-1 receptor (GLP-1R) agonistsHoang, Huy N., Song, Kun, Hill, Timothy A., Derksen, David R., Edmonds, David J., Kok, W. Mei, Limberakis, Chris, Liras, Spiros, Loria, Paula M., Mascitti, Vincent, Mathiowetz, Alan M., Mitchell, Justin M., Piotrowski, David W., Price, David A., Stanton, Robert V., Suen, Jacky Y., Withka, Jane M., Griffith, David A. and Fairlie, David P. (2015). Short hydrophobic peptides with cyclic constraints are potent glucagon-like peptide-1 receptor (GLP-1R) agonists. Journal of Medicinal Chemistry, 58 (9), 4080-4085. doi: 10.1021/acs.jmedchem.5b00166 |
|
2015 Journal Article Comparing sixteen scoring functions for predicting biological activities of ligands for protein targetsXu, Weijun, Lucke, Andrew J. and Fairlie, David P. (2015). Comparing sixteen scoring functions for predicting biological activities of ligands for protein targets. Journal of Molecular Graphics and Modelling, 57, 76-88. doi: 10.1016/j.jmgm.2015.01.009 |
|
2015 Journal Article Inhibiting histone deacetylase 1 suppresses both inflammation and bone loss in arthritisCantley, Melissa D., Fairlie, David P., Bartold, P. Mark, Marino, Victor, Gupta, Praveer K. and Haynes, David R. (2015). Inhibiting histone deacetylase 1 suppresses both inflammation and bone loss in arthritis. Rheumatology, 54 (9), 1713-1723. doi: 10.1093/rheumatology/kev022 |
|
2015 Journal Article Facile synthesis of mono- and bis-methylated Fmoc-Dap, -Dab and -Orn amino acidsLindahl, Fredrik, Hoang, Huy N., Fairlie, David P. and Cooper, Matthew A. (2015). Facile synthesis of mono- and bis-methylated Fmoc-Dap, -Dab and -Orn amino acids. Chemical Communications, 51 (21), 4496-4498. doi: 10.1039/c4cc09780g |
|
2015 Journal Article Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme systemHalili, Maria A., Bachu, Prabhakar, Lindahl, Fredrik, Bechara, Cherine, Mohanty, Biswaranjan, Reid, Robert C., Scanlon, Martin, Robinson, Carol V., Fairlie, David P. and Martin, Jennifer L. (2015). Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system. ACS Chemical Biology, 10 (4), 957-964. doi: 10.1021/cb500988r |
|
2015 Journal Article Toward peptide-based inhibitors as therapies for Parkinson's diseaseMason, Jody M. and Fairlie, David P. (2015). Toward peptide-based inhibitors as therapies for Parkinson's disease. Future Medicinal Chemistry, 7 (16), 2103-2105. doi: 10.4155/fmc.15.139 |
|
2014 Journal Article Peptide inhibitors of the Escherichia coli DsbA oxidative machinery essential for bacterial virulenceDuprez, Wilko, Premkumar, Lakshmanane, Halili, Maria A., Lindahl, Fredrik, Reid, Robert C., Fairlie, David P. and Martin, Jennifer L. (2014). Peptide inhibitors of the Escherichia coli DsbA oxidative machinery essential for bacterial virulence. Journal of Medicinal Chemistry, 58 (2), 577-587. doi: 10.1021/jm500955s |
|
2014 Journal Article Rational design and synthesis of orally bioavailable peptides guided by NMR amide temperature coefficientsWang, Conan K., Northfield, Susan E., Colless, Barbara, Chaousis, Stephanie, Hamernig, Ingrid, Lohman, Rink-Jan, Nielsen, Daniel S., Schroeder, Christina I., Liras, Spiros, Price, David, A., Fairlie, David and Craik, David J. (2014). Rational design and synthesis of orally bioavailable peptides guided by NMR amide temperature coefficients. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 111 (49), 17504-17509. doi: 10.1073/pnas.1417611111 |
|
2014 Journal Article Potent heterocyclic ligands for human complement C3a receptorReid, Robert C., Yau, Mei-Kwan, Singh, Ranee, Hamidon, Johan K., Lim, Junxian, Stoermer, Martin J. and Fairlie, David P. (2014). Potent heterocyclic ligands for human complement C3a receptor. Journal of Medicinal Chemistry, 57 (20), 8459-8470. doi: 10.1021/jm500956p |
