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2013 Journal Article Downsizing a human inflammatory protein to a small molecule with equal potency and functionalityReid, Robert C., Yau, Mei-Kwan, Singh, Ranee, Hamidon, Johan K., Reed, Anthony N., Chu, Peifei, Suen, Jacky Y., Stoermer, Martin J., Blakeney, Jade S., Lim, Junxian, Faber, Jonathan M. and David P. Fairlie, (2013). Downsizing a human inflammatory protein to a small molecule with equal potency and functionality. Nature Communications, 4 (2802) 2802, 1-9. doi: 10.1038/ncomms3802 |
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2026 Journal Article A Stable Isopterin Mimic of a Potent Bacterial Stimulant of T CellsMak, Jeffrey Y. W., Hoang, Huy N., Awad, Wael, Lim, Xin Yi, Laurie, Damica D., Rivero, Ryan J. D., McCluskey, James, Corbett, Alexandra J., Rossjohn, Jamie and Fairlie, David P. (2026). A Stable Isopterin Mimic of a Potent Bacterial Stimulant of T Cells. Chemistry – A European Journal e71494, e71494. doi: 10.1002/chem.71494 |
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2026 Journal Article The MHC-I related protein 1 MR1 can bind host purine catabolitesAbdelaal, Mohamed R., Lim, Xin Yi, Mak, Jeffrey Y. W., Fairlie, David P., McCluskey, James, Corbett, Alexandra J., Gherardin, Nicholas A., Awad, Wael and Rossjohn, Jamie (2026). The MHC-I related protein 1 MR1 can bind host purine catabolites. Journal of Biological Chemistry 113428, 113428-113428. doi: 10.1016/j.jbc.2026.113428 |
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2026 Journal Article Cytosolic delivery of bacterial metabolites by riboflavin transporters promotes MR1 antigen presentation and MAIT cell recognitionCruz-Gomez, Sebastian, Lim, Hui Jing, Nijagal, Brunda, Yang, Yuting, Lau, Nicole, Mak, Jeffrey Y. W., Fairlie, David P., Newton, Hayley, Salio, Mariolina, Villadangos, Jose A. and McWilliam, Hamish E. G. (2026). Cytosolic delivery of bacterial metabolites by riboflavin transporters promotes MR1 antigen presentation and MAIT cell recognition. Immunology and Cell Biology, 104 (6) imcb.70130, 595-608. doi: 10.1111/imcb.70130 |
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2026 Journal Article Myeloid HDAC7 drives liver inflammation and systemic glucose dysregulation during diet‐induced obesityWang, Yizhuo, Ramnath, Divya, Das Gupta, Kaustav, Prakrithi, P., Bisht, Kavita, Miller, Gregory C., Xiong, Zherui, Wan, Yujun, Tejo, Ellen N., Curson, James E. B., Abrol, Rishika, Keshvari, Sahar, Gunther, Kimberley S., Atkinson, Jordan D., Loh, Zhixuan, Engel, Jessica A., Engwerda, Christian R., Burgener, Sabrina Sofia, Schroder, Kate, Fairlie, David P., Clouston, Andrew D., Powell, Elizabeth E., Irvine, Katharine M., Sullivan, Mitchell A., Lévesque, Jean‐Pierre, Nguyen, Quan, Sweet, Matthew J. and Karunakaran, Denuja (2026). Myeloid HDAC7 drives liver inflammation and systemic glucose dysregulation during diet‐induced obesity. Clinical and Translational Immunology, 15 (6) e70100, 1-20. doi: 10.1002/cti2.70100 |
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2026 Journal Article Utility and limitations of the methyl diaminobenzene-bodipy fluorescent biosensor for detecting methylglyoxal in cellsPonvattanaporn, Rangsima, Le, Jeremy P., Li, Zhimo, Rivero, Ryan J. D., Mak, Jeffrey Y. W., Fairlie, David P., McWilliam, Hamish E. G., Hachani, Abderrahman, Corbett, Alexandra J. and Patton, Timothy (2026). Utility and limitations of the methyl diaminobenzene-bodipy fluorescent biosensor for detecting methylglyoxal in cells. Acs Omega, 11 (22), 33104-33111. doi: 10.1021/acsomega.6c02955 |
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2026 Journal Article Hydroxamic acids as HDAC inhibitor drug leads for malariaDawood, Wisam A., Macdonald, Jacinta R., Anzenhofer, Christian, Skinner-Adams, Tina S., Reid, Robert C., Kurz, Thomas, Fairlie, David P. and Andrews, Katherine T. (2026). Hydroxamic acids as HDAC inhibitor drug leads for malaria. Medicinal Research Reviews med.70055. doi: 10.1002/med.70055 |
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2026 Journal Article Restoration of mucosa-associated invariant T-cell function in healthcare-associated bacterial infections supports recovery of carbapenem efficacy against resistant bacteria ex vivoXue, Yiting, Karim, Asad Mustafa, Sia, Wan Rong, Han, Fei, Chan, Kai Lin, Chua, Nathalie Grace, Hadadi, Leila, Liu, Zhenyu, Mak, Jeffrey Y. W., Fairlie, David P., Wang, Lin-Fa, Sandberg, Johan K., Kwa, Andrea Lay-Hoon and Leeansyah, Edwin (2026). Restoration of mucosa-associated invariant T-cell function in healthcare-associated bacterial infections supports recovery of carbapenem efficacy against resistant bacteria ex vivo. The Journal of Infectious Diseases, 233 (5) jiag151, e1203-e1214. doi: 10.1093/infdis/jiag151 |
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2026 Journal Article Experimenteller Nachweis der metallbezogenen Funktion eines CyanobactinsBaur, Philipp, Hill, Timothy A., Wu, Kai‐Chen, Lim, Junxian, Paterson, Brett M., Velmurugan, Gunasekaran, Degnan, Bernard M., Fairlie, David P. and Comba, Peter (2026). Experimenteller Nachweis der metallbezogenen Funktion eines Cyanobactins. Angewandte Chemie, 138 (25) e8567749. doi: 10.1002/ange.8567749 |
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2026 Journal Article Experimental evidence for a metal-related function of a cyanobactinBaur, Philipp, Hill, Timothy A., Wu, Kai-Chen, Lim, Junxian, Paterson, Brett M., Velmurugan, Gunasekaran, Degnan, Bernard M., Fairlie, David P. and Comba, Peter (2026). Experimental evidence for a metal-related function of a cyanobactin. Angewandte Chemie-International Edition, 65 (25). doi: 10.1002/anie.8567749 |
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2026 Journal Article Mitochondrial fission mediates an evolutionarily conserved antibacterial defense responseKapetanovic, Ronan, Afroz, Syeda Farhana, Curson, James E. B., Kirmes, Ina, Ramnath, Divya, Nothjunge, Stephan, Liu, Jinting, Atkinson, Jordan D., Ahier, Arnaud, Raven, Karoline D., Bosch, Marta, Keller, Bernhard, Lawrence, Grace M. E. P., Gupta, Kaustav Das, Shakespear, Melanie R., Ferguson, Charles, Stocks, Claudia J., Bokil, Nilesh J., Matthias, Gabriele, Nguyen, Tam T. K., Khalil, Zeinab G., Reid, Robert C., Hansford, Karl A., Hansbro, Philip M., Cooper, Matthew A., Schembri, Mark A., Blumenthal, Antje, Schroder, Kate, Fairlie, David P. ... Sweet, Matthew J. (2026). Mitochondrial fission mediates an evolutionarily conserved antibacterial defense response. Science Immunology, 11 (118) eaed2623. doi: 10.1126/sciimmunol.aed2623 |
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2026 Journal Article The NF-κB transcription factor RelA directs mucosal-associated invariant T-cell developmentFulford, Thomas S, Koay, Hui-Fern, Grumont, Raelene, Johnson, Darryl N, Scheer, Sebastian, Nel, Hendrik J, Thomas, Ranjeny, Mak, Jeffrey YW, Fairlie, David P, Teh, Charis E, Gray, Daniel HD, Bryant, Vanessa L, Zaph, Colby, O'Reilly, Lorraine A, Gerondakis, Steven and Godfrey, Dale I (2026). The NF-κB transcription factor RelA directs mucosal-associated invariant T-cell development. Immunology and Cell Biology, 104 (4) imcb.70096, 329-344. doi: 10.1111/imcb.70096 |
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2026 Journal Article Macrophage MR1 antigen presentation promotes MAIT cell immunity and lung microbiota modulationDeng, Jieru, Yan, Yuting, Zhang, Xiaoyue, Walsh, Calum J., Montassier, Emmanuel, Sinha, Debajyoti, Wang, Huimeng, Mousavizadeh, Atieh, Ashayeripanah, Mitra, Mak, Jeffrey Y. W., Koay, Hui-Fern, Poch, Tobias, Alexandre, Yannick O., Mueller, Scott N., Vasanthakumar, Ajithkumar, Stinear, Tim P., Jameson, Vanta J., Perez-Gonzalez, Alexis, Kingham, Jenny, Phan, Tri Giang, Potemkin, Nikita, Dryburgh, Lachlan, Schroeder, Jan, Fairlie, David P., Mackay, Laura K., Chen, Zhenjun, Cook, Laura, Hachani, Abderrahman, Corbett, Alexandra J. ... McWilliam, Hamish E. G. (2026). Macrophage MR1 antigen presentation promotes MAIT cell immunity and lung microbiota modulation. Science, 391 (6782) eadr6322, 1-14. doi: 10.1126/science.adr6322 |
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2025 Journal Article Genome of venomous caterpillar Doratifera vulnerans reveals recruitment of immune peptides and their adaptation as pain-inducing toxinsGoudarzi, Mohaddeseh H., Robinson, Samuel D., Cardoso, Fernanda C., Suryamohan, Kushal, Lawrence, Nicole, Eagles, David A., Hoang, Huy N., Vetter, Irina, Fairlie, David P., Seshagiri, Somasekar, King, Glenn F. and Walker, Andrew A. (2025). Genome of venomous caterpillar Doratifera vulnerans reveals recruitment of immune peptides and their adaptation as pain-inducing toxins. Proceedings of the National Academy of Sciences, 122 (49) e2513640122, 1-11. doi: 10.1073/pnas.2513640122 |
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2025 Journal Article Histone deacetylase 7 mediates lipopolysaccharide-inducible mitochondrial fission in macrophagesAbrol, Rishika, Afroz, Syeda Farhana, Curson, James E. B., Raven, Karoline D., Das Gupta, Kaustav, Gunther, Kimberley S., Jones, Alun, Reid, Robert C., Xiong, Zherui, Gunter, Jennifer H., Engel, Jessica A., Engwerda, Christian R., Blumenthal, Antje, Fairlie, David P., Parton, Robert G., Zuryn, Steven, Kapetanovic, Ronan, Ramnath, Divya and Sweet, Matthew J. (2025). Histone deacetylase 7 mediates lipopolysaccharide-inducible mitochondrial fission in macrophages. Journal of Cell Science, 138 (19) jcs.264376, 1-14. doi: 10.1242/jcs.264376 |
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2025 Journal Article Liver microsome stability of N-methylated cyclic hexapeptides is decreased by the presence of cis-amide bondsHoang, Huy N., Fairlie, David P. and Hill, Timothy A. (2025). Liver microsome stability of N-methylated cyclic hexapeptides is decreased by the presence of cis-amide bonds. Australian Journal of Chemistry, 78 (10) CH25080, 1-8. doi: 10.1071/ch25080 |
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2025 Journal Article A molecular basis underpinning TRBV28+ T cell receptor recognition of MR1-antigenAwad, Wael, Gherardin, Nicholas A., Ciacchi, Lisa, Keller, Andrew N., Liu, Ligong, Fairlie, David P., McCluskey, James, Godfrey, Dale I. and Rossjohn, Jamie (2025). A molecular basis underpinning TRBV28+ T cell receptor recognition of MR1-antigen. Journal of Biological Chemistry, 301 (8) 110416, 1-14. doi: 10.1016/j.jbc.2025.110416 |
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2025 Journal Article Pro-ferroptotic lipids as key control points for caveola formation and disassemblyWu, Yeping, Lim, Ye-Wheen, McMahon, Kerrie-Ann, Martel, Nick, Rae, James, Lo, Harriet P., Gao, Ya, Tillu, Vikas, Larsson, Elin, Lundmark, Richard, Levic, Daniel S., Bagnat, Michel, Lim, Junxian, Fairlie, David P., Pol, Albert, Collins, Brett M., Ariotti, Nicholas, Hall, Thomas E. and Parton, Robert G. (2025). Pro-ferroptotic lipids as key control points for caveola formation and disassembly. Cell Reports, 44 (6) 115789, 115789. doi: 10.1016/j.celrep.2025.115789 |
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2025 Journal Article Hydrolases & Lipases in GtoPdb v.2025.2Alexander, Stephen P. H., Doherty, Patrick, Fairlie, David, Fowler, Christopher J., Overall, Christopher M., Rawlings, Neil, Southan, Christopher and Turner, Anthony J. (2025). Hydrolases & Lipases in GtoPdb v.2025.2. IUPHAR/BPS Guide to Pharmacology CITE, 2025 (2), 1-11. doi: 10.2218/gtopdb/f799/2025.2 |
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2025 Journal Article Herpes simplex virus type 1 impairs mucosal-associated invariant T cellsStern, Lauren, Emanuel, Zoe, Traves, Renee, Willis, Katherine, Purohit, Shivam K., Samer, Carolyn, Mak, Jeffrey Y. W., Fairlie, David P., Tscharke, David C., Corbett, Alexandra J., Abendroth, Allison and Slobedman, Barry (2025). Herpes simplex virus type 1 impairs mucosal-associated invariant T cells. mBio, 16 (5), e0388724. doi: 10.1128/mbio.03887-24 |
