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2021 Journal Article PAR2-induced tissue factor synthesis by primary cultures of human kidney tubular epithelial cells is modified by glucose availabilityHumphries, Tyrone L. R., Shen, Kunyu, Iyer, Abishek, Johnson, David W., Gobe, Glenda C., Nikolic-Paterson, David, Fairlie, David P. and Vesey, David A. (2021). PAR2-induced tissue factor synthesis by primary cultures of human kidney tubular epithelial cells is modified by glucose availability. International Journal of Molecular Sciences, 22 (14) 7532, 1-12. doi: 10.3390/ijms22147532 |
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2021 Journal Article Targeting Class IIa HDACs: insights from henotypes and inhibitorsLiu, Ligong, Dong, Lilong, Bourguet, Erika and Fairlie, David P. (2021). Targeting Class IIa HDACs: insights from henotypes and inhibitors. Current Medicinal Chemistry, 28 (42), 8628-8672. doi: 10.2174/0929867328666210629160647 |
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2021 Journal Article Late‐stage hydrocarbon conjugation and cyclisation in synthetic peptides and proteinsAraujo, Aline D., Nguyen, Huy T. and Fairlie, David P. (2021). Late‐stage hydrocarbon conjugation and cyclisation in synthetic peptides and proteins. ChemBioChem, 22 (10), 1784-1789. doi: 10.1002/cbic.202000796 |
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2021 Journal Article Front Cover: Late‐Stage Hydrocarbon Conjugation and Cyclisation in Synthetic Peptides and Proteins (ChemBioChem 10/2021)Araujo, Aline D., Nguyen, Huy T. and Fairlie, David P. (2021). Front Cover: Late‐Stage Hydrocarbon Conjugation and Cyclisation in Synthetic Peptides and Proteins (ChemBioChem 10/2021). ChemBioChem, 22 (10), 1686-1686. doi: 10.1002/cbic.202100189 |
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2021 Journal Article Expression of protease activated receptor-2 is reduced in renal cell carcinoma biopsies and cell linesMorais, Christudas, Rajandram, Retnagowri, Blakeney, Jade S., Iyer, Abishek, Suen, Jacky Y., Johnson, David W., Gobe, Glenda C., Fairlie, David P. and Vesey, David A. (2021). Expression of protease activated receptor-2 is reduced in renal cell carcinoma biopsies and cell lines. PLoS One, 16 (3) e0248983, e0248983. doi: 10.1371/journal.pone.0248983 |
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2021 Journal Article Identification and phenotype of MAIT cells in cattle and their response to bacterial infectionsEdmans, Matthew D., Connelley, Timothy K., Jayaraman, Siddharth, Vrettou, Christina, Vordermeier, Martin, Mak, Jeffrey Y. W., Liu, Ligong, Fairlie, David P., Maze, Emmanuel Atangana, Chrun, Tiphany, Klenerman, Paul, Eckle, Sidonia B. G., Tchilian, Elma and Benedictus, Lindert (2021). Identification and phenotype of MAIT cells in cattle and their response to bacterial infections. Frontiers in Immunology, 12 627173, 627173. doi: 10.3389/fimmu.2021.627173 |
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2021 Journal Article PAR2 activation on human kidney tubular epithelial cells induces tissue factor synthesis, that enhances blood clottingIyer, Abishek, Humphries, Tyrone L. R., Owens, Evan P., Zhao, Kong-Nan, Masci, Paul P., Johnson, David W., Nikolic-Paterson, David, Gobe, Glenda C., Fairlie, David P. and Vesey, David A. (2021). PAR2 activation on human kidney tubular epithelial cells induces tissue factor synthesis, that enhances blood clotting. Frontiers in Physiology, 12 615428, 615428. doi: 10.3389/fphys.2021.615428 |
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2021 Journal Article Connecting hydrophobic surfaces in cyclic peptides increases membrane permeabilityHoang, Huy N., Hill, Timothy A. and Fairlie, David P. (2021). Connecting hydrophobic surfaces in cyclic peptides increases membrane permeability. Angewandte Chemie International Edition, 60 (15), 8385-8390. doi: 10.1002/anie.202012643 |
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2021 Journal Article Mucosal-associated invariant t cell effector function is an intrinsic cell property that can be augmented by the metabolic cofactor α-ketoglutarateHowson, Lauren J., Li, Jasmine, von Borstel, Anouk, Barugahare, Adele, Mak, Jeffrey Y. W., Fairlie, David P., McCluskey, James, Turner, Stephen J., Davey, Martin S. and Rossjohn, Jamie (2021). Mucosal-associated invariant t cell effector function is an intrinsic cell property that can be augmented by the metabolic cofactor α-ketoglutarate. The Journal of Immunology, 206 (7) ji2001048, 1425-1435. doi: 10.4049/jimmunol.2001048 |
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2021 Journal Article HDAC7 inhibition by phenacetyl and phenylbenzoyl hydroxamatesMak, Jeffrey Y. W., Wu, Kai-Chen, Gupta, Praveer K., Barbero, Sheila, McLaughlin, Maddison G., Lucke, Andrew J., Tng, Jiahui, Lim, Junxian, Loh, Zhixuan, Sweet, Matthew J, Reid, Robert C., Liu, Ligong and Fairlie, David P. (2021). HDAC7 inhibition by phenacetyl and phenylbenzoyl hydroxamates. Journal of Medicinal Chemistry, 64 (4), 2186-2204. doi: 10.1021/acs.jmedchem.0c01967 |
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2021 Journal Article PAR2 induces ovarian cancer cell motility by merging three signalling pathways to transactivate EGFRJiang, Yuhong, Lim, Junxian, Wu, Kai‐Chen, Xu, Weijun, Suen, Jacky Y. and Fairlie, David P. (2021). PAR2 induces ovarian cancer cell motility by merging three signalling pathways to transactivate EGFR. British Journal of Pharmacology, 178 (4) bph.15332, 913-932. doi: 10.1111/bph.15332 |
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2021 Journal Article Mechanotransduction activates RhoA in the neighbors of apoptotic epithelial cells to engage apical extrusionDuszyc, Kinga, Gomez, Guillermo A., Lagendijk, Anne K., Yau, Mei-Kwan, Nanavati, Bageshri Naimish, Gliddon, Briony L., Hall, Thomas E., Verma, Suzie, Hogan, Benjamin M., Pitson, Stuart M., Fairlie, David P., Parton, Robert G. and Yap, Alpha S. (2021). Mechanotransduction activates RhoA in the neighbors of apoptotic epithelial cells to engage apical extrusion. Current Biology, 31 (6), 1326-1336.e5. doi: 10.1016/j.cub.2021.01.003 |
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2021 Journal Article Activation of protease-activated receptor 2 is associated with blood pressure regulation and proteinuria reduction in metabolic syndromeMaruyama-Fumoto, Kana, McGuire, John J., Fairlie, David P., Shinozuka, Kazumasa and Kagota, Satomi (2021). Activation of protease-activated receptor 2 is associated with blood pressure regulation and proteinuria reduction in metabolic syndrome. Clinical and Experimental Pharmacology and Physiology, 48 (2), 211-220. doi: 10.1111/1440-1681.13431 |
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2021 Journal Article Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-MycMadden, Sarah K., de Araujo, Aline Dantas, Gerhardt, Mara, Fairlie, David P. and Mason, Jody M. (2021). Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc. Molecular Cancer, 20 (1) 3, 3. doi: 10.1186/s12943-020-01291-6 |
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2021 Journal Article A nucleotide analog prevents colitis associated cancer via Β-catenin independently of inflammation and autophagySheng, Yong Hua, Giri, Rabina, Davies, Julie, Schreiber, Veronika, Alabbas, Saleh, Movva, Ramya, He, Yaowu, Wu, Andy, Hooper, John, McWhinney, Brett, Oancea, Iulia, Kijanka, Gregor, Hasnain, Sumaira, Lucke, Andrew J., Fairlie, David P., McGuckin, Michael A., Florin, Timothy H. and Begun, Jakob (2021). A nucleotide analog prevents colitis associated cancer via Β-catenin independently of inflammation and autophagy. Cellular and Molecular Gastroenterology and Hepatology, 11 (1), 33-53. doi: 10.1016/j.jcmgh.2020.05.012 |
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2021 Journal Article Fortified coiled coils: enhancing eechanical stability with lactam or metal staplesLópez-García, Patricia, de Araujo, Aline D., Bergues-Pupo, Ana E., Tunn, Isabell, Fairlie, David P. and Blank, Kerstin G. (2021). Fortified coiled coils: enhancing eechanical stability with lactam or metal staples. Angewandte Chemie - International Edition, 60 (1) anie.202006971, 232-236. doi: 10.1002/anie.202006971 |
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2020 Journal Article MR1-restricted T cells with MAIT-like characteristics are functionally conserved in the Pteropid Bat Pteropus alectoLeeansyah, Edwin, Hey, Ying Ying, Sia, Wan Rong, Ng, Justin Han Jia, Gulam, Muhammad Yaaseen, Boulouis, Caroline, Zhu, Feng, Ahn, Matae, Mak, Jeffrey Y.W., Fairlie, David P., Kwa, Andrea Lay Hoon, Sandberg, Johan K. and Wang, Lin-Fa (2020). MR1-restricted T cells with MAIT-like characteristics are functionally conserved in the Pteropid Bat Pteropus alecto. iScience, 23 (12) 101876, 101876. doi: 10.1016/j.isci.2020.101876 |
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2020 Journal Article Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibitionKennedy, Amanda J., Sundström, Linda, Geschwindner, Stefan, Poon, Eunice K. Y., Jiang, Yuhong, Chen, Rongfeng, Cooke, Rob, Johnstone, Shawn, Madin, Andrew, Lim, Junxian, Liu, Qingqi, Lohman, Rink-Jan, Nordqvist, Anneli, Fridén-Saxin, Maria, Yang, Wenzhen, Brown, Dean G., Fairlie, David P. and Dekker, Niek (2020). Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition. Communications Biology, 3 (1) 782, 782. doi: 10.1038/s42003-020-01504-0 |
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2020 Journal Article Artificially induced MAIT cells inhibit M. bovis BCG but not M. tuberculosis during in vivo pulmonary infectionYu, Huifeng, Yang, Amy, Derrick, Steven, Mak, Jeffrey Y. W., Liu, Ligong, Fairlie, David P. and Cowley, Siobhan (2020). Artificially induced MAIT cells inhibit M. bovis BCG but not M. tuberculosis during in vivo pulmonary infection. Scientific Reports, 10 (1) 13579, 13579. doi: 10.1038/s41598-020-70615-9 |
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2020 Journal Article Mechanische Verstärkung von Coiled Coils mit Lactam und Histidin‐Metall‐KlammernLópez‐García, Patricia, Araujo, Aline D., Bergues‐Pupo, Ana E., Tunn, Isabell, Fairlie, David P. and Blank, Kerstin G. (2020). Mechanische Verstärkung von Coiled Coils mit Lactam und Histidin‐Metall‐Klammern. Angewandte Chemie, 133 (1), 234-239. doi: 10.1002/ange.202006971 |
