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2018

Journal Article

Chemically Diverse Helix-Constrained Peptides Using Selenocysteine Crosslinking

Dantas de Araujo, Aline, Perry, Samuel R. and Fairlie, David P. (2018). Chemically Diverse Helix-Constrained Peptides Using Selenocysteine Crosslinking. Organic Letters, 20 (5), 1453-1456. doi: 10.1021/acs.orglett.8b00233

Chemically Diverse Helix-Constrained Peptides Using Selenocysteine Crosslinking

2018

Journal Article

Human blood MAIT cell subsets defined using MR1 tetramers

Gherardin, Nicholas A., Souter, Michael N. T., Koay, Hui-Fern, Mangas, Kirstie M., Seemann, Torsten, Stinear, Timothy P., Eckle, Sidonia B. G., Berzins, Stuart P., d'Udekem, Yves, Konstantinov, Igor E., Fairlie, David P., Ritchie, David S., Neeson, Paul J., Pellicci, Daniel G., Uldrich, Adam P., McCluskey, James and Godfrey, Dale I. (2018). Human blood MAIT cell subsets defined using MR1 tetramers. Immunology and Cell Biology, 96 (5), 507-525. doi: 10.1111/imcb.12021

Human blood MAIT cell subsets defined using MR1 tetramers

2018

Journal Article

A potent antagonist of protease-activated receptor 2 that inhibits multiple signaling functions in human cancer cells

Jiang, Yuhong, Yau, Mei-Kwan, Lim, Junxian, Wu, Kai-Chen, Xu, Weijun, Suen, Jacky Y and Fairlie, David P (2018). A potent antagonist of protease-activated receptor 2 that inhibits multiple signaling functions in human cancer cells. The Journal of pharmacology and experimental therapeutics, 364 (2), 246-257. doi: 10.1124/jpet.117.245027

A potent antagonist of protease-activated receptor 2 that inhibits multiple signaling functions in human cancer cells

2018

Journal Article

Mucosal-Associated Invariant T Cells Augment Immunopathology and Gastritis in Chronic Helicobacter pylori Infection

D'Souza, Criselle, Pediongco, Troi, Wang, Huimeng, Scheerlinck, Jean-Pierre Y., Kostenko, Lyudmila, Esterbauer, Robyn, Stent, Andrew W., Eckle, Sidonia B. G., Meehan, Bronwyn S., Strugnell, Richard A., Cao, Hanwei, Liu, Ligong, Mak, Jeffrey Y. W., Lovrecz, George, Lu, Louis, Fairlie, David P., Rossjohn, Jamie, McCluskey, James, Every, Alison L., Chen, Zhenjun and Corbett, Alexandra J. (2018). Mucosal-Associated Invariant T Cells Augment Immunopathology and Gastritis in Chronic Helicobacter pylori Infection. Journal of Immunology, 200 (5), 1901-1916. doi: 10.4049/jimmunol.1701512

Mucosal-Associated Invariant T Cells Augment Immunopathology and Gastritis in Chronic Helicobacter pylori Infection

2018

Journal Article

Contiguous hydrophobic and charged surface patches in short helix-constrained peptides drive cell permeability

Perry, Samuel R, Hill, Timothy A, de Araujo, Aline D, Hoang, Huy N and Fairlie, David P (2018). Contiguous hydrophobic and charged surface patches in short helix-constrained peptides drive cell permeability. Organic & biomolecular chemistry, 16 (3), 367-371. doi: 10.1039/c7ob02952g

Contiguous hydrophobic and charged surface patches in short helix-constrained peptides drive cell permeability

2018

Conference Publication

Stereoelectronic effects on dienophile separation influence the Diels–Alder synthesis of molecular clefts

Stoermer, Martin J., Wickramasinghe, Wasantha A., Byriel, Karl A., Hockless, David C. R., Skelton, Brian W., Sobolev, Alexandre N., White, Alan H., Mak, Jeffrey Y. W. and Fairlie, David P. (2018). Stereoelectronic effects on dienophile separation influence the Diels–Alder synthesis of molecular clefts. 2018 Royal Society of Chemistry Twitter Conference, London, United Kingdom (held online), 6-7 March 2018. London, United Kingdom: Royal Society of Chemistry.

Stereoelectronic effects on dienophile separation influence the Diels–Alder synthesis of molecular clefts

2018

Journal Article

Chemical approaches to modulating complement-mediated diseases

Iyer, Abishek, Xu, Weijun, Reid, Robert C and Fairlie, David P (2018). Chemical approaches to modulating complement-mediated diseases. Journal of Medicinal Chemistry, 61 (8), 3253-3276. doi: 10.1021/acs.jmedchem.7b00882

Chemical approaches to modulating complement-mediated diseases

2018

Conference Publication

RNA-sequencing analysis of biopsies from chronic liver disease patients identifies gene signatures associated with progressive liver disease

Ramnath, D., Irvine, K., Lukowski, S., Horsfall, L., Loh, K., Clouston, A., Patel, P., Iyer, A., Lampe, G., Stow, J., Schroder, K., Fairlie, D., Powell, J., Powell, E. and Sweet, M. (2018). RNA-sequencing analysis of biopsies from chronic liver disease patients identifies gene signatures associated with progressive liver disease. International Liver Congress (ILC), Paris, France, 11-15 April, 2018. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/S0168-8278(18)31040-7

RNA-sequencing analysis of biopsies from chronic liver disease patients identifies gene signatures associated with progressive liver disease

2018

Conference Publication

Recipient mucosal-associated invariant T cells control graft-versus-host-disease within the colon

Varelias, Antiopi, Bunting, Mark, Ormerod, Kate, Koyama, Motoko, Olver, Stuart, Straube, Jasmin, Kuns, Rachel, Robb, Renee, Henden, Andrea, Cooper, Leanne, Lachner, Nancy, Gartlan, Kate, Lantz, Olivier J., Kjer-Nielsen, Lars, Mak, Jeffrey, Fairlie, David, Clouston, Andrew, McCluskey, James, Rossjohn, Jamie, Lane, Steven, Hugenholtz, Phil and Hill, Geoff (2018). Recipient mucosal-associated invariant T cells control graft-versus-host-disease within the colon. Immunology Meeting, Austin Tx, 4-8 May 2018. Bethesda, MD United States: American Association of Immunologists.

Recipient mucosal-associated invariant T cells control graft-versus-host-disease within the colon

2018

Conference Publication

PAR-2 does not contribute to tubular damage or renal fibrosis in the obstructed kidney

Han, Y., Ma, F., Ozols, E., Chew, P., Vesey, D., Gobe, G., Morais, C., Lohman, R., Suen, J., Fairlie, D. and Nikolic-Paterson, D. (2018). PAR-2 does not contribute to tubular damage or renal fibrosis in the obstructed kidney. 54th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Sydney, Australia, 8–12 September 2018. Richmond, VIC, Australia: Wiley-Blackwell. doi: 10.1111/nep.13441

PAR-2 does not contribute to tubular damage or renal fibrosis in the obstructed kidney

2017

Journal Article

Stereoelectronic Effects on Dienophile Separation Influence the Diels–Alder Synthesis of Molecular Clefts

Stoermer, Martin J., Wickramasinghe, Wasantha A., Byriel, Karl A., Hockless, David C. R., Skelton, Brian W., Sobolev, Alexandre N., White, Allan H., Mak, Jeffrey Y. W. and Fairlie, David P. (2017). Stereoelectronic Effects on Dienophile Separation Influence the Diels–Alder Synthesis of Molecular Clefts. European Journal of Organic Chemistry, 2017 (45), 6793-6796. doi: 10.1002/ejoc.201701319

Stereoelectronic Effects on Dienophile Separation Influence the Diels–Alder Synthesis of Molecular Clefts

2017

Journal Article

Protease activated receptor 2 controls myelin development, resiliency and repair

Yoon, Hyesook, Radulovic, Maja, Walters, Grant, Paulsen, Alex R., Drucker, Kristen, Starski, Phillip, Wu, Jianmin, Fairlie, David P. and Scarisbrick, Isobel A. (2017). Protease activated receptor 2 controls myelin development, resiliency and repair. GLIA, 65 (12), 2070-2086. doi: 10.1002/glia.23215

Protease activated receptor 2 controls myelin development, resiliency and repair

2017

Journal Article

Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun

Baxter, Daniel, Perry, Samuel R., Hill, Timothy A., Kok, W. Mei, Zaccai, Nathan R., Brady, R. Leo, Fairlie, David P. and Mason, Jody M. (2017). Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun. ACS Chemical Biology, 12 (8), 2051-2061. doi: 10.1021/acschembio.7b00303

Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun

2017

Journal Article

Quinazolinone derivatives as inhibitors of homologous recombinase RAD51

Ward, Ambber, Dong, Lilong, Harris, Jonathan M., Khanna, Kum Kum, Al-Ejeh, Fares, Fairlie, David P., Wiegmans, Adrian P. and Liu, Ligong (2017). Quinazolinone derivatives as inhibitors of homologous recombinase RAD51. Bioorganic and Medicinal Chemistry Letters, 27 (14), 3096-3100. doi: 10.1016/j.bmcl.2017.05.039

Quinazolinone derivatives as inhibitors of homologous recombinase RAD51

2017

Journal Article

Orally absorbed cyclic peptides

Nielsen, Daniel S., Shepherd, Nicholas E., Xu, Weijun, Lucke, Andrew J., Stoermer, Martin J. and Fairlie, David P. (2017). Orally absorbed cyclic peptides. Chemical Reviews, 117 (12), 8094-8128. doi: 10.1021/acs.chemrev.6b00838

Orally absorbed cyclic peptides

2017

Journal Article

Europium-labeled synthetic C3a protein as a novel fluorescent probe for human complement C3a receptor

Dantas de Araujo, Aline, Wu, Chongyang, Wu, Kai-Chen, Reid, Robert C., Durek, Thomas, Lim, Junxian and Fairlie, David P. (2017). Europium-labeled synthetic C3a protein as a novel fluorescent probe for human complement C3a receptor. Bioconjugate Chemistry, 28 (6), 1669-1676. doi: 10.1021/acs.bioconjchem.7b00132

Europium-labeled synthetic C3a protein as a novel fluorescent probe for human complement C3a receptor

2017

Journal Article

Biased signaling by agonists of protease activated receptor 2

Jiang, Yuhong, Yau, Mei-Kwan, Kok, W. Mei, Lim, Junxian, Wu, Kai-Chen, Liu, Ligong, Hill, Timothy A., Suen, Jacky Y. and Fairlie, David P. (2017). Biased signaling by agonists of protease activated receptor 2. ACS Chemical Biology, 12 (5), 1217-1226. doi: 10.1021/acschembio.6b01088

Biased signaling by agonists of protease activated receptor 2

2017

Journal Article

Tolyporphin macrocycles from the cyanobacterium Tolypothrix nodosa selectively bind copper and silver and reverse multidrug resistance

Prinsep, Michele R., Appleton, Trevor G., Hanson, Graeme R., Lane, Ian, Smith, Charles D., Puddick, Jonathan and Fairlie, David P. (2017). Tolyporphin macrocycles from the cyanobacterium Tolypothrix nodosa selectively bind copper and silver and reverse multidrug resistance. Inorganic Chemistry, 56 (10), 5577-5585. doi: 10.1021/acs.inorgchem.6b03000

Tolyporphin macrocycles from the cyanobacterium Tolypothrix nodosa selectively bind copper and silver and reverse multidrug resistance

2017

Journal Article

Insecticidal activities of histone deacetylase inhibitors against a dipteran parasite of sheep, Lucilia cuprina

Bagnall, Neil H., Hines, Barney M., Lucke, Andrew J., Gupta, Praveer K., Reid, Robert C., Fairlie, David P. and Kotze, Andrew C. (2017). Insecticidal activities of histone deacetylase inhibitors against a dipteran parasite of sheep, Lucilia cuprina. International Journal for Parasitology: Drugs and Drug Resistance, 7 (1), 51-60. doi: 10.1016/j.ijpddr.2017.01.001

Insecticidal activities of histone deacetylase inhibitors against a dipteran parasite of sheep, Lucilia cuprina

2017

Journal Article

The ribosomal protein S19 suppresses antitumor immune responses via the complement C5a receptor 1

Markiewski, Maciej M., Vadrevu, Surya Kumari, Sharma, Sharad K., Chintala, Navin Kumar, Ghouse, Shanawaz, Cho, Jun-Hung, Fairlie, David P., Paterson, Yvonne, Astrinidis, Aristotelis and Karbowniczek, Magdalena (2017). The ribosomal protein S19 suppresses antitumor immune responses via the complement C5a receptor 1. Journal of Immunology, 198 (7), 2989-2999. doi: 10.4049/jimmunol.1602057

The ribosomal protein S19 suppresses antitumor immune responses via the complement C5a receptor 1