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2020 Other Outputs Priming programed Mucosal-Associated Invariant T cells protect against systemic or local bacterial infectionZhao, Zhe, Shi, Mai, Zhu, Tianyuan, Wang, Huimeng, Pediongco, Troi, Lim, Xin Yi, Meehan, Bronwyn, Nelson, Adam, Fairlie, David, Mak, Jeffrey, Eckle, Sidonia, Rossjohn, Jamie, McCluskey, James, Corbett, Alexandra and Chen, Zhenjun (2020). Priming programed Mucosal-Associated Invariant T cells protect against systemic or local bacterial infection. doi: 10.21203/rs.3.rs-39302/v1 |
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2020 Journal Article Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coliBoulouis, Caroline, Sia, Wan Rong, Gulam, Muhammad Yaaseen, Teo, Jocelyn Qi Min, Png, Yi Tian, Phan, Thanh Kha, Mak, Jeffrey Y. W., Fairlie, David P., Poon, Ivan K. H., Koh, Tse Hsien, Bergman, Peter, Lim, Chwee Ming, Wang, Lin-Fa, Kwa, Andrea Lay Hoon, Sandberg, Johan K. and Leeansyah, Edwin (2020). Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli. PLoS Biology, 18 (6) e3000644, e3000644. doi: 10.1371/journal.pbio.3000644 |
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2020 Journal Article Systemic delivery of peptides by the oral route: formulation and medicinal chemistry approachesBrayden, D. J., Hill, T. A., Fairlie, D. P., Maher, S. and Mrsny, R. J. (2020). Systemic delivery of peptides by the oral route: formulation and medicinal chemistry approaches. Advanced Drug Delivery Reviews, 157, 2-36. doi: 10.1016/j.addr.2020.05.007 |
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2020 Journal Article A divergent transcriptional landscape underpins the development and functional branching of MAIT cellsKoay, Hui Fern, Su, Shian, Amann-Zalcenstein, Daniela, Daley, Stephen R, Comerford, Iain, Whyte, Carly E, Konstantinov, Igor E, d’Udekem, Yves, Baldwin, Tracey, Hickey, Peter F, Berzins, Stuart P, Mak, Jeffrey Y.W., Kallies, Axel, Chen, Zhenjun, Nussing, Simone, Kedzierska, Katherine, Mackay, Laura K, McColl, Shaun R, Deenick, Elissa K, Fairlie, David P, McCluskey, James, Goodnow, Christopher C, Ritchie, Matthew E, Belz, Gabrielle T, Naik, Shalin H, Pellicci, Daniel G and Godfrey, Dale I (2020). A divergent transcriptional landscape underpins the development and functional branching of MAIT cells. The Journal of Immunology, 204 (1_Supplement), 223.8-223.8. doi: 10.4049/jimmunol.204.supp.223.8 |
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2020 Journal Article Virus-mediated suppression of the antigen presentation molecule MR1McSharry, Brian P., Samer, Carolyn, McWilliam, Hamish E.G., Ashley, Caroline L., Yee, Michael B., Steain, Megan, Liu, Ligong, Fairlie, David P., Kinchington, Paul R., McCluskey, James, Abendroth, Allison, Villadangos, Jose A., Rossjohn, Jamie and Slobedman, Barry (2020). Virus-mediated suppression of the antigen presentation molecule MR1. Cell Reports, 30 (9), 2948-2962.e4. doi: 10.1016/j.celrep.2020.02.017 |
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2020 Journal Article Class IIa histone deacetylases drive toll-like receptor-inducible glycolysis and macrophage inflammatory responses via pyruvate kinase M2Das Gupta, Kaustav, Shakespear, Melanie R., Curson, James E.B., Murthy, Ambika M.V., Iyer, Abishek, Hodson, Mark P., Ramnath, Divya, Tillu, Vikas A., von Pein, Jessica B., Reid, Robert C., Tunny, Kathryn, Hohenhaus, Daniel M., Moradi, Shayli Varasteh, Kelly, Gregory M., Kobayashi, Takumi, Gunter, Jennifer H., Stevenson, Alexander J., Xu, Weijun, Luo, Lin, Jones, Alun, Johnston, Wayne A., Blumenthal, Antje, Alexandrov, Kirill, Collins, Brett M., Stow, Jennifer L., Fairlie, David P. and Sweet, Matthew J. (2020). Class IIa histone deacetylases drive toll-like receptor-inducible glycolysis and macrophage inflammatory responses via pyruvate kinase M2. Cell Reports, 30 (8), 2712-2728.e8. doi: 10.1016/j.celrep.2020.02.007 |
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2020 Journal Article Potent thiophene antagonists of human complement C3a receptor with anti-inflammatory activityRowley, Jessica A., Reid, Robert C., Poon, Eunice K. Y., Wu, Kai-Chen, Lim, Junxian, Lohman, Rink-Jan, Hamidon, Johan K., Yau, Mei-Kwan, Halili, Maria A., Durek, Thomas, Iyer, Abishek and Fairlie, David P. (2020). Potent thiophene antagonists of human complement C3a receptor with anti-inflammatory activity. Journal of Medicinal Chemistry, 63 (2) acs.jmedchem.9b00927, 529-541. doi: 10.1021/acs.jmedchem.9b00927 |
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2020 Journal Article Correction: Twists or turns: stabilising alpha vs. beta turns in tetrapeptidesHoang, Huy N., Hill, Timothy A., Ruiz-Gómez, Gloria, Diness, Frederik, Mason, Jody M., Wu, Chongyang, Abbenante, Giovanni, Shepherd, Nicholas E. and Fairlie, David P. (2020). Correction: Twists or turns: stabilising alpha vs. beta turns in tetrapeptides. Chemical Science, 11 (28), 7511-7511. doi: 10.1039/d0sc90138e |
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2020 Journal Article High cell permeability does not predict oral bioavailability for analogues of cyclic heptapeptide sanguinamide ANielsen, Daniel S., Lohman, Rink-Jan, Hoang, Huy N., Fairlie, David P. and Hill, Timothy A. (2020). High cell permeability does not predict oral bioavailability for analogues of cyclic heptapeptide sanguinamide A. Australian Journal of Chemistry, 73 (4), 344-351. doi: 10.1071/ch19479 |
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2020 Journal Article MAIT cells promote tumor initiation, growth and metastases via tumor MR1Yan, Juming, Allen, Stacey, McDonald, Elizabeth, Das, Indrajit, Mak, Jeffrey Y. W., Liu, Ligong, Fairlie, David P., Meehan, Bronwyn S., Chen, Zhenjun, Corbett, Alexandra J., Varelias, Antiopi, Smyth, Mark J. and Teng, Michele W. L. (2020). MAIT cells promote tumor initiation, growth and metastases via tumor MR1. Cancer Discovery, 10 (1), 124-141. doi: 10.1158/2159-8290.cd-19-0569 |
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2019 Journal Article A class of gamma delta T cell receptors recognize the underside of the antigen-presenting molecule MR1Le Nours, Jerome, Gherardin, Nicholas A., Ramarathinam, Sri H., Awad, Wael, Wiede, Florian, Gully, Benjamin S., Khandokar, Yogesh, Praveena, T., Wubben, Jacinta M., Sandow, Jarrod J., Webb, Andrew I., von Borstel, Anouk, Rice, Michael T., Redmond, Samuel J., Seneviratna, Rebecca, Sandoval-Romero, Maria L., Li, Shihan, Souter, Michael N. T., Eckle, Sidonia B. G., Corbett, Alexandra J., Reid, Hugh H., Liu, Ligong, Fairlie, David P., Giles, Edward M., Westall, Glen P., Tothill, Richard W., Davey, Martin S., Berry, Richard, Tiganis, Tony ... Rossjohn, Jamie (2019). A class of gamma delta T cell receptors recognize the underside of the antigen-presenting molecule MR1. Science, 366 (6472), 1522-1527. doi: 10.1126/science.aav3900 |
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2019 Journal Article A novel long‐range n to π* interaction secures the smallest known α‐helix in waterHoang, Huy N., Wu, Chongyang, Hill, Timothy A., Dantas de Araujo, Aline, Bernhardt, Paul V., Liu, Ligong and Fairlie, David P. (2019). A novel long‐range n to π* interaction secures the smallest known α‐helix in water. Angewandte Chemie, 131 (52), 19049-19053. doi: 10.1002/ange.201911277 |
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2019 Journal Article Characterization of human Mucosal-associated Invariant T (MAIT) cellsSouter, Michael N.T., Loh, Liyen, Li, Shihan, Meehan, Bronwyn S., Gherardin, Nicholas A., Godfrey, Dale I., Rossjohn, Jamie, Fairlie, David P., Kedzierska, Katherine, Pellicci, Daniel G., Chen, Zhenjun, Kjer-Nielsen, Lars, Corbett, Alexandra J., McCluskey, James and Eckle, Sidonia B. G. (2019). Characterization of human Mucosal-associated Invariant T (MAIT) cells. Current Protocols in Immunology, 127 (1) e90, e90. doi: 10.1002/cpim.90 |
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2019 Journal Article Characterization and purification of Mouse Mucosal-Associated Invariant T (MAIT) cellsChen, Zhenjun, Wang, Huimeng, D'Souza, Criselle, Koay, Hui-Fern, Meehan, Bronwyn, Zhao, Zhe, Pediongco, Troi, Shi, Mai, Zhu, Tianyuan, Wang, Bingjie, Kjer-Nielsen, Lars, Eckle, Sidonia B. G., Rossjohn, Jamie, Fairlie, David P., Godfrey, Dale I., Strugnell, Richard A., McCluskey, James and Corbett, Alexandra J. (2019). Characterization and purification of Mouse Mucosal-Associated Invariant T (MAIT) cells. Current Protocols in Immunology, 127 (1) e89, e89. doi: 10.1002/cpim.89 |
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2019 Journal Article A divergent transcriptional landscape underpins the development and functional branching of MAIT cellsKoay, H-. F., Su, S., Amann-Zalcenstein, D., Daley, S. R., Comerford, I., Miosge, L., Whyte, C. E., Konstantinov, I. E., d'Udekem, Y., Baldwin, T., Hickey, P. F., Berzins, S. P., Mak, J. Y. W., Sontani, Y., Roots, C. M., Sidwell, T., Kallies, A., Chen, Z., Nüssing, S., Kedzierska, K., Mackay, L. K., McColl, S. R., Deenick, E. K., Fairlie, D. P., McCluskey, J., Goodnow, C. C., Ritchie, M. E., Belz, G. T., Naik, S. H. ... Godfrey, D. I. (2019). A divergent transcriptional landscape underpins the development and functional branching of MAIT cells. Science Immunology, 4 (41) eaay6039, eaay6039. doi: 10.1126/sciimmunol.aay6039 |
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2019 Journal Article IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infectionWang, Huimeng, Kjer-Nielsen, Lars, Shi, Mai, D'Souza, Criselle, Pediongco, Troi J., Cao, Hanwei, Kostenko, Lyudmila, Lim, Xin Yi, Eckle, Sidonia B. G., Meehan, Bronwyn S., Zhu, Tianyuan, Wang, Bingjie, Zhao, Zhe, Mak, Jeffrey Y. W., Fairlie, David P., Teng, Michele W. L., Rossjohn, Jamie, Yu, Di, de St Groth, Barbara Fazekas, Lovrecz, George, Lu, Louis, McCluskey, James, Strugnell, Richard A., Corbett, Alexandra J. and Chen, Zhenjun (2019). IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection. Science Immunology, 4 (41) eaaw0402, eaaw0402. doi: 10.1126/sciimmunol.aaw0402 |
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2019 Journal Article Mirror image pairs of cyclic hexapeptides have different oral bioavailabilities and metabolic stabilitiesLohman, Rink-Jan, Nielsen, Daniel S., Kok, W. Mei, Hoang, Huy N., Hill, Timothy A. and Fairlie, David P. (2019). Mirror image pairs of cyclic hexapeptides have different oral bioavailabilities and metabolic stabilities. Chemical Communications, 55 (89), 13362-13365. doi: 10.1039/c9cc06234c |
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2019 Journal Article Computer modelling and synthesis of deoxy and monohydroxy analogues of a ribitylaminouracil bacterial metabolite that potently activates human T cellsLer, Geraldine J. M., Xu, Weijun, Mak, Jeffrey Y. W., Liu, Ligong, Bernhardt, Paul V. and Fairlie, David P (2019). Computer modelling and synthesis of deoxy and monohydroxy analogues of a ribitylaminouracil bacterial metabolite that potently activates human T cells. Chemistry – A European Journal, 25 (68) chem.201903732, 15594-15608. doi: 10.1002/chem.201903732 |
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2019 Journal Article Protease-activated receptor 2 does not contribute to renal inflammation or fibrosis in the obstructed kidneyMa, Frank Y., Han, Yingjie, Ozols, Elyce, Chew, Phyllis, Vesey, David A., Gobe, Glenda C., Morais, Christudas, Lohman, Rink-Jan, Suen, Jacky Y., Johnson, David W., Fairlie, David P. and Nikolic-Paterson, David J. (2019). Protease-activated receptor 2 does not contribute to renal inflammation or fibrosis in the obstructed kidney. Nephrology, 24 (9) nep.13635, 983-991. doi: 10.1111/nep.13635 |
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2019 Journal Article Diverse MR1-restricted T cells in mice and humansKoay, Hui-Fern, Gherardin, Nicholas A., Xu, Calvin, Seneviratna, Rebecca, Zhao, Zhe, Chen, Zhenjun, Fairlie, David P., McCluskey, James, Pellicci, Daniel G., Uldrich, Adam P. and Godfrey, Dale I. (2019). Diverse MR1-restricted T cells in mice and humans. Nature Communications, 10 (1) 2243, 2243. doi: 10.1038/s41467-019-10198-w |
