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2023 Journal Article Selective carbon-hydrogen bond hydroxylation using an engineered cytochrome P450 peroxygenaseAkter, Jinia, Stockdale, Tegan P., Child, Stella A., Lee, Joel H. Z., De Voss, James J. and Bell, Stephen G. (2023). Selective carbon-hydrogen bond hydroxylation using an engineered cytochrome P450 peroxygenase. Journal of Inorganic Biochemistry, 244 112209, 1-9. doi: 10.1016/j.jinorgbio.2023.112209 |
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2023 Journal Article The bacterial cytochrome P450 (CYP) CYP125 enzymes can competitively oxidise sitosterol in the presence of cholesterolDoherty, Daniel Z., Ghith, Amna, Ho, Ava, De Voss, James J. and Bell, Stephen G. (2023). The bacterial cytochrome P450 (CYP) CYP125 enzymes can competitively oxidise sitosterol in the presence of cholesterol. Chemical Communications, 59 (61), 9392-9395. doi: 10.1039/d3cc02312e |
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2023 Journal Article Characterization of the cholesterol biosynthetic pathway in Dioscorea transversaSalisbury, Lauren J., Fletcher, Stephen J., Stok, Jeanette E., Churchman, Luke R., Blanchfield, Joanne T. and De Voss, James J. (2023). Characterization of the cholesterol biosynthetic pathway in Dioscorea transversa. Journal of Biological Chemistry, 299 (6) 104768, 1-16. doi: 10.1016/j.jbc.2023.104768 |
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2023 Journal Article Engineering C–C bond cleavage activity into a P450 monooxygenase enzymeMiller, Justin C., Lee, Joel H. Z., Mclean, Mark A., Chao, Rebecca R., Stone, Isobella S. J., Pukala, Tara L., Bruning, John B., De Voss, James J., Schuler, Mary A., Sligar, Stephen G. and Bell, Stephen G. (2023). Engineering C–C bond cleavage activity into a P450 monooxygenase enzyme. Journal of the American Chemical Society, 145 (16), 9207-9222. doi: 10.1021/jacs.3c01456 |
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2023 Journal Article Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteriaMu, Andre, Klare, William P., Baines, Sarah L., Ignatius Pang, C. N., Guérillot, Romain, Harbison-Price, Nichaela, Keller, Nadia, Wilksch, Jonathan, Nhu, Nguyen Thi Khanh, Phan, Minh-Duy, Keller, Bernhard, Nijagal, Brunda, Tull, Dedreia, Dayalan, Saravanan, Chua, Hwa Huat Charlie, Skoneczny, Dominik, Koval, Jason, Hachani, Abderrahman, Shah, Anup D., Neha, Nitika, Jadhav, Snehal, Partridge, Sally R., Cork, Amanda J., Peters, Kate, Bertolla, Olivia, Brouwer, Stephan, Hancock, Steven J., Álvarez-Fraga, Laura, De Oliveira, David M. P. ... Walker, Mark J. (2023). Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria. Nature Communications, 14 (1) 1530, 1-21. doi: 10.1038/s41467-023-37200-w |
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2023 Journal Article Cymredoxin, a [2Fe–2S] ferredoxin, supports catalytic activity of the p-cymene oxidising P450 enzyme CYP108N12Giang, Peter D., Churchman, Luke R., Stok, Jeanette E., Bell, Stephen G. and De Voss, James J. (2023). Cymredoxin, a [2Fe–2S] ferredoxin, supports catalytic activity of the p-cymene oxidising P450 enzyme CYP108N12. Archives of Biochemistry and Biophysics, 737 109549, 109549. doi: 10.1016/j.abb.2023.109549 |
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2022 Journal Article Investigating the active oxidants involved in cytochrome P450 catalyzed sulfoxidation reactionsPodgorski, Matthew N., Coleman, Tom, Churchman, Luke R., Bruning, John B., De Voss, James J. and Bell, Stephen G. (2022). Investigating the active oxidants involved in cytochrome P450 catalyzed sulfoxidation reactions. Chemistry: A European Journal, 28 (72) e202202428, 1-12. doi: 10.1002/chem.202202428 |
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2022 Journal Article Exploring the factors which result in cytochrome P450 catalyzed desaturation versus hydroxylationColeman, Tom, Doherty, Daniel Z., Zhang, Ting, Podgorski, Matthew N., Qiao, Ruihong, Lee, Joel H. Z., Bruning, John B., De Voss, James J., Zhou, Weihong and Bell, Stephen G. (2022). Exploring the factors which result in cytochrome P450 catalyzed desaturation versus hydroxylation. Chemistry - An Asian Journal, 17 (24) e202200986, 1-14. doi: 10.1002/asia.202200986 |
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2022 Journal Article Enabling aromatic hydroxylation in a cytochrome P450 monooxygenase rnzyme through protein engineeringColeman, Tom, Lee, Joel, Kirk, Alicia M, Doherty, Daniel Z, Podgorski, Matthew N, Pinidiya, Dilshi K, Bruning, John B, De Voss, James J, Krenske, Elizabeth H and Bell, Stephen Graham (2022). Enabling aromatic hydroxylation in a cytochrome P450 monooxygenase rnzyme through protein engineering. Chemistry: A European Journal, 28 (67) e202201895, 1-14. doi: 10.1002/chem.202201895 |
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2022 Journal Article CYP108N12 initiates p-cymene biodegradation in Rhodococcus globerulusGiang, Peter D., Churchman, Luke R., Stok, Jeanette E., Soo, Rochelle M. and De Voss, James J. (2022). CYP108N12 initiates p-cymene biodegradation in Rhodococcus globerulus. Archives of Biochemistry and Biophysics, 730 109410, 109410. doi: 10.1016/j.abb.2022.109410 |
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2022 Journal Article Phytochemical composition of Denhamia obscura (A. Rich.) Meisn. Ex Walp. root bark, seeds and leavesJesus, Matheus Carpinelli De, Wapling, Johanna, Kiem, Eunice, Stockdale, Tegan, Whittaker, Jacob J., Clegg, Jack K., Leach, David, Church, Taylah, Collins, Raelene, Leach, Greg, Hewitt, David, De Voss, James J. and Blanchfield, Joanne T. (2022). Phytochemical composition of Denhamia obscura (A. Rich.) Meisn. Ex Walp. root bark, seeds and leaves. Arkivoc, 2022 (4), 123-142. doi: 10.24820/ark.5550190.p011.828 |
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2022 Journal Article Synthesis of obtusifoliol and analogues as CYP51 substratesChurchman, Luke R., Salisbury, Lauren J. and De Voss, James J. (2022). Synthesis of obtusifoliol and analogues as CYP51 substrates. Organic and Biomolecular Chemistry, 20 (36), 7316-7324. doi: 10.1039/d2ob01307j |
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2022 Journal Article The structures of the steroid binding CYP142 cytochrome P450 enzymes from Mycobacterium ulcerans and Mycobacterium marinumGhith, Amna, Doherty, Daniel Z., Bruning, John B., Russell, Robert A., De Voss, James J. and Bell, Stephen G. (2022). The structures of the steroid binding CYP142 cytochrome P450 enzymes from Mycobacterium ulcerans and Mycobacterium marinum. ACS Infectious Diseases, 8 (8), 1606-1617. doi: 10.1021/acsinfecdis.2c00215 |
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2022 Journal Article The cytochrome P450 OxyA from the kistamicin biosynthesis cyclization cascade is highly sensitive to oxidative damageGreule, Anja, Izoré, Thierry, Machell, Daniel, Hansen, Mathias H., Schoppet, Melanie, De Voss, James J., Charkoudian, Louise K., Schittenhelm, Ralf B., Harmer, Jeffrey R. and Cryle, Max J. (2022). The cytochrome P450 OxyA from the kistamicin biosynthesis cyclization cascade is highly sensitive to oxidative damage. Frontiers in Chemistry, 10 868240, 868240. doi: 10.3389/fchem.2022.868240 |
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2022 Journal Article Different geometric requirements for cytochrome P450-catalyzed aliphatic versus aromatic hydroxylation results in chemoselective oxidationColeman, Tom, Kirk, Alicia M., Lee, Joel H. Z., Doherty, Daniel Z., Bruning, John B., Krenske, Elizabeth H., De Voss, James J. and Bell, Stephen G. (2022). Different geometric requirements for cytochrome P450-catalyzed aliphatic versus aromatic hydroxylation results in chemoselective oxidation. ACS Catalysis, 12 (2), 1258-1267. doi: 10.1021/acscatal.1c05483 |
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2022 Journal Article To be, or not to be, an inhibitor: a comparison of Azole interactions with and oxidation by a cytochrome P450 enzymePodgorski, Matthew N., Coleman, Tom, Giang, Peter D., Wang, C. Ruth, Bruning, John B., Bernhardt, Paul V., De Voss, James J. and Bell, Stephen G. (2022). To be, or not to be, an inhibitor: a comparison of Azole interactions with and oxidation by a cytochrome P450 enzyme. Inorganic Chemistry, 61 (1) acs.inorgchem.1c02786, 236-245. doi: 10.1021/acs.inorgchem.1c02786 |
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2021 Journal Article The stereoselective oxidation of para-substituted benzenes by a cytochrome P450 biocatalystChao, Rebecca R., Lau, Ian C.-K., Coleman, Tom, Churchman, Luke R., Child, Stella A., Lee, Joel H. Z., Bruning, John B., De Voss, James J. and Bell, Stephen G. (2021). The stereoselective oxidation of para-substituted benzenes by a cytochrome P450 biocatalyst. Chemistry - A European Journal, 27 (59), 14765-14777. doi: 10.1002/chem.202102757 |
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2021 Journal Article The inactivation by curcumin-mediated photosensitization of Botrytis cinerea apores isolated from strawberry fruitsHuang, Li, Yong, Ken W. L., Fernando, W. Chrishanthi, Carpinelli de Jesus, Matheus, De Voss, James J., Sultanbawa, Yasmina and Fletcher, Mary T. (2021). The inactivation by curcumin-mediated photosensitization of Botrytis cinerea apores isolated from strawberry fruits. Toxins, 13 (3) 196, 196. doi: 10.3390/toxins13030196 |
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2021 Journal Article Understanding the mechanistic requirements for efficient and stereoselective alkene epoxidation by a cytochrome P450 enzymeColeman, Tom, Kirk, Alicia M., Chao, Rebecca R., Podgorski, Matthew N., Harbort, Joshua S., Churchman, Luke R., Bruning, John B., Bernhardt, Paul V., Harmer, Jeffrey R., Krenske, Elizabeth H., De Voss, James J. and Bell, Stephen G. (2021). Understanding the mechanistic requirements for efficient and stereoselective alkene epoxidation by a cytochrome P450 enzyme. ACS Catalysis, 11 (4), 1995-2010. doi: 10.1021/acscatal.0c04872 |
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2020 Journal Article Caco-2 cell permeability of flavonoids and saponins from Gynostemma pentaphyllum: the immortal herbAhmed, Iftekhar, Leach, David N., Wohlmuth, Hans, De Voss, James J. and Blanchfield, Joanne T. (2020). Caco-2 cell permeability of flavonoids and saponins from Gynostemma pentaphyllum: the immortal herb. ACS Omega, 5 (34) acsomega.0c02180, 21561-21569. doi: 10.1021/acsomega.0c02180 |
