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2025 Journal Article Characterisation of the Self‐Sufficient Cytochrome <scp>P450 CYP116B234</scp> From <i>Rhodococcus globerulus</i> and Its Suggested Native Role in 2‐Hydroxyphenylacetic Acid MetabolismKundral, Simran, Beamish, Hannah, Giang, Peter D., Salisbury, Lauren J., Nouwens, Amanda S., Khare, Sunil K., Bernhardt, Paul V., Harmer, Jeffrey R., Bell, Stephen G. and De Voss, James J. (2025). Characterisation of the Self‐Sufficient Cytochrome P450 CYP116B234 From Rhodococcus globerulus and Its Suggested Native Role in 2‐Hydroxyphenylacetic Acid Metabolism. Microbial Biotechnology, 18 (3) e70125, e70125. doi: 10.1111/1751-7915.70125 |
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2025 Journal Article Characterisation of the Cytochrome P450 Monooxygenase CYP116B46 from <i>Tepidiphilus thermophilus</i> as a Homogentisic Acid Generating Enzyme and its Conversion to a PeroxygenaseAkter, Jina, Lee, Joel H. Z., Whelan, Fiona, De Voss, James J. and Bell, Stephen G. (2025). Characterisation of the Cytochrome P450 Monooxygenase CYP116B46 from Tepidiphilus thermophilus as a Homogentisic Acid Generating Enzyme and its Conversion to a Peroxygenase. ChemBioChem, 26 (5) e202400880, e202400880. doi: 10.1002/cbic.202400880 |
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2025 Journal Article An Asynchronous, Concerted Mechanism for Cytochrome P450-Catalyzed Dehydrogenation: A Combined Deuterium Labeling and QM/MM StudyKirk, Alicia M., Stok, Jeanette E., Wong, Siew Hoon, Coleman, Tom, Challinor, Victoria L., Herring, Joel N., Bruning, John B., Bernhardt, Paul V., Bell, Stephen G., Krenske, Elizabeth H. and De Voss, James J. (2025). An Asynchronous, Concerted Mechanism for Cytochrome P450-Catalyzed Dehydrogenation: A Combined Deuterium Labeling and QM/MM Study. ACS Catalysis, 15 (2), 1274-1286. doi: 10.1021/acscatal.4c06278 |
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2024 Journal Article The biarylitides: understanding the structure and biosynthesis of a fascinating class of Cytochrome P450 modified RiPP natural productsPadva, Leo, Gullick, Jemma, Coe, Laura J., Hansen, Mathias, De Voss, James, Crüsemann, Max and Cryle, Max J. (2024). The biarylitides: understanding the structure and biosynthesis of a fascinating class of Cytochrome P450 modified RiPP natural products. ChemBioChem e202400916. doi: 10.1002/cbic.202400916 |
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2024 Journal Article Loss of fluorine during crosslinking by the biarylitide P450<sub>Blt</sub> proceeds due to restricted peptide orientationZhao, Yongwei, Gullick, Jemma, Hansen, Mathias H., Coe, Laura, Treisman, Maxine, Schittenhelm, Ralf B., McKay, Alasdair, Murray, Lauren A. M., Tailhades, Julien, De Voss, James J., Krenske, Elizabeth H. and Cryle, Max J. (2024). Loss of fluorine during crosslinking by the biarylitide P450Blt proceeds due to restricted peptide orientation. Chemical Communications, 60 (94), 13951-13954. doi: 10.1039/d4cc04092a |
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2024 Journal Article Amphiphilic heparinoids as potent antiviral agents against SARS-CoV-2Chhabra, Mohit, Shanthamurthy, Chethan D., Kumar, Nanjudaswamy Vijendra, Mardhekar, Sandhya, Vishweshwara, Sharath S., Wimmer, Norbert, Modhiran, Naphak, Watterson, Daniel, Amarilla, Alberto A., Cha, Jonathan S., Beckett, James R., De Voss, James J., Kayal, Yasmin, Vlodavsky, Israel, Dorsett, Lauren R., Smith, Raymond A. A., Gandhi, Neha S., Kikkeri, Raghavendra and Ferro, Vito (2024). Amphiphilic heparinoids as potent antiviral agents against SARS-CoV-2. Journal of Medicinal Chemistry, 67 (14), 11885-11916. doi: 10.1021/acs.jmedchem.4c00487 |
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2024 Journal Article Structural diversity in nudibranch chemistry: elucidation of norditerpenes with a dendrillane scaffold from the Australian nudibranch Goniobranchus coiForster, Louise C., Pierens, Gregory K., De Voss, James J. and Garson, Mary J. (2024). Structural diversity in nudibranch chemistry: elucidation of norditerpenes with a dendrillane scaffold from the Australian nudibranch Goniobranchus coi. Australian Journal of Chemistry, 77 (7) CH24073, 1-8. doi: 10.1071/ch24073 |
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2024 Journal Article Reassignment of the structure of a tryptophan‐containing cyclic tripeptide produced by the biarylitide crosslinking cytochrome P450bltCoe, Laura J., Zhao, Yongwei, Padva, Leo, Keto, Angus, Schittenhelm, Ralf, Tailhades, Julien, Pierens, Greg, Krenske, Elizabeth H., Crüsemann, Max, De Voss, James and Cryle, Max J. (2024). Reassignment of the structure of a tryptophan‐containing cyclic tripeptide produced by the biarylitide crosslinking cytochrome P450blt. Chemistry: A European Journal, 30 (38) e202400988. doi: 10.1002/chem.202400988 |
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2024 Journal Article Cytochrome P450Blt enables versatile peptide cyclisation to generate histidine and tyrosine containing crosslinked tripeptide building blocks (vol 61, e202204957, 2022)Coe, L. J., Zhao, Y., Padva, L., Keto, A., Schittenhelm, R., Tailhades, J., Pierens, G., Krenske, E. H., Crusemann, M., De Voss, J. and Cryle, M. J. (2024). Cytochrome P450Blt enables versatile peptide cyclisation to generate histidine and tyrosine containing crosslinked tripeptide building blocks (vol 61, e202204957, 2022). Angewandte Chemie-International Edition, 63 (26) e202408719. doi: 10.1002/anie.202408719 |
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2024 Journal Article Selective α-hydroxyketone formation and subsequent C–C bond cleavage by cytochrome P450 monooxygenase enzymesLee, Joel H. Z., Coleman, Tom, Mclean, Mark A., Podgorski, Matthew N., Hayball, Eva F., Stone, Isobella S. J., Bruning, John B., Whelan, Fiona, De Voss, James J., Sligar, Stephen G. and Bell, Stephen G. (2024). Selective α-hydroxyketone formation and subsequent C–C bond cleavage by cytochrome P450 monooxygenase enzymes. ACS Catalysis, 14 (11), 8958-8971. doi: 10.1021/acscatal.4c01766 |
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2024 Journal Article Synthesis of steroidal inhibitors for Mycobacterium tuberculosisChurchman, Luke R., Beckett, James R., Tan, Lendl, Woods, Kyra, Doherty, Daniel Z., Ghith, Amna, Bernhardt, Paul V., Bell, Stephen G., West, Nicholas P. and De Voss, James J. (2024). Synthesis of steroidal inhibitors for Mycobacterium tuberculosis. The Journal of Steroid Biochemistry and Molecular Biology, 239 106479, 1-16. doi: 10.1016/j.jsbmb.2024.106479 |
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2024 Journal Article Engineering peroxygenase activity into cytochrome P450 monooxygenases through modification of the oxygen binding regionPodgorski, Matthew N., Akter, Jinia, Churchman, Luke R., Bruning, John B., De Voss, James J. and Bell, Stephen G. (2024). Engineering peroxygenase activity into cytochrome P450 monooxygenases through modification of the oxygen binding region. ACS Catalysis, 14 (10), 7426-7443. doi: 10.1021/acscatal.4c01326 |
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2024 Journal Article An engineered biarylitide cross-linking P450 from RiPP biosynthesis generates alternative cyclic peptidesTreisman, Maxine, Coe, Laura, Zhao, Yongwei, Sasi, Vishnu Mini, Gullick, Jemma, Hansen, Mathias H., Ly, Aviva, Leichthammer, Victor, Hess, Caroline, Machell, Daniel L., Schittenhelm, Ralf B., Hooper, Joel, Jackson, Colin J., Tailhades, Julien, De Voss, James J. and Cryle, Max J. (2024). An engineered biarylitide cross-linking P450 from RiPP biosynthesis generates alternative cyclic peptides. Organic Letters, 26 (9), 1828-1833. doi: 10.1021/acs.orglett.3c04366 |
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2024 Journal Article CYP108N14: a monoterpene monooxygenase from Rhodococcus globerulusGiang, Peter D., Churchman, Luke R., Buczynski, Julia B., Bell, Stephen G., Stok, Jeanette E. and De Voss, James J. (2024). CYP108N14: a monoterpene monooxygenase from Rhodococcus globerulus. Archives of Biochemistry and Biophysics, 752 109852, 1-8. doi: 10.1016/j.abb.2023.109852 |
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2024 Journal Article Structural insights into a side chain cross-linking Biarylitide P450 from RiPP biosynthesisHansen, Mathias H., Keto, Angus, Treisman, Maxine, Sasi, Vishnu Mini, Coe, Laura, Zhao, Yongwei, Padva, Leo, Hess, Caroline, Leichthammer, Victor, Machell, Daniel L., Schittenhelm, Ralf B., Jackson, Colin J., Tailhades, Julien, Crüsemann, Max, De Voss, James J., Krenske, Elizabeth H. and Cryle, Max J. (2024). Structural insights into a side chain cross-linking Biarylitide P450 from RiPP biosynthesis. ACS Catalysis, 14 (2), 812-826. doi: 10.1021/acscatal.3c05417 |
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2023 Journal Article Synthesis of substituted norcaranes for use as probes of enzyme mechanismsChurchman, Luke R., Giang, Peter D., Buczynski, Julia B., Stok, Jeanette E., Bell, Stephen G. and De Voss, James J. (2023). Synthesis of substituted norcaranes for use as probes of enzyme mechanisms. Organic and Biomolecular Chemistry, 21 (48), 9647-9658. doi: 10.1039/d3ob01571h |
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2023 Journal Article Differentiating dyes: A Spectroscopic investigation into the composition of scarlet bloodroot (Haemodorum coccineum R.Br.) rhizomeCarpinelli de Jesus, Matheus, Church, Taylah, Wapling, Johanna A., Collins, Raelene, Leach, Gregory J., Leach, David, De Voss, James J. and Blanchfield, Joanne T. (2023). Differentiating dyes: A Spectroscopic investigation into the composition of scarlet bloodroot (Haemodorum coccineum R.Br.) rhizome. Molecules, 28 (21) 7422, 1-14. doi: 10.3390/molecules28217422 |
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2023 Journal Article Efficient biocatalytic C–H bond oxidation: an engineered heme-thiolate peroxygenase from a thermostable cytochrome P450Gee, Alecia R., Stone, Isobella S. J., Stockdale, Tegan P., Pukala, Tara L., De Voss, James J. and Bell, Stephen G. (2023). Efficient biocatalytic C–H bond oxidation: an engineered heme-thiolate peroxygenase from a thermostable cytochrome P450. Chemical Communications, 59 (90), 13486-13489. doi: 10.1039/d3cc04626e |
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2023 Journal Article The oxidation of oxygen and sulfur‐containing heterocycles by cytochrome P450 enzymesPodgorski, Matthew N, Keto, Angus B, Coleman, Tom, Bruning, John B, De Voss, James J, Krenske, Elizabeth H and Bell, Stephen Graham (2023). The oxidation of oxygen and sulfur‐containing heterocycles by cytochrome P450 enzymes. Chemistry – A European Journal, 29 (50) e202301371, e202301371. doi: 10.1002/chem.202301371 |
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2023 Journal Article Selective carbon-hydrogen bond hydroxylation using an engineered cytochrome P450 peroxygenaseAkter, Jinia, Stockdale, Tegan P., Child, Stella A., Lee, Joel H. Z., De Voss, James J. and Bell, Stephen G. (2023). Selective carbon-hydrogen bond hydroxylation using an engineered cytochrome P450 peroxygenase. Journal of Inorganic Biochemistry, 244 112209, 1-9. doi: 10.1016/j.jinorgbio.2023.112209 |
