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2023 Journal Article Optimization of an α-aminonaphthylmethylphosphonic acid inhibitor of purple acid phosphatase using rational structure-based design approachesFeder, Daniel, Mohd-Pahmi, Siti Hajar, Adibi, Hadi, Guddat, Luke W., Schenk, Gerhard, McGeary, Ross P. and Hussein, Waleed M. (2023). Optimization of an α-aminonaphthylmethylphosphonic acid inhibitor of purple acid phosphatase using rational structure-based design approaches. European Journal of Medicinal Chemistry, 254 115383, 1-19. doi: 10.1016/j.ejmech.2023.115383 |
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2023 Journal Article Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtABSun, Shan, Gao, Yan, Yang, Xiaolin, Yang, Xiuna, Hu, Tianyu, Jingxi, Liang, Xiong, Zhiqi, Ran, Yuting, Ren, Pengxuan, Bai, Fang, Guddat, Luke W, Yang, Haitao, Rao, Zihe and Zhang, Bing (2023). Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB. Protein and Cell, 14 (6), 448-458. doi: 10.1093/procel/pwac060 |
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2023 Journal Article Structure of the human ATP synthaseLai, Yuezheng, Zhang, Yuying, Zhou, Shan, Xu, Jinxu, Du, Zhanqiang, Feng, Ziyan, Yu, Long, Zhao, Ziqing, Wang, Weiwei, Tang, Yanting, Yang, Xiuna, Guddat, Luke W., Liu, Fengjiang, Gao, Yan, Rao, Zihe and Gong, Hongri (2023). Structure of the human ATP synthase. Molecular Cell, 83 (12), 2137-2147.e4. doi: 10.1016/j.molcel.2023.04.029 |
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2023 Journal Article Cryo-EM structures of a prokaryotic heme transporter CydDCZhu, Chen, Shi, Yanfeng, Yu, Jing, Zhao, Wenhao, Li, Lingqiao, Jingxi, Liang, Yang, Xiaolin, Zhang, Bing, Zhao, Yao, Gao, Yan, Chen, Xiaobo, Yang, Xiuna, Zhang, Lu, Guddat, Luke W., Liu, Lei, Yang, Haitao, Rao, Zihe and Li, Jun (2023). Cryo-EM structures of a prokaryotic heme transporter CydDC. Protein and Cell, 14 (12), 919-923. doi: 10.1093/procel/pwad022 |
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2023 Journal Article Structure of the human respiratory complex IIDu, Zhanqiang, Zhou, Xiaoting, Lai, Yuezheng, Xu, Jinxu, Zhang, Yuying, Zhou, Shan, Feng, Ziyan, Yu, Long, Tang, Yanting, Wang, Weiwei, Yu, Lu, Tian, Changlin, Ran, Ting, Chen, Hongming, Guddat, Luke W., Liu, Fengjiang, Gao, Yan, Rao, Zihe and Gong, Hongri (2023). Structure of the human respiratory complex II. Proceedings of the National Academy of Sciences, 120 (18) e2216713120, e2216713120. doi: 10.1073/pnas.2216713120 |
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2023 Journal Article Crystal structure of the commercial herbicide, amidosulfuron, in complex with Arabidopsis thaliana acetohydroxyacid synthaseCheng, Yan, Lonhienne, Thierry, Garcia, Mario. D., Williams, Craig M., Schenk, Gerard and Guddat, Luke W. (2023). Crystal structure of the commercial herbicide, amidosulfuron, in complex with Arabidopsis thaliana acetohydroxyacid synthase. Journal of Agricultural and Food Chemistry, 71 (13), 5117-5126. doi: 10.1021/acs.jafc.2c08528 |
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2023 Journal Article Structural and functional insight into the mechanism of the Fe‐S cluster‐dependent dehydratase from Paralcaligenes ureilyticusBayaraa, Tenuun, Lonhienne, Thierry, Sutiono, Samuel, Melse, Okke, Brück, Thomas B., Marcellin, Esteban, Bernhardt, Paul V., Boden, Mikael, Harmer, Jeffrey R., Sieber, Volker, Guddat, Luke W. and Schenk, Gerhard (2023). Structural and functional insight into the mechanism of the Fe‐S cluster‐dependent dehydratase from Paralcaligenes ureilyticus. Chemistry: A European Journal, 29 (9) e202203140, 1-13. doi: 10.1002/chem.202203140 |
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2022 Journal Article Structural basis of resistance to herbicides that target acetohydroxyacid synthaseLonhienne, Thierry, Cheng, Yan, Garcia, Mario D., Hu, Shu Hong, Low, Yu Shang, Schenk, Gerhard, Williams, Craig M. and Guddat, Luke W. (2022). Structural basis of resistance to herbicides that target acetohydroxyacid synthase. Nature Communications, 13 (1) 3368, 3368. doi: 10.1038/s41467-022-31023-x |
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2022 Journal Article A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitorsYan, Liming, Huang, Yucen, Ge, Ji, Liu, Zhenyu, Lu, Pengchi, Huang, Bo, Gao, Shan, Wang, Junbo, Tan, Liping, Ye, Sihan, Yu, Fengxi, Lan, Weiqi, Xu, Shiya, Zhou, Feng, Shi, Lei, Guddat, Luke W., Gao, Yan, Rao, Zihe and Lou, Zhiyong (2022). A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185 (23), 4347-4360. doi: 10.1016/j.cell.2022.09.037 |
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2022 Journal Article Engineering indel and substitution variants of diverse and ancient enzymes using Graphical Representation of Ancestral Sequence Predictions (GRASP)Foley, Gabriel, Mora, Ariane, Ross, Connie M., Bottoms, Scott, Sützl, Leander, Lamprecht, Marnie L., Zaugg, Julian, Essebier, Alexandra, Balderson, Brad, Newell, Rhys, Thomson, Raine E. S., Kobe, Bostjan, Barnard, Ross T., Guddat, Luke, Schenk, Gerhard, Carsten, Jörg, Gumulya, Yosephine, Rost, Burkhard, Haltrich, Dietmar, Sieber, Volker, Gillam, Elizabeth M. J. and Bodén, Mikael (2022). Engineering indel and substitution variants of diverse and ancient enzymes using Graphical Representation of Ancestral Sequence Predictions (GRASP). PL o S Computational Biology, 18 (10) e1010633, e1010633. doi: 10.1371/journal.pcbi.1010633 |
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2022 Journal Article Structure-based design of anti-mycobacterial drug leads that target the mycolic acid transporter MmpL3Hu, Tianyu, Yang, Xiaolin, Liu, Fengjiang, Sun, Shan, Xiong, Zhiqi, Liang, Jingxi, Yang, Xiaobao, Wang, Haofeng, Yang, Xiuna, Guddat, Luke W., Yang, Haitao, Rao, Zihe and Zhang, Bing (2022). Structure-based design of anti-mycobacterial drug leads that target the mycolic acid transporter MmpL3. Structure, 30 (10), 1395-1402.e4. doi: 10.1016/j.str.2022.07.009 |
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2022 Journal Article Enhancing the Thermal and Kinetic Stability of Ketol-Acid Reductoisomerase, a Central Catalyst of a Cell-Free Enzyme Cascade for the Manufacture of Platform ChemicalsLv, You, Zheng, Shan, Goldenzweig, Adi, Liu, Fengjiang, Gao, Yan, Yang, Xiuna, Kandale, Ajit, McGeary, Ross P., Williams, Simon, Kobe, Bostjan, Schembri, Mark A., Landsberg, Michael J., Wu, Bin, Brück, Thomas B., Sieber, Volker, Boden, Mikael, Rao, Zihe, Fleishman, Sarel J., Schenk, Gerhard and Guddat, Luke W. (2022). Enhancing the Thermal and Kinetic Stability of Ketol-Acid Reductoisomerase, a Central Catalyst of a Cell-Free Enzyme Cascade for the Manufacture of Platform Chemicals. Applied Biosciences, 1 (2), 163-178. doi: 10.3390/applbiosci1020011 |
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2022 Journal Article Genome-guided analysis of seven weed species reveals conserved sequence and structural features of key gene targets for herbicide developmentShah, Sarah, Lonhienne, Thierry, Murray, Cody-Ellen, Chen, Yibi, Dougan, Katherine E., Low, Yu Shang, Williams, Craig M., Schenk, Gerhard, Walter, Gimme H., Guddat, Luke W. and Chan, Cheong Xin (2022). Genome-guided analysis of seven weed species reveals conserved sequence and structural features of key gene targets for herbicide development. Frontiers in Plant Science, 13 909073. doi: 10.3389/fpls.2022.909073 |
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2022 Journal Article Dihydroxy‐acid dehydratases from pathogenic bacteria: emerging drug targets to combat antibiotic resistanceBayaraa, Tenuun, Gaete, Jose, Sutiono, Samuel, Kurz, Julia, Lonhienne, Thierry, Harmer, Jeffrey R., Bernhardt, Paul V., Sieber, Volker, Guddat, Luke and Schenk, Gerhard (2022). Dihydroxy‐acid dehydratases from pathogenic bacteria: emerging drug targets to combat antibiotic resistance. Chemistry: A European Journal, 28 (44) e202200927, 1-14. doi: 10.1002/chem.202200927 |
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2022 Journal Article Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2Zhao, Yao, Zhu, Yan, Liu, Xiang, Jin, Zhenming, Duan, Yinkai, Zhang, Qi, Wu, Chengyao, Feng, Lu, Du, Xiaoyu, Zhao, Jinyi, Shao, Maolin, Zhang, Bing, Yang, Xiuna, Wu, Lijie, Ji, Xiaoyun, Guddat, Luke W., Yang, Kailin, Rao, Zihe and Yang, Haitao (2022). Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2. Proceedings of the National Academy of Sciences, 119 (16) e2117142119, 1-9. doi: 10.1073/pnas.2117142119 |
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2022 Journal Article Herbicides that inhibit acetolactate synthaseLonhienne, Thierry, Garcia, Mario Daniel, Low, Yu Shang and Guddat, Luke W. (2022). Herbicides that inhibit acetolactate synthase. Frontiers of Agricultural Science and Engineering, 9 (1), 155-160. doi: 10.15302/J-FASE-2021420 |
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2022 Journal Article Stereo-defined acyclic nucleoside phosphonates are selective and potent inhibitors of parasite 6-oxopurine phosphoribosyltransferasesKlejch, Tomáš, Keough, Dianne T., King, Gordon, Doleželová, Eva, Česnek, Michal, Buděšínský, Miloš, Zíková, Alena, Janeba, Zlatko, Guddat, Luke W. and Hocková, Dana (2022). Stereo-defined acyclic nucleoside phosphonates are selective and potent inhibitors of parasite 6-oxopurine phosphoribosyltransferases. Journal of Medicinal Chemistry, 65 (5), 4030-4057. doi: 10.1021/acs.jmedchem.1c01881 |
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2021 Journal Article Conformational changes in a macrolide antibiotic binding protein from Mycobacterium smegmatis upon ADP bindingZhang, Qingqing, Liu, Xiang, Liu, Huijuan, Zhang, Bingjie, Yang, Haitao, Mi, Kaixia, Guddat, Luke W. and Rao, Zihe (2021). Conformational changes in a macrolide antibiotic binding protein from Mycobacterium smegmatis upon ADP binding. Frontiers in Microbiology, 12 780954, 780954. doi: 10.3389/fmicb.2021.780954 |
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2021 Journal Article Triazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leadsLow, Y. S., Garcia, M. D., Lonhienne, T., Fraser, J. A., Schenk, G. and Guddat, L. W. (2021). Triazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leads. Scientific Reports, 11 (1) 21055. doi: 10.1038/s41598-021-00349-9 |
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2021 Journal Article Author Correction: Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF (Nature Communications, (2020), 11, 1, (4245), 10.1038/s41467-020-18011-9)Gong, Hongri, Gao, Yan, Zhou, Xiaoting, Xiao, Yu, Wang, Weiwei, Tang, Yanting, Zhou, Shan, Zhang, Yuying, Ji, Wenxin, Yu, Lu, Tian, Changlin, Lam, Sin Man, Shui, Guanghou, Guddat, Luke W., Wong, Luet-Lok, Wang, Quan and Rao, Zihe (2021). Author Correction: Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF (Nature Communications, (2020), 11, 1, (4245), 10.1038/s41467-020-18011-9). Nature Communications, 12 (1) 1370, 1370. doi: 10.1038/s41467-021-21616-3 |
