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2022 Journal Article Retinoic acid signaling acts as a rheostat to balance Treg functionThangavelu, Govindarajan, Andrejeva, Gabriela, Bolivar-Wagers, Sara, Jin, Sujeong, Zaiken, Michael C., Loschi, Michael, Aguilar, Ethan G., Furlan, Scott N., Brown, Chrysothemis C., Lee, Yu-Chi, Hyman, Cameron McDonald, Feser, Colby J., Panoskaltsis-Mortari, Angela, Hippen, Keli L., MacDonald, Kelli P., Murphy, William J., Maillard, Ivan, Hill, Geoffrey R., Munn, David H., Zeiser, Robert, Kean, Leslie S., Rathmell, Jeffrey C., Chi, Hongbo, Noelle, Randolph J. and Blazar, Bruce R. (2022). Retinoic acid signaling acts as a rheostat to balance Treg function. Cellular and Molecular Immunology, 19 (7), 820-833. doi: 10.1038/s41423-022-00869-y |
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2022 Journal Article BET-bromodomain and EZH2 inhibitor–treated chronic GVHD mice have blunted germinal centers with distinct transcriptomesZaiken, Michael C., Flynn, Ryan, Paz, Katelyn G., Rhee, Stephanie Y., Jin, Sujeong, Mohamed, Fathima A., Saha, Asim, Thangavelu, Govindarajan, Park, Paul M.C., Hemming, Matthew L., Sage, Peter T., Sharpe, Arlene H., DuPage, Michel, Bluestone, Jeffrey A., Panoskaltsis-Mortari, Angela, Cutler, Corey S., Koreth, John, Antin, Joseph H., Soiffer, Robert J., Ritz, Jerome, Luznik, Leo, Maillard, Ivan, Hill, Geoffrey R., MacDonald, Kelli P.A., Munn, David H., Serody, Jonathan S., Murphy, William J., Kean, Leslie S., Zhang, Yi ... Blazar, Bruce R. (2022). BET-bromodomain and EZH2 inhibitor–treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes. Blood, 139 (19), 2983-2997. doi: 10.1182/blood.2021014557 |
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2022 Journal Article ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosisNalkurthi, Christina, Schroder, Wayne A., Melino, Michelle, Irvine, Katharine M., Nyuydzefe, Melanie, Chen, Wei, Liu, Jing, Teng, Michele WL., Hill, Geoffrey R., Bertolino, Patrick, Blazar, Bruce R., Miller, Gregory C., Clouston, Andrew D., Zanin-Zhorov, Alexandra and MacDonald, Kelli PA. (2022). ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis. JHEP Reports, 4 (1) 100386, 1-14. doi: 10.1016/j.jhepr.2021.100386 |
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2021 Journal Article CMV exposure drives long-term CD57+ CD4 memory T-cell inflation following allogeneic stem cell transplantYeh, Albert C., Varelias, Antiopi, Reddy, Anupama, Barone, Sierra M., Olver, Stuart D., Chilson, Kate, Onstad, Lynn E., Ensbey, Kathleen S., Henden, Andrea S, Samson, Luke, Jaeger, Carla A, Bi, Timothy, Dahlman, Kimberly B., Kim, Tae Kon, Zhang, Ping, Degli-Esposti, Mariapia A., Newell, Evan W., Jagasia, Madan H., Irish, Jonathan M., Lee, Stephanie J. and Hill, Geoffrey R. (2021). CMV exposure drives long-term CD57+ CD4 memory T-cell inflation following allogeneic stem cell transplant. Blood, 138 (26), 2874-2885. doi: 10.1182/blood.2020009492 |
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2021 Journal Article Peritransplant glucocorticoids redistribute donor T cells to the bone marrow and prevent relapse after haploidentical SCTInoue, Takayuki, Koyama, Motoko, Kaida, Katsuji, Ikegame, Kazuhiro, Ensbey, Kathleen S., Samson, Luke, Takahashi, Shuichiro, Zhang, Ping, Minnie, Simone A., Maruyama, Satoshi, Ishii, Shinichi, Daimon, Takashi, Fukuda, Takahiro, Nakamae, Hirohisa, Ara, Takahide, Maruyama, Yumiko, Ishiyama, Ken, Ichinohe, Tatsuo, Atsuta, Yoshiko, Blazar, Bruce R., Furlan, Scott N., Ogawa, Hiroyasu and Hill, Geoffrey R. (2021). Peritransplant glucocorticoids redistribute donor T cells to the bone marrow and prevent relapse after haploidentical SCT. JCI Insight, 6 (22) e153551. doi: 10.1172/jci.insight.153551 |
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2021 Journal Article Mouse models of antigen presentation in hematopoietic stem cell transplantationKoyama, Motoko and Hill, Geoffrey R. (2021). Mouse models of antigen presentation in hematopoietic stem cell transplantation. Frontiers in Immunology, 12 715893. doi: 10.3389/fimmu.2021.715893 |
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2021 Journal Article The pathophysiology and treatment of graft-versus-host disease: Lessons learnt from animal modelsTeshima, Takanori and Hill, Geoffrey R. (2021). The pathophysiology and treatment of graft-versus-host disease: Lessons learnt from animal models. Frontiers in Immunology, 12 715424. doi: 10.3389/fimmu.2021.715424 |
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2021 Journal Article IFN-λ therapy prevents severe gastrointestinal graft-versus-host diseaseHenden, Andrea S., Koyama, Motoko, Robb, Renee J., Forero, Adriana, Kuns, Rachel D., Chang, Karshing, Ensbey, Kathleen S., Varelias, Antiopi, Kazakoff, Stephen H., Waddell, Nicole, Clouston, Andrew D., Giri, Rabina, Begun, Jakob, Blazar, Bruce R., Degli-Esposti, Mariapia A., Kotenko, Sergei V., Lane, Steven W., Bowerman, Kate L., Savan, Ram, Hugenholtz, Philip, Gartlan, Kate H. and Hill, Geoffrey R. (2021). IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease. Blood, 138 (8), 722-737. doi: 10.1182/blood.2020006375 |
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2021 Journal Article Current Concepts and Advances in Graft-Versus-Host Disease ImmunologyHill, Geoffrey R., Betts, Brian C., Tkachev, Victor, Kean, Leslie S. and Blazar, Bruce R. (2021). Current Concepts and Advances in Graft-Versus-Host Disease Immunology. Annual Review of Immunology, 39 (1), 19-49. doi: 10.1146/annurev-immunol-102119-073227 |
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2021 Journal Article Autologous stem cell transplantation for myeloma: Cytoreduction or an immunotherapy?Minnie, Simone A. and Hill, Geoffrey R. (2021). Autologous stem cell transplantation for myeloma: Cytoreduction or an immunotherapy?. Frontiers in Immunology, 12 651288. doi: 10.3389/fimmu.2021.651288 |
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2021 Journal Article Blood and marrow transplantation during the emerging COVID-19 pandemic: the Seattle approachUeda Oshima, Masumi, Sandmaier, Brenda M., Petersdorf, Effie, Flowers, Mary E., Hill, Geoffrey R., Lee, Stephanie J., Appelbaum, Frederick R., Carpenter, Paul A., Baker, K. Scott, Connelly-Smith, Laura, McCool, Andrea, Elgar, Suni, Pergam, Steven A., Liu, Catherine, Stewart, F. Marc and Mielcarek, Marco (2021). Blood and marrow transplantation during the emerging COVID-19 pandemic: the Seattle approach. Bone Marrow Transplantation, 56 (2), 305-313. doi: 10.1038/s41409-020-01068-x |
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2021 Journal Article A phase 3 double-blind study of the addition of tocilizumab versus placebo to cyclosporin/methotrexate GvHD prophylaxisKennedy, Glen, Tey, Siok-Keen, Buizen, Luke, Varelias, Antiopi, Gartlan, Kate H., Curley, Cameron, Olver, Stuart, Chang, Karshing, Butler, Jason, Misra, Ashish, Subramoniapillai, Elango, Morton, Anthony, Durrant, Simon, Henden, Andrea S, Moore, John, Ritchie, David S, Gottlieb, David, Cooney, Julian P, Paul, Sanjoy K and Hill, Geoffrey R. (2021). A phase 3 double-blind study of the addition of tocilizumab versus placebo to cyclosporin/methotrexate GvHD prophylaxis. Blood, 137 (14), 1970-1979. doi: 10.1182/blood.2020009050 |
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2020 Journal Article IL-27 signalling regulates glycolysis in Th1 cells to limit immunopathology during infectionMontes de Oca, Marcela, de Labastida Rivera, Fabian, Winterford, Clay, Frame, Teija C. M., Ng, Susanna S., Amante, Fiona H., Edwards, Chelsea L., Bukali, Luzia, Wang, Yulin, Uzonna, Jude E., Kuns, Rachel D., Zhang, Ping, Kabat, Agnieszka, Klein Geltink, Ramon I., Pearce, Edward J., Hill, Geoffrey R. and Engwerda, Christian R. (2020). IL-27 signalling regulates glycolysis in Th1 cells to limit immunopathology during infection. PLoS Pathogens, 16 (10) e1008994, e1008994. doi: 10.1371/journal.ppat.1008994 |
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2020 Journal Article The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammationNg, Susanna S., De Labastida Rivera, Fabian, Yan, Juming, Corvino, Dillon, Das, Indrajit, Zhang, Ping, Kuns, Rachel, Chauhan, Shashi Bhushan, Hou, Jiajie, Li, Xian-Yang, Frame, Teija C. M., McEnroe, Benjamin A., Moore, Eilish, Na, Jinrui, Engel, Jessica A., Soon, Megan S. F., Singh, Bhawana, Kueh, Andrew J., Herold, Marco J., Montes de Oca, Marcela, Singh, Siddharth Sankar, Bunn, Patrick T., Aguilera, Amy Roman, Casey, Mika, Braun, Matthias, Ghazanfari, Nazanin, Wani, Shivangi, Wang, Yulin, Amante, Fiona H. ... Engwerda, Christian R. (2020). The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation. Nature Immunology, 21 (10), 1205-1218. doi: 10.1038/s41590-020-0758-6 |
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2020 Journal Article Dissecting the biology of allogeneic HSCT to enhance the GvT effect whilst minimizing GvHDBlazar, Bruce R., Hill, Geoffrey R. and Murphy, William J. (2020). Dissecting the biology of allogeneic HSCT to enhance the GvT effect whilst minimizing GvHD. Nature Reviews Clinical Oncology, 17 (8), 475-492. doi: 10.1038/s41571-020-0356-4 |
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2020 Journal Article Cytokines and costimulation in acute graft-versus-host diseaseHill, Geoffrey R. and Koyama, Motoko (2020). Cytokines and costimulation in acute graft-versus-host disease. Blood, 136 (4), 418-428. doi: 10.1182/blood.2019000952 |
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2020 Journal Article Single-cell transcriptomics of alloreactive CD4+ T cells over time reveals divergent fates during gut graft-versus-host diseaseEngel, Jessica A., Lee, Hyun Jae, Williams, Cameron G., Kuns, Rachel, Olver, Stuart, Lansink, Lianne Im, Soon, Megan Sf, Andersen, Stacey B., Powell, Joseph E., Svensson, Valentine, Teichmann, Sarah A., Hill, Geoffrey R., Varelias, Antiopi, Koyama, Motoko and Haque, Ashraful (2020). Single-cell transcriptomics of alloreactive CD4+ T cells over time reveals divergent fates during gut graft-versus-host disease. JCI Insight, 5 (13) 137990. doi: 10.1172/jci.insight.137990 |
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2020 Journal Article ASC modulates CTL cytotoxicity and transplant outcome independent of the inflammasomeCheong, Melody, Gartlan, Kate H., Lee, Jason S., Tey, Siok-Keen, Zhang, Ping, Kuns, Rachel D., Andoniou, Christopher E., Martins, Jose Paulo, Chang, Karshing, Sutton, Vivien R., Kelly, Greg, Varelias, Antiopi, Vuckovic, Slavica, Markey, Kate A., Boyle, Glen M., Smyth, Mark J., Engwerda, Christian R., MacDonald, Kelli P.A., Trapani, Joseph A., Degli-Esposti, Mariapia A., Koyama, Motoko and Hill, Geoffrey R. (2020). ASC modulates CTL cytotoxicity and transplant outcome independent of the inflammasome. Cancer Immunology Research, 8 (8), 1085-1098. doi: 10.1158/2326-6066.cir-19-0653 |
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2020 Journal Article Experiences and unmet needs of family members requested to donate haematopoietic stem cells to an ill relative: findings from a prospective multi-centre studyZomerdijk, Nienke, Turner, Jane, Hill, Geoffrey R. and Gottlieb, David (2020). Experiences and unmet needs of family members requested to donate haematopoietic stem cells to an ill relative: findings from a prospective multi-centre study. Supportive Care in Cancer, 29 (2), 635-644. doi: 10.1007/s00520-020-05520-y |
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2020 Journal Article Immunotherapy of multiple myelomaMinnie, Simone A. and Hill, Geoffrey R. (2020). Immunotherapy of multiple myeloma. The Journal of Clinical Investigation, 130 (4), 1565-1575. doi: 10.1172/JCI129205 |
