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2021 Journal Article IFN-λ therapy prevents severe gastrointestinal graft-versus-host diseaseHenden, Andrea S., Koyama, Motoko, Robb, Renee J., Forero, Adriana, Kuns, Rachel D., Chang, Karshing, Ensbey, Kathleen S., Varelias, Antiopi, Kazakoff, Stephen H., Waddell, Nicole, Clouston, Andrew D., Giri, Rabina, Begun, Jakob, Blazar, Bruce R., Degli-Esposti, Mariapia A., Kotenko, Sergei V., Lane, Steven W., Bowerman, Kate L., Savan, Ram, Hugenholtz, Philip, Gartlan, Kate H. and Hill, Geoffrey R. (2021). IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease. Blood, 138 (8), 722-737. doi: 10.1182/blood.2020006375 |
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2021 Journal Article Current Concepts and Advances in Graft-Versus-Host Disease ImmunologyHill, Geoffrey R., Betts, Brian C., Tkachev, Victor, Kean, Leslie S. and Blazar, Bruce R. (2021). Current Concepts and Advances in Graft-Versus-Host Disease Immunology. Annual Review of Immunology, 39 (1), 19-49. doi: 10.1146/annurev-immunol-102119-073227 |
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2021 Journal Article Autologous stem cell transplantation for myeloma: Cytoreduction or an immunotherapy?Minnie, Simone A. and Hill, Geoffrey R. (2021). Autologous stem cell transplantation for myeloma: Cytoreduction or an immunotherapy?. Frontiers in Immunology, 12 651288. doi: 10.3389/fimmu.2021.651288 |
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2021 Journal Article Blood and marrow transplantation during the emerging COVID-19 pandemic: the Seattle approachUeda Oshima, Masumi, Sandmaier, Brenda M., Petersdorf, Effie, Flowers, Mary E., Hill, Geoffrey R., Lee, Stephanie J., Appelbaum, Frederick R., Carpenter, Paul A., Baker, K. Scott, Connelly-Smith, Laura, McCool, Andrea, Elgar, Suni, Pergam, Steven A., Liu, Catherine, Stewart, F. Marc and Mielcarek, Marco (2021). Blood and marrow transplantation during the emerging COVID-19 pandemic: the Seattle approach. Bone Marrow Transplantation, 56 (2), 305-313. doi: 10.1038/s41409-020-01068-x |
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2021 Journal Article A phase 3 double-blind study of the addition of tocilizumab versus placebo to cyclosporin/methotrexate GvHD prophylaxisKennedy, Glen, Tey, Siok-Keen, Buizen, Luke, Varelias, Antiopi, Gartlan, Kate H., Curley, Cameron, Olver, Stuart, Chang, Karshing, Butler, Jason, Misra, Ashish, Subramoniapillai, Elango, Morton, Anthony, Durrant, Simon, Henden, Andrea S, Moore, John, Ritchie, David S, Gottlieb, David, Cooney, Julian P, Paul, Sanjoy K and Hill, Geoffrey R. (2021). A phase 3 double-blind study of the addition of tocilizumab versus placebo to cyclosporin/methotrexate GvHD prophylaxis. Blood, 137 (14), 1970-1979. doi: 10.1182/blood.2020009050 |
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2020 Journal Article IL-27 signalling regulates glycolysis in Th1 cells to limit immunopathology during infectionMontes de Oca, Marcela, de Labastida Rivera, Fabian, Winterford, Clay, Frame, Teija C. M., Ng, Susanna S., Amante, Fiona H., Edwards, Chelsea L., Bukali, Luzia, Wang, Yulin, Uzonna, Jude E., Kuns, Rachel D., Zhang, Ping, Kabat, Agnieszka, Klein Geltink, Ramon I., Pearce, Edward J., Hill, Geoffrey R. and Engwerda, Christian R. (2020). IL-27 signalling regulates glycolysis in Th1 cells to limit immunopathology during infection. PLoS Pathogens, 16 (10) e1008994, e1008994. doi: 10.1371/journal.ppat.1008994 |
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2020 Journal Article The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammationNg, Susanna S., De Labastida Rivera, Fabian, Yan, Juming, Corvino, Dillon, Das, Indrajit, Zhang, Ping, Kuns, Rachel, Chauhan, Shashi Bhushan, Hou, Jiajie, Li, Xian-Yang, Frame, Teija C. M., McEnroe, Benjamin A., Moore, Eilish, Na, Jinrui, Engel, Jessica A., Soon, Megan S. F., Singh, Bhawana, Kueh, Andrew J., Herold, Marco J., Montes de Oca, Marcela, Singh, Siddharth Sankar, Bunn, Patrick T., Aguilera, Amy Roman, Casey, Mika, Braun, Matthias, Ghazanfari, Nazanin, Wani, Shivangi, Wang, Yulin, Amante, Fiona H. ... Engwerda, Christian R. (2020). The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation. Nature Immunology, 21 (10), 1205-1218. doi: 10.1038/s41590-020-0758-6 |
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2020 Journal Article Dissecting the biology of allogeneic HSCT to enhance the GvT effect whilst minimizing GvHDBlazar, Bruce R., Hill, Geoffrey R. and Murphy, William J. (2020). Dissecting the biology of allogeneic HSCT to enhance the GvT effect whilst minimizing GvHD. Nature Reviews Clinical Oncology, 17 (8), 475-492. doi: 10.1038/s41571-020-0356-4 |
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2020 Journal Article Cytokines and costimulation in acute graft-versus-host diseaseHill, Geoffrey R. and Koyama, Motoko (2020). Cytokines and costimulation in acute graft-versus-host disease. Blood, 136 (4), 418-428. doi: 10.1182/blood.2019000952 |
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2020 Journal Article Single-cell transcriptomics of alloreactive CD4+ T cells over time reveals divergent fates during gut graft-versus-host diseaseEngel, Jessica A., Lee, Hyun Jae, Williams, Cameron G., Kuns, Rachel, Olver, Stuart, Lansink, Lianne Im, Soon, Megan Sf, Andersen, Stacey B., Powell, Joseph E., Svensson, Valentine, Teichmann, Sarah A., Hill, Geoffrey R., Varelias, Antiopi, Koyama, Motoko and Haque, Ashraful (2020). Single-cell transcriptomics of alloreactive CD4+ T cells over time reveals divergent fates during gut graft-versus-host disease. JCI Insight, 5 (13) 137990, 1-19. doi: 10.1172/jci.insight.137990 |
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2020 Journal Article ASC modulates CTL cytotoxicity and transplant outcome independent of the inflammasomeCheong, Melody, Gartlan, Kate H., Lee, Jason S., Tey, Siok-Keen, Zhang, Ping, Kuns, Rachel D., Andoniou, Christopher E., Martins, Jose Paulo, Chang, Karshing, Sutton, Vivien R., Kelly, Greg, Varelias, Antiopi, Vuckovic, Slavica, Markey, Kate A., Boyle, Glen M., Smyth, Mark J., Engwerda, Christian R., MacDonald, Kelli P.A., Trapani, Joseph A., Degli-Esposti, Mariapia A., Koyama, Motoko and Hill, Geoffrey R. (2020). ASC modulates CTL cytotoxicity and transplant outcome independent of the inflammasome. Cancer Immunology Research, 8 (8), 1085-1098. doi: 10.1158/2326-6066.cir-19-0653 |
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2020 Journal Article Experiences and unmet needs of family members requested to donate haematopoietic stem cells to an ill relative: findings from a prospective multi-centre studyZomerdijk, Nienke, Turner, Jane, Hill, Geoffrey R. and Gottlieb, David (2020). Experiences and unmet needs of family members requested to donate haematopoietic stem cells to an ill relative: findings from a prospective multi-centre study. Supportive Care in Cancer, 29 (2), 635-644. doi: 10.1007/s00520-020-05520-y |
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2020 Journal Article Immunotherapy of multiple myelomaMinnie, Simone A. and Hill, Geoffrey R. (2020). Immunotherapy of multiple myeloma. The Journal of Clinical Investigation, 130 (4), 1565-1575. doi: 10.1172/JCI129205 |
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2020 Journal Article Type I interferons suppress anti-parasitic immunity and can be targeted to improve treatment of visceral leishmaniasisKumar, Rajiv, Bunn, Patrick T., Singh, Siddharth Sankar, Ng, Susanna S., Montes de Oca, Marcela, De Labastida Rivera, Fabian, Chauhan, Shashi Bhushan, Singh, Neetu, Faleiro, Rebecca J., Edwards, Chelsea L., Frame, Teija C.M., Sheel, Meru, Austin, Rebecca J., Lane, Steven W., Bald, Tobias, Smyth, Mark J., Hill, Geoffrey.R., Best, Shannon E., Haque, Ashraful, Corvino, Dillon, Waddell, Nic, Koufariotis, Lambross, Mukhopadhay, Pamela, Rai, Madhukar, Chakravarty, Jaya, Singh, Om Prakash, Sacks, David, Nylen, Susanne, Uzonna, Jude ... Engwerda, Christian R. (2020). Type I interferons suppress anti-parasitic immunity and can be targeted to improve treatment of visceral leishmaniasis. Cell Reports, 30 (8), 2512-2525.e9. doi: 10.1016/j.celrep.2020.01.099 |
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2020 Journal Article Long-lived regulatory T cells generated during severe bronchiolitis in infancy influence later progression to asthmaLynch, Jason P., Werder, Rhiannon B., Curren, Bodie F., Sikder, Md. Al Amin, Ullah, Ashik, Sebina, Ismail, Rashid, Ridwan B., Zhang, Vivian, Upham, John W., Hill, Geoff R., Steptoe, Raymond J. and Phipps, Simon (2020). Long-lived regulatory T cells generated during severe bronchiolitis in infancy influence later progression to asthma. Mucosal Immunology, 13 (4), 652-664. doi: 10.1038/s41385-020-0268-8 |
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2020 Journal Article Continuous pre- and post-transplant exposure to a disease-associated gut microbiome promotes hyper-acute graft-versus-host disease in wild-type miceBowerman, Kate L., Varelias, Antiopi, Lachner, Nancy, Kuns, Rachel D., Hill, Geoffrey R. and Hugenholtz, Philip (2020). Continuous pre- and post-transplant exposure to a disease-associated gut microbiome promotes hyper-acute graft-versus-host disease in wild-type mice. Gut Microbes, 11 (4), 1-17. doi: 10.1080/19490976.2019.1705729 |
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2020 Journal Article Inhibition of inositol kinase B controls acute and chronic graft-versus-host diseaseThangavelu, Govindarajan, Du, Jing, Paz, Katelyn G., Loschi, Michael, Zaiken, Michael C., Flynn, Ryan, Taylor, Patricia A., Kirchmeier, Andrew Kemal, Panoskaltsis-Mortari, Angela, Luznik, Leo, MacDonald, Kelli P., Hill, Geoffrey R., Maillard, Ivan, Munn, David H., Serody, Jonathan S., Murphy, William J., Miklos, David, Cutler, Corey S., Koreth, John, Antin, Joseph H., Soiffer, Robert J., Ritz, Jerome, Dahlberg, Carol, Miller, Andrew T. and Blazar, Bruce R. (2020). Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease. Blood, 135 (1), 28-40. doi: 10.1182/blood.2019000032 |
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2019 Journal Article MHC class II antigen presentation by the intestinal epithelium initiates graft-versus-host disease and is influenced by the microbiotaKoyama, Motoko, Mukhopadhyay, Pamela, Schuster, Iona S., Henden, Andrea S., Hülsdünker, Jan, Varelias, Antiopi, Vetizou, Marie, Kuns, Rachel D., Robb, Renee J., Zhang, Ping, Blazar, Bruce B., Thomas, Ranjeny, Begun, Jakob, Waddell, Nicola, Trinchieri, Giorgio, Zeiser, Robert, Clouston, Andrew D., Degli-Esposti, Mariapia A. and Hill, Geoffrey R. (2019). MHC class II antigen presentation by the intestinal epithelium initiates graft-versus-host disease and is influenced by the microbiota. Immunity, 51 (5), 885-898. doi: 10.1016/j.immuni.2019.08.011 |
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2019 Journal Article Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populationsAustin, Rebecca J., Straube, Jasmin, Bruedigam, Claudia, Pali, Gabor, Jacquelin, Sebastien, Vu, Therese, Green, Joanne, Gräsel, Julius, Lansink, Lianne, Cooper, Leanne, Lee, Shin-Jye, Chen, Nien-Tsu, Lee, Chung-Wei, Haque, Ashraful, Heidel, Florian H., D’Andrea, Richard, Hill, Geoff R., Mullally, Ann, Milsom, Michael D., Bywater, Megan and Lane, Steven W. (2019). Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations. Leukemia, 34 (4), 1075-1089. doi: 10.1038/s41375-019-0638-y |
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2019 Journal Article Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHDKoehn, Brent H., Saha, Asim, McDonald-Hyman, Cameron, Loschi, Michael, Thangavelu, Govindarajan, Ma, Lie, Zaiken, Michael, Dysthe, Josh, Krepps, Walker, Panthera, Jamie, Hippen, Keli, Jameson, Stephen C., Miller, Jeffrey S., Cooper, Matthew A., Farady, Christopher J., Iwawaki, Takao, Ting, Jenny P-Y, Serody, Jonathan S., Murphy, William J., Hill, Geoffrey R., Murray, Peter J., Bronte, Vincenzo, Munn, David H., Zeiser, Robert and Blazar, Bruce R. (2019). Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD. Blood, 134 (19), 1670-1682. doi: 10.1182/blood.2019001950 |
