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2021 Journal Article Stable colony-stimulating factor 1 fusion protein treatment increases hematopoietic stem cell pool and enhances their mobilisation in miceKaur, Simranpreet, Sehgal, Anuj, Wu, Andy C., Millard, Susan M., Batoon, Lena, Sandrock, Cheyenne J., Ferrari-Cestari, Michelle, Levesque, Jean-Pierre, Hume, David A., Raggatt, Liza J. and Pettit, Allison R. (2021). Stable colony-stimulating factor 1 fusion protein treatment increases hematopoietic stem cell pool and enhances their mobilisation in mice. Journal of Hematology and Oncology, 14 (1) 3, 1-19. doi: 10.1186/s13045-020-00997-w |
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2020 Journal Article Neurogenic heterotopic ossifications develop independently of granulocyte‐colony stimulating factor and neutrophilsTseng, Hsu‐Wen, Kulina, Irina, Salga, Marjorie, Fleming, Whitney, Vaquette, Cedryck, Genêt, François, Levesque, Jean‐Pierre and Alexander, Kylie A (2020). Neurogenic heterotopic ossifications develop independently of granulocyte‐colony stimulating factor and neutrophils. Journal of Bone and Mineral Research, 35 (11) jbmr.4118, 2242-2251. doi: 10.1002/jbmr.4118 |
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2020 Journal Article When the nervous system turns skeletal muscles into bones: how to solve the conundrum of neurogenic heterotopic ossificationAlexander, Kylie A., Tseng, Hsu-Wen, Salga, Marjorie, Genêt, François and Levesque, Jean-Pierre (2020). When the nervous system turns skeletal muscles into bones: how to solve the conundrum of neurogenic heterotopic ossification. Current Osteoporosis Reports, 18 (6), 666-676. doi: 10.1007/s11914-020-00636-w |
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2020 Journal Article Bacterial lipopolysaccharides suppress erythroblastic islands and erythropoiesis in the bone marrow in an extrinsic and G- CSF-, IL-1-, and TNF-independent mannerBisht, Kavita, Tay, Joshua, Wellburn, Rebecca N., McGirr, Crystal, Fleming, Whitney, Nowlan, Bianca, Barbier, Valerie, Winkler, Ingrid G. and Levesque, Jean-Pierre (2020). Bacterial lipopolysaccharides suppress erythroblastic islands and erythropoiesis in the bone marrow in an extrinsic and G- CSF-, IL-1-, and TNF-independent manner. Frontiers in Immunology, 11 583550, 1-16. doi: 10.3389/fimmu.2020.583550 |
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2020 Journal Article Acute myeloid leukemia chemo-resistance is mediated by E-selectin receptor CD162 in bone marrow nichesErbani, Johanna, Tay, Joshua, Barbier, Valerie, Levesque, Jean-Pierre and Winkler, Ingrid G. (2020). Acute myeloid leukemia chemo-resistance is mediated by E-selectin receptor CD162 in bone marrow niches. Frontiers in Cell and Developmental Biology, 8 668, 668. doi: 10.3389/fcell.2020.00668 |
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2020 Journal Article Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistanceBarbier, Valerie, Erbani, Johanna, Fiveash, Corrine, Davies, Julie M., Tay, Joshua, Tallack, Michael R., Lowe, Jessica, Magnani, John L., Pattabiraman, Diwakar R., Perkins, Andrew C., Lisle, Jessica, Rasko, John E. J., Levesque, Jean-Pierre and Winkler, Ingrid G. (2020). Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance. Nature Communications, 11 (1) 2042, 2042. doi: 10.1038/s41467-020-15817-5 |
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2020 Journal Article Imaging flow cytometry reveals that granulocyte colony-stimulating factor treatment causes loss of erythroblastic islands in the mouse bone marrowTay, Joshua, Bisht, Kavita, McGirr, Crystal, Millard, Susan M., Pettit, Allison R., Winkler, Ingrid G. and Levesque, Jean-Pierre (2020). Imaging flow cytometry reveals that granulocyte colony-stimulating factor treatment causes loss of erythroblastic islands in the mouse bone marrow. Experimental Hematology, 82, 33-42. doi: 10.1016/j.exphem.2020.02.003 |
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2020 Journal Article CD27, CD201, FLT3, CD48, and CD150 cell surface staining identifies long-term mouse hematopoietic stem cells in immunodeficient non-obese diabetic severe combined immune deficient derived strainsNowlan, Bianca, Williams, Elizabeth D., Doran, Michael R. and Levesque, Jean-Pierre (2020). CD27, CD201, FLT3, CD48, and CD150 cell surface staining identifies long-term mouse hematopoietic stem cells in immunodeficient non-obese diabetic severe combined immune deficient derived strains. Haematologica, 105 (1), 71-82. doi: 10.3324/haematol.2018.212910 |
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2019 Journal Article Oncostatin M is a novel niche factor that restrains hematopoietic stem cell mobilization in response to G-CSF and CXCR4 antagonist plerixaforBisht, Kavita, McGirr, Crystal, Alexander, Kylie A, Fleming, Whitney, Sims, Natalie, Newen, Gerhard Müller-, Winkler, Ingrid G and Levesque, Jean-Pierre (2019). Oncostatin M is a novel niche factor that restrains hematopoietic stem cell mobilization in response to G-CSF and CXCR4 antagonist plerixafor. Blood, 134 (Supplement_1), 4469-4469. doi: 10.1182/blood-2019-127431 |
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2019 Journal Article Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2Brennan, Faith H., Jogia, Trisha, Gillespie, Ellen R., Blomster, Linda V., Li, Xaria X., Nowlan, Bianca, Williams, Gail M., Jacobson, Esther, Osborne, Geoff W., Meunier, Frederic A., Taylor, Stephen M., Campbell, Kate E., MacDonald, Kelli P.A., Levesque, Jean-Pierre, Woodruff, Trent M. and Ruitenberg, Marc J. (2019). Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2. JCI Insight, 4 (9) e98254. doi: 10.1172/jci.insight.98254 |
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2019 Journal Article Inhibition of JAK1/2 Tyrosine Kinases Reduces Neurogenic Heterotopic Ossification After Spinal Cord InjuryAlexander, Kylie A., Tseng, Hsu-Wen, Fleming, Whitney, Jose, Beulah, Salga, Marjorie, Kulina, Irina, Millard, Susan M., Pettit, Allison R., Genet, Francois and Levesque, Jean-Pierre (2019). Inhibition of JAK1/2 Tyrosine Kinases Reduces Neurogenic Heterotopic Ossification After Spinal Cord Injury. Frontiers in Immunology, 10 (MAR) 377. doi: 10.3389/fimmu.2019.00377 |
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2019 Journal Article HIF prolyl hydroxylase inhibitor FG-4497 enhances mouse hematopoietic stem cell mobilization via VEGFR2/KDRBisht, Kavita, Brunck, Marion E., Matsumoto, Taichi, McGirr, Crystal, Nowlan, Bianca, Fleming, Whitney, Keech, Thomas, Magor, Graham, Perkins, Andrew C., Davies, Julie, Walkinshaw, Gail, Flippin, Lee, Winkler, Ingrid G. and Levesque, Jean-Pierre (2019). HIF prolyl hydroxylase inhibitor FG-4497 enhances mouse hematopoietic stem cell mobilization via VEGFR2/KDR. Blood Advances, 3 (3), 406-418. doi: 10.1182/bloodadvances.2018017566 |
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2019 Journal Article Blocking neuromuscular junctions with botulinum toxin A injection enhances neurological heterotopic ossification development after spinal cord injury in miceSalga, Marjorie, Tseng, Hsu-Wen, Alexander, Kylie A., Jose, Beulah, Vaquette, Cedryck, Debaud, Charlotte, Gatin, Laure, Genêt, François and Levesque, Jean-Pierre (2019). Blocking neuromuscular junctions with botulinum toxin A injection enhances neurological heterotopic ossification development after spinal cord injury in mice. Annals of Physical and Rehabilitation Medicine, 62 (3), 189-192. doi: 10.1016/j.rehab.2019.01.005 |
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2018 Journal Article Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftmentKaur, Simranpreet, Raggatt, Liza J., Millard, Susan M., Wu, Andy C., Batoon, Lena, Jacobsen, Rebecca N., Winkler, Ingrid G., MacDonald, Kelli P., Perkins, Andrew C., Hume, David A., Levesque, Jean-Pierre and Pettit, Allison R. (2018). Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment. Blood, 132 (7), 735-749. doi: 10.1182/blood-2018-01-829663 |
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2017 Journal Article Macrophages Driving Heterotopic Ossification: Convergence of Genetically-Driven and Trauma-Driven MechanismsLevesque, Jean-Pierre, Sims, Natalie A., Pettit, Allison R., Alexander, Kylie A., Tseng, Hsu-Wen, Torossian, Frédéric, Genêt, François, Lataillade, Jean-Jacques and Le Bousse-Kerdilès, Marie-Caroline (2017). Macrophages Driving Heterotopic Ossification: Convergence of Genetically-Driven and Trauma-Driven Mechanisms. Journal of Bone and Mineral Research, 33 (2), 365-366. doi: 10.1002/jbmr.3346 |
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2017 Journal Article Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossificationsTorossian, Frédéric, Guerton, Bernadette, Anginot, Adrienne, Alexander, Kylie A., Desterke, Christophe , Soave, Sabrina, Tseng, Hsu-Wen, Arouche, Nassim, Boutin, Laetitia, Kulina, Irina, Salga, Marjorie, Jose, Beulah, Pettit, Allison R., Clay, Denis, Rochet, Nathalie, Vlachos, Erica, Genet, Guillaume, Debaud, Charlotte, Denormandie, Philippe, Genet, François, Sims, Natalie A., Banzet, Sébastien, Levesque, Jean-Pierre, Lataillade, Jean-Jacques and Le Bousse-Kerdilès, Marie-Caroline (2017). Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications. JCI Insight, 2 (21) e96034. doi: 10.1172/jci.insight.96034 |
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2017 Journal Article CD169+ macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repairBatoon, Lena, Millard, Susan Marie, Wullschleger, Martin Eduar, Preda, Corina, Wu, Andy Chiu-Ku, Kaur, Simranpreet, Tseng, Hsu-Wen, Hume, David Arthur, Levesque, Jean-Pierre, Raggatt, Liza Jane and Pettit, Allison Robyn (2017). CD169+ macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repair. Biomaterials, 196, 51-66. doi: 10.1016/j.biomaterials.2017.10.033 |
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2017 Journal Article Peripheral denervation participates in heterotopic ossification in a spinal cord injury modelDebaud, Charlotte, Salga, Marjorie, Begot, Laurent, Holy, Xavier, Chedik, Malha, de l'Escalopier, Nicolas, Torossian, Frederic, Levesque, Jean-Pierre, Lataillade, Jean-Jacques, Le Bousse-Kerdiles, Marie-Caroline and Genet, Francois (2017). Peripheral denervation participates in heterotopic ossification in a spinal cord injury model. PLoS One, 12 (8) e0182454, e0182454. doi: 10.1371/journal.pone.0182454 |
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2017 Journal Article HIF-1α-stabilizing agent FG-4497 rescues human CD34+ cell mobilization in response to G-CSF in immunodeficient miceNowlan, Bianca, Futrega, Kathryn, Brunck, Marion, Walkinshaw, Gail, Flippin, Lee E., Doran, Michael R. and Levesque, Jean-Pierre (2017). HIF-1α-stabilizing agent FG-4497 rescues human CD34+ cell mobilization in response to G-CSF in immunodeficient mice. Experimental Hematology, 52, 50-55. doi: 10.1016/j.exphem.2017.05.004 |
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2017 Journal Article Engineering a humanized bone organ model in mice to study bone metastasesMartine, Laure C., Holzapfel, Boris M., McGovern, Jacqui A., Wagner, Ferdinand, Quent, Verena M., Hesami, Parisa, Wunner, Felix M., Vaquette, Cedryck, De-Juan-Pardo, Elena M., Brown, Toby D., Nowlan, Bianca, Wu, Dan Jing, Hutmacher, Cosmo Orlando, Moi, Davide, Oussenko, Tatiana, Piccinini, Elia, Zandstra, Peter W., Mazzieri, Roberta, Levesque, Jean-Pierre, Dalton, Paul D., Taubenberger, Anna V. and Hutmacher, Dietmar W. (2017). Engineering a humanized bone organ model in mice to study bone metastases. Nature Protocols, 12 (4), 639-663. doi: 10.1038/nprot.2017.002 |
