![Dr Amanda Kijas](/sites/default/files/profiles/11397.jpeg)
Overview
Background
I am a passionate research scientist who joined Professor Alan Rowans group in 2017 to develop novel wound management agents and investigate the interface between material science and cellular responses. These projects focus on studying cellular responses within 3D matrices of defined properties where we can investigate the role of biophysical and biochemical interactions in real time and with applied mechanical force using a confocal rheometer. Extracellular matrices are a large focus, acting as dynamic platforms not only providing a physical scaffold with defined mechanical properties but also act as a repository for biochemical based signalling molecules and interaction domains, orchestrating biological responses. Matrices composed of synthetic or naturally derived material, offer different and overlapping array of advantageous in the context of cell behaviour. We are exploring both types in isolation and as composite and hybrid materials to tailor the biophysical aspects to the specific applications. By combining these matrices with bioactive components we are empowering the materials to bring about the biochemical responses in defined ways, enabling the investigation of both fundamental biological processes as well as development of clinically relevant agents.
Availability
- Dr Amanda Kijas is:
- Available for supervision
Qualifications
- Bachelor (Honours), Flinders University
- Doctor of Philosophy, Uppsala University
Works
Search Professor Amanda Kijas’s works on UQ eSpace
2024
Journal Article
The Potential of Sugarcane Waste-Derived Cellulose Fibres as Haemostatic Agents
Malone, Siobhan, Yegappan, Ramanathan, Kijas, Amanda, Gemmell, Anna, Rowan, Alan, Rajah, Divya, Kim, Minjun, Lauko, Jan and Amiralian, Nasim (2024). The Potential of Sugarcane Waste-Derived Cellulose Fibres as Haemostatic Agents. Polymers, 16 (12) 1654, 1654. doi: 10.3390/polym16121654
2023
Journal Article
Entry and exit of extracellular vesicles to and from the blood circulation
Iannotta, Dalila, A, Amruta, Kijas, Amanda W., Rowan, Alan E. and Wolfram, Joy (2023). Entry and exit of extracellular vesicles to and from the blood circulation. Nature Nanotechnology, 19 (1), 137-20. doi: 10.1038/s41565-023-01522-z
2023
Journal Article
Snake venom-defined fibrin architecture dictates fibroblast survival and differentiation
Wang, Zhao, Lauko, Jan, Kijas, Amanda W., Gilbert, Elliot P., Turunen, Petri, Yegappan, Ramanathan, Zou, Dongxiu, Mata, Jitendra and Rowan, Alan E. (2023). Snake venom-defined fibrin architecture dictates fibroblast survival and differentiation. Nature Communications, 14 (1) 1029, 1-16. doi: 10.1038/s41467-023-36437-9
2022
Journal Article
Snake venom hydrogels as a rapid hemostatic agent for uncontrolled bleeding
Yegappan, Ramanathan, Lauko, Jan, Wang, Zhao, Lavin, Martin F., Kijas, Amanda W. and Rowan, Alan E. (2022). Snake venom hydrogels as a rapid hemostatic agent for uncontrolled bleeding. Advanced Healthcare Materials, 11 (15) 2200574, 2200574. doi: 10.1002/adhm.202200574
2022
Journal Article
The Mechanosensory Role of Osteocytes and Implications for Bone Health and Disease States
Choi, Jung Un Ally, Kijas, Amanda W., Lauko, Jan and Rowan, Alan E. (2022). The Mechanosensory Role of Osteocytes and Implications for Bone Health and Disease States. Frontiers in Cell and Developmental Biology, 9 770143, 770143. doi: 10.3389/fcell.2021.770143
2021
Journal Article
Heterodyne Brillouin microscopy for biomechanical imaging
Taylor, Michael A., Kijas, Amanda W., Wang, Zhao, Lauko, Jan and Rowan, Alan E. (2021). Heterodyne Brillouin microscopy for biomechanical imaging. Biomedical Optics Express, 12 (10) 6259, 6259-6268. doi: 10.1364/boe.435869
2020
Journal Article
Correction of ATM mutations in iPS cells from two ataxia-telangiectasia patients restores DNA damage and oxidative stress responses
Ovchinnikov, Dmitry A., Withey, Sarah L., Leeson, Hannah C., Lei, U. Wang, Sundarrajan, Ashmitha, Junday, Keerat, Pewarchuk, Michelle, Yeo, Abrey J., Kijas, Amanda W., Lavin, Martin F. and Wolvetang, Ernst J. (2020). Correction of ATM mutations in iPS cells from two ataxia-telangiectasia patients restores DNA damage and oxidative stress responses. Human Molecular Genetics, 29 (6), 990-1001. doi: 10.1093/hmg/ddaa023
2020
Journal Article
Simultaneous targeting of DNA replication and homologous recombination in glioblastoma with a polyether ionophore
Lim, Yi Chieh, Ensbey, Kathleen S., Offenhäuser, Carolin, D'souza, Rochelle C. J., Cullen, Jason K., Stringer, Brett W., Quek, Hazel, Bruce, Zara C., Kijas, Amanda, Cianfanelli, Valentina, Mahboubi, Bijan, Smith, Fiona, Jeffree, Rosalind L., Wiesmüeller, Lisa, Wiegmans, Adrian P., Bain, Amanda, Lombard, Fanny J., Roberts, Tara L., Khanna, Kum Kum, Lavin, Martin F., Kim, Baek, Hamerlik, Petra, Johns, Terrance G., Coster, Mark J., Boyd, Andrew W. and Day, Bryan W. (2020). Simultaneous targeting of DNA replication and homologous recombination in glioblastoma with a polyether ionophore. Neuro-Oncology, 22 (2), 216-228. doi: 10.1093/neuonc/noz159
2017
Book Chapter
Assaying for radioresistant DNA synthesis, the hallmark feature of the intra-S-phase checkpoint using a DNA fiber technique
Kijas, Amanda W. and Lavin, Martin F. (2017). Assaying for radioresistant DNA synthesis, the hallmark feature of the intra-S-phase checkpoint using a DNA fiber technique. ATM kinase: methods and protocols. (pp. 13-23) edited by Sergei V. Kozlov. New York, NY, United States: Humana Press. doi: 10.1007/978-1-4939-6955-5_2
2016
Journal Article
Therapeutic targets and investigated treatments for Ataxia-Telangiectasia
Lavin, Martin F., Yeo, Abrey J., Kijas, Amanda W., Wolvetang, Ernst, Sly, Peter D., Wainwright, Claire and Sinclair, Kate (2016). Therapeutic targets and investigated treatments for Ataxia-Telangiectasia. Expert Opinion on Orphan Drugs, 4 (12), 1263-1276. doi: 10.1080/21678707.2016.1254618
2015
Journal Article
ATM-dependent phosphorylation of all three members of the MRN complex: from sensor to adaptor
Lavin, Martin F., Kozlov, Sergei, Gatei, Magtouf and Kijas, Amanda W. (2015). ATM-dependent phosphorylation of all three members of the MRN complex: from sensor to adaptor. Biomolecules, 5 (4) A31, 2877-2902. doi: 10.3390/biom5042877
2015
Journal Article
ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1
Kijas, Amanda W., Lim, Yi Chieh, Bolderson, Emma, Cerosaletti, Karen, Gatei, Magtouf, Jakob, Burkhard, Tobias, Frank, Taucher-Scholz, Gisela, Gueven, Nuri, Oakley, Greg, Concannon, Patrick, Wolvetang, Ernst, Khanna, Kum Kum, Wiesmuller, Lisa and Lavin, Martin F. (2015). ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1. Nucleic Acids Research, 43 (17), 8352-8367. doi: 10.1093/nar/gkv754
2014
Journal Article
RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress
Gatei, Magtouf, Kijas, Amanda W., Biard, Denis, Dork, Thilo and Lavin, Martin F. (2014). RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress. Human Molecular Genetics, 23 (16) ddu141, 4232-4248. doi: 10.1093/hmg/ddu141
2013
Journal Article
A patient-derived olfactory stem cell disease model for ataxia-telangiectasia
Stewart, Romal, Kozlov, Sergei, Matigian, Nicholas, Wali, Gautam, Gatei, Magtouf, Sutharsan, Ratneswary, Bellette, Bernadette, Kijas, Amanda Wraith, Cochrane, Julie, Coulthard, Mark, Perry, Chris, Sinclair, Kate, Mackay-Sim, Alan and Lavin, Martin F. (2013). A patient-derived olfactory stem cell disease model for ataxia-telangiectasia. Human Molecular Genetics, 22 (12), 2495-2509. doi: 10.1093/hmg/ddt101
2012
Journal Article
A role for homologous recombination and abnormal cell-cycle progression in radioresistance of glioma-initiating cells
Lim, Yi Chieh, Roberts, Tara L., Day, Bryan W., Harding, Angus, Kozlov, Sergei, Kijas, Amanda W., Ensbey, Kathleen S., Walker, David G. and Lavin, Martin F. (2012). A role for homologous recombination and abnormal cell-cycle progression in radioresistance of glioma-initiating cells. Molecular Cancer Therapeutics, 11 (9), 1863-1872. doi: 10.1158/1535-7163.MCT-11-1044
2012
Conference Publication
Response of glioma initiating cells to ionising radiation
Lim, Y. C., Roberts, T., Day, B., Harding, A., Ensbey, K., Kozlov, S., Kijas, A., Walker, D. and Lavin, M. (2012). Response of glioma initiating cells to ionising radiation. Targeting Cancer from Diagnosis to Cure & 5th Annual COGNO Annual Scientific Meeting, Brisbane, QLD, Australia, 8-10 August 2012. Chichester, West Sussex, United Kingdom: Wiley-Blackwell. doi: 10.1111/j.1743-7563.2012.01586_2.x
2011
Journal Article
ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control
Gatei, Magtouf, Jakob, Burkhard, Chen, Philip, Kijas, Amanda W., Becherel, Olivier J., Gueven, Nuri, Birrell, Geoff, Lee, Ji-Hoon, Paull, Tanya T., Lerenthal, Yaniv, Fazry, Shazrul, Taucher-Scholtz, Gisela, Kalb, Reinhard, Schindler, Detlev, Waltes, Regina, Doerk, Thilo and Lavin, Martin F. (2011). ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control. Journal of Biological Chemistry, 286 (36), 31542-31556. doi: 10.1074/jbc.M111.258152
2011
Journal Article
Autophosphorylation and ATM activation: Additional sites add to the complexity
Kozlov, Sergei V., Graham, Mark E., Jakob, Burkhard, Tobias, Frank, Kijas, Amanda W., Tanuji, Marcel, Chen, Philip, Robinson, Phillip J., Taucher-Scholz, Gisela, Suzuki, Keiji, So, Sairai, Chen, David and Lavin, Martin F. (2011). Autophosphorylation and ATM activation: Additional sites add to the complexity. The Journal of Biological Chemistry, 286 (11), 9107-9119. doi: 10.1074/jbc.M110.204065
2010
Journal Article
CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response
Becherel, Olivier J., Jakob, Burkhard, Cherry, Amy L., Gueven, Nuri, Fusser, Markus, Kijas, Amanda W., Peng, Cheng, Katyal, Sachin, McKinnon, Peter J., Chen, Junjie, Epe, Bernd, Smerdon, Stephen J., Taucher-Scholz, Gisela and Lavin, Martin F. (2010). CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response. Nucleic Acids Research, 38 (5) gkp1149, 1489-1503. doi: 10.1093/nar/gkp1149
2010
Book Chapter
ATM mediated signaling defends the integrity of the genome
Lavin, Martin F., Gatei, Magtouf, Chen, Philip, Kijas, Amanda and Kozlov, Sergei (2010). ATM mediated signaling defends the integrity of the genome. Handbook of Cell Signaling. (pp. 2171-2183) edited by Ralph A. Bradshaw and Edward A. Dennis. Amsterdam, The Netherlands: Elsevier Inc.. doi: 10.1016/B978-0-12-374145-5.00263-1
Supervision
Availability
- Dr Amanda Kijas is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Next generation bleeding control agents
Principal Advisor
Other advisors: Professor Alan Rowan
-
-
Doctor Philosophy
Stress stiffening biomaterials driving differentiation
Associate Advisor
Other advisors: Professor Alan Rowan
-
Doctor Philosophy
Characterisation of Cytoskeleton information transfer
Associate Advisor
Other advisors: Professor Alan Rowan
-
Doctor Philosophy
Investigation of Matrix Regulation of Wound Repair
Associate Advisor
Other advisors: Dr Katharine Irvine, Professor Alan Rowan
-
Doctor Philosophy
REGULATION OF STEM CELL FATE IN RGD-FUNCTIONALIZED BIOMIMETIC HYDROGEL
Associate Advisor
Other advisors: Professor Alan Rowan
Completed supervision
-
2023
Doctor Philosophy
Understanding the science and application of snake venom proteins in wound management
Associate Advisor
Other advisors: Professor Alan Rowan
-
2023
Doctor Philosophy
Snake venom-controlled fibrin networks for wound healing studies
Associate Advisor
Other advisors: Professor Alan Rowan
-
2022
Doctor Philosophy
Control of osteocyte behaviour by tailoring extracellular matrix
Associate Advisor
Other advisors: Professor Alan Rowan
Media
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