Dr Oliver Rawashdeh
Dr

Oliver Rawashdeh

Email: 
Phone: 
+61 7 336 52706

Background

I received my Bachelor's in Biology (2001) from Yarmouk University in Jordan, followed by postgraduate degrees from the University of Houston in Houston-Texas (2002-2007). My studies are integrative in nature, joining the best of both the Neuroscience world and Circadian Biology (the study of biological clocks). In the laboratory of Prof. Arnold Eskin, I investigated how processes as complex as learning and memory are modulated by biological clocks i.e. the circadian (about 24 hours) system, using Aplysia californica as the experimental model. After completing my Master's in Science in 2005, my research focused on the mechanism by which biological clocks modulate learning and memory. This work was performed in the laboratories of Prof. Gregg Cahill and Prof. Greg Roman, experts in chronobiology and behavioral neuroscience, respectively. Using Zebrafish as a model system, I investigated the role of melatonin, a night-time restricted hormonal signal, in modulating long-term memory consolidation. My findings, published in Science in 2007, shows that the circadian system via the cyclic night-time confined synthesis/release of melatonin “the hormone of darkness” functions as a modulator, shaping daily variations in the efficiency by which memories are processed. After receiving my Ph.D. in 2007, I joined as a postdoctoral fellow the laboratory of the pharmacologist and melatonin researcher Prof. Margarita Dubocovich. My postdoctoral work engaged in elucidating the role of melatonin in circadian physiology and pharmacology during development and ageing in rodents (Mus musculus) and non-human primates (Macaca mulatta) at the Feinberg School of Medicine (Northwestern University-Chicago) and the State University of New York (SUNY). From 2010-2015, I held a teaching/research position in the Dr. Senckenbergische Anatomy and the Dept. of Neurology at the Goethe University in Frankfurt-Germany. During this time, I was involved in teaching gross human anatomy while continuing my endeavor in understanding the mechanistics involved in shaping memory processes (acquisition, consolidation and retrieval) by the circadian system.

Availability

Dr Oliver Rawashdeh is:
Available for supervision
Media expert

Fields of research

Animal behaviour Animal neurobiology Animal physiology - systems Biological Sciences Biomedical and Clinical Sciences Cell neurochemistry Education Health Sciences Mathematical Sciences Neurosciences Signal transduction Systems biology Zoology

Qualifications

  • Masters (Coursework) of Science, University of Houston
  • Doctor of Philosophy, University of Houston

Research impacts

I have always been intrigueed by the importance of the biological time-keeping system in regulating physiological and behavioural processes as complex and important as learning and memory. A memory is a defining factor of who we are, similar to a passport or fingerprint "we are our memories". The efficiency by which we aqcuire new information (learning) and form memories is dependent on temporal factors generated by our inner time-keeping system, the circadian system, which imposes regulatory actions on anatomical structures inlcuding those pivotal for memory processing. This phenomenon has deep fundamental evolutionary roots, since the circadian modulation of learning and memory is conserved across species, as we and others have demonstrated. My research focuses on identifying the biological clocks and pacemakers that regulate hippocampus-dependent learning and memory processes and deciphering the means of communication between the circadian clock and the limbic system (anatomical structures specialized in the generation, processing and storrage of informations and emotions). hence, the memories that shape our behavior are based on theinformation we efficiently aquire, which is dependent on the time-of-day when information processing takes place.

Humans are under the mercy of increasingly accelerating technological advancements and slaves to our own and growing greed. Our bodies are not designed to function to meet such demands, simply because evolution is lagging behind! Since we are less likely to change and cure the directionality of modern-life style and its demands, a fundamental understanding to how the circadian system interacts to modulate physiology, particularly memory processing, will aid in providing therapeutics aimed to enhance our adaptability (metabolic, cognitive...etc) to continuous and rapid temporal shifts.

Search Professor Oliver Rawashdeh’s works on UQ eSpace

45 works between 2005 and 2025
All (45) Journal Article (39) Conference Publication (5) Other Outputs (1)

21 - 40 of 45 works

2020

Journal Article

Circadian Hygiene in the ICU Environment (CHIE) study

Boots, Rob, Mead, Gabrielle, Rawashdeh, Oliver, Bellapart, Judith, Townsend, Shane, Paratz, Jenny, Garner, Nicholas, Clement, Pierre, Oddy, David and On behalf of the Circadian Investigators in Critical Illness (2020). Circadian Hygiene in the ICU Environment (CHIE) study. Critical Care and Resuscitation, 22 (4), 361-369. doi: 10.51893/2020.4.oa9

Circadian Hygiene in the ICU Environment (CHIE) study

2020

Journal Article

CircaCompare: a method to estimate and statistically support differences in mesor, amplitude and phase, between circadian rhythms

Parsons, Rex, Parsons, Richard, Garner, Nicholas, Oster, Henrik and Rawashdeh, Oliver (2020). CircaCompare: a method to estimate and statistically support differences in mesor, amplitude and phase, between circadian rhythms. Bioinformatics, 36 (4), 1208-1212. doi: 10.1093/bioinformatics/btz730

CircaCompare: a method to estimate and statistically support differences in mesor, amplitude and phase, between circadian rhythms

2020

Journal Article

The concept of coupling in the mammalian circadian clock-network

Pilorz, Violetta, Astiz, Mariana, Heinen, Keno Ole, Rawashdeh, Oliver and Oster, Henrik (2020). The concept of coupling in the mammalian circadian clock-network. Journal of Molecular Biology, 432 (12), 3618-3638. doi: 10.1016/j.jmb.2019.12.037

The concept of coupling in the mammalian circadian clock-network

2019

Journal Article

At the intersection of microbiota and circadian clock: are sexual dimorphism and growth hormones the missing link to pathology? Circadian clock and microbiota: potential egffect on growth hormone and sexual development

Weger, Benjamin D., Rawashdeh, Oliver and Gachon, Frédéric (2019). At the intersection of microbiota and circadian clock: are sexual dimorphism and growth hormones the missing link to pathology? Circadian clock and microbiota: potential egffect on growth hormone and sexual development. BioEssays, 41 (9) 1900059, e1900059. doi: 10.1002/bies.201900059

At the intersection of microbiota and circadian clock: are sexual dimorphism and growth hormones the missing link to pathology? Circadian clock and microbiota: potential egffect on growth hormone and sexual development

2019

Journal Article

Periconceptional maternal alcohol consumption leads to behavioural changes in adult and aged offspring and alters the expression of hippocampal genes associated with learning and memory and regulators of the epigenome

Lucia, D., Burgess, D., Cullen, C. L., Dorey, E. S., Rawashdeh, O. and Moritz, K. M. (2019). Periconceptional maternal alcohol consumption leads to behavioural changes in adult and aged offspring and alters the expression of hippocampal genes associated with learning and memory and regulators of the epigenome. Behavioural Brain Research, 362, 249-257. doi: 10.1016/j.bbr.2019.01.009

Periconceptional maternal alcohol consumption leads to behavioural changes in adult and aged offspring and alters the expression of hippocampal genes associated with learning and memory and regulators of the epigenome

2019

Journal Article

Coupling the circadian clock to homeostasis: the role of Period in timing physiology

Kim, Pureum, Oster, Henrik, Lehnert, Hendrik, Schmid, Sebastian M, Salamat, Nicole, Barclay, Johanna L, Maronde, Erik, Inder, Warrick and Rawashdeh, Oliver (2019). Coupling the circadian clock to homeostasis: the role of Period in timing physiology. Endocrine Reviews, 40 (1), 66-95. doi: 10.1210/er.2018-00049

Coupling the circadian clock to homeostasis: the role of Period in timing physiology

2018

Journal Article

Early postnatal development of the visual cortex in mice with retinal degeneration

Himmelhan, D. K., Rawashdeh, O. and Oelschläger, H. H. A. (2018). Early postnatal development of the visual cortex in mice with retinal degeneration. Mechanisms of Development, 151, 1-9. doi: 10.1016/j.mod.2018.03.002

Early postnatal development of the visual cortex in mice with retinal degeneration

2018

Conference Publication

Periconceptional alcohol exposure results in sex-specific alterations to circadian rhythms of blood glucose and plasma corticosterone in rat offspring

Wing, Michael J. E., Burgess, Danielle, Zanfirache, Diana, Rawashdeh, Oliver and Moritz, Karen (2018). Periconceptional alcohol exposure results in sex-specific alterations to circadian rhythms of blood glucose and plasma corticosterone in rat offspring. Joint Annual Scientific Meetings of the Endocrine Society of Australia and the Society for Reproductive Biology 2017, Perth, WA, Australia, 27-30 August 2017. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/cen.13727

Periconceptional alcohol exposure results in sex-specific alterations to circadian rhythms of blood glucose and plasma corticosterone in rat offspring

2018

Conference Publication

Alterations to circadian rhythms of blood glucose and plasma corticosterone in rat offspring following exposure to alcohol around conception

Wing, M. J., Burgess, Di., Lucia, D., Rawashdeh, O. and Moritz, K. M. (2018). Alterations to circadian rhythms of blood glucose and plasma corticosterone in rat offspring following exposure to alcohol around conception. 41st Annual Scientific Meeting of the Research Society on Alcoholism, San Diego, California, 16-20 June 2018 . Malden, MA, United States: Wiley-Blackwell .

Alterations to circadian rhythms of blood glucose and plasma corticosterone in rat offspring following exposure to alcohol around conception

2018

Journal Article

Clocking in time to gate memory processes: the circadian clock is part of the ins and outs of memory

Rawashdeh, Oliver, Parsons, Rex and Maronde, Erik (2018). Clocking in time to gate memory processes: the circadian clock is part of the ins and outs of memory. Neural Plasticity, 2018 6238989, 6238989-11. doi: 10.1155/2018/6238989

Clocking in time to gate memory processes: the circadian clock is part of the ins and outs of memory

2018

Conference Publication

Maternal alcohol consumption around conception leads to sex specific behavioural changes in rat offspring

Lucia, D., Burgess, D. J., Cullen, C. L., Rawashdeh, O. and Moritz, K. M. (2018). Maternal alcohol consumption around conception leads to sex specific behavioural changes in rat offspring. 41st Annual Scientific Meeting of the Research Society on Alcoholism, San Diego, CA, United States, 16-20 June 2018. Malden, MA, United States: Wiley-Blackwell.

Maternal alcohol consumption around conception leads to sex specific behavioural changes in rat offspring

2017

Journal Article

Learned motivation drives circadian physiology in the absence of the master circadian clock

Rawashdeh, Oliver, Clough, Shannon J. , Hudson, Randall L. and Dubocovich, Margarita L. (2017). Learned motivation drives circadian physiology in the absence of the master circadian clock. FASEB Journal, 31 (1), 388-399. doi: 10.1096/fj.201600926R

Learned motivation drives circadian physiology in the absence of the master circadian clock

2017

Journal Article

The hippocampal autophagic machinery is depressed in the absence of the circadian clock protein PER1 that may lead to vulnerability during cerebral ischemia

Rami, Abdalhaq, Fekadu, Julia and Rawashdeh, Oliver (2017). The hippocampal autophagic machinery is depressed in the absence of the circadian clock protein PER1 that may lead to vulnerability during cerebral ischemia. Current Neurovascular Research, 14 (3), 207-214. doi: 10.2174/1567202614666170619083239

The hippocampal autophagic machinery is depressed in the absence of the circadian clock protein PER1 that may lead to vulnerability during cerebral ischemia

2016

Journal Article

Period1 gates the circadian modulation of memory-relevant signaling in mouse hippocampus by regulating the nuclear shuttling of the CREB kinase pP90RSK

Rawashdeh, Oliver, Jilg, Antje, Maronde, Erik, Fahrenkrug, Jan and Stehle, Joerg H. (2016). Period1 gates the circadian modulation of memory-relevant signaling in mouse hippocampus by regulating the nuclear shuttling of the CREB kinase pP90RSK. Journal of Neurochemistry, 138 (5), 731-745. doi: 10.1111/jnc.13689

Period1 gates the circadian modulation of memory-relevant signaling in mouse hippocampus by regulating the nuclear shuttling of the CREB kinase pP90RSK

2016

Journal Article

Ribosomal RNA - A tail wagging the dog?

Stehle, Jorg H. and Rawashdeh, Oliver (2016). Ribosomal RNA - A tail wagging the dog?. Journal of Neurochemistry, 136 (4), 673-676. doi: 10.1111/jnc.13499

Ribosomal RNA - A tail wagging the dog?

2014

Journal Article

PERIOD1 coordinates hippocampal rhythms and memory processing with daytime

Rawashdeh, Oliver, Jilg, Antje, Jedlicka, Peter, Slawska, Jolanta, Thomas, Lukas, Saade, Anastasia, Schwarzacher, Stephan W. and Stehle, Joerg H. (2014). PERIOD1 coordinates hippocampal rhythms and memory processing with daytime. Hippocampus, 24 (6), 712-723. doi: 10.1002/hipo.22262

PERIOD1 coordinates hippocampal rhythms and memory processing with daytime

2014

Journal Article

Long-term effects of maternal separation on the responsiveness of the circadian system to melatonin in the diurnal nonhuman primate (Macaca mulatta)

Rawashdeh, Oliver and Dubocovich, Margarita L. (2014). Long-term effects of maternal separation on the responsiveness of the circadian system to melatonin in the diurnal nonhuman primate (Macaca mulatta). Journal of Pineal Research, 56 (3), 254-263. doi: 10.1111/jpi.12118

Long-term effects of maternal separation on the responsiveness of the circadian system to melatonin in the diurnal nonhuman primate (Macaca mulatta)

2012

Journal Article

The hormonal Zeitgeber melatonin: role as a circadian modulator in memory processing

Rawashdeh, Oliver and Maronde, Erik (2012). The hormonal Zeitgeber melatonin: role as a circadian modulator in memory processing. Frontiers in Molecular Neuroscience, 5 (FEBRUARY 2012), 1-6. doi: 10.3389/fnmol.2012.00027

The hormonal Zeitgeber melatonin: role as a circadian modulator in memory processing

2011

Journal Article

A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases

Stehle, Joerg H., Saade, Anastasia, Rawashdeh, Oliver, Ackermann, Katrin, Jilg, Antje, Sebesteny, Tamas and Maronde, Erik (2011). A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases. Journal of Pineal Research, 51 (1), 17-43. doi: 10.1111/j.1600-079X.2011.00856.x

A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases

2011

Journal Article

Circadian periods of sensitivity for ramelteon on the onset of running-wheel activity and the peak of suprachiasmatic nucleus neuronal firing rhythms in C3HHeN mice

Rawashdeh, Oliver, Hudson, Randall L., Stepien, Iwona and Dubocovich, Margarita L. (2011). Circadian periods of sensitivity for ramelteon on the onset of running-wheel activity and the peak of suprachiasmatic nucleus neuronal firing rhythms in C3HHeN mice. Chronobiology International, 28 (1), 31-38. doi: 10.3109/07420528.2010.532894

Circadian periods of sensitivity for ramelteon on the onset of running-wheel activity and the peak of suprachiasmatic nucleus neuronal firing rhythms in C3HHeN mice

Past funding

  • 2020 - 2024
    The clock as a therapeutic target to improve sleep quality and circadian dysfunction in Parkinson's disease: fighting neurodegeneration by treating chronodegeneration.
    NHMRC IDEAS Grants
    Open grant
  • 2019
    Advanced Brightfield and Fluorescent High Speed and Throughput Slide Scanner for biological, medical, materials science, and agricultural applications
    UQ Major Equipment and Infrastructure
    Open grant

Availability

Dr Oliver Rawashdeh is:
Available for supervision

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Available projects

  • Deciphering the role of clock genes in the transduction of photic information to the master biological clock

    Project:

    The project aims to identify the components and mechanistics involved in resetting the body’s master circadian clock in the suprachiasmatic nucleus. A detailed understanding of how time-cues entrain the biological clock will be key to develop pharmacological approaches that are aimed to enhance our adaptability to temporal environmental changes i.e. adjusting the speed by which our clocks tick.

    Background:

    Jetlag and Social-lag are terms used to describe symptoms associated with the disruption of the body’s “internal clock”. This disruption, or desynchronosis, can occur (1) when flying across multiple time zones, (2) during shiftwork, (3) due to a misalgnment between the body’s internal clock and social time and (4) in diseases and during ageing. The symptoms include loss of appetite, insomnia, mild depression, altered mood, headaches, nausea and reduced physical and mental performance. Jetlag symptoms gradually wear off as the body adapts to the new time zone and social cycles. Thus, accelerating the adaptation process or reinstating circadian rhythms in disease and during ageing means reducing symptomatology and improving the quality of life.

    Scholarship:

    This project is fully funded and inlcudes a scholarship top-up.

  • Sleep and circadian dysfunction in neurodegenerative diseases.

    Project:

    We have a long-term interdisciplinary research program to study sleep and circadian rhythms in neurodegenerative disorders. The expertise of our collaborative groups spans from chronobiology, neuroscience, pharmacology, to engineering and maths. Together we are working on urgent translational research questions. We are seeking highly motivated, curiosity-driven students interested in joining the team to pursue a Ph.D. in Neuroscience in the area of sleep and circadian rhythms in neurodegeneration and related therapeutic avenues. The Ph.D. candidates will take interest and leadership in formulating scientific questions, develop new techniques, and mechanistic/therapeutic solutions. Training to design experiments and learn new methods will be provided. The Ph.D. candidate will be supported by lab staff. Unique lab skills in emerging fields and initiatives within the broad framework are welcomed.

    Educational background:

    A BSc. Honours (Class1) or MSc. in science, biomedical sciences, biomedical engineering, neurosciences, biochemistry, or related disciplines is required. Candidates with experience in small animal neuroscience research, biochemistry, animal behaviour, are strongly encouraged to apply.

    Scholarship:

    This project is fully funded and includes a scholarship and top-up funds.

  • Modelling the interaction between sleep and the biological clock in health and disease

    Project:

    We have a long-term interdisciplinary research program to study sleep and circadian rhythms in health and disease (e.g., neurodegenerative disorders). The expertise of our collaborative groups spans from chronobiology, neuroscience, and pharmacology. Together we are working on urgent translational research questions. For this project, we are seeking a highly motivated, curiosity-driven student interested in the Neuroscience of sleep and circadian rhythms, specifically on the mathematical modeling of the regulatory interaction between the biological clock and sleep in health and disease. The Ph.D. candidate will take interest and leadership in formulating scientific questions, develop new techniques, and mechanistic/therapeutic solutions. Training to design experiments and learn new methods will be provided. The Ph.D. candidate will be supported by lab staff. We welcome unique lab skills in emerging fields and initiatives within the broad framework.

    Educational background:

    A bachelor’s in Science, BioMed, Mathematics, Engineering, and Computer science are welcome.

    Scholarship:

    This project is fully funded, scholarships and top-up funds are also available.

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Dr Oliver Rawashdeh directly for media enquiries about:

  • Chronomedicine
  • Chronopharmacology
  • Circadian clocks
  • Circadian rhythms
  • Hippocampus
  • Jetlag
  • Learning & Memory
  • Melatonin
  • Neurogenerative Diseases
  • Parkinson's Disease
  • Sleep

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