
Overview
Background
Dr Loic Yengo is a Professor of Statistical Genomics at The University of Queensland (UQ) and Group Leader of the Statistical Genomics Laboratory within UQ’s Institute for Molecular Bioscience. He was awarded a prestigious Snow Medical Research Fellowship in 2024 to dramatically advance the use of genomics to prevent chronic disease such as type 2 diabetes, heart disease and Alzheimer’s, with a particular focus on increasing participation of people with diverse ancestries. After completing a PhD in applied mathematics and statistics at the University of Lille (France) in 2014, he joined UQ in 2016 for postdoctoral training in Quantitative and Statistical Genetics. Loic started his own lab in 2020 to investigate the causes and consequences of genetic variation within and between human populations. His group develops and applies novel statistical methods to analyse large volumes of genomic data. Loic’s research has contributed to improving understanding of the genetic and phenotypic consequences of non-random mating (inbreeding and assortative mating) in human populations and has led to identifying novel genetic variants associated with complex traits and diseases. Loic was named among the top 40 rising stars of research by The Australian newspaper in 2021 and received the UQ Foundation research excellence award the same year. Loic is the 2022 recipient of the Ruth Stephens Gani Medal of the Australian Academy of Science recognizing outstanding contributions to research in human genetics, and was named in Nature Medicine’s 2022 Yearbook among 11 early-career researchers “to watch”.
In 2024, he was the recipient of the American Society of Human Genetics Early Career Award and a Snow Medical Research Foundation Fellowship to accelerate the deployment of genomic risk prediction in the clinic and improve the benefit of genomic medicine in all populations.
Availability
- Professor Loic Yengo is:
- Available for supervision
Qualifications
- Doctor of Philosophy, Université Lille 1 - Sciences et Technologies
Research impacts
The research in the Yengo Lab contributes to the discovery of genes and biological pathways involved in the etiology of multifactorial diseases such as obesity and type 2 diabetes. The ultimate goal of our research is to better understand what genes underlie inter-individual variation in disease susceptibility and help translate that knowledge into new and personalised therapies.
Works
Search Professor Loic Yengo’s works on UQ eSpace
2016
Journal Article
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
Schumann, Gunter, Liu, Chunyu, O'Reilly, Paul, Gao, He, Song, Parkyong, Xu, Bing, Ruggeri, Barbara, Amin, Najaf, Jia, Tianye, Preis, Sarah, Lepe, Marcelo Segura, Akira, Shizuo, Barbieri, Caterina, Baumeister, Sebastian, Cauchi, Stephane, Clarke, Toni-Kim, Enroth, Stefan, Fischer, Krista, Hallfors, Jenni, Harris, Sarah E., Hieber, Saskia, Hofer, Edith, Hottenga, Jouke-Jan, Johansson, Asa, Joshi, PeterK., Kaartinen, Niina, Laitinen, Jaana, Lemaitre, Rozenn, Loukola, Anu ... Elliott, Paul (2016). KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference. Proceedings of the National Academy of Sciences, 113 (50), 14372-14377. doi: 10.1073/pnas.1611243113
2016
Journal Article
Associations between type 2 diabetes-related genetic scores and metabolic traits, in obese and normal-weight youths
Morandi, Anita, Bonnefond, Amelie, Lobbens, Stephane, Yengo, Loic, del Giudice, Emanuele Miraglia, Grandone, Anna, Levy-Marchal, Claire, Weill, Jacques, Maffeis, Claudio and Froguel, Philippe (2016). Associations between type 2 diabetes-related genetic scores and metabolic traits, in obese and normal-weight youths. Journal of Clinical Endocrinology and Metabolism, 101 (11), 4244-4250. doi: 10.1210/jc.2016-2432
2016
Journal Article
Genome-wide analysis identifies 12 loci influencing human reproductive behavior
Barban, Nicola, Jansen, Rick, de Vlaming, Ronald, Vaez, Ahmad, Mandemakers, Jornt J., Tropf, Felix C., Shen, Xia, Wilson, James F., Chasman, Daniel I., Nolte, Illa M., Tragante, Vinicius, van der Laan, Sander W., Perry, John R. B., Kong, Augustine, Ahluwalia, Tarunveer S., Albrecht, Eva, Yerges-Armstrong, Laura, Atzmon, Gil, Auro, Kirsi, Ayers, Kristin, Bakshi, Andrew, Ben-Avraham, Danny, Berger, Klaus, Bergman, Aviv, Bertram, Lars, Bielak, Lawrence F., Bjornsdottir, Gyda, Bonder, Marc Jan, Broer, Linda ... Mills, Melinda C. (2016). Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nature Genetics, 48 (12), 1462-1472. doi: 10.1038/ng.3698
2016
Journal Article
Detection of human adaptation during the past 2000 years
Field, Yair, Boyle, Evan A., Telis, Natalie, Gao, Ziyue, Gaulton, Kyle J., Golan, David, Yengo, Loic, Rocheleau, Ghislain, Froguel, Philippe, McCarthy, Mark I. and Pritchard, Jonathan K. (2016). Detection of human adaptation during the past 2000 years. Science, 354 (6313), 1-10. doi: 10.1126/science.aag0776
2016
Journal Article
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
Ehret, G.B., Ferreira, T., Chasman, D.I., Jackson, A.U., Schmidt, E.M., Johnson, T., Thorleifsson, G., Luan, J., Donnelly, L.A., Kanoni, S., Petersen, A.-K., Pihur, V., Strawbridge, R.J., Shungin, D., Hughes, M.F., Meirelles, O., Kaakinen, M., Bouatia-Naji, N., Kristiansson, K., Shah, S., Kleber, M.E., Guo, X., Lyytikainen, L.-P., Fava, C., Eriksson, N., Nolte, I.M., Magnusson, P.K., Salfati, E.L., Rallidis, L.S. ... Munroe, P.B. (2016). The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nature Genetics, 48 (10), 1171-1184. doi: 10.1038/ng.3667
2016
Journal Article
Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profiling
Yengo, Loic, Arredouani, Abdelilah, Marre, Michel, Roussel, Ronan, Vaxillaire, Martine, Falchi, Mario, Haoudi, Abdelali, Tichet, Jean, Balkau, Beverley, Bonnefond, Amelie and Froguel, Philippe (2016). Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profiling. Molecular Metabolism, 5 (10), 918-925. doi: 10.1016/j.molmet.2016.08.011
2016
Journal Article
Genomic insights into the origin of farming in the ancient Near East
Lazaridis, Iosif, Nadel, Dani, Rollefson, Gary, Merrett, Deborah C., Rohland, Nadin, Mallick, Swapan, Fernandes, Daniel, Novak, Mario, Gamarra, Beatriz, Sirak, Kendra, Connell, Sarah, Stewardson, Kristin, Harney, Eadaoin, Fu, Qiaomei, Gonzalez-Fortes, Gloria, Jones, Eppie R., Roodenberg, Songul Alpaslan, Lengyel, Gyorgy, Bocquentin, Fanny, Gasparian, Boris, Monge, Janet M., Gregg, Michael, Eshed, Vered, Mizrahi, Ahuva-Sivan, Meiklejohn, Christopher, Gerritsen, Fokke, Bejenaru, Luminita, Blueher, Matthias, Campbell, Archie ... Reich, David (2016). Genomic insights into the origin of farming in the ancient Near East. Nature, 536 (7617), 419-424. doi: 10.1038/nature19310
2016
Journal Article
Variable clustering in high-dimensional linear regression: The R package clere
Yengo, Loic, Jacques, Julien, Biernacki, Christophe and Canouil, Mickael (2016). Variable clustering in high-dimensional linear regression: The R package clere. The R Journal, 8 (1), 92-106. doi: 10.32614/rj-2016-006
2016
Journal Article
The genetic architecture of type 2 diabetes
Fuchsberger, Christian, Flannick, Jason, Teslovich, Tanya M., Mahajan, Anubha, Agarwala, Vineeta, Gaulton, Kyle J., Ma, Clement, Fontanillas, Pierre, Moutsianas, Loukas, McCarthy, Davis J., Rivas, Manuel A., Perry, John R. B., Sim, Xueling, Blackwell, Thomas W., Robertson, Neil R., Rayner, N. William, Cingolani, Pablo, Locke, Adam E., Tajes, Juan Fernandez, Highland, Heather M., Dupuis, Josee, Chines, Peter S., Lindgren, Cecilia M., Hartl, Christopher, Jackson, Anne U., Chen, Han, Huyghe, Jeroen R., van de Bunt, Martijn, Pearson, Richard D. ... McCarthy, Mark I. (2016). The genetic architecture of type 2 diabetes. Nature, 536 (7614), 41-47. doi: 10.1038/nature18642
2016
Journal Article
Post-bariatric surgery changes in quinolinic and xanthurenic acid concentrations are associated with glucose homeostasis
Favennec, Marie, Hennart, Benjamin, Verbanck, Marie, Pigeyre, Marie, Caiazzo, Robert, Raverdy, Violeta, Verkindt, Helene, Leloire, Audrey, Guillemin, Gilles J., Yengo, Loic, Allorge, Delphine, Froguel, Philippe, Pattou, Francois and Poulain-Godefroy, Odile (2016). Post-bariatric surgery changes in quinolinic and xanthurenic acid concentrations are associated with glucose homeostasis. Plos One, 11 (6) e0158051, e0158051. doi: 10.1371/journal.pone.0158051
2016
Journal Article
Erratum: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (PLoS Genet (2015) 11:10 (e1005378) DOI: 10.1371/journal.pgen.1005378)
Winkler, Thomas W., Justice, Anne E., Graff, Mariaelisa, Barata, Llilda, Feitosa, Mary F., Chu, Su, Czajkowski, Jacek, Esko, Tõnu, Fall, Tove, Kilpeläinen, Tuomas O., Lu, Yingchang, Mägi, Reedik, Mihailov, Evelin, Pers, Tune H., Rüeger, Sina, Teumer, Alexander, Ehret, Georg B., Ferreira, Teresa, Heard-Costa, Nancy L., Karjalainen, Juha, Lagou, Vasiliki, Mahajan, Anubha, Neinast, Michael D., Prokopenko, Inga, Simino, Jeannette, Teslovich, Tanya M., Jansen, Rick, Westra, Harm-Jan, White, Charles C. ... Loos, Ruth J.F. (2016). Erratum: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (PLoS Genet (2015) 11:10 (e1005378) DOI: 10.1371/journal.pgen.1005378). PLoS Genetics, 12 (6) e1006166. doi: 10.1371/JOURNAL.PGEN.1006166
2016
Journal Article
KAT2B is required for pancreatic beta cell adaptation to metabolic stress by controlling the unfolded protein response
Rabhi, Nabil, Denechaud, Pierre-Damien, Gromada, Xavier, Hannou, Sarah Anissa, Zhang, Hongbo, Rashid, Talha, Salas, Elisabet, Durand, Emmanuelle, Sand, Olivier, Bonnefond, Amelie, Yengo, Loic, Chavey, Carine, Bonner, Caroline, Kerr-Conte, Julie, Abderrahmani, Amar, Auwerx, Johan, Fajas, Lluis, Froguel, Philippe and Annicotte, Jean-Sebastien (2016). KAT2B is required for pancreatic beta cell adaptation to metabolic stress by controlling the unfolded protein response. Cell Reports, 15 (5), 1051-1061. doi: 10.1016/j.celrep.2016.03.079
2016
Journal Article
Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms
Horikoshi, Momoko, Pasquali, Lorenzo, Wiltshire, Steven, Huyghe, Jeroen R., Mahajan, Anubha, Asimit, Jennifer L., Ferreira, Teresa, Locke, Adam E., Robertson, Neil R., Wang, Xu, Sim, Xueling, Fujita, Hayato, Hara, Kazuo, Young, Robin, Zhang, Weihua, Choi, Sungkyoung, Chen, Han, Kaur, Ismeet, Takeuchi, Fumihiko, Fontanillas, Pierre, Thuillier, Dorothee, Yengo, Loic, Below, Jennifer E., Tam, Claudia H. T., Wu, Ying, Abecasis, Goncalo, Altshuler, David, Bell, Graeme I., Blangero, John ... Morris, Andrew P. (2016). Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms. Human Molecular Genetics, 25 (10) ddw048, 2070-2081. doi: 10.1093/hmg/ddw048
2016
Journal Article
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Lu, Yingchang, Day, Felix R., Gustafsson, Stefan, Buchkovich, Martin L., Na, Jianbo, Bataille, Veronique, Cousminer, Diana L., Dastani, Zari, Drong, Alexander W., Esko, Tonu, Evans, David M., Falchi, Mario, Feitosa, Mary F., Ferreira, Teresa, Hedman, Asa K., Haring, Robin, Hysi, Pirro G., Iles, Mark M., Justice, Anne E., Kanoni, Stavroula, Lagou, Vasiliki, Li, Rui, Li, Xin, Locke, Adam, Lu, Chen, Magi, Reedik, Perry, John R. B., Pers, Tune H., Qi, Qibin ... Loos, Ruth J. F. (2016). New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nature Communications, 7 (1) 10495, 10495-10495. doi: 10.1038/ncomms10495
2016
Journal Article
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Pattaro, Cristian, Teumer, Alexander, Gorski, Mathias, Chu, Audrey Y., Li, Man, Mijatovic, Vladan, Garnaas, Maija, Tin, Adrienne, Sorice, Rossella, Li, Yong, Taliun, Daniel, Olden, Matthias, Foster, Meredith, Yang, Qiong, Chen, Ming-Huei, Pers, Tune H., Johnson, Andrew D., Ko, Yi-An, Fuchsberger, Christian, Tayo, Bamidele, Nalls, Michael, Feitosa, Mary F., Isaacs, Aaron, Dehghan, Abbas, d'Adamo, Pio, Adeyemo, Adebowale, Dieffenbach, Aida Karina, Zonderman, Alan B., Nolte, Ilja M. ... Fox, Caroline S. (2016). Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nature Communications, 7 (1) 10023. doi: 10.1038/ncomms10023
2016
Journal Article
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index
Felix, Janine F., Bradfield, Jonathan P., Monnereau, Claire, van der Valk, Ralf J. P., Stergiakouli, Evie, Chesi, Alessandra, Gaillard, Romy, Feenstra, Bjarke, Thiering, Elisabeth, Kreiner-Moller, Eskil, Mahajan, Anubha, Pitkanen, Niina, Joro, Raimo, Cavadino, Alana, Huikari, Ville, Franks, Steve, Groen-Blokhuis, Maria M., Cousminer, Diana L., Marsh, Julie A., Lehtimaki, Terho, Curtin, John A., Vioque, Jesus, Ahluwalia, Tarunveer S., Myhre, Ronny, Price, Thomas S., Vilor-Tejedor, Natalia, Yengo, Loic, Grarup, Niels, Ntalla, Ioanna ... Jaddoe, Vincent W. V. (2016). Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Human Molecular Genetics, 25 (2), 389-403. doi: 10.1093/hmg/ddv472
2015
Journal Article
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
Gaulton, Kyle J., Ferreira, Teresa, Lee, Yeji, Raimondo, Anne, Maegi, Reedik, Reschen, Michael E., Mahajan, Anubha, Locke, Adam, Rayner, N. William, Robertson, Neil, Scott, Robert A., Prokopenko, Inga, Scott, Laura J., Green, Todd, Sparso, Thomas, Thuillier, Dorothee, Yengo, Loic, Grallert, Harald, Wahl, Simone, Franberg, Mattias, Strawbridge, Rona J., Kestler, Hans, Chheda, Himanshu, Eisele, Lewin, Gustafsson, Stefan, Steinthorsdottir, Valgerdur, Thorleifsson, Gudmar, Qi, Lu, Karssen, Lennart C. ... Morris, Andrew P. (2015). Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nature Genetics, 47 (12), 1415-1425. doi: 10.1038/ng.3437
2015
Journal Article
The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation
Favennec, Marie, Hennart, Benjamin, Caiazzo, Robert, Leloire, Audrey, Yengo, Loic, Verbanck, Marie, Arredouani, Abdelilah, Marre, Michel, Pigeyre, Marie, Bessede, Alban, Guillemin, Gilles J., Chinetti, Giulia, Staels, Bart, Pattou, Francois, Balkau, Beverley, Allorge, Delphine, Froguel, Philippe and Poulain-Godefroy, Odile (2015). The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation. Obesity, 23 (10), 2066-2074. doi: 10.1002/oby.21199
2015
Journal Article
The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study
Winkler, Thomas W., Justice, Anne E., Graff, Mariaelisa, Barata, Llilda, Feitosa, Mary F., Chu, Su, Czajkowski, Jacek, Esko, Tonu, Fall, Tove, Kilpelainen, Tuomas O., Lu, Yingchang, Magi, Reedik, Mihailov, Evelin, Pers, Tune H., Rueeger, Sina, Teumer, Alexander, Ehret, Georg B., Ferreira, Teresa, Heard-Costa, Nancy L., Karjalainen, Juha, Lagou, Vasiliki, Mahajan, Anubha, Neinast, Michael D., Prokopenko, Inga, Simino, Jeannette, Teslovich, Tanya M., Jansen, Rick, Westra, Harm-Jan, White, Charles C. ... Loos, Ruth J. F. (2015). The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study. PL o S Genetics, 11 (10) e1005378, 1-42. doi: 10.1371/journal.pgen.1005378
2015
Journal Article
Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: A nested case-control study
Chambers, John C., Loh, Marie, Lehne, Benjamin, Drong, Alexander, Kriebel, Jennifer, Motta, Valeria, Wahl, Simone, Elliott, Hannah R., Rota, Federica, Scott, William R., Zhang, Weihua, Tan, Sian-Tsung, Campanella, Gianluca, Chadeau-Hyam, Marc, Yengo, Loic, Richmond, Rebecca C., Adamowicz-Brice, Martyna, Afzal, Uzma, Bozaoglu, Kiymet, Mok, Zuan Yu, Ng, Hong Kiat, Pattou, Francois, Prokisch, Holger, Rozario, Michelle Ann, Tarantini, Letizia, Abbott, James, Ala-Korpela, Mika, Albetti, Benedetta, Ammerpohl, Ole ... Kooner, Jaspal S. (2015). Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: A nested case-control study. Lancet Diabetes and Endocrinology, 3 (7), 526-534. doi: 10.1016/S2213-8587(15)00127-8
Funding
Current funding
Past funding
Supervision
Availability
- Professor Loic Yengo is:
- Available for supervision
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Available projects
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Genetic and Molecular consequences of non-random mating in humans
Short Project description. This projects aims at utilising genetic and phenotypic data from ~500,000 participants of the UK Biobank to investigate phenotypic and genetic patterns induced by non-random mating in humans. Two forms of non-random mating will be investigated: assortative mating (resemblance between spouses) and inbreeding (mating between relatives). Findings from this project have implications in the analysis and interpretation of genome-wide association studies. The project will involve advanced modelling and statistical analyses of large volumes of data (genotyped and imputed SNP data, whole-exome sequencing, gene-expression, brain-imaging derived-traits).
Candidate. Candidates with a background in quantitative/population genetics, statistics, mathematics and other quantitative fields will be considered. Programming skills (R, python, C/C++) and prior experience in analysing genetic data (e.g. GWAS) is desirable. (Note: if required, lectures on fundamental concepts of quantitative and population genetics can be taken as part of the PhD training).
The Team. The successful candidate will be doing their research within the Program in Complex Traits Genomics (PCTG) Lab co-led by Professors Jian Yang, Naomi Wray and Peter Visscher, who are internationally recognized leaders in the field of complex traits genetics and have been recently listed among the world’s top one per cent most cited researchers of their field. PCTG provides a stimulating and highly interdisciplinary environment for PhD candidates to form and develop their research.
PhD advisor. Dr Loic Yengo is a senior research officer of the Institute of Molecular Bioscience at the University of Queensland, Australia; and the Statistical Genetics Team leader within PCTG. He did his PhD in applied mathematics and is an expert in statistical modelling and analysis of genetic data. His research interests intersect quantitative genetics, genetic epidemiology and sociogenomics.
Expected start. First semester of 2020.
Contact. If you’re interested, please send your CV and cover letter and two references to Dr Loic Yengo: l.yengo@imb.uq.edu.au
URLs
The team PCTG: http://cnsgenomics.com/
PhD advisor: https://scholar.google.fr/citations?user=iv8dxlIAAAAJ&hl=en
Supervision history
Current supervision
-
Doctor Philosophy
Investigating the time and tissue dependent genetic architecture of complex traits
Principal Advisor
Other advisors: Dr Nicole Warrington
-
Doctor Philosophy
Statistical methods and application to analyses genome and trait data from large biobanks
Associate Advisor
Other advisors: Dr Kathryn Kemper, Professor Peter Visscher
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Doctor Philosophy
New approaches to quantify the genetic cause of disease
Associate Advisor
Other advisors: Professor Nathan Palpant
Completed supervision
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2024
Doctor Philosophy
Genomic signature of non-random mating in human complex traits
Principal Advisor
Other advisors: Professor Peter Visscher
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2021
Doctor Philosophy
Within and Across Populations Complex Traits and Diseases Prediction Using Summary Statistics from Large-scale Genome-wide Association Studies
Principal Advisor
Other advisors: Professor Peter Visscher
Media
Enquiries
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