Overview
Background
Visscher joined the University of Queensland in 2011, where he is Professor of Quantitative Genetics. He is a Laureate Fellow of the Australian Research Council. Visscher was elected a Fellow of the Australian Academy of Science in 2010, a Fellow of the Royal Society (London) in 2018 and a Foreign Member of the Royal Netherlands Academy of Arts and Sciences in 2018.
Visscher’s research is about genetic variation for complex traits (including quantitative traits and disease) in populations, with the broad aim to understand and quantify the causes and consequences of human trait variation.
Prof Peter Visscher, Prof Naomi Wray and Prof Jian Yang together comprise the Executive Team of the Program in Complex Trait Genomics (PCTG). PCTG comprises a critical mass of more than 30 post-doctoral researchers plus research assistants and students, all supported by external grant funding. Their skills lie in the ability to develop and apply statistical methods within the framework of quantitative, population and statistical genetics and to use theory to understand and predict results from data analyses. They play leading roles in the international research consortia. The focus of current research activities is in the detection and fine-mapping of loci underlying complex traits (including common disease), based upon theoretical studies and applications of methods to large datasets, in population genetics studies using theoretical approaches and high-density genetic marker data, and in systems genomics studies.
Availability
- Professor Peter Visscher is:
- Available for supervision
Fields of research
Qualifications
- Masters (Coursework) of Science, University of Edinburgh
- Doctor of Philosophy, University of Edinburgh
Research impacts
Visscher's research focuses on understanding individual differences betweeen people in traits that are important for health outcomes and ageing. A better understanding of the genes that underlie variation in risk to diseases may lead to better treatments.
Works
Search Professor Peter Visscher’s works on UQ eSpace
2024
Journal Article
Distinct genetic liability profiles define clinically relevant patient strata across common diseases
Trastulla, Lucia, Dolgalev, Georgii, Moser, Sylvain, Jiménez-Barrón, Laura T., Andlauer, Till F. M., von Scheidt, Moritz, Ruderfer, Douglas M., Ripke, Stephan, McQuillin, Andrew, Stahl, Eli A., Domenici, Enrico, Adolfsson, Rolf, Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A., Begemann, Martin, Belliveau, Richard A., Bene, Judit, Bergen, Sarah E., Bevilacqua, Elizabeth, Bigdeli, Tim B., Black, Donald W., Blackwood, Douglas H. R., Borglum, Anders D., Bramon, Elvira, Bruggeman, Richard ... Ziller, Michael J. (2024). Distinct genetic liability profiles define clinically relevant patient strata across common diseases. Nature Communications , 15 (1) 5534. doi: 10.1038/s41467-024-49338-2
2024
Journal Article
Genetic influence on within-person longitudinal change in anthropometric traits in the UK Biobank
Kemper, Kathryn E., Sidorenko, Julia, Wang, Huanwei, Hayes, Ben J., Wray, Naomi R., Yengo, Loic, Keller, Matthew C., Goddard, Michael and Visscher, Peter M. (2024). Genetic influence on within-person longitudinal change in anthropometric traits in the UK Biobank. Nature Communications, 15 (1) 3776, 3776. doi: 10.1038/s41467-024-47802-7
2024
Journal Article
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
Keaton, Jacob M., Kamali, Zoha, Xie, Tian, Vaez, Ahmad, Williams, Ariel, Goleva, Slavina B., Ani, Alireza, Evangelou, Evangelos, Hellwege, Jacklyn N., Yengo, Loic, Young, William J., Traylor, Matthew, Giri, Ayush, Zheng, Zhili, Zeng, Jian, Chasman, Daniel I., Morris, Andrew P., Caulfield, Mark J., Hwang, Shih-Jen, Kooner, Jaspal S., Conen, David, Attia, John R., Morrison, Alanna C., Loos, Ruth J. F., Kristiansson, Kati, Schmidt, Reinhold, Hicks, Andrew A., Pramstaller, Peter P., Nelson, Christopher P. ... ICBP Consortium (2024). Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits. Nature Genetics, 56 (5), 1-14. doi: 10.1038/s41588-024-01714-w
2024
Journal Article
Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries
Zheng, Zhili, Liu, Shouye, Sidorenko, Julia, Wang, Ying, Lin, Tian, Yengo, Loic, Turley, Patrick, Ani, Alireza, Wang, Rujia, Nolte, Ilja M., Snieder, Harold, Aguirre-Gamboa, Raul, Deelen, Patrick, Franke, Lude, Kuivenhoven, Jan A., Lopera Maya, Esteban A., Sanna, Serena, Swertz, Morris A., Vonk, Judith M., Wijmenga, Cisca, Yang, Jian, Wray, Naomi R., Goddard, Michael E., Visscher, Peter M., Zeng, Jian and LifeLines Cohort Study (2024). Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries. Nature Genetics, 56 (5), 1-11. doi: 10.1038/s41588-024-01704-y
2024
Journal Article
Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content
Li, Yanni, Van Den Berg, Eline H., Kurilshikov, Alexander, Zhernakova, Dasha V., Gacesa, Ranko, Hu, Shixian, Lopera-Maya, Esteban A., Zhernakova, Alexandra, Aguirre-Gamboa, Raul, Deelen, Patrick, Franke, Lude, Kuivenhoven, Jan A., Lopera-Maya, Esteban A., Nolte, Ilja M., Sanna, Serena, Snieder, Harold, Swertz, Morris A., Visscher, Peter M., Vonk, Judith M., Wijmenga, Cisca, De Meijer, Vincent E., Sanna, Serena, Dullaart, Robin P. F., Blokzijl, Hans, Festen, Eleonora A. M., Fu, Jingyuan and Weersma, Rinse K. (2024). Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content. Genomics, Proteomics and Bioinformatics, 22 (2) qzae031. doi: 10.1093/gpbjnl/qzae031
2024
Journal Article
Genetic control of DNA methylation is largely shared across European and East Asian populations
Hatton, Alesha A., Cheng, Fei-Fei, Lin, Tian, Shen, Ren-Juan, Chen, Jie, Zheng, Zhili, Qu, Jia, Lyu, Fan, Harris, Sarah E., Cox, Simon R., Jin, Zi-Bing, Martin, Nicholas G., Fan, Dongsheng, Montgomery, Grant W., Yang, Jian, Wray, Naomi R., Marioni, Riccardo E., Visscher, Peter M. and McRae, Allan F. (2024). Genetic control of DNA methylation is largely shared across European and East Asian populations. Nature Communications, 15 (1) 2713, 1-12. doi: 10.1038/s41467-024-47005-0
2024
Journal Article
Unravelling the complex causal effects of substance use behaviours on common diseases
Xue, Angli, Zhu, Zhihong, Wang, Huanwei, Jiang, Longda, Visscher, Peter M., Zeng, Jian and Yang, Jian (2024). Unravelling the complex causal effects of substance use behaviours on common diseases. Communications Medicine, 4 (1) ARTN 43, 43. doi: 10.1038/s43856-024-00473-3
2024
Journal Article
Host genetic regulation of human gut microbial structural variation
Zhernakova, Daria V., Wang, Daoming, Liu, Lei, Andreu-Sánchez, Sergio, Zhang, Yue, Ruiz-Moreno, Angel J., Peng, Haoran, Plomp, Niels, Del Castillo-Izquierdo, Ángela, Gacesa, Ranko, Lopera-Maya, Esteban A., Temba, Godfrey S., Kullaya, Vesla I., van Leeuwen, Sander S., Aguirre-Gamboa, Raul, Deelen, Patrick, Franke, Lude, Kuivenhoven, Jan A., Nolte, Ilja M., Sanna, Serena, Snieder, Harold, Swertz, Morris A., Visscher, Peter M., Vonk, Judith M., Xavier, Ramnik J., de Mast, Quirijn, Joosten, Leo A. B., Riksen, Niels P., Rutten, Joost H. W. ... Fu, Jingyuan (2024). Host genetic regulation of human gut microbial structural variation. Nature, 625 (7996), 813-821. doi: 10.1038/s41586-023-06893-w
2024
Journal Article
Erratum: Autism-related dietary preferences mediate autism-gut microbiome associations (Cell (2021) 184(24) (5916–5931.e17), (S0092867421012319), (10.1016/j.cell.2021.10.015))
Yap, Chloe X., Henders, Anjali K., Alvares, Gail A., Wood, David L.A., Krause, Lutz, Tyson, Gene W., Restuadi, Restuadi, Wallace, Leanne, McLaren, Tiana, Hansell, Narelle K., Cleary, Dominique, Grove, Rachel, Hafekost, Claire, Harun, Alexis, Holdsworth, Helen, Jellett, Rachel, Khan, Feroza, Lawson, Lauren P., Leslie, Jodie, Frenk, Mira Levis, Masi, Anne, Mathew, Nisha E., Muniandy, Melanie, Nothard, Michaela, Miller, Jessica L., Nunn, Lorelle, Holtmann, Gerald, Strike, Lachlan T., de Zubicaray, Greig I. ... Gratten, Jacob (2024). Erratum: Autism-related dietary preferences mediate autism-gut microbiome associations (Cell (2021) 184(24) (5916–5931.e17), (S0092867421012319), (10.1016/j.cell.2021.10.015)). Cell, 187 (2), 495-510. doi: 10.1016/j.cell.2023.12.001
2023
Journal Article
OTTERS: a powerful TWAS framework leveraging summary-level reference data
Dai, Qile, Zhou, Geyu, Zhao, Hongyu, Võsa, Urmo, Franke, Lude, Battle, Alexis, Teumer, Alexander, Lehtimäki, Terho, Raitakari, Olli T., Esko, Tõnu, Agbessi, Mawussé, Ahsan, Habibul, Alves, Isabel, Andiappan, Anand Kumar, Arindrarto, Wibowo, Awadalla, Philip, Battle, Alexis, Beutner, Frank, Jan Bonder, Marc, Boomsma, Dorret I., Christiansen, Mark W., Claringbould, Annique, Deelen, Patrick, Favé, Marie-Julie, Frayling, Timothy, Gharib, Sina A., Gibson, Greg, Heijmans, Bastiaan T., Hemani, Gibran ... Yang, Jingjing (2023). OTTERS: a powerful TWAS framework leveraging summary-level reference data. Nature Communications, 14 (1) 1271, 1-13. doi: 10.1038/s41467-023-36862-w
2023
Journal Article
Cross-ancestry analyses identify new genetic loci associated with 25-hydroxyvitamin D
Wang, Xiaotong, Hivert, Valentin, Groot, Shiane, Wang, Ying, Yengo, Loic, McGrath, John J., Kemper, Kathryn E., Visscher, Peter M., Wray, Naomi R. and Revez, Joana A. (2023). Cross-ancestry analyses identify new genetic loci associated with 25-hydroxyvitamin D. PLoS Genetics, 19 (11) e1011033, e1011033. doi: 10.1371/journal.pgen.1011033
2023
Conference Publication
Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries
Zeng, Jian, Zheng, Zhili, Liu, Shouye, Sidorenko, Julia, Yengo, Loic, Turley, Patrick, Ani, Alireza, Wang, Rujia, Nolte, Ilja, Snieder, Harold, Yang, Jian, Wray, Naomi, Goddard, Michael and Visscher, Peter (2023). Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries. World Congress of Psychiatric Genetics (WCPG), Montreal, ON, Canada, 10 - 14 October 2023. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/j.euroneuro.2023.08.063
2023
Journal Article
Community-wide genome sequencing reveals 30 years of Darwin’s finch evolution
Enbody, Erik D., Sendell-Price, Ashley T., Sprehn, C. Grace, Rubin, Carl-Johan, Visscher, Peter M., Grant, B. Rosemary, Grant, Peter R. and Andersson, Leif (2023). Community-wide genome sequencing reveals 30 years of Darwin’s finch evolution. Science, 381 (6665) eadf6218, 1-10. doi: 10.1126/science.adf6218
2023
Journal Article
Boosting the power of genome-wide association studies within and across ancestries by using polygenic scores
Campos, Adrian I., Namba, Shinichi, Lin, Shu-Chin, Nam, Kisung, Sidorenko, Julia, Wang, Huanwei, Kamatani, Yoichiro, The Biobank Japan Project, Wang, Ling-Hua, Lee, Seunggeun, Lin, Yen-Feng, Feng, Yen-Chen Anne, Okada, Yukinori, Visscher, Peter M. and Yengo, Loic (2023). Boosting the power of genome-wide association studies within and across ancestries by using polygenic scores. Nature Genetics, 55 (10), 1769-1776. doi: 10.1038/s41588-023-01500-0
2023
Journal Article
Chromosomal inversion polymorphisms shape human brain morphology
Wang, Hao, Makowski, Carolina, Zhang, Yanxiao, Qi, Anna, Kaufmann, Tobias, Smeland, Olav B., Fiecas, Mark, Yang, Jian, Visscher, Peter M. and Chen, Chi-Hua (2023). Chromosomal inversion polymorphisms shape human brain morphology. Cell Reports, 42 (8) 112896, 112896. doi: 10.1016/j.celrep.2023.112896
2023
Journal Article
Joint analysis of GWAS and multi-omics QTL summary statistics reveals a large fraction of GWAS signals shared with molecular phenotypes
Wu, Yang, Qi, Ting, Wray, Naomi R., Visscher, Peter M., Zeng, Jian and Yang, Jian (2023). Joint analysis of GWAS and multi-omics QTL summary statistics reveals a large fraction of GWAS signals shared with molecular phenotypes. Cell Genomics, 3 (8) 100344, 100344. doi: 10.1016/j.xgen.2023.100344
2023
Journal Article
Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent NRXN1 and ABCB11 disruptions
Maury, Eduardo A., Sherman, Maxwell A., Genovese, Giulio, Gilgenast, Thomas G., Kamath, Tushar, Burris, S. J., Rajarajan, Prashanth, Flaherty, Erin, Akbarian, Schahram, Chess, Andrew, McCarroll, Steven A., Loh, Po-Ru, Phillips-Cremins, Jennifer E., Brennand, Kristen J., Macosko, Evan Z., Walters, James T.R., O'Donovan, Michael, Sullivan, Patrick, Marshall, Christian R., Merico, Daniele, Thiruvahindrapuram, Bhooma, Wang, Zhouzhi, Scherer, Stephen W., Howrigan, Daniel P, Ripke, Stephan, Bulik-Sullivan, Brendan, Farh, Kai-How, Fromer, Menachem, Goldstein, Jacqueline I. ... Walsh, Christopher A. (2023). Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent NRXN1 and ABCB11 disruptions. Cell Genomics, 3 (8) 100356, 1-21. doi: 10.1016/j.xgen.2023.100356
2023
Journal Article
Polygenic risk prediction: why and when out-of-sample prediction R2 can exceed SNP-based heritability
Wang, Xiaotong, Walker, Alicia, Revez, Joana A., Ni, Guiyan, Visscher, Peter M., Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F.M., Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T.F., Bigdeli, Tim B., Binder, Elisabeth B., Bryois, Julien, Buttenschøn, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard, Clarke, Toni-Kim, Coleman, Jonathan R.I., Colodro-Conde, Lucía ... Sullivan, Patrick F. (2023). Polygenic risk prediction: why and when out-of-sample prediction R2 can exceed SNP-based heritability. The American Journal of Human Genetics, 110 (7), 1207-1215. doi: 10.1016/j.ajhg.2023.06.006
2023
Journal Article
Rare genetic variants underlie outlying levels of DNA methylation and gene-expression
Chundru, V. Kartik, Marioni, Riccardo E., Pendergast, James G. D., Lin, Tian, Beveridge, Allan J., Martin, Nicholas G, Montgomery, Grant W., Hume, David A., Deary, Ian J., Visscher, Peter M., Wray, Naomi R. and McRae, Allan F. (2023). Rare genetic variants underlie outlying levels of DNA methylation and gene-expression. Human Molecular Genetics, 32 (11), 1912-1921. doi: 10.1093/hmg/ddad028
2023
Journal Article
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia
Hsu, Yu-Han H., Pintacuda, Greta, Liu, Ruize, Nacu, Eugeniu, Kim, April, Tsafou, Kalliopi, Petrossian, Natalie, Crotty, William, Suh, Jung Min, Riseman, Jackson, Martin, Jacqueline M., Biagini, Julia C., Mena, Daya, Ching, Joshua K.T., Malolepsza, Edyta, Li, Taibo, Singh, Tarjinder, Ge, Tian, Egri, Shawn B., Tanenbaum, Benjamin, Stanclift, Caroline R., Apffel, Annie M., Ripke, Stephan, Neale, Benjamin M., Corvin, Aiden, Walters, James T.R., Farh, Kai-How, Holmans, Peter A., Lee, Phil ... Lage, Kasper (2023). Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia. iScience, 26 (5) 106701, 1-28. doi: 10.1016/j.isci.2023.106701
Funding
Current funding
Past funding
Supervision
Availability
- Professor Peter Visscher is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
-
Complex trait genetics
We have several PhD projects are available in our research group. The projects are about quantitative genetic methods and application to large datasets to answer fundamental questions about the genetic basis of quantitative traits and disease in human populations. There are many traits that we study, including gene expression, gene methylation, height and body-mass-index, psychiatric disease and neurogenetic conditions.
Specific Project: Maximising genomic predictions in biobank-style data
Contact: Kathryn Kemper, k.kemper@imb.uq.edu.au
Complex traits in humans, such as height and body mass index, are influenced by environmental and genetic factors. Genetic factors affecting a trait can be further subdivided into genetic factors shared between or within families, and population-level genetic information. To date, genomic analyses have primarily focused on population-level genetic information. The aim of this project is to utilise and combine all possible sources of information to increase the accuracy of genomic predictions for complex traits in biobank-style data. The applicant will work on large datasets such as the UK Biobank which, in the near future, will have whole genome sequence information on approximately 500K individuals and extensive phenotypes.
Supervision history
Current supervision
-
Doctor Philosophy
Statistical methods and application to analyses genome and trait data from large biobanks
Principal Advisor
Other advisors: Dr Kathryn Kemper, Associate Professor Loic Yengo
-
Doctor Philosophy
Genomic signature of non-random mating in human complex traits
Associate Advisor
Other advisors: Associate Professor Loic Yengo
-
Doctor Philosophy
Genetic architecture and evolution of complex traits across populations in humans
Associate Advisor
Other advisors: Professor Naomi Wray, Dr Fleur Garton, Dr Jian Zeng
Completed supervision
-
2022
Doctor Philosophy
Using whole-genome sequence data to elucidate complex trait variation
Principal Advisor
-
2020
Doctor Philosophy
Genetic and genomic analyses on ageing and age-related complex traits
Principal Advisor
Other advisors: Dr Allan McRae
-
2010
Doctor Philosophy
Mitochondrial and autosomal genetic analyses in the Australian population
Principal Advisor
Other advisors: Dr Allan McRae
-
2024
Doctor Philosophy
Quantitative genetics approaches to elucidate the role of DNA methylation in complex trait variation
Associate Advisor
Other advisors: Dr Allan McRae
-
2024
Doctor Philosophy
Insights into pleiotropic effects across the human genome for complex traits and diseases
Associate Advisor
Other advisors: Dr Allan McRae
-
2022
Doctor Philosophy
Genetic analyses of complex traits using biobank data
Associate Advisor
Other advisors: Professor Naomi Wray
-
2021
Doctor Philosophy
Within and Across Populations Complex Traits and Diseases Prediction Using Summary Statistics from Large-scale Genome-wide Association Studies
Associate Advisor
Other advisors: Associate Professor Loic Yengo
-
2020
Doctor Philosophy
Genetic Differentiation of Human Complex Traits across Worldwide Populations
Associate Advisor
-
2020
Doctor Philosophy
Improving fine-mapping methodology using DNA methylation as a model trait
Associate Advisor
Other advisors: Professor Naomi Wray, Dr Allan McRae
-
2019
Doctor Philosophy
Sexual dimorphism in human gene expression
Associate Advisor
Other advisors: Dr Allan McRae
-
2019
Doctor Philosophy
Systems Genomics of Parkinson's Disease
Associate Advisor
Other advisors: Honorary Professor Jake Gratten
-
2017
Doctor Philosophy
Characterization of the genetic and environmental factors driving gene expression variability
Associate Advisor
-
2017
Doctor Philosophy
The Genetic Architecture of Psychiatric Disorders
Associate Advisor
Other advisors: Professor Naomi Wray
Media
Enquiries
For media enquiries about Professor Peter Visscher's areas of expertise, story ideas and help finding experts, contact our Media team: