Overview
Background
Naomi Wray is the Michael Davys Professor in the Department of Psychiatry, University of Oxford. She holds an appointment at the Institute for Molecular Bioscience (IMB) within the University of Queensland. She joined UQ Queensland Brain Institute in 2011 moving to the IMB in 2015. She was Head of the Centre for Population & Disease Genomics within IMB 2018-2023. Her Oxford appointment started in 2023.
Her research focuses on development and application of quantitative genetics and genomics methodologies across complex diseases, disorders and traits, but particularly psychiatric-related traits.
She is a National Health and Medical Research Council (NHMRC) Leadership Fellow, a Fellow of the Australian Academy of Science and a Fellow of the Australian Academy of Health and Medical Science. In 2020 she was awarded the NHMRC Elizabeth Blackburn Award for Leadership in Basic Science and the 2021 International Society of Psychiatric Genetics Ming Tsuang Lifetime Achievement Award. She is a Clarivate Highly Cited researcher.
She was Director of the Program in Complex Trait Genomics (PCTG) funded as an NHMRC Program Grant 2017-2022. She plays a key role in the International Psychiatric Genomics Consortium and established the sporadic ALS Australia systems genomics consortium (SALSA) funded by the MND Research Australia IceBucket Challenge and FightMND. She is a co-investigator on the Australian Genetics of Depression Study (AGDS) and is currently launching the AGDS-Cello project focussed on establishing a cell line resource from participants with a detailed history of anti-depressant use and response measures. She is part of an NHMRC Synergy (2023-2027) "Rhythms and blues: Personalising care for body clock dysfunction in mood disorders".
She is secretary of the International Society of Psychiatric Genetics, and is on the editorial advisory boards of JAMA Psychiatry, Neuron, Royal Society Open and Research Directions: Depression.
Availability
- Professor Naomi Wray is:
- Not available for supervision
Qualifications
- Doctor of Philosophy, University of Edinburgh
Research interests
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Genetics of complex genetic traits, disease and disorders
Quantitative genetics methodology Genetics of Psychiatric Disorder Genetics of Motor Neurone Disease Genetics of Cognitive Ageing Systems Genomics
Works
Search Professor Naomi Wray’s works on UQ eSpace
2026
Journal Article
Association between polygenic liability to depression and lifetime depression in at-risk adolescents
Byrne, Enda M., Gillespie, Nathan A., Najman, Jake M., Henders, Anjali K., Mitchell, Brittany L., Dwyer, Dominic, Hartmann, Simon, Cavve, Blake S., Amminger, G. Paul, Clark, Scott, Gao, Caroline, Lin, Ashleigh, Schmaal, Lianne, Thompson, Andrew, Wood, Stephen J., Wigman, J.T.W, Yung, Alison R., Medland, Sarah E., Crouse, Jacob J., Scott, Jan, Scott, James G., Williams, Gail M., Nelson, Barnaby, Martin, Nicholas G., Hickie, Ian B., Wray, Naomi R. and Middeldorp, Christel M. (2026). Association between polygenic liability to depression and lifetime depression in at-risk adolescents. Molecular Psychiatry, 1-9. doi: 10.1038/s41380-026-03917-5
2026
Journal Article
F17. IMMUNE-BRAIN POLYGENIC RISK ARCHITECTURE AND CLINICAL HETEROGENEITY IN PSYCHIATRIC DISORDERS
Mellon-Whelan, Aisling, McGrath, Isabelle, Wray, Naomi and Lynall, Mary-Ellen (2026). F17. IMMUNE-BRAIN POLYGENIC RISK ARCHITECTURE AND CLINICAL HETEROGENEITY IN PSYCHIATRIC DISORDERS. European Neuropsychopharmacology, 111 113412, 113412. doi: 10.1016/j.euroneuro.2026.113412
2026
Journal Article
THE PREDICTION OF SYMPTOM SEVERITY IN CHILDREN AND PARENTS IN A CLINICAL COHORT OF FAMILIES WITH CHILDREN WITH NEURODEVELOPMENTAL PROBLEMS
Middeldorp, Christel M., Galligan, Dana, Gangaraju, Swathi, Wray, Naomi and Byrne, Enda (2026). THE PREDICTION OF SYMPTOM SEVERITY IN CHILDREN AND PARENTS IN A CLINICAL COHORT OF FAMILIES WITH CHILDREN WITH NEURODEVELOPMENTAL PROBLEMS. European Neuropsychopharmacology, 111 113018, 113018. doi: 10.1016/j.euroneuro.2026.113018
2026
Journal Article
T8. DISENTANGLING CAUSAL AND CORRELATED IMMUNE SIGNALS IN PSYCHIATRIC DISORDERS USING MULTI-TISSUE FUNCTIONAL GENOMICS
McGrath, Isabelle, Mellon-Whelan, Aisling, Walker, Alicia, Zhou, Ruolan, Wray, Naomi and Lynall, Mary-Ellen (2026). T8. DISENTANGLING CAUSAL AND CORRELATED IMMUNE SIGNALS IN PSYCHIATRIC DISORDERS USING MULTI-TISSUE FUNCTIONAL GENOMICS. European Neuropsychopharmacology, 111 113265, 113265. doi: 10.1016/j.euroneuro.2026.113265
2026
Journal Article
A GWAS META-ANALYSIS OF PSYCHOTIC DEPRESSION LEVERAGING HEALTH-RECORD, PRESCRIPTION AND SELF-REPORT DATA
McGrath, Isabelle, Group, PGC-MDD Working, Wray, Naomi and Lynall, Mary-Ellen (2026). A GWAS META-ANALYSIS OF PSYCHOTIC DEPRESSION LEVERAGING HEALTH-RECORD, PRESCRIPTION AND SELF-REPORT DATA. European Neuropsychopharmacology, 111 112983, 112983. doi: 10.1016/j.euroneuro.2026.112983
2026
Journal Article
THE SHARED GENETICS BETWEEN BRAIN STRUCTURE AND PSYCHIATRIC DISORDERS: FROM GWAS TO DEVELOPMENTAL MECHANISMS
He, Yuankai, Ebneabassi, Amir, Gu, Yuanjun, Riegis, Clara, Pearson, Bess, Polimanti, Renato, Grove, Jakob, Børglum, Anders, Astle, Duncan, Rittman, Tim, Wray, Naomi, Won, Hyejung, Bethlehem, Richard A.I., Bullmore, Edward and Warrier, Varun (2026). THE SHARED GENETICS BETWEEN BRAIN STRUCTURE AND PSYCHIATRIC DISORDERS: FROM GWAS TO DEVELOPMENTAL MECHANISMS. European Neuropsychopharmacology, 111 112978, 112978. doi: 10.1016/j.euroneuro.2026.112978
2026
Journal Article
67. MIND THE GAP: QUANTIFYING AND MITIGATING THE IMPACT OF VARIANT MISSINGNESS ON POLYGENIC SCORES WITHIN THE GENOPRED PIPELINE
Pain, Oliver, Wang, Xiaotong, Visscher, Peter and Wray, Naomi (2026). 67. MIND THE GAP: QUANTIFYING AND MITIGATING THE IMPACT OF VARIANT MISSINGNESS ON POLYGENIC SCORES WITHIN THE GENOPRED PIPELINE. European Neuropsychopharmacology, 111 113094, 113094. doi: 10.1016/j.euroneuro.2026.113094
2026
Journal Article
ONE MODEL DOES NOT FIT ALL: HETEROGENEITY IN POLYGENIC PROFILES OF ADHD ACROSS FOUR DEVELOPMENTAL STAGES
Ge, Fenfen, Wang, Yue, Agerbo, Esben, Benros, Michael, Wray, Naomi, Demontis, Ditte, Musliner, Katherine, Bo Mortensen, Preben, Petersen, Liselotte and Vilhjalmsson, Bjarni (2026). ONE MODEL DOES NOT FIT ALL: HETEROGENEITY IN POLYGENIC PROFILES OF ADHD ACROSS FOUR DEVELOPMENTAL STAGES. European Neuropsychopharmacology, 111 112989, 112989. doi: 10.1016/j.euroneuro.2026.112989
2026
Journal Article
F117. GENETIC LIABILITY TO ANTIPSYCHOTIC MEDICATION SIDE-EFFECTS IN THE UK BIOBANK
Proctor, Sasha, McGrath, Isabelle, Halstead, Sean, Pillinger, Toby, Upthegrove, Rachel, Wray, Naomi and Yap, Chloe (2026). F117. GENETIC LIABILITY TO ANTIPSYCHOTIC MEDICATION SIDE-EFFECTS IN THE UK BIOBANK. European Neuropsychopharmacology, 111 113512, 113512. doi: 10.1016/j.euroneuro.2026.113512
2026
Journal Article
An Internal-Standard-Integrated Digital SERS Immunoassay for Accurate and Precise Trace-Level Cytokine Quantification in Plasma
Zhang, Yiwen, Farokhinejad, Fahimeh, Crouse, Jacob J., Shin, Mirim, Henders, Anjali K., Wallace, Leanne M., Lobb, Richard J., Antaw, Fiach, Wray, Naomi R., Hickie, Ian B., Wuethrich, Alain and Trau, Matt (2026). An Internal-Standard-Integrated Digital SERS Immunoassay for Accurate and Precise Trace-Level Cytokine Quantification in Plasma. Analytical Chemistry. doi: 10.1021/acs.analchem.6c03298
2026
Conference Publication
Unsupervised Variant Clustering Identifies Genetic Subtypes of Disease
Mizikovsky, Dalia, Wray, Naomi, Shah, Sonia and Palpant, Nathan (2026). Unsupervised Variant Clustering Identifies Genetic Subtypes of Disease. HOBOKEN: WILEY.
2026
Conference Publication
Heterogeneity in Sleep-Wake and Circadian Rhythm Disturbance Profiles in Young People With Emerging Mood Disorders: Clinical and Genetic Correlates
Shin, Mirim, Carpenter, Joanne S., Tonini, Emiliana, Lin, Tian, Scott, Elizabeth M., Wray, Naomi, Scott, Jan, Crouse, Jacob J. and Hickie, Ian (2026). Heterogeneity in Sleep-Wake and Circadian Rhythm Disturbance Profiles in Young People With Emerging Mood Disorders: Clinical and Genetic Correlates. 28th Annual Conference of the International-Society-for-Bipolar-Disorders, Vancouver Canada, Sep 28-30, 2026. HOBOKEN: WILEY.
2026
Conference Publication
Cohort Profile: The First 400 Children, Adolescents, and Young Adults in the Neurobiology Youth Follow-Up Study
Shin, Mirim, Nichles, Alissa, Zmicerevska, Natalia, Song, Yun Ju, Phung, Elizabeth, Janiszewski, Connie, Park, Minji, Carpenter, Joanne, Tonini, Emiliana, Iorfino, Frank, Lin, Tian, Wray, Naomi R., Scott, Elizabeth M. and Crouse, Jacob J. (2026). Cohort Profile: The First 400 Children, Adolescents, and Young Adults in the Neurobiology Youth Follow-Up Study. HOBOKEN: WILEY.
2026
Conference Publication
Developing and Evaluating a Cross-Cutting "Circadian Depression" Phenotype
Crouse, Jacob, Tonini, Emiliana, Carpenter, Joanne S., Shin, Mirim, Mitchell, Brittany L., Byrne, Enda M., Hockey, Samuel H., Wray, Naomi R., Lind, Penelope A., Medland, Sarah E., Merikangas, Kathleen R., Martin, Nicholas G., Scott, Jan, Scott, Elizabeth M. and Hickie, Ian B. (2026). Developing and Evaluating a Cross-Cutting "Circadian Depression" Phenotype. 28th Annual Conference of the International-Society-for-Bipolar-Disorders, Vancouver Canada, Sep 28-30, 2026. HOBOKEN: WILEY.
2026
Conference Publication
Rethinking Covariate Adjustment in Psychiatric Biomarker Research: A Framework Applied to UK Biobank Blood Samples
Shin, Mirim, Crouse, Jacob J., Hickie, Ian B., Wray, Naomi and Albinana, Clara (2026). Rethinking Covariate Adjustment in Psychiatric Biomarker Research: A Framework Applied to UK Biobank Blood Samples. 28th Annual Conference of the International-Society-for-Bipolar-Disorders, Vancouver Canada, Sep 28-30, 2026. HOBOKEN: WILEY.
2026
Conference Publication
Prescription medication use, healthcare utilisation and genetic risk for addiction: a phenome-wide association and Mendelian randomization study
Graczyk, M. M., Albinana, C., Lee, A., Christodoulou, M. D., Deak, J. D., Burgess, S., Wray, N. R., Gelernter, J. and Topiwala, A. (2026). Prescription medication use, healthcare utilisation and genetic risk for addiction: a phenome-wide association and Mendelian randomization study. 37th World Congress of Neuropsychopharmacology (CINP) / Joint Meeting of the Scandinavian-College-of-Neuropsychopharmacology, Glasgow Scotland, Jun 26-29, 2026. OXFORD: OXFORD UNIV PRESS. doi: 10.1093/ijnp/pyag040.436
2026
Journal Article
Atypical depression is associated with a distinct clinical, neurobiological, treatment response, and polygenic risk profile
Shin, Mirim, Crouse, Jacob J., Lin, Tian, Byrne, Enda M., Mitchell, Brittany L., Lind, Penelope A., Parker, Richard, Mckenna, Sarah, Tonini, Emiliana, Carpenter, Joanne S., Merikangas, Kathleen R., Wray, Naomi R., Medland, Sarah E., Martin, Nicholas G. and Hickie, Ian B. (2026). Atypical depression is associated with a distinct clinical, neurobiological, treatment response, and polygenic risk profile. Biological Psychiatry, 100 (5), 525-535. doi: 10.1016/j.biopsych.2026.01.003
2026
Journal Article
Optimizing study design for clinically useful peripheral molecular biomarker discovery in psychiatry: a review
Yap, Chloe X., Henders, Anjali K., Wray, Naomi R. and Upthegrove, Rachel (2026). Optimizing study design for clinically useful peripheral molecular biomarker discovery in psychiatry: a review. JAMA Psychiatry. doi: 10.1001/jamapsychiatry.2026.2299
2026
Journal Article
Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder
ter Kuile, Abigail R., Mitchell, Brittany L., Lee, Sang Hyuck, Morneau-Vaillancourt, Geneviève, Skelton, Megan, Coleman, Jonathan R. I., Davies, Helena L., Mundy, Jessica, Peel, Alicia J., Hübel, Christopher, Davies, Molly R., Fürtjes, Anna E., Ahmad, Zain, Lin, Yuhao, Adey, Brett N., McGregor, Thomas, Palmos, Alish, Zvrskovec, Johan, Hotopf, Matthew, Kalsi, Gursharan, Smith, Daniel J., Veale, David, Walters, James T. R., Armour, Chérie, Hirsch, Colette R., McIntosh, Andrew M., Wray, Naomi R., Medland, Sarah E., Byrne, Enda M. ... Eley, Thalia C. (2026). Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder. Molecular Psychiatry, 1-14. doi: 10.1038/s41380-026-03677-2
2026
Journal Article
Correction: “There’s no representation”: a qualitative study of attitudes and motivations towards genomic research participation among Australian South Asians
Nathan, Vaishnavi, Akbar, Heena, McInerney-Leo, Aideen, Gilroy, Deborah, Henders, Anjali, Naresh, Reema, Choudhury, Nahid, Waqar, Maleeha, Shah, Sonia, Yanes, Tatiane, on behalf of the South Asian Genes and Health in Australia (SAGHA) research team, Atherton, John, Greaves, Kim, McGaughran, Julie, McInerney-Leo, Aideen, Mehta, Divya, Villani, Rehan Marie, Wallis, Katharine and Wray, Naomi R. (2026). Correction: “There’s no representation”: a qualitative study of attitudes and motivations towards genomic research participation among Australian South Asians. European Journal of Human Genetics, 34 (8), 1190-1190. doi: 10.1038/s41431-026-02157-z
Funding
Current funding
Past funding
Supervision
Availability
- Professor Naomi Wray is:
- Not available for supervision
Supervision history
Current supervision
-
Doctor Philosophy
Understanding child and parent mental health over time: evidence from a neurodevelopmental clinical cohort
Associate Advisor
Other advisors: Dr Enda Byrne
-
Doctor Philosophy
Genetic architecture and evolution of complex traits across populations in humans
Associate Advisor
Other advisors: Professor Peter Visscher, Dr Yuliangzi Sun, Dr Fleur Garton, Dr Jian Zeng
Completed supervision
-
2025
Doctor Philosophy
Multi-Omic Analyses of a Clinical Trial Cohort of Young People at Ultra-High Risk for Psychosis
Principal Advisor
Other advisors: Dr Enda Byrne, Professor Allan McRae
-
2022
Doctor Philosophy
Studying the effects of DNA methylation variation across neurodegenerative disorders
Principal Advisor
Other advisors: Professor Allan McRae
-
2022
Doctor Philosophy
Genetic analyses of complex traits using biobank data
Principal Advisor
Other advisors: Professor Peter Visscher
-
2021
Doctor Philosophy
A Complex Trait Genomics Approach to Investigating Amyotrophic Lateral Sclerosis
Principal Advisor
Other advisors: Professor Allan McRae
-
2017
Doctor Philosophy
The Genetic Architecture of Psychiatric Disorders
Principal Advisor
Other advisors: Professor Peter Visscher
-
2016
Doctor Philosophy
The Role of Cytokines and Inflammatory Markers in Depression in Adolescents
Principal Advisor
Other advisors: Professor James Scott, Honorary Professor Nick Martin
-
2026
Doctor Philosophy
Leveraging multi-omic and epidemiological data to understand endometriosis and its symptomatology
Associate Advisor
Other advisors: Dr Sally Mortlock, Professor Allan McRae
-
2024
Doctor Philosophy
Using genomic data to advance understanding of heart failure aetiology
Associate Advisor
Other advisors: Associate Professor Sonia Shah
-
2024
Doctor Philosophy
Development and application of statistical methods to identify genes and cell types associated with complex traits
Associate Advisor
Other advisors: Dr Jian Zeng
-
2024
Doctor Philosophy
Complement Modulation of Peripheral Immunity in Motor Neurone Disease and Huntington's Disease
Associate Advisor
Other advisors: Dr John Lee, Professor Trent Woodruff
-
2023
Doctor Philosophy
The Genomics of Perinatal Depression
Associate Advisor
Other advisors: Dr Enda Byrne
-
2022
Doctor Philosophy
Systems biology of motor neurone disease
Associate Advisor
Other advisors: Associate Professor Shyuan Ngo, Professor Allan McRae
-
2022
Doctor Philosophy
Multi-omics data offer systemic insights into autism
Associate Advisor
Other advisors: Professor Gerald Holtmann, Honorary Professor Jake Gratten
-
2022
Doctor Philosophy
Exploring the influence of genetics and heritability on the heterogeneity of ADHD presentations
Associate Advisor
Other advisors: Honorary Professor Sarah Medland
-
2020
Doctor Philosophy
Improving fine-mapping methodology using DNA methylation as a model trait
Associate Advisor
Other advisors: Professor Peter Visscher, Professor Allan McRae
-
2020
Doctor Philosophy
Genetic influences on substance use behaviour, substance use disorders and psychiatric disorders
Associate Advisor
Other advisors: Honorary Professor Sarah Medland, Honorary Professor Nick Martin, Dr Lucia Colodro-Conde
-
2018
Master Philosophy
Integrating genome-wide association study data with gene expression to understand complex traits and common diseases
Associate Advisor
Other advisors: Professor Allan McRae, Honorary Professor Jake Gratten
Media
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