
Overview
Background
The objective of my research is to improve understanding of the genetic etiology and biological mechanisms underlying risk of common psychiatric disorders, particularly those with onset during childhood and adolescence. As a Senior Research Fellow at the Child Health Research Centre, I lead a number of domestic and international collaborations that evaluate the association between polygenic risk scores, environmental variables and behaviour during childhood and adolescence. My group applies innovative statistical methods to large longitudinal datasets with information from infancy through to adulthood and to evaluate genetic and environmental contributions to risk to mental health problems. In addition, our research focuses on the potential clinical utility of polygenic risk scores in psychiatry. I have contributed to major advances in understanding of the etiology of a number of psychiatric disorders, with a major focus on depression
PhD and Honours projects are available in the group. Please contact me for more information.
Availability
- Dr Enda Byrne is:
- Available for supervision
Qualifications
- Doctor of Philosophy, The University of Queensland
Research interests
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Genomic Technologies
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Statistical and Computational methods
Research impacts
My research has contributed to advances in a number of fields through the identification of previously unknown genetic variants that contribute to risk to complex disorders. The identification of these variants opens up new avenues for developing drug targets to target the biological pathways in which they are found.
Works
Search Professor Enda Byrne’s works on UQ eSpace
2024
Journal Article
The effect of polygenic liability to mental disorders on COVID-19 outcomes in people with depression: the mediating role of anxiety
Monistrol-Mula, Anna, Felez-Nobrega, Mireia, Byrne, Enda M., Lind, Penelope A., Hickie, Ian B., Martin, Nicholas G., Medland, Sarah E., Colodro-Conde, Lucía and Mitchell, Brittany L. (2024). The effect of polygenic liability to mental disorders on COVID-19 outcomes in people with depression: the mediating role of anxiety. Psychological Medicine, 54 (15), 4140-4149. doi: 10.1017/s0033291724001983
2024
Journal Article
Development and temporal validation of a clinical prediction model of transition to psychosis in individuals at ultra-high risk in the UHR 1000+ cohort
Hartmann, Simon, Dwyer, Dominic, Cavve, Blake, Byrne, Enda M., Scott, Isabelle, Gao, Caroline, Wannan, Cassandra, Yuen, Hok Pan, Hartmann, Jessica, Lin, Ashleigh, Wood, Stephen J., Wigman, Johanna T.W., Middeldorp, Christel M., Thompson, Andrew, Amminger, Paul, Schlögelhofer, Monika, Riecher-Rössler, Anita, Chen, Eric Y.H., Hickie, Ian B., Phillips, Lisa J., Schäfer, Miriam R., Mossaheb, Nilufar, Smesny, Stefan, Berger, Gregor, de Haan, Lieuwe, Nordentoft, Merete, Verma, Swapna, Nieman, Dorien H., McGorry, Patrick D. ... Nelson, Barnaby (2024). Development and temporal validation of a clinical prediction model of transition to psychosis in individuals at ultra-high risk in the UHR 1000+ cohort. World Psychiatry, 23 (3), 400-410. doi: 10.1002/wps.21240
2024
Conference Publication
Cohort Profile: Improving Outcomes Of Mental Health (IOMH) A Longitudinal Clinical Study Of Families With Children With Neurodevelopmental Problems
Galligan, Dana, Payne, Leanne, Sullivan, Daniel, Bhadravathi Lokeshappa, Madhura, Ziser, Laura, Nunn, Lorelle, Wallace, Leanne, Sanders, Matthew, Cobham, Vanessa, Wray, Naomi, Henders, Anjali, Byrne, Enda, Heussler, Helen and Middeldorp, Christel M. (2024). Cohort Profile: Improving Outcomes Of Mental Health (IOMH) A Longitudinal Clinical Study Of Families With Children With Neurodevelopmental Problems. World Congress of Psychiatric Genetics WCPG 2024, Singapore, 15-19 October 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2024.08.469
2024
Journal Article
Genome-wide meta-analysis of ascertainment and symptom structures of major depression in case-enriched and community cohorts
Adams, Mark J., Thorp, Jackson G., Jermy, Bradley S., Kwong, Alex S. F., Kõiv, Kadri, Grotzinger, Andrew D., Nivard, Michel G., Marshall, Sally, Milaneschi, Yuri, Baune, Bernhard T., Müller-Myhsok, Bertram, Penninx, Brenda W. J. H., Boomsma, Dorret I., Levinson, Douglas F., Breen, Gerome, Pistis, Giorgio, Grabe, Hans J., Tiemeier, Henning, Berger, Klaus, Rietschel, Marcella, Magnusson, Patrik K., Uher, Rudolf, Hamilton, Steven P., Lucae, Susanne, Lehto, Kelli, Li, Qingqin S., Byrne, Enda M., Hickie, Ian B., Martin, Nicholas G. ... Derks, Eske M. (2024). Genome-wide meta-analysis of ascertainment and symptom structures of major depression in case-enriched and community cohorts. Psychological Medicine, 54 (12), 3459-3468. doi: 10.1017/s0033291724001880
2024
Journal Article
Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression
Crouse, Jacob J., Park, Shin Ho, Byrne, Enda M., Mitchell, Brittany L., Scott, Jan, Medland, Sarah E., Lin, Tian, Wray, Naomi R., Martin, Nicholas G. and Hickie, Ian B. (2024). Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression. Molecular Psychiatry, 29 (9), 2765-2773. doi: 10.1038/s41380-024-02492-x
2024
Journal Article
Markers of positive affect and brain state synchrony discriminate melancholic from non-melancholic depression using naturalistic stimuli
Mosley, Philip E., van der Meer, Johan N., Hamilton, Lachlan H. W., Fripp, Jurgen, Parker, Stephen, Jeganathan, Jayson, Breakspear, Michael, Parker, Richard, Holland, Rebecca, Mitchell, Brittany L., Byrne, Enda, Hickie, Ian B., Medland, Sarah E., Martin, Nicholas G. and Cocchi, Luca (2024). Markers of positive affect and brain state synchrony discriminate melancholic from non-melancholic depression using naturalistic stimuli. Molecular Psychiatry. doi: 10.1038/s41380-024-02699-y
2024
Journal Article
Combining clinical with cognitive or magnetic resonance imaging data for predicting transition to psychosis in ultra high-risk patients: data from the PACE 400 cohort
Hartmann, Simon, Cearns, Micah, Pantelis, Christos, Dwyer, Dominic, Cavve, Blake, Byrne, Enda, Scott, Isabelle, Yuen, Hok Pan, Gao, Caroline, Allott, Kelly, Lin, Ashleigh, Wood, Stephen J., Wigman, Johanna T.W., Amminger, G. Paul, McGorry, Patrick D., Yung, Alison R., Nelson, Barnaby and Clark, Scott R. (2024). Combining clinical with cognitive or magnetic resonance imaging data for predicting transition to psychosis in ultra high-risk patients: data from the PACE 400 cohort. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 9 (4), 417-428. doi: 10.1016/j.bpsc.2023.11.009
2024
Journal Article
Comprehensive sex-stratified genetic analysis of 28 blood biomarkers and depression reveals a significant association between depression and low levels of total protein in females
Kiewa, Jacqueline, Meltzer-Brody, Samantha, Milgrom, Jeannette, Guintivano, Jerry, Hickie, Ian B., Whiteman, David C., Olsen, Catherine M., Medland, Sarah E., Martin, Nicholas G., Wray, Naomi R. and Byrne, Enda M. (2024). Comprehensive sex-stratified genetic analysis of 28 blood biomarkers and depression reveals a significant association between depression and low levels of total protein in females. Complex Psychiatry, 10 (1-4), 19-34. doi: 10.1159/000538058
2024
Journal Article
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference
Meng, Xiangrui, Navoly, Georgina, Giannakopoulou, Olga, Levey, Daniel F., Koller, Dora, Pathak, Gita A., Koen, Nastassja, Lin, Kuang, Adams, Mark J., Renteria, Miguel E., Feng, Yanzhe, Gaziano, J. Michael, Stein, Dan J., Zar, Heather J., Campbell, Megan L., van Heel, David A., Trivedi, Bhavi, Finer, Sarah, McQuillin, Andrew, Bass, Nick, Chundru, V. Kartik, Martin, Hilary C., Huang, Qin Qin, Valkovskaya, Maria, Chu, Chia-Yi, Kanjira, Susan, Kuo, Po-Hsiu, Chen, Hsi-Chung, Tsai, Shih-Jen ... BioBank Japan Project (2024). Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference. Nature Genetics, 56 (2), 222-233. doi: 10.1038/s41588-023-01596-4
2024
Journal Article
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference
Meng, Xiangrui, Navoly, Georgina, Giannakopoulou, Olga, Levey, Daniel F., Koller, Dora, Pathak, Gita A., Koen, Nastassja, Lin, Kuang, Adams, Mark J., Rentería, Miguel E., Feng, Yanzhe, Gaziano, J. Michael, Stein, Dan J., Zar, Heather J., Campbell, Megan L., van Heel, David A., Trivedi, Bhavi, Finer, Sarah, McQuillin, Andrew, Bass, Nick, Chundru, V. Kartik, Martin, Hilary C., Huang, Qin Qin, Valkovskaya, Maria, Chu, Chia-Yi, Kanjira, Susan, Kuo, Po-Hsiu, Chen, Hsi-Chung, Tsai, Shih-Jen ... BioBank Japan Project (2024). Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference. Nature Genetics, 56 (2), 222-233. doi: 10.1038/s41588-023-01596-4
2024
Journal Article
Changes in sleep patterns in people with a history of depression during the COVID-19 pandemic: a natural experiment
Shin, Mirim, Crouse, Jacob J., Byrne, Enda M., Mitchell, Brittany L., Lind, Penelope, Parker, Richard, Tonini, Emiliana, Carpenter, Joanne S., Wray, Naomi R., Colodro-Conde, Lucia, Medland, Sarah E. and Hickie, Ian B. (2024). Changes in sleep patterns in people with a history of depression during the COVID-19 pandemic: a natural experiment. BMJ Mental Health, 27 (1) e301067, e301067. doi: 10.1136/bmjment-2024-301067
2024
Journal Article
Evening chronotypes with depression report poorer outcomes of SSRIs: A survey-based study of self-ratings
Crouse, Jacob J., Park, Shin Ho, Byrne, Enda M., Mitchell, Brittany L., Chan, Karina, Scott, Jan, Medland, Sarah E., Martin, Nicholas G., Wray, Naomi R. and Hickie, Ian B. (2024). Evening chronotypes with depression report poorer outcomes of SSRIs: A survey-based study of self-ratings. Biological Psychiatry, 96 (1), 4-14. doi: 10.1016/j.biopsych.2023.12.023
2023
Journal Article
Meta-analyses of genome-wide association studies for postpartum depression
Guintivano, Jerry, Byrne, Enda M., Kiewa, Jacqueline, Yao, Shuyang, Bauer, Anna E., Aberg, Karolina A., Adams, Mark J., Campbell, Archie, Campbell, Megan L., Choi, Karmel W., Corfield, Elizabeth C., Havdahl, Alexandra, Hucks, Donald, Koen, Nastassja, Lu, Yi, Maegbaek, Merete L., Mullaer, Jimmy, Peterson, Roseann E., Raffield, Laura M., Sallis, Hannah M., Sealock, Julia M., Walker, Alicia, Watson, Hunna J., Xiong, Ying, Yang, Jessica M. K., Anney, Richard J. L., Gordon-Smith, Katherine, Hubbard, Leon, Jones, Lisa A. ... Sullivan, Patrick (2023). Meta-analyses of genome-wide association studies for postpartum depression. American Journal of Psychiatry, 180 (12), 884-895. doi: 10.1176/appi.ajp.20230053
2023
Journal Article
Discontinuation of antidepressant treatment: a retrospective cohort study on more than 20,000 participants
Garcia-Marin, Luis M., Mulcahy, Aoibhe, Byrne, Enda M., Medland, Sarah E., Wray, Naomi R., Chafota, Freddy, Lind, Penelope A., Martin, Nicholas G., Hickie, Ian B., Rentería, Miguel E. and Campos, Adrian I. (2023). Discontinuation of antidepressant treatment: a retrospective cohort study on more than 20,000 participants. Annals of General Psychiatry, 22 (1) 49, 1-8. doi: 10.1186/s12991-023-00480-z
2023
Journal Article
Using electronic health record data to predict future self‐harm or suicidal ideation in young people treated by child and youth mental health services
Tennakoon, Gayani, Byrne, Enda M., Vaithianathan, Rhema and Middeldorp, Christel M. (2023). Using electronic health record data to predict future self‐harm or suicidal ideation in young people treated by child and youth mental health services. Suicide and Life-Threatening Behavior, 53 (5), 853-869. doi: 10.1111/sltb.12988
2023
Journal Article
A common genetic factor underlies genetic risk for gynaecological and reproductive disorders and is correlated with risk to depression
Kiewa, Jacqueline, Mortlock, Sally, Meltzer-Brody, Samantha, Middeldorp, Christel, Wray, Naomi R. and Byrne, Enda M. (2023). A common genetic factor underlies genetic risk for gynaecological and reproductive disorders and is correlated with risk to depression. Neuroendocrinology, 113 (10), 1059-1075. doi: 10.1159/000533413
2023
Journal Article
GWAS meta-analysis of suicide attempt: identification of 12 genome-wide significant loci and implication of genetic risks for specific health factors
Docherty, Anna R., Mullins, Niamh, Ashley-Koch, Allison E., Qin, Xuejun, Coleman, Jonathan R.I., Shabalin, Andrey, Kang, JooEun, Murnyak, Balasz, Wendt, Frank, Adams, Mark, Campos, Adrian I., DiBlasi, Emily, Fullerton, Janice M., Kranzler, Henry R., Bakian, Amanda V., Monson, Eric T., Rentería, Miguel E., Walss-Bass, Consuelo, Andreassen, Ole A., Behera, Chittaranjan, Bulik, Cynthia M., Edenberg, Howard J., Kessler, Ronald C., Mann, J. John, Nurnberger, John I., Pistis, Giorgio, Streit, Fabian, Ursano, Robert J., Polimanti, Renato ... German Borderline Genomics Consortium (2023). GWAS meta-analysis of suicide attempt: identification of 12 genome-wide significant loci and implication of genetic risks for specific health factors. American Journal of Psychiatry, 180 (10), 723-738. doi: 10.1176/appi.ajp.21121266
2023
Journal Article
The association between trauma exposure, polygenic risk and individual depression symptoms
Thorp, Jackson G., Gerring, Zachary F., Colodro-Conde, Lucía, Byrne, Enda M., Medland, Sarah E., Middeldorp, Christel M. and Derks, Eske M. (2023). The association between trauma exposure, polygenic risk and individual depression symptoms. Psychiatry Research, 321 115101, 1-8. doi: 10.1016/j.psychres.2023.115101
2023
Journal Article
Polygenic risk scores and the prediction of onset of mood and psychotic disorders in adolescents and young adults
Scott, Jan, Crouse, Jacob J., Medland, Sarah, Byrne, Enda, Iorfino, Frank, Mitchell, Brittany, Gillespie, Nathan A., Martin, Nicholas, Wray, Naomi and Hickie, Ian B. (2023). Polygenic risk scores and the prediction of onset of mood and psychotic disorders in adolescents and young adults. Early Intervention in Psychiatry, 18 (6), 397-405. doi: 10.1111/eip.13472
2022
Journal Article
Phenotypic and genetic factors associated with donation of DNA and consent to record linkage for prescription history in the Australian Genetics of Depression Study
Gomez, Lina, Díaz-Torres, Santiago, Colodro-Conde, Lucía, Garcia-Marin, Luis M., Yap, Chloe X., Byrne, Enda M., Yengo, Loic, Lind, Penelope A., Wray, Naomi R., Medland, Sarah E., Hickie, Ian B., Lupton, Michelle K., Rentería, Miguel E., Martin, Nicholas G. and Campos, Adrian I. (2022). Phenotypic and genetic factors associated with donation of DNA and consent to record linkage for prescription history in the Australian Genetics of Depression Study. European Archives of Psychiatry and Clinical Neuroscience, 273 (6), 1359-1368. doi: 10.1007/s00406-022-01527-0
Funding
Current funding
Past funding
Supervision
Availability
- Dr Enda Byrne is:
- Available for supervision
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Available projects
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Gene Environment interactions in Mental health trajectories of Youth (Youth-GEMs)
Mental health problems are common in young people, with life-long enduring impacts on individuals, families and societies. More than 63% of mental disorders throughout the life span emerge before 24 years of age, peaking at 14.5-18 years. Adolescence and young adulthood represent a critical period that forecasts the level of mental wellbeing over lifetime and interventions early in life may be critical in preventing later mental illness.
The Child and Youth Mental Health Group is part of an Australian and European Union-funded consortium called Youth-GEMs that seeks to characterise and model trajectories of mental health in youth. In collaboration with researchers from universities in Europe, this project will combine datasets from longitudinal cohort studies from around the world to investigate the interplay between genetic, epigenetic, and environmental risk in influencing mental health across development.
This project will involve advanced data analytics and statistical inference and will involve combining and analysing different types of data including genetic, clinical and environmental data. The ultimate goal is to develop predictive tools that can be used to aid clinical decision-making in youth mental health.
We are seeking a motivated PhD scholar with a background in genetics, biomedical science, psychology, data science, machine learning or a related field to join our team and work closely with collaborators overseas on this project. There is also the possibility to spend time overseas at one of the collaborating labs.
Supervision history
Current supervision
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Doctor Philosophy
Gene Environment interactions in Mental health trajectories of Youth
Principal Advisor
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Doctor Philosophy
Genetics of childhood onset psychiatric symptoms, their persistence and comorbidity with other traits
Principal Advisor
Other advisors: Professor Naomi Wray
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Doctor Philosophy
Genetics of Neurodevelopmental Disorders and associated comorbidities
Principal Advisor
Other advisors: Dr Allan McRae
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Doctor Philosophy
ELUCIDATING LIFESTYLE AND GENETIC FACTORS UNDERLYING DEPRESSION HETEROGENEITY AND TREATMENT RESPONSE
Associate Advisor
Other advisors: Professor Naomi Wray
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Doctor Philosophy
Multi-Omic Analyses of a Clinical Trial Cohort of Young People at Ultra-High Risk for Psychosis
Associate Advisor
Other advisors: Dr Allan McRae, Professor Naomi Wray
Completed supervision
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2023
Doctor Philosophy
The Genomics of Perinatal Depression
Principal Advisor
Other advisors: Professor Naomi Wray
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2023
Doctor Philosophy
Embracing Complexity in Psychiatric Genetics: Investigating Heterogeneity and Pleiotropy in Depression and Major Psychiatric Disorders
Associate Advisor
Other advisors: Honorary Professor Sarah Medland
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2022
Doctor Philosophy
Genetic and Environmental Influences on Sleep and Internalising Symptoms in Adolescence
Associate Advisor
Media
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