Overview
Background
The objective of my research is to improve understanding of the genetic etiology and biological mechanisms underlying risk of common psychiatric disorders, particularly those with onset during childhood and adolescence. As a Senior Research Fellow at the Child Health Research Centre, I lead a number of domestic and international collaborations that evaluate the association between polygenic risk scores, environmental variables and behaviour during childhood and adolescence. My group applies innovative statistical methods to large longitudinal datasets with information from infancy through to adulthood and to evaluate genetic and environmental contributions to risk to mental health problems. In addition, our research focuses on the potential clinical utility of polygenic risk scores in psychiatry. I have contributed to major advances in understanding of the etiology of a number of psychiatric disorders, with a major focus on depression
PhD and Honours projects are available in the group. Please contact me for more information.
Availability
- Dr Enda Byrne is:
- Available for supervision
Qualifications
- Doctor of Philosophy, The University of Queensland
Research interests
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Genomic Technologies
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Statistical and Computational methods
Research impacts
My research has contributed to advances in a number of fields through the identification of previously unknown genetic variants that contribute to risk to complex disorders. The identification of these variants opens up new avenues for developing drug targets to target the biological pathways in which they are found.
Works
Search Professor Enda Byrne’s works on UQ eSpace
2022
Journal Article
Dynamic networks of psychological symptoms, impairment, substance use, and social support: the evolution of psychopathology among emerging adults
Crouse, Jacob J., Ho, Nicholas, Scott, Jan, Parker, Richard, Park, Shin Ho, Couvy-Duchesne, Baptiste, Mitchell, Brittany, Byrne, Enda M., Hermens, Daniel F., Medland, Sarah E., Martin, Nicholas G., Gillespie, Nathan A. and Hickie, Ian B. (2022). Dynamic networks of psychological symptoms, impairment, substance use, and social support: the evolution of psychopathology among emerging adults. European Psychiatry, 65 (1) e32, 1-24. doi: 10.1192/j.eurpsy.2022.23
2022
Journal Article
Multi-trait genetic analysis identifies auto-immune loci associated with cutaneous melanoma
Liyanage, Upekha, MacGregor, Stuart, Bishop, D. Timothy, Shi, Jianxin, An, Jiyuan, Ong, Jue Sheng, Han, Xikun, Scolyer, Richard A., Martin, Nicholas G., Medland, Sarah E., Byrne, Enda M., Green, Adèle C., Saw, Robyn P. M., Thompson, John F., Stretch, Jonathan, Spillane, Andrew, Jiang, Yunxuan, Tian, Chao, 23andMe Research Team, Gordon, Scott G., Duffy, David L., Olsen, Catherine M., Whiteman, David C., Long, Georgina V., Iles, Mark M., Landi, Maria Teresa and Law, Matthew H. (2022). Multi-trait genetic analysis identifies auto-immune loci associated with cutaneous melanoma. The Journal of Investigative Dermatology, 142 (6), 1607-1616. doi: 10.1016/j.jid.2021.08.449
2022
Journal Article
Identifying the Common Genetic Basis of Antidepressant Response
Pain, Oliver, Hodgson, Karen, Trubetskoy, Vassily, Ripke, Stephan, Marshe, Victoria S., Adams, Mark J., Byrne, Enda M., Campos, Adrian I., Carrillo-Roa, Tania, Cattaneo, Annamaria, Als, Thomas D., Souery, Daniel, Dernovsek, Mojca Z., Fabbri, Chiara, Hayward, Caroline, Henigsberg, Neven, Hauser, Joanna, Kennedy, James L., Lenze, Eric J., Lewis, Glyn, Müller, Daniel J., Martin, Nicholas G., Mulsant, Benoit H., Mors, Ole, Perroud, Nader, Porteous, David J., Rentería, Miguel E., Reynolds, Charles F., Rietschel, Marcella ... Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2022). Identifying the Common Genetic Basis of Antidepressant Response. Biological Psychiatry Global Open Science, 2 (2), 115-126. doi: 10.1016/j.bpsgos.2021.07.008
2022
Journal Article
Perinatal depression is associated with a higher polygenic risk for major depressive disorder than non-perinatal depression
Kiewa, Jacqueline, Meltzer‐Brody, Samantha, Milgrom, Jeanette, Guintivano, Jerry, Hickie, Ian B., Whiteman, David C., Olsen, Catherine M., Colodro‐Conde, Lucía, Medland, Sarah E., Martin, Nicholas G., Wray, Naomi R. and Byrne, Enda M. (2022). Perinatal depression is associated with a higher polygenic risk for major depressive disorder than non-perinatal depression. Depression and Anxiety, 39 (3), 182-191. doi: 10.1002/da.23232
2022
Journal Article
Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders, and known risk factors
Mullins, Niamh, Kang, JooEun, Campos, Adrian I., Coleman, Jonathan R I, Edwards, Alexis C., Galfalvy, Hanga, Levey, Daniel F., Lori, Adriana, Shabalin, Andrey, Starnawska, Anna, Su, Mei-Hsin, Watson, Hunna J., Adams, Mark, Awasthi, Swapnil, Gandal, Michael, Hafferty, Jonathan D., Hishimoto, Akitoyo, Kim, Minsoo, Okazaki, Satoshi, Otsuka, Ikuo, Ripke, Stephan, Ware, Erin B., Bergen, Andrew W., Berrettini, Wade H., Bohus, Martin, Brandt, Harry, Chang, Xiao, Chen, Wei J., Chen, Hsi-Chung ... Ruderfer, Douglas M. (2022). Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders, and known risk factors. Biological Psychiatry, 91 (3), 313-327. doi: 10.1016/j.biopsych.2021.05.029
2022
Journal Article
Impact of CYP2C19 metaboliser status on SSRI response: a retrospective study of 9500 participants of the Australian Genetics of Depression Study
Campos, Adrian I., Byrne, Enda M., Mitchell, Brittany L., Wray, Naomi R., Lind, Penelope A., Licinio, Julio, Medland, Sarah E., Martin, Nicholas G., Hickie, Ian B. and Rentería, Miguel E. (2022). Impact of CYP2C19 metaboliser status on SSRI response: a retrospective study of 9500 participants of the Australian Genetics of Depression Study. The Pharmacogenomics Journal, 22 (2), 130-135. doi: 10.1038/s41397-022-00267-7
2021
Journal Article
Potential genetic overlap between insomnia and sleep symptoms in major depressive disorder: a polygenic risk score analysis
Melhuish Beaupre, Lindsay M., Tiwari, Arun K., Gonçalves, Vanessa F., Zai, Clement C., Marshe, Victoria S., Lewis, Cathryn M., Martin, Nicholas G., McIntosh, Andrew M., Adams, Mark J., Baune, Bernhard T., Levinson, Doug F., Boomsma, Dorret I., Penninx, Brenda W. J. H., Breen, Gerome, Hamilton, Steve, Awasthi, Swapnil, Ripke, Stephan, Jones, Lisa, Jones, Ian, Byrne, Enda M., Hickie, Ian B., Potash, James P., Shi, Jianxin, Weissman, Myrna M., Milaneschi, Yuri, Shyn, Stanley I., Geus, Eco J. C. de, Willemsen, Gonneke, Brown, Gregory M. and Kennedy, James L. (2021). Potential genetic overlap between insomnia and sleep symptoms in major depressive disorder: a polygenic risk score analysis. Frontiers in Psychiatry, 12 734077, 734077. doi: 10.3389/fpsyt.2021.734077
2021
Journal Article
Understanding genetic risk factors for common side effects of antidepressant medications
Campos, Adrian I., Mulcahy, Aoibhe, Thorp, Jackson G., Wray, Naomi R., Byrne, Enda M., Lind, Penelope A., Medland, Sarah E., Martin, Nicholas G., Hickie, Ian B. and Rentería, Miguel E. (2021). Understanding genetic risk factors for common side effects of antidepressant medications. Communications Medicine, 1 (1) 45, 1-10. doi: 10.1038/s43856-021-00046-8
2021
Journal Article
The Australian Genetics of Depression Study: new risk loci and dissecting heterogeneity between subtypes
Mitchell, Brittany L., Campos, Adrian I., Whiteman, David C., Olsen, Catherine M., Gordon, Scott D., Walker, Adam J., Dean, Olivia M., Berk, Michael, Hickie, Ian B., Medland, Sarah E., Wray, Naomi R., Martin, Nicholas G. and Byrne, Enda M. (2021). The Australian Genetics of Depression Study: new risk loci and dissecting heterogeneity between subtypes. Biological Psychiatry, 92 (3), 227-235. doi: 10.1016/j.biopsych.2021.10.021
2021
Journal Article
Genetic and environmental influences on sleep-wake behaviours in adolescence
O'Callaghan, Victoria S., Hansell, Narelle K., Guo, Wei, Carpenter, Joanne S., Shou, Haochang, Strike, Lachlan T., Crouse, Jacob J., McAloney, Kerrie, McMahon, Katie L., Byrne, Enda M., Burns, Jane M., Martin, Nicholas G., Hickie, Ian B., Merikangas, Kathleen R. and Wright, Margaret J. (2021). Genetic and environmental influences on sleep-wake behaviours in adolescence. Sleep Advances, 2 (1) zpab018, zpab018. doi: 10.1093/sleepadvances/zpab018
2021
Journal Article
Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk
Miles, Amy E., Dos Santos, Fernanda C., Byrne, Enda M., Renteria, Miguel E., McIntosh, Andrew M., Adams, Mark J., Pistis, Giorgio, Castelao, Enrique, Preisig, Martin, Baune, Bernhard T., Schubert, K. Oliver, Lewis, Cathryn M., Jones, Lisa A., Jones, Ian, Uher, Rudolf, Smoller, Jordan W., Perlis, Roy H., Levinson, Douglas F., Potash, James B., Weissman, Myrna M., Shi, Jianxin, Lewis, Glyn, Penninx, Brenda W. J. H., Boomsma, Dorret I., Hamilton, Steven P., Sibille, Etienne, Hariri, Ahmad R., Nikolova, Yuliya S. and Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2021). Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk. Neuropsychopharmacology, 46 (13), 2304-2311. doi: 10.1038/s41386-021-01189-x
2021
Conference Publication
SYMPTOM-LEVEL GENETIC MODELLING OF DEPRESSION AND ANXIETY
Thorp, Jackson, Campos, Adrian, Grotzinger, Andrew, Gerring, Zachary, An, Jiyuan, Ong, JueSheng, Wang, Wei, Shringarpure, Suyash, Byrne, Enda, MacGregor, Stuart, Martin, Nicholas, Medland, Sarah, Middeldorp, Christel and Derks, Eske (2021). SYMPTOM-LEVEL GENETIC MODELLING OF DEPRESSION AND ANXIETY. World Congress of Psychiatric Genetics (WCPG), Electr Network, Oct 11-15, 2021. AMSTERDAM: ELSEVIER. doi: 10.1016/j.euroneuro.2021.07.080
2021
Conference Publication
GENOME-WIDE ANALYSIS OF THE ANXIETY DISORDER SPECTRUM
ter Kuile, Abigail, Davies, Molly, Purves, Kirstin, Coleman, Jonathan, Hubel, Christopher, Kalsi, Gursharan, Mundy, Jessica, Skelton, Megan, Morneau-Vaillancourt, Genevieve, Mundy, Jessica, Zvrskovec, Johan, Armour, Cherie, Jones, Ian R., McIntosh, Andrew M., Walters, James T. R., Smith, Daniel J., Hotopf, Matthew, Medland, Sarah, Byrne, Enda, Wray, Naomi, Thorp, Jackson, Mitchell, Brittany, Martin, Nick, Breen, Gerome and Eley, Thalia (2021). GENOME-WIDE ANALYSIS OF THE ANXIETY DISORDER SPECTRUM. World Congress of Psychiatric Genetics (WCPG), Electr Network, Oct 11-15, 2021. AMSTERDAM: ELSEVIER. doi: 10.1016/j.euroneuro.2021.08.103
2021
Journal Article
Polygenic risk scores derived from varying definitions of depression and risk of depression
Mitchell, Brittany L., Thorp, Jackson G., Wu, Yeda, Campos, Adrian I., Nyholt, Dale R., Gordon, Scott D., Whiteman, David C., Olsen, Catherine M., Hickie, Ian B., Martin, Nicholas G., Medland, Sarah E., Wray, Naomi R. and Byrne, Enda M. (2021). Polygenic risk scores derived from varying definitions of depression and risk of depression. JAMA Psychiatry, 78 (10), 1152-1160. doi: 10.1001/jamapsychiatry.2021.1988
2021
Journal Article
Genetic risk for chronic pain is associated with lower antidepressant effectiveness: converging evidence for a depression subtype
Campos, Adrián I., Ngo, Trung Thanh, Medland, Sarah E., Wray, Naomi R., Hickie, Ian B., Byrne, Enda M., Martin, Nicholas G. and Rentería, Miguel E. (2021). Genetic risk for chronic pain is associated with lower antidepressant effectiveness: converging evidence for a depression subtype. Australian and New Zealand Journal of Psychiatry, 56 (9) 00048674211031491, 1-10. doi: 10.1177/00048674211031491
2021
Journal Article
Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits
Martin, Joanna, Khramtsova, Ekaterina A., Goleva, Slavina B., Blokland, Gabriëlla A.M., Traglia, Michela, Walters, Raymond K., Hübel, Christopher, Coleman, Jonathan R.I., Breen, Gerome, Børglum, Anders D., Demontis, Ditte, Grove, Jakob, Werge, Thomas, Bralten, Janita, Bulik, Cynthia M., Lee, Phil H., Mathews, Carol A., Peterson, Roseann E., Winham, Stacey J., Wray, Naomi, Edenberg, Howard J., Guo, Wei, Yao, Yin, Neale, Benjamin M., Faraone, Stephen V., Petryshen, Tracey L., Weiss, Lauren A., Duncan, Laramie E., Goldstein, Jill M. ... Stahl, Eli (2021). Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits. Biological Psychiatry, 89 (12), 1127-1137. doi: 10.1016/j.biopsych.2020.12.024
2021
Journal Article
Erratum: Alzheimer's disease genetic risk and sleep phenotypes in healthy young men: Association with more slow waves and daytime sleepiness (SLEEP DOI: 10.1093/sleep/zsaa137)
Muto, Vincenzo, Koshmanova, Ekaterina, Ghaemmaghami, Pouya, Jaspar, Mathieu, Meyer, Christelle, Elansary, Mahmoud, Van Egroo, Maxime, Chylinski, Daphne, Berthomier, Christian, Brandewinder, Marie, Mouraux, Charlotte, Schmidt, Christina, Hammad, Gregory, Coppieters, Wouter, Ahariz, Naima, Degueldre, Christian, Luxen, Andre, Salmon, Eric, Phillips, Christophe, Archer, Simon N, Yengo, Loic, Byrne, Enda, Collette, Fabienne, Georges, Michel, Dijk, Derk-Jan, Maquet, Pierre, Visscher, Peter M and Vandewalle, Gilles (2021). Erratum: Alzheimer's disease genetic risk and sleep phenotypes in healthy young men: Association with more slow waves and daytime sleepiness (SLEEP DOI: 10.1093/sleep/zsaa137). Sleep, 44 (5) zsaa137. doi: 10.1093/sleep/zsab079
2021
Journal Article
Symptom-level modelling unravels the shared genetic architecture of anxiety and depression
Thorp, Jackson G., Campos, Adrian I., Grotzinger, Andrew D., Gerring, Zachary F., An, Jiyuan, Ong, Jue-Sheng, Wang, Wei, Shringarpure, Suyash, Byrne, Enda M., MacGregor, Stuart, Martin, Nicholas G., Medland, Sarah E., Middeldorp, Christel M. and Derks, Eske M. (2021). Symptom-level modelling unravels the shared genetic architecture of anxiety and depression. Nature Human Behaviour, 5 (10), 1432-1442. doi: 10.1038/s41562-021-01094-9
2021
Journal Article
Comorbid chronic pain and depression: shared risk factors and differential antidepressant effectiveness
Roughan, William H., Campos, Adrián I., García-Marín, Luis M., Cuéllar-Partida, Gabriel, Lupton, Michelle K., Hickie, Ian B., Medland, Sarah E., Wray, Naomi R., Byrne, Enda M., Ngo, Trung Thanh, Martin, Nicholas G. and Rentería, Miguel E. (2021). Comorbid chronic pain and depression: shared risk factors and differential antidepressant effectiveness. Frontiers in Psychiatry, 12 643609, 1-13. doi: 10.3389/fpsyt.2021.643609
2021
Journal Article
Can network analysis of self-reported psychopathology shed light on the core phenomenology of bipolar disorders in adolescents and young adults?
Scott, Jan, Crouse, Jacob J., Ho, Nicholas, Carpenter, Joanne, Martin, Nicholas, Medland, Sarah, Parker, Richard, Byrne, Enda, Couvy-Duchesne, Baptiste, Mitchell, Brittany, Merikangas, Kathleen, Gillespie, Nathan A. and Hickie, Ian (2021). Can network analysis of self-reported psychopathology shed light on the core phenomenology of bipolar disorders in adolescents and young adults?. Bipolar Disorders, 23 (6), 584-594. doi: 10.1111/bdi.13067
Funding
Current funding
Past funding
Supervision
Availability
- Dr Enda Byrne is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Available projects
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Gene Environment interactions in Mental health trajectories of Youth (Youth-GEMs)
Mental health problems are common in young people, with life-long enduring impacts on individuals, families and societies. More than 63% of mental disorders throughout the life span emerge before 24 years of age, peaking at 14.5-18 years. Adolescence and young adulthood represent a critical period that forecasts the level of mental wellbeing over lifetime and interventions early in life may be critical in preventing later mental illness.
The Child and Youth Mental Health Group is part of an Australian and European Union-funded consortium called Youth-GEMs that seeks to characterise and model trajectories of mental health in youth. In collaboration with researchers from universities in Europe, this project will combine datasets from longitudinal cohort studies from around the world to investigate the interplay between genetic, epigenetic, and environmental risk in influencing mental health across development.
This project will involve advanced data analytics and statistical inference and will involve combining and analysing different types of data including genetic, clinical and environmental data. The ultimate goal is to develop predictive tools that can be used to aid clinical decision-making in youth mental health.
We are seeking a motivated PhD scholar with a background in genetics, biomedical science, psychology, data science, machine learning or a related field to join our team and work closely with collaborators overseas on this project. There is also the possibility to spend time overseas at one of the collaborating labs.
Supervision history
Current supervision
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Doctor Philosophy
Genetics of Neurodevelopmental Disorders and associated comorbidities
Principal Advisor
Other advisors: Professor Allan McRae
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Doctor Philosophy
Genetics of childhood onset psychiatric symptoms, their persistence and comorbidity with other traits
Principal Advisor
Other advisors: Professor Naomi Wray
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Doctor Philosophy
Gene Environment interactions in Mental health trajectories of Youth
Principal Advisor
Completed supervision
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2023
Doctor Philosophy
The Genomics of Perinatal Depression
Principal Advisor
Other advisors: Professor Naomi Wray
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2025
Doctor Philosophy
Multi-Omic Analyses of a Clinical Trial Cohort of Young People at Ultra-High Risk for Psychosis
Associate Advisor
Other advisors: Professor Allan McRae, Professor Naomi Wray
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2023
Doctor Philosophy
Embracing Complexity in Psychiatric Genetics: Investigating Heterogeneity and Pleiotropy in Depression and Major Psychiatric Disorders
Associate Advisor
Other advisors: Honorary Professor Sarah Medland
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2022
Doctor Philosophy
Genetic and Environmental Influences on Sleep and Internalising Symptoms in Adolescence
Associate Advisor
Media
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