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Professor Gerald Holtmann
Professor

Gerald Holtmann

Email: 
Phone: 
+61 7 3176 7792

Overview

Background

Prof Holtmann is a Clinical Academic in the field of Gastroenterology & Hepatology and Director of Clinical Innovation. He is also Director of the Department of Gastroenterology & Hepatology at the Princess Alexandra Hospital in Queensland and serves on the Board of Directors of the West Moreton Hospital and Health Service and UQ Healthcare. He is a Fellow of Royal Australian Collge of Physicians (RACP, Sydney), the Royal College of Physicians (RCP, London) and Fellow of the Australian Academy of Health and Medical Sciences (AAHMS, Canberra). Besides his Medical Qualifications he also obtained a Master of Business Administration. After completing the clinical training in Medicine and Gastroenterology at the University of Essen in Germany and the Mayo Clinic in Rochester, Minnesota in the United States, he has gained substantial leadership and managerial experience within the health care setting as Director of large Gastroenterology Departments, CEO and General Manager of a University Hospital and Health Care Facilities and has served on the Board of the University Hospital Essen in Germany. His research is in the field of Neurogastroenterology has resulted in peer reviewed publications in key journal including the NEJM, Lancet, Gastroenterology and Gut. More recently his rersearch focus is on the role of the gut microbiome, mucosal and systemic inflammation and brain-gut interactions.

Availability

Professor Gerald Holtmann is:
Available for supervision
Media expert

Works

Search Professor Gerald Holtmann’s works on UQ eSpace

531 works between 1986 and 2025

1 - 20 of 531 works

2025

Journal Article

Is the biogeography of the mucosa-associated microbiota a key factor affecting primary sclerosing cholangitis disease course and treatment?

Lim, Yenkai, Kang, Seungha, Shah, Ayesha, Holtmann, Gerald and Morrison, Mark (2025). Is the biogeography of the mucosa-associated microbiota a key factor affecting primary sclerosing cholangitis disease course and treatment?. Gut, 74 (4), 692-693. doi: 10.1136/gutjnl-2024-334069

Is the biogeography of the mucosa-associated microbiota a key factor affecting primary sclerosing cholangitis disease course and treatment?

2025

Journal Article

Decoding the Gut-Brain Axis: A Journey Towards Targeted Interventions for Disorders-of-Gut-Brain Interaction

Holtmann, Gerald, Moniruzzaman, M D and Shah, Ayesha (2025). Decoding the Gut-Brain Axis: A Journey Towards Targeted Interventions for Disorders-of-Gut-Brain Interaction. Digestive diseases (Basel, Switzerland), 1-14. doi: 10.1159/000543845

Decoding the Gut-Brain Axis: A Journey Towards Targeted Interventions for Disorders-of-Gut-Brain Interaction

2025

Journal Article

Small intestinal bacterial overgrowth in chronic liver disease: an updated systematic review and meta-analysis of case-control studies

Shah, Ayesha, Spannenburg, Liam, Thite, Parag, Morrison, Mark, Fairlie, Thomas, Koloski, Natasha, Kashyap, Purna C., Pimentel, Mark, Rezaie, Ali, Gores, Gregory J., Jones, Michael P. and Holtmann, Gerald (2025). Small intestinal bacterial overgrowth in chronic liver disease: an updated systematic review and meta-analysis of case-control studies. eClinicalMedicine, 80 103024, 103024-80. doi: 10.1016/j.eclinm.2024.103024

Small intestinal bacterial overgrowth in chronic liver disease: an updated systematic review and meta-analysis of case-control studies

2025

Journal Article

Guselkumab in patients with moderately to severely active ulcerative colitis (QUASAR): phase 3 double-blind, randomised, placebo-controlled induction and maintenance studies

Rubin, David T., Allegretti, Jessica R, Panés, Julián, Shipitofsky, Nicole, Yarandi, Shadi S, Huang, Kuan-Hsiang Gary, Germinaro, Matthew, Wilson, Rebbecca, Zhang, Hongyan, Johanns, Jewel, Feagan, Brian G, Hisamatsu, Tadakazu, Lichtenstein, Gary R, Bressler, Brian, Peyrin-Biroulet, Laurent, Sands, Bruce E, Dignass, Axel, Abrahamovych, Orest, Abu-Farsakh, Niazy, Afanasieva, Halyna, Akpinar, Hale, Kharrat, Houssam Al, Altintas, Engin, Altwegg, Romain, Andreev, Pavel, Aomatsu, Kazuki, Araki, Hiroshi, Argollo, Marjorie, Ariel, Federico ... Zureikat, Firas (2025). Guselkumab in patients with moderately to severely active ulcerative colitis (QUASAR): phase 3 double-blind, randomised, placebo-controlled induction and maintenance studies. The Lancet, 405 (10472), 33-49. doi: 10.1016/S0140-6736(24)01927-5

Guselkumab in patients with moderately to severely active ulcerative colitis (QUASAR): phase 3 double-blind, randomised, placebo-controlled induction and maintenance studies

2025

Journal Article

Economic evaluations of non-pharmacological interventions for treating disorders of gut-brain interaction: a scoping review

Pak, Anton, O'Grady, Madeline, Holtmann, Gerald, Shah, Ayesha and Tuffaha, Haitham (2025). Economic evaluations of non-pharmacological interventions for treating disorders of gut-brain interaction: a scoping review. PharmacoEconomics, 43 (3) e14578, 249-269. doi: 10.1007/s40273-024-01455-y

Economic evaluations of non-pharmacological interventions for treating disorders of gut-brain interaction: a scoping review

2024

Journal Article

A pathophysiologic framework for the overlap of disorders of gut-brain interaction and the role of the gut microbiome

Shah, Ayesha, Lee, Yeong Yeh, Suzuki, Hidekazu, Tan-Loh, Joash, Siah, Kewin Tien Ho, Gwee, Kok-Ann, Fairlie, Thomas, Talley, Nicholas J., Ghoshal, Uday C, Wang, Yen-Po, Kim, Yong Sung and Holtmann, Gerald (2024). A pathophysiologic framework for the overlap of disorders of gut-brain interaction and the role of the gut microbiome. Gut Microbes, 16 (1) 2413367, 1-16. doi: 10.1080/19490976.2024.2413367

A pathophysiologic framework for the overlap of disorders of gut-brain interaction and the role of the gut microbiome

2024

Journal Article

Post‐colonoscopy upper gastrointestinal malignancies in positive immunochemical fecal occult blood test patients: an Australian data linkage study

Pakneshan, Sahar, Moy, Naomi, Shah, Ayesha, Koloski, Natasha, Jones, Mike P., Talley, Nicholas J. and Holtmann, Gerald (2024). Post‐colonoscopy upper gastrointestinal malignancies in positive immunochemical fecal occult blood test patients: an Australian data linkage study. Journal of Gastroenterology and Hepatology, 39 (12), 2811-2816. doi: 10.1111/jgh.16799

Post‐colonoscopy upper gastrointestinal malignancies in positive immunochemical fecal occult blood test patients: an Australian data linkage study

2024

Conference Publication

Small intestinal bacterial overgrowth as assessed by breath testing: a prospective evaluation against the 'gold standard' small bowel aspirate and culture

Hansen, Teressa, Shah, Ayesha, Fairlie, Tom, Koloski, Natasha, Jones, Michael, Morrion, Mark and Holtmann, Gerald (2024). Small intestinal bacterial overgrowth as assessed by breath testing: a prospective evaluation against the 'gold standard' small bowel aspirate and culture. 5th Meeting of the Federation of Neurogastroenterology and Motility (FNM 2024), Bangkok, Thailand, 6 - 8 November 2024. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing.

Small intestinal bacterial overgrowth as assessed by breath testing: a prospective evaluation against the 'gold standard' small bowel aspirate and culture

2024

Conference Publication

Oral contraceptives are strongly associated with an increased risk of irritable bowel syndrome but not functional dyspepsia among women in primary care

Koloski, Natasha, Jones, Michael, Shah, Ayesha, Holtmann, Gerald and Talley, Nicholas (2024). Oral contraceptives are strongly associated with an increased risk of irritable bowel syndrome but not functional dyspepsia among women in primary care. 5th Meeting of the Federation of Neurogastroenterology and Motility (FNM 2024), Bangkok, Thailand, 6 - 8 November 2024. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/nmo.14902

Oral contraceptives are strongly associated with an increased risk of irritable bowel syndrome but not functional dyspepsia among women in primary care

2024

Journal Article

Costs and benefits of a formal quality framework for colonoscopy: economic evaluation

Pakneshan, Sahar, Moy, Naomi, O'Connor, Sam, Hourigan, Luke, Messmann, Helmut, Shah, Ayesha, Dulleck, Uwe and Holtmann, G.J. (2024). Costs and benefits of a formal quality framework for colonoscopy: economic evaluation. Endoscopy International Open, 12 (11), E1334-E1341. doi: 10.1055/a-2444-6292

Costs and benefits of a formal quality framework for colonoscopy: economic evaluation

2024

Conference Publication

Psychological distress does not explain the association between some disorders of gut brain interaction and eating disorders among primary care patients

Koloski, Natasha, Jones, Michael, Shah, Ayesha, Holtmann, Gerald and Talley, Nicholas (2024). Psychological distress does not explain the association between some disorders of gut brain interaction and eating disorders among primary care patients. 5th Meeting of the Federation of Neurogastroenterology and Motility (FNM 2024), Bangkok, Thailand, 6 - 8 November 2024. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing.

Psychological distress does not explain the association between some disorders of gut brain interaction and eating disorders among primary care patients

2024

Journal Article

Diagnostic classification systems for disorders of gut‐brain interaction should include psychological symptoms

Jones, Michael P., Holtmann, Gerald J., Tack, Jan, Carbonne, Florencia, Chey, William, Koloski, Natasha, Shah, Ayesha, Bangdiwala, Shrikant I., Sperber, Ami D., Palsson, Olafur S. and Talley, Nicholas J. (2024). Diagnostic classification systems for disorders of gut‐brain interaction should include psychological symptoms. Neurogastroenterology & Motility, 36 (12) e14940. doi: 10.1111/nmo.14940

Diagnostic classification systems for disorders of gut‐brain interaction should include psychological symptoms

2024

Journal Article

The biogeography of the mucosa-associated microbiome in health and disease

Sternes, Peter R., Shah, Ayesha, Ayala Pintos, Camila, Fairlie, Thomas, Koloski, Natasha, Kang, Seungha, Tousignant, Kaylyn D., McIlroy, Simon J., Morrison, Mark, Tyson, Gene W. and Holtmann, Gerald J. (2024). The biogeography of the mucosa-associated microbiome in health and disease. Frontiers in Microbiology, 15 1454910, 1-14. doi: 10.3389/fmicb.2024.1454910

The biogeography of the mucosa-associated microbiome in health and disease

2024

Conference Publication

Small intestinal bacterial overgrowth as assessed by breath testing: a prospective evaluation to the gold standard aspirate

Shah, Ayesha, Hansen, Teressa, Fairlie, Thomas, Koloski, Natasha, Jones, Mike and Holtmann, Gerald (2024). Small intestinal bacterial overgrowth as assessed by breath testing: a prospective evaluation to the gold standard aspirate. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2024, Adelaide, SA Australia, 14-16 September 2024. Richmond, VIC Australia: John Wiley & Sons.

Small intestinal bacterial overgrowth as assessed by breath testing: a prospective evaluation to the gold standard aspirate

2024

Conference Publication

Value based assessment of same day upper and lower endoscopy for patients referred for colonoscopy with a positive immunochemical feacal occult blood test

Shah, Ayesha, Moy, Naomi, Whaley, Amanda, Hansen, Teressa, Virgo, Kate, Dulleck, Uwe, Koloski, Natasha, Jones, Mike and Holtmann, Gerald (2024). Value based assessment of same day upper and lower endoscopy for patients referred for colonoscopy with a positive immunochemical feacal occult blood test. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2024, Adelaide, SA Australia, 14-16 September 2024. Richmond, VIC Australia: John Wiley & Sons.

Value based assessment of same day upper and lower endoscopy for patients referred for colonoscopy with a positive immunochemical feacal occult blood test

2024

Conference Publication

Simethicone suppresses the growth of microbes cultured from the human duodenal mucosa

Fairlie, Thomas, Shah, Ayesha, Lim, Yenkai, Teh, Jing-Jie, Schooth, Lauren, Morrison, Mark and Holtmann, Gerald (2024). Simethicone suppresses the growth of microbes cultured from the human duodenal mucosa. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2024, Adelaide, SA Australia, 14-16 September 2024. Richmond, VIC Australia: John Wiley & Sons.

Simethicone suppresses the growth of microbes cultured from the human duodenal mucosa

2024

Conference Publication

The duodenal mucosa-associated microbiota differs in patients based on their Rome IV classification, and has variable effects on duodenal spheroid barrier function subjects

Schooth, Lauren, Burns, Grace, Minahan, Kyra, Teh, Jing-Jie, Fairlie, Tom, Shah, Ayesha, Holtmann, Gerald and Morrison, Mark (2024). The duodenal mucosa-associated microbiota differs in patients based on their Rome IV classification, and has variable effects on duodenal spheroid barrier function subjects. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2024, Adelaide, SA Australia, 14-16 September 2024. Richmond, VIC Australia: John Wiley & Sons.

The duodenal mucosa-associated microbiota differs in patients based on their Rome IV classification, and has variable effects on duodenal spheroid barrier function subjects

2024

Journal Article

A multifaceted ecological approach to explore links between environmental factors and the epidemiology of disorders of gut–brain interaction

Fairlie, Thomas, Shah, Ayesha, Wong, Reuben K., Fang, Xiucai, Ghoshal, Uday C., Kashyap, Purna C., Mulak, Agata, Lee, Yeong Yeh, Sperber, Ami D., Koloski, Natasha, Moy, Naomi, Talley, Nicholas J., Jones, Michael P. and Holtmann, Gerald (2024). A multifaceted ecological approach to explore links between environmental factors and the epidemiology of disorders of gut–brain interaction. Neurogastroenterology and Motility, 36 (9) e14866, 1-13. doi: 10.1111/nmo.14866

A multifaceted ecological approach to explore links between environmental factors and the epidemiology of disorders of gut–brain interaction

2024

Conference Publication

Tofacitinib demonstrates preliminary efficacy in induction of remission in chronic pouchitis

Khoo, Emi, Amiss, Anna, Lindsay, Niamh, Fernandes, Richard, Gilmore, Robert, Ding, John Nik, Connor, Susan J., Bryant, Robert, White, Lauren, Mohsen, Waled, Leong, Rupert, Ardalan, Zaid, Croft, Anthony, De Cruz, Peter, Lynch, Kate, An, Yoon-Kyo, Holtmann, Gerald and Begun, Jakob (2024). Tofacitinib demonstrates preliminary efficacy in induction of remission in chronic pouchitis. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2024, Adelaide, SA Australia, 14-16 September 2024. Richmond, VIC Australia: John Wiley & Sons.

Tofacitinib demonstrates preliminary efficacy in induction of remission in chronic pouchitis

2024

Conference Publication

The biogeography of the mucosa-associated microbiota is associated with the presence and symptom severity of inflammatory bowel disease, proton pump inhibitor usage, and visceral sensitivity

Sternes, Peter, Shah, Ayesha, Pintos, Camila Ayela, Fairlie, Thomas, Koloski, Natasha, Kang, Seungha, Mcilroy, Simon, Morrison, Mark, Tyson, Gene and Holtmann, Gerald (2024). The biogeography of the mucosa-associated microbiota is associated with the presence and symptom severity of inflammatory bowel disease, proton pump inhibitor usage, and visceral sensitivity. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2024, Adelaide, SA Australia, 14-16 September 2024. Richmond, VIC Australia: John Wiley & Sons.

The biogeography of the mucosa-associated microbiota is associated with the presence and symptom severity of inflammatory bowel disease, proton pump inhibitor usage, and visceral sensitivity

Funding

Current funding

  • 2022 - 2026
    ARC Training Centre for Behavioural Insights for Technology Adoption (BITA) (ARC Industrial Transformation Training Centre Administered by QUT)
    Queensland University of Technology
    Open grant
  • 2021 - 2025
    A practice change for patients with severe chronic, clinically unexplained gastrointestinal symptoms: A randomised, controlled intervention to assess efficacy and cost-effectiveness
    NHMRC IDEAS Grants
    Open grant
  • 2020 - 2025
    Targeting the gut microbiome as a treatment for Primary Sclerosing Cholangitis: The Queensland Clinical Network Study
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant

Past funding

  • 2020 - 2024
    Modulation of the Gastrointestinal Microbiome with probiotics and subsequent Methane production as a novel approach to treat constipation: A Proof of Principle Study (TRI Sport Grant led by PAH)
    Metro South Hospital and Health Service
    Open grant
  • 2019 - 2024
    Centre for Research Excellence in Digestive Health (NHMRC CRE administered by University of Newcastle)
    University of Newcastle
    Open grant
  • 2016
    Establishing a gnotobiotic germ-free mouse facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    The Australian human microbiota project-microbe isolation facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2018
    Pathophysiology of functional dyspepsia: Integration of upper gut function, inflammation and a systems biology approach.
    NHMRC Project Grant
    Open grant
  • 2014 - 2017
    Functional dyspepsia: Characterisation of the immunopathology and testing a novel therapeutic strategy (NHMRC Project Grant administered by the University of Newcastle)
    University of Newcastle
    Open grant

Supervision

Availability

Professor Gerald Holtmann is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Reimagining Health Equity and Access in Colorectal Cancer Screening. A population perspective

    Principal Advisor

    Other advisors: Dr Ayesha Shah

  • Doctor Philosophy

    IBD and mental health tools: a holistic approach to discovery and appropriate tool.

    Principal Advisor

    Other advisors: Dr Ayesha Shah

  • Doctor Philosophy

    Effects the COVID-19 pandemic on the outcome and management of highly prevalent gastrointestinal conditions

    Principal Advisor

    Other advisors: Dr Ayesha Shah

  • Doctor Philosophy

    Effects the COVID-19 pandemic on the outcome and management of highly prevalent gastrointestinal conditions

    Principal Advisor

    Other advisors: Dr Ayesha Shah

  • Doctor Philosophy

    Reimagining Health Equity and Access in Colorectal Cancer Screening. A population perspective.

    Principal Advisor

    Other advisors: Dr Ayesha Shah

  • Doctor Philosophy

    Equitability and Accessibility of Faecal Occult Blood Test Based Colorectal Cancer Screening for Disadvantaged Communities.

    Principal Advisor

  • Doctor Philosophy

    The role of the gut microbiome in alcohol related liver disease

    Associate Advisor

    Other advisors: Professor Jason Connor, Dr Paul Clark

  • Doctor Philosophy

    Study of TOfacitinib for the treatment of chronic Pouchitis

    Associate Advisor

    Other advisors: Associate Professor Jakob Begun

  • Doctor Philosophy

    Study of TOfacitinib for the treatment of chronic Pouchitis

    Associate Advisor

    Other advisors: Associate Professor Jakob Begun

  • Doctor Philosophy

    Exercise training on people with severe chronic, clinically unexplained gastrointestinal symptoms: A randomised, controlled trial.

    Associate Advisor

    Other advisors: Professor Jeff Coombes

Completed supervision

Media

Enquiries

Contact Professor Gerald Holtmann directly for media enquiries about:

  • colon cancer screening
  • Gastroenterology
  • Gut Health
  • Microbiome
  • Neurogastroenterology

Need help?

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communications@uq.edu.au