Overview
Background
After receiving a PhD on immune regulation from La Sorbonne Universitas in France, Anne-Sophie joined Prof. Ian Frazer’s lab in Australia where she led a highly successful and independent research program on the mechanisms of immune tolerance in human papillomavirus (HPV)-associated lesions in mice. She then joined the field of autoimmune diseases with Prof. Ranjeny Thomas. In Type 1 Diabetes, her pre-clinical data showed the feasibility of an antigen-specific liposome targeted immunotherapy in pre-diabetic mice and led to the first-in-human clinical trial using liposome nanoparticles. In Spondyloarthropathy, her interest is focused on deciphering the link between the gut microbiome, the immune system and the development of arthritic inflammation.
Availability
- Dr Anne-Sophie Bergot is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Pierre and Marie Curie University
Research interests
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Bugs in the gut and arthritis in SkG mice and in SpA patients
IL-23 dependent spondylitis, arthritis and ileitis recapitulate human spondyloarthropathy (SpA) in 1,3-beta-glucan (curdlan)-treated SKG mice. Human SpA patients and SKG mice have fecal dysbiosis, with increased gram-negative Bacteroidaceae and Porphyromonadaceae. In SKG mice, anti-IL-23 therapy supports homeostatic bacteria and gut integrity and is sufficient to prevent the development of arthritis. So I'm interested to know how pathobionts and commensals impact the development of SpA using the SKG mouse model. My current interest is also to confirm my findings in human patients with SpA who have simultaneous gut inflammation or not. Cool tools = germ-free mice, bacteria (anaerobic, aerobic) cultures, fluorescence in situ hybridization (FISH), confocal imaging, FACS analysis, genomic work Questions = -How do the bacteria get to the inflamed joint? -Is this a cause of inflammation or are they attracted there as a consequence of in situ inflammation? -Are gut bacteria cargo-ed from one site to another and which cell can do that? -Is this part of a defective clearance mechanism ? -Are bacteria or cargo-ed bacteria circulating through blood vessels? -How can this be prevented?
Works
Search Professor Anne-Sophie Bergot’s works on UQ eSpace
2024
Conference Publication
POS0303 CROSSING THE BARRIERS: DYSBIOSIS AND SUBCLINICAL UTERINE INFLAMMATION IN THE PATHOGENESIS OF AxSpA IN FEMALES. ANOTHER BREAK IN THE WALL?
Mauro, D., Vecellio, M., Schmid, E., Bergot, A. S., Forte, G., Stingo, A., Salzillo, A., Pastore, A., Aretini, P., Ciancio, A., Pantano, I., Saccone, G., Zullo, F., Montecucco, C., Rizzo, A., Schett, G., Thomas, R., Zaiss, M. M. and Ciccia, F. (2024). POS0303 CROSSING THE BARRIERS: DYSBIOSIS AND SUBCLINICAL UTERINE INFLAMMATION IN THE PATHOGENESIS OF AxSpA IN FEMALES. ANOTHER BREAK IN THE WALL?. BMJ Publishing Group Ltd and European League Against Rheumatism. doi: 10.1136/annrheumdis-2024-eular.4993
2024
Conference Publication
POS0313 INTESTINAL NEUROINFLAMMATION IN SPA IS CORRELATED WITH DYSBIOSIS
Forte, G., Mauro, D., Bergot, A. S., Cameron, A., Ciancio, A., Scalise, G., Salzillo, A., Pantano, I., Panarese, I., Vespere, G., De Luca, L., Desena, G., Napolitano, V., Franco, R., Provitera, V., Thomas, R. and Ciccia, F. (2024). POS0313 INTESTINAL NEUROINFLAMMATION IN SPA IS CORRELATED WITH DYSBIOSIS. BMJ Publishing Group Ltd and European League Against Rheumatism. doi: 10.1136/annrheumdis-2024-eular.5422
2023
Conference Publication
Goblet cell specific anti-apoptotic role of interleukin-24 in spondyloarthritis-associated ileitis
Cameron, A., Giri, R., Begun, J., Wells, T., Bergot, A. S. and Thomas, R. (2023). Goblet cell specific anti-apoptotic role of interleukin-24 in spondyloarthritis-associated ileitis. EULAR 2023 European Congress of Rheumatology, Milan, Italy, 31 May-3 June 2023. London, United Kingdom: BMJ Group. doi: 10.1136/annrheumdis-2023-eular.1346
2023
Conference Publication
The interplay of IL-23, probiotic and pathobiont bacteria in the pathogenesis of ileitis and spondyloarthritis in the SKG mouse model
Bergot, Anne-Sophie, Cai, Benjamin, Giri, Rabina, Cameron, Amy, Duggan, Emily, Lim, Kai, Rehaume, Linda, Morrison, Mark, Begun, Jakob and Thomas, Ranjeny (2023). The interplay of IL-23, probiotic and pathobiont bacteria in the pathogenesis of ileitis and spondyloarthritis in the SKG mouse model. 2023 Australian Rheumatology Association (ARA) 63rd Annual Scientific Meeting, Hobart, TAS, Australia, 6–9 May 2023. Hoboken, NJ, United States: Wiley.
2023
Journal Article
Genetically encoded Runx3 and CD4+ intestinal epithelial lymphocyte deficiencies link SKG mouse and human predisposition to spondyloarthropathy
Bhuyan, Zaied Ahmed, Rahman, M. Arifur, Maradana, Muralidhara Rao, Mehdi, Ahmed M., Bergot, Anne-Sophie, Simone, Davide, El-Kurdi, Marya, Garrido-Mesa, Jose, Cai, Cheng Bang Benjamin, Cameron, Amy J., Hanson, Aimee L., Nel, Hendrik J., Kenna, Tony, Leo, Paul, Rehaume, Linda, Brown, Matthew A., Ciccia, Francesco and Thomas, Ranjeny (2023). Genetically encoded Runx3 and CD4+ intestinal epithelial lymphocyte deficiencies link SKG mouse and human predisposition to spondyloarthropathy. Clinical Immunology, 247 109220, 1-14. doi: 10.1016/j.clim.2022.109220
2023
Journal Article
Islet‐specific CD8+ T cells gain effector function in the gut lymphoid tissues via bystander activation not molecular mimicry
Okada, Mirei, Zhang, Vivian, Loaiza Naranjo, Jeniffer D., Tillett, Bree J., Wong, F. Susan, Steptoe, Raymond J., Bergot, Anne‐Sophie and Hamilton‐Williams, Emma E (2023). Islet‐specific CD8+ T cells gain effector function in the gut lymphoid tissues via bystander activation not molecular mimicry. Immunology and Cell Biology, 101 (1), 36-48. doi: 10.1111/imcb.12593
2022
Journal Article
Secreted NF-κB suppressive microbial metabolites modulate gut inflammation
Giri, Rabina, Hoedt, Emily C., Khushi, Shamsunnahar, Salim, Angela A., Bergot, Anne-Sophie, Schreiber, Veronika, Thomas, Ranjeny, McGuckin, Michael A., Florin, Timothy H., Morrison, Mark, Capon, Robert J., Ó Cuív, Páraic and Begun, Jakob (2022). Secreted NF-κB suppressive microbial metabolites modulate gut inflammation. Cell Reports, 39 (2) 110646, 110646. doi: 10.1016/j.celrep.2022.110646
2022
Journal Article
Tolerance induction by liposomes targeting a single CD8 epitope IGRP in a model of type 1 diabetes is impeded by co-targeting a CD4 islet epitope
Buckle, Irina, Loaiza Naranjo, Jeniffer D., Bergot, Anne-Sophie, Zhang, Vivian, Talekar, Meghna, Steptoe, Raymond J., Thomas, Ranjeny and Hamilton-Williams, Emma E. (2022). Tolerance induction by liposomes targeting a single CD8 epitope IGRP in a model of type 1 diabetes is impeded by co-targeting a CD4 islet epitope. Immunology and Cell Biology, 100 (1), 33-48. doi: 10.1111/imcb.12506
2021
Journal Article
Inflammasome activation in ankylosing spondylitis is associated to gut dysbiosis
Guggino, Giuliana, Mauro, Daniele, Rizzo, Aroldo, Alessandro, Riccardo, Raimondo, Stefania, Bergot, Anne-Sophie, Rahman, M Arifur, Ellis, Jonathan J., Milling, Simon, Lories, Rik, Elewaut, Dirk, Brown, Matthew A., Thomas, Ranjeny and Ciccia, Francesco (2021). Inflammasome activation in ankylosing spondylitis is associated to gut dysbiosis. Arthritis and Rheumatology, 73 (7) art.41644, 1189-1199. doi: 10.1002/art.41644
2021
Journal Article
CD4+CD25+CD127hi cell frequency predicts disease progression in type 1 diabetes
Narsale, Aditi, Lam, Breanna, Moya, Rosa, Lu, TingTing, Mandelli, Alessandra, Gotuzzo, Irene, Pessina, Benedetta, Giamporcaro, Gianmaria, Geoffrey, Rhonda, Buchanan, Kerry, Harris, Mark, Bergot, Anne-Sophie, Thomas, Ranjeny, Hessner, Martin J., Battaglia, Manuela, Serti, Elisavet and Davies, Joanna D. (2021). CD4+CD25+CD127hi cell frequency predicts disease progression in type 1 diabetes. JCI Insight, 6 (2) e136114. doi: 10.1172/jci.insight.136114
2021
Journal Article
Proinsulin‐specific T‐cell responses correlate with estimated c‐peptide and predict partial remission duration in type 1 diabetes
Musthaffa, Yassmin, Hamilton‐Williams, Emma E, Nel, Hendrik J., Bergot, Anne‐Sophie, Mehdi, Ahmed M., Harris, Mark and Thomas, Ranjeny (2021). Proinsulin‐specific T‐cell responses correlate with estimated c‐peptide and predict partial remission duration in type 1 diabetes. Clinical & Translational Immunology, 10 (7) e1315, e1315. doi: 10.1002/cti2.1315
2020
Journal Article
A Question of Tolerance—Antigen-Specific Immunotherapy for Type 1 Diabetes
Loaiza Naranjo, Jeniffer D., Bergot, Anne-Sophie, Buckle, Irina and Hamilton-Williams, Emma E. (2020). A Question of Tolerance—Antigen-Specific Immunotherapy for Type 1 Diabetes. Current Diabetes Reports, 20 (12) 70, 70. doi: 10.1007/s11892-020-01363-3
2020
Conference Publication
Curdlan-induced Villous Permeability, Luminal Pathobiont Translocation to the Ileal Crypts, Ileitis and Arthritis Are Mitigated by Clostridia in Colonised Germ-free SKG Mice
Bergot, Anne-Sophie, Giri, Rabina, Cameron, Amy, Duggan, Emily, Loayza, Jeimy Jimenez, Morrison, Mark, Rehaume, Linda, Begun, Jakob and Thomas, Ranjeny (2020). Curdlan-induced Villous Permeability, Luminal Pathobiont Translocation to the Ileal Crypts, Ileitis and Arthritis Are Mitigated by Clostridia in Colonised Germ-free SKG Mice. Annual Meeting of the American-College-of-Rheumatology (ACR), Electr Network, Nov 05-09, 2020. HOBOKEN: WILEY.
2020
Journal Article
The microbiome and rheumatoid arthritis
Bergot, Anne-Sophie, Giri, Rabina and Thomas, Ranjeny (2020). The microbiome and rheumatoid arthritis. Best Practice and Research: Clinical Rheumatology, 33 (6) 101497, 101497. doi: 10.1016/j.berh.2020.101497
2020
Journal Article
Regulatory T cells induced by single-peptide liposome immunotherapy suppress islet-Specific T cell responses to multiple antigens and protect from autoimmune diabetes
Bergot, Anne-Sophie, Buckle, Irina, Cikaluru, Sumana, Naranjo, Jennifer Loaiza, Wright, Casey Maree, Zheng, Guoliang, Talekar, Meghna, Hamilton-Williams, Emma E. and Thomas, Ranjeny (2020). Regulatory T cells induced by single-peptide liposome immunotherapy suppress islet-Specific T cell responses to multiple antigens and protect from autoimmune diabetes. Journal of Immunology, 204 (7), ji1901128-1797. doi: 10.4049/jimmunol.1901128
2019
Conference Publication
CD4+CD25+CD127HI cells correlate with length of remission in type 1 diabetes: validated in a multi-site study
Narsale, A., Moya, R., Robertson, H., Payne, D., Lu, T. T., Geoffery, R., Buchanan, K., Harris, M., Bergot, A. S., Thomas, R., Hessner, M., Battaglia, M., Serti, E. and Davies, J. (2019). CD4+CD25+CD127HI cells correlate with length of remission in type 1 diabetes: validated in a multi-site study. International Conference on Lymphocyte Engineering (ICLE), London, United Kingdom, 13-15 September 2019. New Rochelle, NY United States: Mary Ann Liebert. doi: 10.1089/hum.2019.29091.abstracts
2018
Conference Publication
Antigen-Specific CD4 regulation by Liposomes encapsulating calcitriol and ChgA mimotope in NOD mice
Bergot, A. S., Buckle,, Wright, C., Talekar, M., Hamilton-Williams, E. and Thomas, R. (2018). Antigen-Specific CD4 regulation by Liposomes encapsulating calcitriol and ChgA mimotope in NOD mice. 15th International Symposium on Dendritic Cells (DC), Aachen, Germany, 10-14 June 2018. Hoboken, NJ, United States: Wiley. doi: 10.1002/eji.201871000
2017
Journal Article
Human papillomavirus E7 oncoprotein expression by keratinocytes alters the cytotoxic mechanisms used by CD8 T cells
Bhat, Purnima, Bergot, Anne-Sophie, Waterhouse, Nigel and Frazer, Ian Hector (2017). Human papillomavirus E7 oncoprotein expression by keratinocytes alters the cytotoxic mechanisms used by CD8 T cells. Oncotarget, 9 (5), 6015-6027. doi: 10.18632/oncotarget.23210
2017
Conference Publication
Antigen specific immunotherapy for autoimmune disease targeting dendritic cells
Bergot, Anne-Sophie, Talekar, Meghna, Nel, Hanno, Galea, Ryan, Harris, Mark, Hamilton-Williams, Emma and Thomas, Ranjeny (2017). Antigen specific immunotherapy for autoimmune disease targeting dendritic cells. 5th Annual Meeting of the International Cytokine and Interferon Society (ICIS), Kanazawa Japan, 29 October - 2 November 2017. London United Kingdom: Elsevier.
2016
Journal Article
Maintenance of peripheral tolerance to islet antigens
Hamilton-Williams, Emma E., Bergot, Anne-Sophie, Reeves, Peta L. S and Steptoe, Raymond J. (2016). Maintenance of peripheral tolerance to islet antigens. Journal of Autoimmunity, 72, 118-125. doi: 10.1016/j.jaut.2016.05.009
Funding
Past funding
Supervision
Availability
- Dr Anne-Sophie Bergot is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
The role of endoplasmic reticulum stress in spondyloarthropathy
Principal Advisor
Other advisors: Professor Ranjeny Thomas, Dr Timothy Wells
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Doctor Philosophy
The interplay of myeloid cells and autoreactive T lymphocytes activated by gut-derived bacteria in spondyloarthropathy
Associate Advisor
Other advisors: Professor Mark Morrison, Professor Ranjeny Thomas
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Doctor Philosophy
Restoration of regulatory T cell responses in type 1 diabetes
Associate Advisor
Other advisors: Dr Janin Chandra, Associate Professor Emma Hamilton-Williams
Completed supervision
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2023
Doctor Philosophy
Nanoparticle delivery systems for antigen-specific immunotherapy in type 1 diabetes
Associate Advisor
Other advisors: Professor Ranjeny Thomas, Associate Professor Emma Hamilton-Williams
Media
Enquiries
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