Overview
Background
After receiving a PhD on immune regulation from La Sorbonne Universitas in France, Anne-Sophie joined Prof. Ian Frazer’s lab in Australia where she led a highly successful and independent research program on the mechanisms of immune tolerance in human papillomavirus (HPV)-associated lesions in mice. She then joined the field of autoimmune diseases with Prof. Ranjeny Thomas. In Type 1 Diabetes, her pre-clinical data showed the feasibility of an antigen-specific liposome targeted immunotherapy in pre-diabetic mice and led to the first-in-human clinical trial using liposome nanoparticles. In Spondyloarthropathy, her interest is focused on deciphering the link between the gut microbiome, the immune system and the development of arthritic inflammation.
Availability
- Dr Anne-Sophie Bergot is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Pierre and Marie Curie University
Research interests
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Bugs in the gut and arthritis in SkG mice and in SpA patients
IL-23 dependent spondylitis, arthritis and ileitis recapitulate human spondyloarthropathy (SpA) in 1,3-beta-glucan (curdlan)-treated SKG mice. Human SpA patients and SKG mice have fecal dysbiosis, with increased gram-negative Bacteroidaceae and Porphyromonadaceae. In SKG mice, anti-IL-23 therapy supports homeostatic bacteria and gut integrity and is sufficient to prevent the development of arthritis. So I'm interested to know how pathobionts and commensals impact the development of SpA using the SKG mouse model. My current interest is also to confirm my findings in human patients with SpA who have simultaneous gut inflammation or not. Cool tools = germ-free mice, bacteria (anaerobic, aerobic) cultures, fluorescence in situ hybridization (FISH), confocal imaging, FACS analysis, genomic work Questions = -How do the bacteria get to the inflamed joint? -Is this a cause of inflammation or are they attracted there as a consequence of in situ inflammation? -Are gut bacteria cargo-ed from one site to another and which cell can do that? -Is this part of a defective clearance mechanism ? -Are bacteria or cargo-ed bacteria circulating through blood vessels? -How can this be prevented?
Works
Search Professor Anne-Sophie Bergot’s works on UQ eSpace
2019
Conference Publication
CD4+CD25+CD127HI cells correlate with length of remission in type 1 diabetes: validated in a multi-site study
Narsale, A., Moya, R., Robertson, H., Payne, D., Lu, T. T., Geoffery, R., Buchanan, K., Harris, M., Bergot, A. S., Thomas, R., Hessner, M., Battaglia, M., Serti, E. and Davies, J. (2019). CD4+CD25+CD127HI cells correlate with length of remission in type 1 diabetes: validated in a multi-site study. International Conference on Lymphocyte Engineering (ICLE), London, United Kingdom, 13-15 September 2019. New Rochelle, NY United States: Mary Ann Liebert. doi: 10.1089/hum.2019.29091.abstracts
2018
Conference Publication
Antigen-Specific CD4 regulation by Liposomes encapsulating calcitriol and ChgA mimotope in NOD mice
Bergot, A. S., Buckle,, Wright, C., Talekar, M., Hamilton-Williams, E. and Thomas, R. (2018). Antigen-Specific CD4 regulation by Liposomes encapsulating calcitriol and ChgA mimotope in NOD mice. 15th International Symposium on Dendritic Cells (DC), Aachen, Germany, 10-14 June 2018. Hoboken, NJ, United States: Wiley. doi: 10.1002/eji.201871000
2017
Journal Article
Human papillomavirus E7 oncoprotein expression by keratinocytes alters the cytotoxic mechanisms used by CD8 T cells
Bhat, Purnima, Bergot, Anne-Sophie, Waterhouse, Nigel and Frazer, Ian Hector (2017). Human papillomavirus E7 oncoprotein expression by keratinocytes alters the cytotoxic mechanisms used by CD8 T cells. Oncotarget, 9 (5), 6015-6027. doi: 10.18632/oncotarget.23210
2017
Conference Publication
Antigen specific immunotherapy for autoimmune disease targeting dendritic cells
Bergot, Anne-Sophie, Talekar, Meghna, Nel, Hanno, Galea, Ryan, Harris, Mark, Hamilton-Williams, Emma and Thomas, Ranjeny (2017). Antigen specific immunotherapy for autoimmune disease targeting dendritic cells. 5th Annual Meeting of the International Cytokine and Interferon Society (ICIS), Kanazawa Japan, 29 October - 2 November 2017. London United Kingdom: Elsevier.
2016
Journal Article
Maintenance of peripheral tolerance to islet antigens
Hamilton-Williams, Emma E., Bergot, Anne-Sophie, Reeves, Peta L. S and Steptoe, Raymond J. (2016). Maintenance of peripheral tolerance to islet antigens. Journal of Autoimmunity, 72, 118-125. doi: 10.1016/j.jaut.2016.05.009
2015
Journal Article
TLR3 drives IRF6-dependent IL-23p19 expression and p19/EBI3 heterodimer formation in keratinocytes
Ramnath, Divya, Tunny, Kathryn, Hohenhaus, Daniel M., Pitts, Claire M., Bergot, Anne-Sophie, Hogarth, P. Mark, Hamilton, John A., Kapetanovic, Ronan, Sturm, Richard A., Scholz, Glen M. and Sweet, Matthew J. (2015). TLR3 drives IRF6-dependent IL-23p19 expression and p19/EBI3 heterodimer formation in keratinocytes. Immunology and Cell Biology, 93 (9), 771-779. doi: 10.1038/icb.2015.77
2015
Journal Article
TCR sequences and tissue distribution discriminate the subsets of naïve and activated/memory Treg cells in mice
Bergot, Anne-Sophie, Chaara, Wahiba, Ruggiero, Eliana, Mariotti-Ferrandiz, Encarnita, Dulauroy, Sophie, Schmidt, Manfred, von Kalle, Christof, Six, Adrien and Klatzmann, David (2015). TCR sequences and tissue distribution discriminate the subsets of naïve and activated/memory Treg cells in mice. European Journal of Immunology, 45 (5), 1524-1534. doi: 10.1002/eji.201445269
2015
Journal Article
Recent progress in vaccination against human papillomavirus-mediated cervical cancer
McKee, Sara J., Bergot, Anne-Sophie and Leggatt, Graham R. (2015). Recent progress in vaccination against human papillomavirus-mediated cervical cancer. Reviews in Medical Virology, 25 (S1), 54-71. doi: 10.1002/rmv.1824
2015
Journal Article
HPV16 E7 expression in skin induces TSLP secretion, type 2 ILC infiltration and atopic dermatitis-like lesions
Bergot, Anne-Sophie, Monnet, Nastasia, Tran, Son Le, Mittal, Deepak, Al-Kouba, Jane, Steptoe, Raymond J., Grimbaldeston, Michele A., Frazer, Ian H. and Wells, James W. (2015). HPV16 E7 expression in skin induces TSLP secretion, type 2 ILC infiltration and atopic dermatitis-like lesions. Immunology and Cell Biology, 93 (6), 540-547. doi: 10.1038/icb.2014.123
2014
Journal Article
HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2- and CCL5- mediated recruitment of mast cells
Bergot, Anne-Sophie, Ford, Neill, Leggatt, Graham R., Wells, James W., Frazer, Ian H. and Grimbaldeston, Michele A. (2014). HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2- and CCL5- mediated recruitment of mast cells. PLoS Pathogens, 10 (10) e1004466, 1-11. doi: 10.1371/journal.ppat.1004466
2014
Journal Article
Human papillomavirus E7 oncoprotein transgenic skin develops an enhanced inflammatory response to 2,4-dinitrochlorobenzene by an arginase-1-dependent mechanism
Tran, Le Son, Bergot, Anne-Sophie, Mattarollo, Stephen R., Mittal, Deepak and Frazer, Ian H. (2014). Human papillomavirus E7 oncoprotein transgenic skin develops an enhanced inflammatory response to 2,4-dinitrochlorobenzene by an arginase-1-dependent mechanism. Journal of Investigative Dermatology, 134 (9), 2438-2446. doi: 10.1038/jid.2014.186
2013
Journal Article
Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7
Mittal, Deepak, Kassianos, Andrew. J, Tran, Lee S., Bergot, Anne-Sophie, Gosmann, Christina, Hofmann, Janin, Blumenthal, Antje, Leggatt, Graham R. and Frazer, Ian H. (2013). Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7. Journal of Investigative Dermatology, 133 (12), 2686-2694. doi: 10.1038/jid.2013.222
2013
Journal Article
Self-specific memory regulatory T cells protect embryos at implantation in mice
Chen, Ting, Darrasse-Jeze, Guillaume, Bergot, Anne-Sophie, Courau, Tristan, Churlaud, Guillaume, Valdivia, Karina, Strominger, Jack L., Ruocco, Maria Grazia, Chaouat, Gerard and Klatzmann, David (2013). Self-specific memory regulatory T cells protect embryos at implantation in mice. The Journal of Immunology, 191 (5), 2273-2281. doi: 10.4049/jimmunol.1202413
2012
Journal Article
Intrathymic injection of lentiviral vector curtails the immune response in the periphery of normal mice
Gottrand, Gaëlle, Taleb. Kahina, Ragon, Isabelle, Bergot, Anne-Sophie, Goldstein, Jeremie D. and Marodon, Gilles (2012). Intrathymic injection of lentiviral vector curtails the immune response in the periphery of normal mice. Journal of Gene Medicine, 14 (2), 90-99. doi: 10.1002/jgm.1650
2012
Conference Publication
Expression of HPV16-E7 oncoprotein in skin exacerbates the contact hypersensitivity response to DNCB
Bergot, A. S., Le Tran, S., Mittal, D., Grimbaldeston, M. A. and Frazer, I. H. (2012). Expression of HPV16-E7 oncoprotein in skin exacerbates the contact hypersensitivity response to DNCB. European Congress of Immunology, Glasgow Scotland, 5-8 September 2012. West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/imm.12002
2011
Journal Article
New approaches to immunotherapy for HPV associated cancer
Bergot, Anne-Sophie, Kassianos, Andrew, Frazer, Ian H. and Mittal, Deepak (2011). New approaches to immunotherapy for HPV associated cancer. Cancers, 3 (3), 3461-3495. doi: 10.3390/cancers3033461
2010
Journal Article
Antigen quality determines the efficiency of antitumor immune responses generated in the absence of regulatory T cells
Bergot, A-S., Durgeau, A., Levacher, B., Colombo, B. M., Cohen, J. L. and Klatzmann, D. (2010). Antigen quality determines the efficiency of antitumor immune responses generated in the absence of regulatory T cells. Cancer Gene Therapy, 17 (9), 645-654. doi: 10.1038/cgt.2010.21
2009
Journal Article
Adoptive Transfer of T Lymphocytes Sensitized against the Prion Protein Attenuates Prion Invasion in Scrapie-Infected Mice
Gourdain, Pauline, Gregoire, Sylvie, Iken, Saci, Bachy, Veronique, Dorban, Gauthier, Chaigneau, Thomas, Debiec, Hanna, Bergot, Anne-Sophie, Renault, Isabelle, Aucouturier, Pierre and Carnaud, Claude (2009). Adoptive Transfer of T Lymphocytes Sensitized against the Prion Protein Attenuates Prion Invasion in Scrapie-Infected Mice. Journal of Immunology, 183 (10), 6619-6628. doi: 10.4049/jimmunol.0804385
2009
Journal Article
Tumor emergence is sensed by self-specific CD44(hi) memory Tregs that create a dominant tolerogenic environment for tumors in mice
Darrasse-Jeze, Guillaume, Bergot, Anne-Sophie, Durgeau, Aurelie, Billiard, Fabienne, Salomon, Benoit L., Cohen, Jose L., Bellier, Bertrand, Podsypanina, Katrina and Klatzmann, David (2009). Tumor emergence is sensed by self-specific CD44(hi) memory Tregs that create a dominant tolerogenic environment for tumors in mice. Journal of Clinical Investigation, 119 (9), 2648-2662. doi: 10.1172/JCI36628
2009
Conference Publication
Regulatory T cells and cancer immunotherapy: Revision of the immunosurveillance of cancer paradigm and therapeutic consequences
Klatzmann, David, Maury, Sebastien, Darrasse-Jeze, Guillame, Bergot, Anne-Sophie, Podsypanina, Katrina, Lemoine, Francois and Cohen, Jose L. (2009). Regulatory T cells and cancer immunotherapy: Revision of the immunosurveillance of cancer paradigm and therapeutic consequences. Combined Meeting of the 17th European-Society-of-Gene-and-Cell-Therapy/16th German-Society-for-Gene-Therapy/4th German-Society-for-Stem-Cell-Research, Hannover Germany, Nov 21-25, 2009. MARY ANN LIEBERT INC.
Funding
Past funding
Supervision
Availability
- Dr Anne-Sophie Bergot is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Restoration of regulatory T cell responses in type 1 diabetes
Associate Advisor
Other advisors: Dr Janin Chandra, Professor Emma Hamilton-Williams
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Doctor Philosophy
The interplay of myeloid cells and autoreactive T lymphocytes activated by gut-derived bacteria in spondyloarthropathy
Associate Advisor
Other advisors: Professor Mark Morrison, Professor Ranjeny Thomas
Completed supervision
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2025
Doctor Philosophy
The Role of Endoplasmic Reticulum Stress in Autoimmune Inflammatory Arthritis
Principal Advisor
Other advisors: Professor Ranjeny Thomas, Associate Professor Timothy Wells
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2023
Doctor Philosophy
Nanoparticle delivery systems for antigen-specific immunotherapy in type 1 diabetes
Associate Advisor
Other advisors: Professor Ranjeny Thomas, Professor Emma Hamilton-Williams
Media
Enquiries
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