Dr Anne-Sophie Bergot
Dr

Anne-Sophie Bergot

Email: 
Phone: 
+61 7 344 34316

Background

After receiving a PhD on immune regulation from La Sorbonne Universitas in France, Anne-Sophie joined Prof. Ian Frazer’s lab in Australia where she led a highly successful and independent research program on the mechanisms of immune tolerance in human papillomavirus (HPV)-associated lesions in mice. She then joined the field of autoimmune diseases with Prof. Ranjeny Thomas. In Type 1 Diabetes, her pre-clinical data showed the feasibility of an antigen-specific liposome targeted immunotherapy in pre-diabetic mice and led to the first-in-human clinical trial using liposome nanoparticles. In Spondyloarthropathy, her interest is focused on deciphering the link between the gut microbiome, the immune system and the development of arthritic inflammation.

Availability

Dr Anne-Sophie Bergot is:
Available for supervision

Fields of research

Immunology Oncology and carcinogenesis

Qualifications

  • Doctor of Philosophy, Pierre and Marie Curie University

Research interests

  • Bugs in the gut and arthritis in SkG mice and in SpA patients

    IL-23 dependent spondylitis, arthritis and ileitis recapitulate human spondyloarthropathy (SpA) in 1,3-beta-glucan (curdlan)-treated SKG mice. Human SpA patients and SKG mice have fecal dysbiosis, with increased gram-negative Bacteroidaceae and Porphyromonadaceae. In SKG mice, anti-IL-23 therapy supports homeostatic bacteria and gut integrity and is sufficient to prevent the development of arthritis. So I'm interested to know how pathobionts and commensals impact the development of SpA using the SKG mouse model. My current interest is also to confirm my findings in human patients with SpA who have simultaneous gut inflammation or not. Cool tools = germ-free mice, bacteria (anaerobic, aerobic) cultures, fluorescence in situ hybridization (FISH), confocal imaging, FACS analysis, genomic work Questions = -How do the bacteria get to the inflamed joint? -Is this a cause of inflammation or are they attracted there as a consequence of in situ inflammation? -Are gut bacteria cargo-ed from one site to another and which cell can do that? -Is this part of a defective clearance mechanism ? -Are bacteria or cargo-ed bacteria circulating through blood vessels? -How can this be prevented?

Search Professor Anne-Sophie Bergot’s works on UQ eSpace

43 works between 2005 and 2024
All (43) Journal Article (28) Conference Publication (15)

41 - 43 of 43 works

2008

Journal Article

Contribution of antibody and T cell-specific responses to the progression of 139A-scrapie in C57BL/6 mice immunized with prion protein peptides

Sacquin, Antoine, Bergot, Anne Sophie, Aucouturier, Pierre and Bruley-Rosset, Martine (2008). Contribution of antibody and T cell-specific responses to the progression of 139A-scrapie in C57BL/6 mice immunized with prion protein peptides. Journal of Immunology, 181 (1), 768-775. doi: 10.4049/jimmunol.181.1.768

Contribution of antibody and T cell-specific responses to the progression of 139A-scrapie in C57BL/6 mice immunized with prion protein peptides

2007

Journal Article

Regulatory T cells prevent CD8 T cell maturation by inhibiting CD4 th cells at tumor sites

Chaput, Nathalie, Darrasse-Jeze, Guillaume, Bergot, Anne-Sophie, Cordier, Corinne, Ngo-Abdalla, Stacie, Klatzmann, David and Azogui, Orly (2007). Regulatory T cells prevent CD8 T cell maturation by inhibiting CD4 th cells at tumor sites. Journal of Immunology, 179 (8), 4969-4978. doi: 10.4049/jimmunol.179.8.4969

Regulatory T cells prevent CD8 T cell maturation by inhibiting CD4 th cells at tumor sites

2005

Journal Article

The murine B cell repertoire is severely selected against endogenous cellular prion protein

Gregoire, S, Bergot, AS, Feraudet, C, Carnaud, C, Aucouturier, P and Rosset, MB (2005). The murine B cell repertoire is severely selected against endogenous cellular prion protein. Journal of Immunology, 175 (10), 6443-6449. doi: 10.4049/jimmunol.175.10.6443

The murine B cell repertoire is severely selected against endogenous cellular prion protein

Past funding

  • 2022
    Linking the presence of live Ileal-derived bacteria in the joint as a triggering factor for the development of Spondyloarthropathy.
    Arthritis Foundation of Australia
    Open grant
  • 2017 - 2018
    Dr Anne-Sophie Bergot - Maternity Funding (Advance Queensland Women's Academic Fund).
    Queensland Government Advance Queensland Women's Academic Fund
    Open grant
  • 2012 - 2013
    ResTeach Funding 2012 0.1 FTE School of Chemistry and Molecular Biosciences
    UQ ResTeach
    Open grant
  • 2011 - 2013
    Skin immune sentinels: roles and functions of immunoregulatory T cells in HPV16 skin infection in mice
    UQ Postdoctoral Research Fellowship
    Open grant

Availability

Dr Anne-Sophie Bergot is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

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