Overview
Background
Dominic Guanzon is a research fellow at the University of Queensland within the Salomon Lab, and supported by the Lions Medical Research Foundation. His expertise lies in the fascinating realm of extracellular vesicles where he is the genomics leader. Dominic’s research involves developing nucleic acid blood tests to diagnose disease. His primary research focus is on predicting chemotherapy response in women diagnosed with ovarian cancer, specifically distinguishing between individuals who respond positively to chemotherapy and those resistant to it (chemoresistance).
Availability
- Dr Dominic Guanzon is:
- Available for supervision
Works
Search Professor Dominic Guanzon’s works on UQ eSpace
2023
Conference Publication
Effect of aspirin on the circulating extracellular vesicle proteomic profile in women at risk for preeclampsia
D'Crus, Angel Nilesh, Jellins, Jessica, Lai, Andrew, Guanzon, Dominic, Carrion, Flavio, Nair, Soumyalekshmi, Hyett, Jon and Salomon, Carlos (2023). Effect of aspirin on the circulating extracellular vesicle proteomic profile in women at risk for preeclampsia. 70th Annual Meeting of the Society for Reproductive Investigation (SRI), Brisbane, QLD, Australia, 21-25 March 2023. Heidelberg, Germany: Springer.
2023
Conference Publication
Unique tissue specific miRNA motifs in placenta and adipose tissue regulate changes in insulin sensitivity in healthy pregnancy and gestational diabetes
Nair, Soumyalekshmi S., Guanzon, Dominic, Jayabalan, Nanthini, Lai, Andrew, Scholz-Romero, Katherin, Carrion, Flavio, Lappas, Martha and Salomon, Carlos (2023). Unique tissue specific miRNA motifs in placenta and adipose tissue regulate changes in insulin sensitivity in healthy pregnancy and gestational diabetes. 70th Annual Meeting of the Society for Reproductive Investigation (SRI), Brisbane, QLD, Australia, 21-25 March 2023. Heidelberg, Germany: Springer.
2021
Journal Article
Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus
Nair, Soumyalekshmi, Guanzon, Dominic, Jayabalan, Nanthini, Lai, Andrew, Scholz-Romero, Katherin, Kalita de Croft, Priyakshi, Ormazabal, Valeska, Palma, Carlos, Diaz, Emilio, McCarthy, Elizabeth A., Shub, Alexis, Miranda, Jezid, Gratacós, Eduard, Crispi, Fátima, Duncombe, Gregory, Lappas, Martha, McIntyre, H. David, Rice, Gregory and Salomon, Carlos (2021). Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus. Journal of Translational Medicine, 19 (1) 360, 1-17. doi: 10.1186/s12967-021-02999-9
2021
Journal Article
Partial Epithelial‐Mesenchymal Transition: Reduced miR‐4792 and miR‐146b‐5p Inversely Correlated with SIAH2 in Migrating Keratinocytes <i>in Vitro</i>
Wager, Lucas J., Guanzon, Dominic, Leavesley, David I., Thompson, Erik W. and Murray, Rachael Z. (2021). Partial Epithelial‐Mesenchymal Transition: Reduced miR‐4792 and miR‐146b‐5p Inversely Correlated with SIAH2 in Migrating Keratinocytes in Vitro. Experimental Dermatology, 30 (12), 1838-1839. doi: 10.1111/exd.14426
2021
Journal Article
Extracellular vesicle transmission of chemoresistance to ovarian cancer cells is associated with hypoxia-induced expression of glycolytic pathway proteins, and prediction of epithelial ovarian cancer disease recurrence
Alharbi, Mona, Lai, Andrew, Sharma, Shayna, Kalita-De Croft, Priyakshi, Godbole, Nihar, Campos, America, Guanzon, Dominic, Salas-Burgos, Alexis, Carrion, Flavio, Zuñiga, Felipe A., Perrin, Lewis, He, Yaowu, Pejovic, Tanja, Winters, Carmen, Morgan, Terry, Hooper, John D., Rice, Gregory E. and Salomon, Carlos (2021). Extracellular vesicle transmission of chemoresistance to ovarian cancer cells is associated with hypoxia-induced expression of glycolytic pathway proteins, and prediction of epithelial ovarian cancer disease recurrence. Cancers, 13 (14) 3388, 1-26. doi: 10.3390/cancers13143388
2020
Journal Article
miRNa signature in small extracellular vesicles and their association with platinum resistance and cancer recurrence in ovarian cancer
Alharbi, Mona, Sharma, Shayna, Guanzon, Dominic, Lai, Andrew, Zuñiga, Felipe, Shiddiky, Muhammad J.A., Yamauchi, Yusuke, Salas-Burgos, Alexis, He, Yaowu, Pejovic, Tanja, Winters, Carmen, Morgan, Terry, Perrin, Lewis, Hooper, John D. and Salomon, Carlos (2020). miRNa signature in small extracellular vesicles and their association with platinum resistance and cancer recurrence in ovarian cancer. Nanomedicine: Nanotechnology, Biology, and Medicine, 28 102207, 102207. doi: 10.1016/j.nano.2020.102207
2020
Conference Publication
Adipose Tissue-Derived Exosomal MicroRNA Regulates Placental Glucose Uptake in Gestational Diabetes Mellitus Pregnancies
Jayabalan, Nanthini, Scholz-Romero, Katherin, Guanzon, Dominic, Lai, Andrew, McIntyre, David, Lappas, Martha and Salomon, Carlos (2020). Adipose Tissue-Derived Exosomal MicroRNA Regulates Placental Glucose Uptake in Gestational Diabetes Mellitus Pregnancies. 80th Scientific Sessions of the American-Diabetes-Association (ADA), Online, 12-16 June 2020. Alexandria, VA United States: American Diabetes Association. doi: 10.2337/db20-1972-P
2020
Conference Publication
Gestational Diabetes-Associated Changes in the Circulating Exosomes in Fetal Circulation Revealed a Potential Role of These Nanovesicles in Fetal Growth and Metabolism
Ormazabal, Valeska, Scholz-Romero, Katherin, Nair, Soumyalekshmi, Guanzon, Dominic, Zuniga, Felipe, McIntyre, David, Lappas, Martha and Salomon, Carlos (2020). Gestational Diabetes-Associated Changes in the Circulating Exosomes in Fetal Circulation Revealed a Potential Role of These Nanovesicles in Fetal Growth and Metabolism. 80th Scientific Sessions of the American Diabetes Association (ADA), Online, 12-16 June 2020. Alexandria, VA United States: American Diabetes Association. doi: 10.2337/db20-1375-P
2020
Journal Article
Protein profile changes in circulating placental extracellular vesicles in term and preterm births: a longitudinal study
Menon, Ramkumar, Debnath, Chirantan, Lai, Andrew, Guanzon, Dominic, Bhatnagar, Shinjini, Kshetrapal, Pallavi, Sheller-Miller, Samantha, Salomon, Carlos and The Garbh-Ini Study team (2020). Protein profile changes in circulating placental extracellular vesicles in term and preterm births: a longitudinal study. Endocrinology, 161 (4) bqaa009. doi: 10.1210/endocr/bqaa009
2020
Journal Article
Regulation of glucose homeostasis by small extracellular vesicles in normal pregnancy and in gestational diabetes
James-Allan, Laura B., Rosario, Frederick J., Barner, Kelsey, Lai, Andrew, Guanzon, Dominic, McIntyre, H. David, Lappas, Martha, Powell, Theresa L., Salomon, Carlos and Jansson, Thomas (2020). Regulation of glucose homeostasis by small extracellular vesicles in normal pregnancy and in gestational diabetes. FASEB Journal, 34 (4) fj.201902522RR, 5724-5739. doi: 10.1096/fj.201902522RR
2019
Journal Article
Downregulation of exosomal miR-192-5p and miR-204-5p in subjects with nonclassic apparent mineralocorticoid excess
Tapia-Castillo, Alejandra, Guanzon, Dominic, Palma, Carlos, Lai, Andrew, Barros, Eric, Allende, Fidel, Vecchiola, Andrea, Fardella, Carlos E., Salomón, Carlos and Carvajal, Cristian A. (2019). Downregulation of exosomal miR-192-5p and miR-204-5p in subjects with nonclassic apparent mineralocorticoid excess. Journal of Translational Medicine, 17 (1) 392, 392. doi: 10.1186/s12967-019-02143-8
2019
Journal Article
DNA Methylation Cancer Biomarkers: Translation to the Clinic
Locke, Warwick J., Guanzon, Dominic, Ma, Chenkai, Liew, Yi Jin, Duesing, Konsta R., Fung, Kim Y.C. and Ross, Jason P. (2019). DNA Methylation Cancer Biomarkers: Translation to the Clinic. Frontiers in Genetics, 10 1150, 1-22. doi: 10.3389/fgene.2019.01150
2019
Journal Article
Ovarian cancer-derived exosomes promote tumor metastasis in vivo an effect modulated by the invasiveness capacity of their originating cells
Alharbi, Mona, Lai, Andrew, Guanzon, Dominic, Palma, Carlos, Zuñiga, Felipe, Perrin, Lewis, He, Yaowu, Hooper, John D and Salomon, Carlos (2019). Ovarian cancer-derived exosomes promote tumor metastasis in vivo an effect modulated by the invasiveness capacity of their originating cells. Clinical Science, 133 (13), CS20190082-1419. doi: 10.1042/cs20190082
2019
Conference Publication
Exosome profiles for normal and complicated pregnancies - a longitudinal study
Nakahara, Angela, Elfeky, Omar, Garvey, Cathryn, Guanzon, Dominic, Longo, Sherri Anne and Salmon, Carlos (2019). Exosome profiles for normal and complicated pregnancies - a longitudinal study. Annual Clinical and Scientific Meeting of the American College of Obstetricians and Gynecologists, Nashville, TN United States, 3-6 May 2019. Philadelphia, PA United States: Lippincott Williams and Wilkins. doi: 10.1097/01.AOG.0000558864.31601.AA
2019
Journal Article
Quantitative proteomics by SWATH-MS of maternal plasma exosomes determine pathways associated with term and preterm birth
Menon, Ramkumar, Dixon, Christopher Luke, Sheller-Miller, Samantha, Fortunato, Stephen J., Saade, George R., Palma, Carlos, Lai, Andrew, Guanzon, Dominic and Salomon, Carlos (2019). Quantitative proteomics by SWATH-MS of maternal plasma exosomes determine pathways associated with term and preterm birth. Endocrinology, 160 (3), 639-650. doi: 10.1210/en.2018-00820
2019
Conference Publication
Exosome profiles for normal and complicated pregnancies - a longitudinal study
Nakahara, A., Elfeky, O., Garvey, C., Guanzon, D., Longo, S. and Salomon, C. (2019). Exosome profiles for normal and complicated pregnancies - a longitudinal study. AFMR/SAFMR/SSCI/SSPR Southern Regional Meetings, New Orleans, LA, United States, 21-23 February 2019. London, United Kingdom: BMJ Group. doi: 10.1136/jim-2018-000974.651
2019
Conference Publication
Circulating exosomal miRNAs from women with ovarian cancer for early detection and real-time monitoring of disease progression
Sharma, Shayna, Lai, Andrew, Guanzon, Dominic, Morgan, Terry, Perrin, Lewis C., Hooper, John D. and Salomon, Carlos (2019). Circulating exosomal miRNAs from women with ovarian cancer for early detection and real-time monitoring of disease progression. 66th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Paris, France, 12-16 March 2019. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719119834079
2019
Conference Publication
Exosomal MiRNA profile in exosomes isolated from adipose tissue explants from normal and gestational diabetes mellitus pregnancies
Jayabalan, Nanthini, Guanzon, Dominic, McIntyre, David, Lappas, Martha and Salomon, Carlos (2019). Exosomal MiRNA profile in exosomes isolated from adipose tissue explants from normal and gestational diabetes mellitus pregnancies. 66th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI) , Paris, France, 12-16 March 2019. Thousand Oaks, CA, United States: Sage.
2019
Journal Article
Quantitative proteomics by SWATH-MS suggest an association between circulating exosomes and maternal metabolic changes in gestational diabetes mellitus
Jayabalan, Nanthini, Lai, Andrew, Nair, Soumyalekshmi, Guanzon, Dominic, Scholz-Romero, Katherin, Palma, Carlos, McIntyre, Harold David, Lappas, Martha and Salomon, Carlos (2019). Quantitative proteomics by SWATH-MS suggest an association between circulating exosomes and maternal metabolic changes in gestational diabetes mellitus. Proteomics, 19 (1-2) 1800164, e1800164. doi: 10.1002/pmic.201800164
2019
Conference Publication
Exosomal protein and miRNA analysis in cervico-vaginal fluid at early gestation from term and preterm pregnancies
Tribe, Rachel M., Jenkins, Holly, Palma, Carlos, Lai, Andrew, Guanzon, Dominic, Hezelgrave, Natasha L., Shennan, Andrew H. and Salomon, Carlos (2019). Exosomal protein and miRNA analysis in cervico-vaginal fluid at early gestation from term and preterm pregnancies. 66th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Paris, France, 12 - 16 March 2019. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719119834079
Funding
Current funding
Supervision
Availability
- Dr Dominic Guanzon is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Epigenetic Drivers and EV-derived signatures for early detection/prediction of Chemoresistance in Ovarian Cancer
Associate Advisor
Other advisors: Professor Carlos Salomon Gallo
-
Doctor Philosophy
Investigating the role of Extracellular Vesicles in chemoresistance to ovarian cancer
Associate Advisor
Other advisors: Honorary Professor John Hooper, Professor Andrew Martin, Professor Carlos Salomon Gallo
Completed supervision
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2026
Doctor Philosophy
Gestational dynamics of extracellular vesicle - associated proteins with low-dose aspirin in pregnancies at high vs low risk of preeclampsia.
Associate Advisor
Other advisors: Dr Andrew Lai, Professor Sailesh Kumar, Professor Carlos Salomon Gallo
-
2026
Doctor Philosophy
Characterization of extracellular vesicle (EV)-associated lipids in the diagnosis of ovarian cancer
Associate Advisor
Other advisors: Honorary Professor John Hooper, Dr Andrew Lai, Professor Carlos Salomon Gallo
Media
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