Overview
Background
Dominic Guanzon is a research fellow at the University of Queensland within the Salomon Lab, and supported by the Lions Medical Research Foundation. His expertise lies in the fascinating realm of extracellular vesicles where he is the genomics leader. Dominic’s research involves developing nucleic acid blood tests to diagnose disease. His primary research focus is on predicting chemotherapy response in women diagnosed with ovarian cancer, specifically distinguishing between individuals who respond positively to chemotherapy and those resistant to it (chemoresistance).
Availability
- Dr Dominic Guanzon is:
- Available for supervision
Works
Search Professor Dominic Guanzon’s works on UQ eSpace
2024
Journal Article
Comparing methylation levels assayed in GC-rich regions with current and emerging methods
Guanzon, Dominic, Ross, Jason P, Ma, Chenkai, Berry, Oliver and Liew, Yi Jin (2024). Comparing methylation levels assayed in GC-rich regions with current and emerging methods. BMC Genomics, 25 (1) 741. doi: 10.1186/s12864-024-10605-7
2024
Journal Article
Enhancing precision targeting of ovarian cancer tumor cells in vivo through extracellular vesicle engineering
Alharbi, Mona, Lai, Andrew, Godbole, Nihar, Guanzon, Dominic, Nair, Soumyalekshmi, Zuñiga, Felipe, Quinn, Alexander, Yang, Mengliu, Wu, Sherry Y. and Salomon, Carlos (2024). Enhancing precision targeting of ovarian cancer tumor cells in vivo through extracellular vesicle engineering. International Journal of Cancer, 155 (8), 1510-1523. doi: 10.1002/ijc.35055
2024
Journal Article
High throughput Surface Epitope Immunoaffinity Isolation of Extracellular Vesicles and Downstream Analysis
Khanabdali, Ramin, Mandrekar, Michelle, Grygiel, Rick, Vo, Phuoc-an, Palma, Carlos, Nikseresht, Sara, Barton, Siena, Shojaee, Mozhgan, Bhuiyan, Sadman, Asari, Kartini, Belzer, Susan, Ansari, Khairul, Coward, Jermaine I, Perrin, Lewis, Hooper, John, Guanzon, Dominic, Lai, Andrew, Salomon, Carlos, Kershner, Kevin, Newton, Christine, Horejsh, Douglas and Rice, Gregory (2024). High throughput Surface Epitope Immunoaffinity Isolation of Extracellular Vesicles and Downstream Analysis. Biology Methods and Protocols, 9 (1) ARTN bpae032, bpae032. doi: 10.1093/biomethods/bpae032
2024
Conference Publication
Changes in extracellular vesicle miRNAs from three-dimensional ovarian cancer cell models reflect physiological changes and cancer survival
Godbole, Nihar, Ravichandran, Akhilandeshwari, Guanzon, Dominic, Lai, Andrew, Carrion, Flavio, de Croft, Priyakshi Kalita, Perrin, Lewis, Hooper, John, Bray, Laura and Salomon, Carlos (2024). Changes in extracellular vesicle miRNAs from three-dimensional ovarian cancer cell models reflect physiological changes and cancer survival. American Association for Cancer Research Annual Meeting 2024, San Diego, CA United States, 5-10 April 2024. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2024-3386
2023
Other Outputs
INOVIQ manuscript
Guanzon, Dominic (2023). INOVIQ manuscript. The University of Queensland. (Dataset) doi: 10.48610/c517a74
2023
Conference Publication
Effect of aspirin on the circulating extracellular vesicle proteomic profile in women at risk for preeclampsia
D'Crus, Angel Nilesh, Jellins, Jessica, Lai, Andrew, Guanzon, Dominic, Carrion, Flavio, Nair, Soumyalekshmi, Hyett, Jon and Salomon, Carlos (2023). Effect of aspirin on the circulating extracellular vesicle proteomic profile in women at risk for preeclampsia. 70th Annual Meeting of the Society for Reproductive Investigation (SRI), Brisbane, QLD, Australia, 21-25 March 2023. Heidelberg, Germany: Springer.
2023
Conference Publication
Unique tissue specific miRNA motifs in placenta and adipose tissue regulate changes in insulin sensitivity in healthy pregnancy and gestational diabetes
Nair, Soumyalekshmi S., Guanzon, Dominic, Jayabalan, Nanthini, Lai, Andrew, Scholz-Romero, Katherin, Carrion, Flavio, Lappas, Martha and Salomon, Carlos (2023). Unique tissue specific miRNA motifs in placenta and adipose tissue regulate changes in insulin sensitivity in healthy pregnancy and gestational diabetes. 70th Annual Meeting of the Society for Reproductive Investigation (SRI), Brisbane, QLD, Australia, 21-25 March 2023. Heidelberg, Germany: Springer.
2021
Journal Article
Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus
Nair, Soumyalekshmi, Guanzon, Dominic, Jayabalan, Nanthini, Lai, Andrew, Scholz-Romero, Katherin, Kalita de Croft, Priyakshi, Ormazabal, Valeska, Palma, Carlos, Diaz, Emilio, McCarthy, Elizabeth A., Shub, Alexis, Miranda, Jezid, Gratacós, Eduard, Crispi, Fátima, Duncombe, Gregory, Lappas, Martha, McIntyre, H. David, Rice, Gregory and Salomon, Carlos (2021). Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus. Journal of Translational Medicine, 19 (1) 360, 1-17. doi: 10.1186/s12967-021-02999-9
2021
Journal Article
Partial Epithelial‐Mesenchymal Transition: Reduced miR‐4792 and miR‐146b‐5p Inversely Correlated with SIAH2 in Migrating Keratinocytes <i>in Vitro</i>
Wager, Lucas J., Guanzon, Dominic, Leavesley, David I., Thompson, Erik W. and Murray, Rachael Z. (2021). Partial Epithelial‐Mesenchymal Transition: Reduced miR‐4792 and miR‐146b‐5p Inversely Correlated with SIAH2 in Migrating Keratinocytes in Vitro. Experimental Dermatology, 30 (12), 1838-1839. doi: 10.1111/exd.14426
2021
Journal Article
Extracellular vesicle transmission of chemoresistance to ovarian cancer cells is associated with hypoxia-induced expression of glycolytic pathway proteins, and prediction of epithelial ovarian cancer disease recurrence
Alharbi, Mona, Lai, Andrew, Sharma, Shayna, Kalita-De Croft, Priyakshi, Godbole, Nihar, Campos, America, Guanzon, Dominic, Salas-Burgos, Alexis, Carrion, Flavio, Zuñiga, Felipe A., Perrin, Lewis, He, Yaowu, Pejovic, Tanja, Winters, Carmen, Morgan, Terry, Hooper, John D., Rice, Gregory E. and Salomon, Carlos (2021). Extracellular vesicle transmission of chemoresistance to ovarian cancer cells is associated with hypoxia-induced expression of glycolytic pathway proteins, and prediction of epithelial ovarian cancer disease recurrence. Cancers, 13 (14) 3388, 1-26. doi: 10.3390/cancers13143388
2020
Journal Article
miRNa signature in small extracellular vesicles and their association with platinum resistance and cancer recurrence in ovarian cancer
Alharbi, Mona, Sharma, Shayna, Guanzon, Dominic, Lai, Andrew, Zuñiga, Felipe, Shiddiky, Muhammad J.A., Yamauchi, Yusuke, Salas-Burgos, Alexis, He, Yaowu, Pejovic, Tanja, Winters, Carmen, Morgan, Terry, Perrin, Lewis, Hooper, John D. and Salomon, Carlos (2020). miRNa signature in small extracellular vesicles and their association with platinum resistance and cancer recurrence in ovarian cancer. Nanomedicine: Nanotechnology, Biology, and Medicine, 28 102207, 102207. doi: 10.1016/j.nano.2020.102207
2020
Journal Article
Protein profile changes in circulating placental extracellular vesicles in term and preterm births: a longitudinal study
Menon, Ramkumar, Debnath, Chirantan, Lai, Andrew, Guanzon, Dominic, Bhatnagar, Shinjini, Kshetrapal, Pallavi, Sheller-Miller, Samantha, Salomon, Carlos and The Garbh-Ini Study team (2020). Protein profile changes in circulating placental extracellular vesicles in term and preterm births: a longitudinal study. Endocrinology, 161 (4) bqaa009. doi: 10.1210/endocr/bqaa009
2020
Journal Article
Regulation of glucose homeostasis by small extracellular vesicles in normal pregnancy and in gestational diabetes
James-Allan, Laura B., Rosario, Frederick J., Barner, Kelsey, Lai, Andrew, Guanzon, Dominic, McIntyre, H. David, Lappas, Martha, Powell, Theresa L., Salomon, Carlos and Jansson, Thomas (2020). Regulation of glucose homeostasis by small extracellular vesicles in normal pregnancy and in gestational diabetes. FASEB Journal, 34 (4) fj.201902522RR, 5724-5739. doi: 10.1096/fj.201902522RR
2019
Journal Article
Downregulation of exosomal miR-192-5p and miR-204-5p in subjects with nonclassic apparent mineralocorticoid excess
Tapia-Castillo, Alejandra, Guanzon, Dominic, Palma, Carlos, Lai, Andrew, Barros, Eric, Allende, Fidel, Vecchiola, Andrea, Fardella, Carlos E., Salomón, Carlos and Carvajal, Cristian A. (2019). Downregulation of exosomal miR-192-5p and miR-204-5p in subjects with nonclassic apparent mineralocorticoid excess. Journal of Translational Medicine, 17 (1) 392, 392. doi: 10.1186/s12967-019-02143-8
2019
Journal Article
DNA Methylation Cancer Biomarkers: Translation to the Clinic
Locke, Warwick J., Guanzon, Dominic, Ma, Chenkai, Liew, Yi Jin, Duesing, Konsta R., Fung, Kim Y.C. and Ross, Jason P. (2019). DNA Methylation Cancer Biomarkers: Translation to the Clinic. Frontiers in Genetics, 10, 1-22. doi: 10.3389/fgene.2019.01150
2019
Journal Article
Ovarian cancer-derived exosomes promote tumor metastasis in vivo an effect modulated by the invasiveness capacity of their originating cells
Alharbi, Mona, Lai, Andrew, Guanzon, Dominic, Palma, Carlos, Zuñiga, Felipe, Perrin, Lewis, He, Yaowu, Hooper, John D and Salomon, Carlos (2019). Ovarian cancer-derived exosomes promote tumor metastasis in vivo an effect modulated by the invasiveness capacity of their originating cells. Clinical Science, 133 (13), CS20190082-1419. doi: 10.1042/cs20190082
2019
Conference Publication
Exosome profiles for normal and complicated pregnancies - a longitudinal study
Nakahara, Angela, Elfeky, Omar, Garvey, Cathryn, Guanzon, Dominic, Longo, Sherri Anne and Salmon, Carlos (2019). Exosome profiles for normal and complicated pregnancies - a longitudinal study. Annual Clinical and Scientific Meeting of the American College of Obstetricians and Gynecologists, Nashville, TN United States, 3-6 May 2019. Philadelphia, PA United States: Lippincott Williams and Wilkins. doi: 10.1097/01.AOG.0000558864.31601.AA
2019
Journal Article
Quantitative proteomics by SWATH-MS of maternal plasma exosomes determine pathways associated with term and preterm birth
Menon, Ramkumar, Dixon, Christopher Luke, Sheller-Miller, Samantha, Fortunato, Stephen J., Saade, George R., Palma, Carlos, Lai, Andrew, Guanzon, Dominic and Salomon, Carlos (2019). Quantitative proteomics by SWATH-MS of maternal plasma exosomes determine pathways associated with term and preterm birth. Endocrinology, 160 (3), 639-650. doi: 10.1210/en.2018-00820
2019
Conference Publication
Exosome profiles for normal and complicated pregnancies - a longitudinal study
Nakahara, A., Elfeky, O., Garvey, C., Guanzon, D., Longo, S. and Salomon, C. (2019). Exosome profiles for normal and complicated pregnancies - a longitudinal study. AFMR/SAFMR/SSCI/SSPR Southern Regional Meetings, New Orleans, LA, United States, 21-23 February 2019. London, United Kingdom: BMJ Group. doi: 10.1136/jim-2018-000974.651
2019
Conference Publication
Exosomal MiRNA profile in exosomes isolated from adipose tissue explants from normal and gestational diabetes mellitus pregnancies
Jayabalan, Nanthini, Guanzon, Dominic, McIntyre, David, Lappas, Martha and Salomon, Carlos (2019). Exosomal MiRNA profile in exosomes isolated from adipose tissue explants from normal and gestational diabetes mellitus pregnancies. 66th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI) , Paris, France, 12-16 March 2019. Thousand Oaks, CA, United States: Sage.
Funding
Current funding
Supervision
Availability
- Dr Dominic Guanzon is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Characterisation of EV-associated lipids in the progression of ovarian cancer
Associate Advisor
Other advisors: Honorary Professor John Hooper, Professor Carlos Salomon Gallo, Dr Andrew Lai
Media
Enquiries
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