Overview
Background
After completing an honours year in genetics in the lab of Professor Paul Ebert (The University of Queensland), Dr Fotheringham obtained a research assistant position in the field of diabetes, sparking a passionate interest in diabetes and diabetes complications, particularly diabetic nephropathy. This led her to undertake and complete a PhD, examining the influence of dietary factors, in particularly advanced glycation end products and macronutrients on renal function in diabetes and aging. Since completing her PhD in 2020, Dr Amelia Fotheringham has worked as a Research Officer in the Glycation and Diabetes Complications Laboratory at Mater Research-UQ. Here she has undertaken projects examining novel treatments for mitochondrial dysfunction in diabetic nephropathy and targeting the AGE-RAGE pathway for type 1 diabetes prevention.
Availability
- Dr Amelia Fotheringham is:
- Available for supervision
Works
Search Professor Amelia Fotheringham’s works on UQ eSpace
2019
Conference Publication
Exploring AGE and sRAGE regulation in response to oral and intravenous glucose loads in individuals with recently diagnosed type 2 diabetes
Fotheringham, A. K., Bagger, J. I., Borg, D. J., McCarthy, D., Vilsboll, T., Knop, F. K. and Forbes, J. M. (2019). Exploring AGE and sRAGE regulation in response to oral and intravenous glucose loads in individuals with recently diagnosed type 2 diabetes. 55th Annual Meeting of the European Association for the Study of Diabetes (EASD), Barcelona, Spain, 16-20 September 2019 . New York, NY, United States: Springer.
2018
Conference Publication
Glucose and insulin profiles during an oral glucose tolerance test (oGTT) are similar between fed and fasted states in a cohort of university students
Akison, Lisa K., Gallo, Linda A., Barclay, Johanna L., Zhuang, Aowen, Chen, Cortina, Fotheringham, Amelia K. and Moritz, Karen M. (2018). Glucose and insulin profiles during an oral glucose tolerance test (oGTT) are similar between fed and fasted states in a cohort of university students. Joint Annual Scientific Meetings of Endocrine Society of Australia (ESA) and Society for Reproductive Biology (SRB), Perth, Australia, 27-30 August 2017. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.
2018
Conference Publication
Body composition to estimate percentage fat mass: comparisons between common clinical methods and gold-standard air displacement plethysmography (BODPOD) in a cohort of university students
Akison, Lisa K., Gallo, Linda A., Barclay, Johanna L., Burgess, Danielle, Keshvari, Sahar, Fotheringham, Amelia K. and Moritz, Karen M. (2018). Body composition to estimate percentage fat mass: comparisons between common clinical methods and gold-standard air displacement plethysmography (BODPOD) in a cohort of university students. Joint Annual Scientific Meetings of Endocrine Society of Australia (ESA) and Society for Reproductive Biology (SRB), Perth, Australia, 27-30 August 2017. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.
2018
Book Chapter
Dietary AGEs in the development and progression of chronic kidney disease
Fotheringham, Amelia K., Gallo, Linda A. and Forbes, Josephine M. (2018). Dietary AGEs in the development and progression of chronic kidney disease. Dietary AGEs and their role in health and disease. (pp. 213-224) edited by Jaime Uribarri. Boca Raton, FI, United States: CRC Press. doi: 10.1201/9781315120041
2017
Journal Article
Perinatal exposure to high dietary advanced glycation end products in transgenic NOD8.3 mice leads to pancreatic beta cell dysfunction
Borg, Danielle J., Yap, Felicia Y. T., Keshvari, Sahar, Simmons, David G., Gallo, Linda A., Fotheringham, Amelia K., Zhuang, Aowen, Slattery, Robyn M., Hasnain, Sumaira Z., Coughlan, Melinda T., Kantharidis, Phillip and Forbes, Josephine M. (2017). Perinatal exposure to high dietary advanced glycation end products in transgenic NOD8.3 mice leads to pancreatic beta cell dysfunction. Islets, 10 (1), 10-24. doi: 10.1080/19382014.2017.1405189
2017
Journal Article
Targeted mitochondrial therapy using MitoQ shows equivalent renoprotection to angiotensin converting enzyme inhibition but no combined synergy in diabetes
Ward, Micheal S.., Flemming, Nicole B., Gallo, Linda A., Fotheringham, Amelia K., McCarthy, Domenica A., Zhuang, Aowen, Tang, Peter H., Borg, Danielle J., Shaw, Hannah, Harvie, Benjamin, Briskey, David R., Roberts, Llion A., Plan, Manuel R., Murphy, Michael P., Hodson, Mark P. and Forbes, Josephine M. (2017). Targeted mitochondrial therapy using MitoQ shows equivalent renoprotection to angiotensin converting enzyme inhibition but no combined synergy in diabetes. Scientific Reports, 7 (1) 15190, 15190. doi: 10.1038/s41598-017-15589-x
2017
Conference Publication
Using the Geometric Framework to Explore the Longitudinal Effects of Dietary Macronutrient Consumption On Markers of Kidney Aging
Fotheringham, A. K., Solon-Biet, S. M., Mcmahon, A. C., Ballard, W. O., Ruohonen, K., Borg, D. J., Raubenheimer, D., Le Couteur, D. G., Simpson, S. J. and Forbes, J. M. (2017). Using the Geometric Framework to Explore the Longitudinal Effects of Dietary Macronutrient Consumption On Markers of Kidney Aging. HOBOKEN: WILEY.
2017
Conference Publication
Lifetime dietary macronutrient intake ratios alter kidney function and structure into old age
Fotheringham, A. K., Solon-Biet, S. M., McMahon, A. C., Ballard, W. O., Ruohonen, K., Borg, D. J., Raubenheimer, D., Le Couteur, D. G., Simpson, S. J. and Forbes, J. M. (2017). Lifetime dietary macronutrient intake ratios alter kidney function and structure into old age. 53rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Lisbon Portugal, Sep 11-15, 2017. NEW YORK: SPRINGER.
2017
Journal Article
Vascular complications in diabetes: old messages, new thoughts
Forbes, Josephine M. and Fotheringham, Amelia K. (2017). Vascular complications in diabetes: old messages, new thoughts. Diabetologia, 60 (11), 2129-2138. doi: 10.1007/s00125-017-4360-x
2016
Conference Publication
Understanding Novel Genetic Factors Underlying Circulating Cystatin C and Kidney Function
Fotheringham, A., Balmer, L., Morahan, G. and Forbes, J. (2016). Understanding Novel Genetic Factors Underlying Circulating Cystatin C and Kidney Function. HOBOKEN: WILEY-BLACKWELL.
2016
Journal Article
Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice
Gallo, Linda A., Ward, Micheal S., Fotheringham, Amelia K., Zhuang, Aowen, Borg, Danielle J., Flemming, Nicole B., Harvie, Ben M., Kinneally, Toni L., Yeh, Shang-Ming, McCarthy, Domenica A., Koepsell, Hermann, Vallon, Volker, Pollock, Carol, Panchapakesan, Usha and Forbes, Josephine M. (2016). Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice. Scientific Reports, 6 (1) 26428, 28124. doi: 10.1038/srep26428
2016
Conference Publication
The SGLT2 Inhibitor, Empagliflozin, Attenuates Some Markers of Renal Fibrosis without Improving Albuminuria in Diabetic <i>Db</i>/<i>Db</i> Mice
Gallo, Linda A., Ward, Micheal S., Fotheringham, Amelia K., Zhuang, Aowen, Koepsell, Hermann, Vallon', Volker, Pollock, Carol, Panchapakesan, Usha and Forbes, Josephine M. (2016). The SGLT2 Inhibitor, Empagliflozin, Attenuates Some Markers of Renal Fibrosis without Improving Albuminuria in Diabetic Db/Db Mice. Experimental Biology Meeting, San Diego Ca, Apr 02-06, 2016. BETHESDA: FEDERATION AMER SOC EXP BIOL.
2016
Conference Publication
The SGLT2 Inhibitor, Empagliflozin, Attenuates Some Markers of Renal Fibrosis without Improving Albuminuria in Diabetic Db/Db Mice
Gallo, Linda A., Ward, Micheal S., Fotheringham, Amelia K., Zhuang, Aowen, Koepsell, Hermann, Vallon, Volker, Pollock, Carol, Panchapakesan, Usha and Forbes, Josephine M. (2016). The SGLT2 Inhibitor, Empagliflozin, Attenuates Some Markers of Renal Fibrosis without Improving Albuminuria in Diabetic Db/Db Mice. Experimental Biology 2016 Meeting, San Diego, CA United States, 1-5 April 2016. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1096/fasebj.30.1_supplement.740.18
2015
Conference Publication
Human soluble receptor for advanced glycation end products therapy reduces autoimmune diabetes in the non-obese diabetic mouse
Leung, S. S.-Y., Borg, D. J., McCarthy, D., Zhuang, A., Fotheringham, A., Di Trapani, G., Groop, P.-H., Knip, M. and Forbes, J. (2015). Human soluble receptor for advanced glycation end products therapy reduces autoimmune diabetes in the non-obese diabetic mouse. Joint Annual Conference of the International Society for Pediatric and Adolescent Diabetes and Australasian Paediatric Endocrine Group (ISPAD+APEG 2015), Brisbane, QLD Australia, 7-10 October 2015. Hoboken, NJ USA: Wiley-Blackwell Publishing. doi: 10.1111/pedi.12309
2015
Conference Publication
Delivery of recombinant human soluble receptor for advanced glycation end products delays autoimmune diabetes in the NOD mouse model
Borg, D. J., Leung, S., Zhuang, A., Fotheringham, A., McCarthy, D., Di Trapani, J., Groop, P. -H., Knip, M. and Forbes, J. (2015). Delivery of recombinant human soluble receptor for advanced glycation end products delays autoimmune diabetes in the NOD mouse model. 51st Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Stockholm, Sweden, 14-18 September 2015. Heidelberg, Germany: Springer. doi: 10.1007/s00125-015-3687-4
2015
Conference Publication
Short-term alagebrium chloride (ALT-711) therapy pre-diabetes for the treatment of Type I Diabetes
Borg, D. J., McCarthy, D., Reeves, P., Ward, M. S., Fotheringham, A. K., Gallo, L. A., Harcourt, B. E., Agrawal, N., Steptoe, R. and Forbes, J. M. (2015). Short-term alagebrium chloride (ALT-711) therapy pre-diabetes for the treatment of Type I Diabetes. Immunology of Diabetes Society 14th International Congress, Munich, Germany, 12-16 April 2015.
2015
Conference Publication
In Db/db mice, Sglt2 inhibition does not improve diabetic nephropathy despite glycaemic improvements
Gallo, L. A., Ward, M. S., Fotheringham, A. K., Pollock, C., Panchapakesan, U. and Forbes, J. M. (2015). In Db/db mice, Sglt2 inhibition does not improve diabetic nephropathy despite glycaemic improvements. 51st Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Canberra, Australia, 7-9 September 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12543
2014
Journal Article
Deletion of bone-marrow-derived receptor for AGEs (RAGE) improves renal function in an experimental mouse model of diabetes
Tesch, Greg, Sourris, Karly C., Summers, Shaun A., McCarthy, Domenica, Ward, Micheal S., Borg, Danielle J., Gallo, Linda A., Fotheringham, Amelia K., Pettit, Allison R., Yap, Felicia Y. T., Harcourt, Brooke E., Tan, Adeline L. Y., Kausman, Joshua Y., Nikolic-Paterson, David, Kitching, Arthur R. and Forbes, Josephine M. (2014). Deletion of bone-marrow-derived receptor for AGEs (RAGE) improves renal function in an experimental mouse model of diabetes. Diabetologia, 57 (9), 1977-1985. doi: 10.1007/s00125-014-3291-z
2014
Conference Publication
Deficiency of rage in bone marrow cells reduces renal injury in diabetic mice
Tesch, G. H., Sourris, K. C., Summers, S. A., Mccarthy, D., Ward, M. S., Borg, D. J., Gallo, L. A., Fotheringham, A. K., Pettit, A., Yap, F. Y. T., Harcourt, B. E., Tan, A. L. Y., Kausman, J. Y., Nikolic-Paterson, D. J., Kitching, A. R. and Forbes, J. M. (2014). Deficiency of rage in bone marrow cells reduces renal injury in diabetic mice. 50th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Melbourne Australia, 25–27 August 2014. Richmond Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12301
2014
Conference Publication
Ager1 overexpression in glomerular podocytes results in renal disease which is exacerbated by diabetes
Zhuang, A., Sourris, K. C, Harcourt, B. E, Penfold, S. A., Fotheringham, A. K., McCarthy, D., Schulz, B. and Forbes, J. M. (2014). Ager1 overexpression in glomerular podocytes results in renal disease which is exacerbated by diabetes. 50th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Melbourne VIC, Australia, 25 - 27 August 2014. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12301
Funding
Past funding
Supervision
Availability
- Dr Amelia Fotheringham is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Early mitochondrial dysfunction in diabetic kidney
Associate Advisor
Other advisors: Dr Irina Buckle, Honorary Professor Josephine Forbes
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Doctor Philosophy
sRAGE as a preventative therapy for T1D and potential biomarker of pregnancy complications
Associate Advisor
Other advisors: Professor Emma Hamilton-Williams, Dr Irina Buckle, Dr Sherman Leung, Honorary Professor Josephine Forbes
-
Doctor Philosophy
The receptor for advanced glycation end products and its role in Type 1 diabetes development
Associate Advisor
Other advisors: Professor Emma Hamilton-Williams, Dr Irina Buckle, Dr Sherman Leung, Honorary Professor Josephine Forbes
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Doctor Philosophy
The Characterisation of Immune Cells in Response To RAGE Antagonism Therapy in Mouse Models of Type 1 Diabetes
Associate Advisor
Other advisors: Professor Benjamin Schulz, Honorary Professor Josephine Forbes, Dr Irina Buckle
Media
Enquiries
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