Dr Aleksandr Kakinen
Dr

Aleksandr Kakinen

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Background

Dr. Aleksandr Kakinen is NHMRC Emerging Leadership Fellow at the Australian Institute for Bioengineering and Nanotechnology, the University of Queensland, Australia. He obtained his Ph.D. degree (2014) at Tallinn University of Technology, Estonia, and worked as a postdoctoral fellow (2016–2020) at Monash Institute of Pharmaceutical Sciences, Monash University, Australia. His research interests range from nanomedicine and amyloids diseases to structural biology and nanotoxicology. Dr. Kakinen has published over 50 peer-reviewed articles in high impact factor journals e.g. Chemical Society Reviews, Advanced Materials, Nature Communications, Nano Letters and ACS Nano. In addition to his scientific activities, Aleksandr is also passionate about scientific design and has founded a design studio that specialises in scientific illustrations and biomedical animations.

Availability

Dr Aleksandr Kakinen is:
Available for supervision

Fields of research

Biomedical and Clinical Sciences Human biophysics Medical physiology Nanomaterials Nanomedicine Nanotoxicology, health and safety Neurosciences

Qualifications

  • Doctor of Philosophy, Tallin Technological University

Research interests

  • Neuroscience

    Neurodegenerative diseases, amyloid diseases.

  • Nanomedicine

  • Nanotechnology

Search Professor Aleksandr Kakinen’s works on UQ eSpace

64 works between 2011 and 2024
All (64) Journal Article (61) Conference Publication (3)

1 - 20 of 64 works

2024

Journal Article

Brain Targeting Nanomedicines: Pitfalls and Promise

Kakinen, Aleksandr, Jiang, Yuhao, Davis, Thomas, Teesalu, Tambet and Saarma, Mart (2024). Brain Targeting Nanomedicines: Pitfalls and Promise. International Journal of Nanomedicine, Volume 19, 4857-4875. doi: 10.2147/ijn.s454553

Brain Targeting Nanomedicines: Pitfalls and Promise

2024

Journal Article

Endothelial leakiness elicited by amyloid protein aggregation

Li, Yuhuan, Ni, Nengyi, Lee, Myeongsang, Wei, Wei, Andrikopoulos, Nicholas, Kakinen, Aleksandr, Davis, Thomas P., Song, Yang, Ding, Feng, Leong, David Tai and Ke, Pu Chun (2024). Endothelial leakiness elicited by amyloid protein aggregation. Nature Communications, 15 (1) 613, 1-18. doi: 10.1038/s41467-024-44814-1

Endothelial leakiness elicited by amyloid protein aggregation

2023

Journal Article

Alzheimer's progenitor amyloid‐β targets and dissolves microbial amyloids and impairs biofilm function

Ali, Syed Aoun, Chung, Ka Hang Karen, Forgham, Helen, Olsen, William P., Kakinen, Aleksandr, Balaji, Arunpandian, Otzen, Daniel E., Davis, Thomas Paul and Javed, Ibrahim (2023). Alzheimer's progenitor amyloid‐β targets and dissolves microbial amyloids and impairs biofilm function. Advanced Science, 10 (29) 2301423, e2301423. doi: 10.1002/advs.202301423

Alzheimer's progenitor amyloid‐β targets and dissolves microbial amyloids and impairs biofilm function

2022

Journal Article

Keeping up with the COVID's—Could siRNA‐based antivirals be a part of the answer?

Forgham, Helen, Kakinen, Aleksandr, Qiao, Ruirui and Davis, Thomas P. (2022). Keeping up with the COVID's—Could siRNA‐based antivirals be a part of the answer?. Exploration, 00 (6) 20220012, 20220012. doi: 10.1002/exp.20220012

Keeping up with the COVID's—Could siRNA‐based antivirals be a part of the answer?

2022

Journal Article

Graphene quantum dots obstruct the membrane axis of Alzheimer's amyloid beta

Tang, Huayuan, Li, Yuhuan, Kakinen, Aleksandr, Andrikopoulos, Nicholas, Sun, Yunxiang, Kwak, Eunbi, Davis, Thomas P., Ding, Feng and Ke, Pu Chun (2022). Graphene quantum dots obstruct the membrane axis of Alzheimer's amyloid beta. Physical Chemistry Chemical Physics, 24 (1), 86-97. doi: 10.1039/d1cp04246g

Graphene quantum dots obstruct the membrane axis of Alzheimer's amyloid beta

2021

Journal Article

Dynamic protein corona of gold nanoparticles with an evolving morphology

Nandakumar, Aparna, Wei, Wei, Siddiqui, Ghizal, Tang, Huayuan, Li, Yuhuan, Kakinen, Aleksandr, Wan, Xulin, Koppel, Kairi, Lin, Sijie, Davis, Thomas P., Leong, David T., Creek, Darren J., Ding, Feng, Song, Yang and Ke, Pu Chun (2021). Dynamic protein corona of gold nanoparticles with an evolving morphology. ACS Applied Materials and Interfaces, 13 (48), 58238-58251. doi: 10.1021/acsami.1c19824

Dynamic protein corona of gold nanoparticles with an evolving morphology

2021

Journal Article

Structure dependent differential modulation of Aβ fibrillization by selenadiazole-based inhibitors

Kalsoom, Umme, Alazmi, Meshari, Farrukh, Hafiz Syed Usama Bin, Chung, Ka Hang Karen, Alshammari, Nawaf, Kakinen, Aleksandr, Chotana, Ghayoor Abbas, Javed, Ibrahim, Davis, Thomas Paul and Saleem, Rahman Shah Zaib (2021). Structure dependent differential modulation of Aβ fibrillization by selenadiazole-based inhibitors. ACS Chemical Neuroscience, 12 (20), 3806-3817. doi: 10.1021/acschemneuro.1c00478

Structure dependent differential modulation of Aβ fibrillization by selenadiazole-based inhibitors

2021

Journal Article

A framework of paracellular transport via nanoparticles‐induced endothelial leakiness

Lee, Myeongsang, Ni, Nengyi, Tang, Huayuan, Li, Yuhuan, Wei, Wei, Kakinen, Aleksandr, Wan, Xulin, Davis, Thomas P., Song, Yang, Leong, David Tai, Ding, Feng and Ke, Pu Chun (2021). A framework of paracellular transport via nanoparticles‐induced endothelial leakiness. Advanced Science, 8 (21) 2102519, e2102519. doi: 10.1002/advs.202102519

A framework of paracellular transport via nanoparticles‐induced endothelial leakiness

2021

Journal Article

Inhibition of amyloid aggregation and toxicity with Janus iron oxide nanoparticles

Andrikopoulos, Nicholas, Song, Zhiyuan, Wan, Xulin, Douek, Alon M., Javed, Ibrahim, Fu, Changkui, Xing, Yanting, Xin, Fangyun, Li, Yuhuan, Kakinen, Aleksandr, Koppel, Kairi, Qiao, Ruirui, Whittaker, Andrew K., Kaslin, Jan, Davis, Thomas P., Song, Yang, Ding, Feng and Ke, Pu Chun (2021). Inhibition of amyloid aggregation and toxicity with Janus iron oxide nanoparticles. Chemistry of Materials, 33 (16) acs.chemmater.1c01947, 6484-6500. doi: 10.1021/acs.chemmater.1c01947

Inhibition of amyloid aggregation and toxicity with Janus iron oxide nanoparticles

2021

Journal Article

Nanotoxicology and nanomedicine: The Yin and Yang of nano-bio interactions for the new decade

Bondarenko, Olesja, Mortimer, Monika, Kahru, Anne, Feliu, Neus, Javed, Ibrahim, Kakinen, Aleksandr, Lin, Sijie, Xia, Tian, Song, Yang, Davis, Thomas P., Lynch, Iseult, Parak, Wolfgang J., Leong, David Tai, Ke, Pu Chun, Chen, Chunying and Zhao, Yuliang (2021). Nanotoxicology and nanomedicine: The Yin and Yang of nano-bio interactions for the new decade. Nano Today, 39 101184, 101184. doi: 10.1016/j.nantod.2021.101184

Nanotoxicology and nanomedicine: The Yin and Yang of nano-bio interactions for the new decade

2021

Journal Article

Ultrasmall molybdenum disulfide quantum dots cage Alzheimer’s amyloid beta to restore membrane fluidity

Li, Yuhuan, Tang, Huayuan, Zhu, Houjuan, Kakinen, Aleksandr, Wang, Di, Andrikopoulos, Nicholas, Sun, Yunxiang, Nandakumar, Aparna, Kwak, Eunbi, Davis, Thomas P., Leong, David Tai, Ding, Feng and Ke, Pu Chun (2021). Ultrasmall molybdenum disulfide quantum dots cage Alzheimer’s amyloid beta to restore membrane fluidity. ACS Applied Materials and Interfaces, 13 (25) acsami.1c06478, 29936-29948. doi: 10.1021/acsami.1c06478

Ultrasmall molybdenum disulfide quantum dots cage Alzheimer’s amyloid beta to restore membrane fluidity

2021

Journal Article

Spontaneous formation of β-sheet nano-barrels during the early aggregation of Alzheimer’s amyloid beta

Sun, Yunxiang, Kakinen, Aleksandr, Wan, Xulin, Moriarty, Niamh, Hunt, Cameron P.J., Li, Yuhuan, Andrikopoulos, Nicholas, Nandakumar, Aparna, Davis, Thomas P., Parish, Clare L., Song, Yang, Ke, Pu Chun and Ding, Feng (2021). Spontaneous formation of β-sheet nano-barrels during the early aggregation of Alzheimer’s amyloid beta. Nano Today, 38 101125, 101125. doi: 10.1016/j.nantod.2021.101125

Spontaneous formation of β-sheet nano-barrels during the early aggregation of Alzheimer’s amyloid beta

2021

Journal Article

In vitro and in vivo models for anti-amyloidosis nanomedicines

Kakinen, Aleksandr, Javed, Ibrahim, Davis, Thomas P. and Ke, Pu Chun (2021). In vitro and in vivo models for anti-amyloidosis nanomedicines. Nanoscale Horizons, 6 (2), 95-119. doi: 10.1039/d0nh00548g

In vitro and in vivo models for anti-amyloidosis nanomedicines

2020

Journal Article

Amyloid aggregation under the lens of liquid–liquid phase separation

Xing, Yanting, Nandakumar, Aparna, Kakinen, Aleksandr, Sun, Yunxiang, Davis, Thomas P., Ke, Pu Chun and Ding, Feng (2020). Amyloid aggregation under the lens of liquid–liquid phase separation. The Journal of Physical Chemistry Letters, 12 (1), 368-378. doi: 10.1021/acs.jpclett.0c02567

Amyloid aggregation under the lens of liquid–liquid phase separation

2020

Journal Article

The membrane axis of Alzheimer's nanomedicine

Li, Yuhuan, Tang, Huayuan, Andrikopoulos, Nicholas, Javed, Ibrahim, Cecchetto, Luca, Nandakumar, Aparna, Kakinen, Aleksandr, Davis, Thomas P., Ding, Feng and Ke, Pu Chun (2020). The membrane axis of Alzheimer's nanomedicine. Advanced NanoBiomed Research, 1 (1) 2000040, 2000040. doi: 10.1002/anbr.202000040

The membrane axis of Alzheimer's nanomedicine

2020

Journal Article

Human plasma protein corona of Aβ amyloid and its impact on islet amyloid polypeptide cross-seeding

Nandakumar, Aparna, Xing, Yanting, Aranha, Ritchlynn R., Faridi, Ava, Kakinen, Aleksandr, Javed, Ibrahim, Koppel, Kairi, Pilkington, Emily H., Purcell, Anthony Wayne, Davis, Thomas P., Faridi, Pouya, Ding, Feng and Ke, Pu Chun (2020). Human plasma protein corona of Aβ amyloid and its impact on islet amyloid polypeptide cross-seeding. Biomacromolecules, 21 (2), 988-998. doi: 10.1021/acs.biomac.9b01650

Human plasma protein corona of Aβ amyloid and its impact on islet amyloid polypeptide cross-seeding

2019

Journal Article

Single-Molecular Heteroamyloidosis of Human Islet Amyloid Polypeptide

Kakinen, Aleksandr, Xing, Yanting, Hegoda Arachchi, Nuwan, Javed, Ibrahim, Feng, Lei, Faridi, Ava, Douek, Alon M., Sun, Yunxiang, Kaslin, Jan, Davis, Thomas P., Higgins, Michael J., Ding, Feng and Ke, Pu Chun (2019). Single-Molecular Heteroamyloidosis of Human Islet Amyloid Polypeptide. Nano Letters, 19 (9), 6535-6546. doi: 10.1021/acs.nanolett.9b02771

Single-Molecular Heteroamyloidosis of Human Islet Amyloid Polypeptide

2019

Journal Article

Inhibition of amyloid beta toxicity in zebrafish with a chaperone-gold nanoparticle dual strategy

Javed, Ibrahim, Peng, Guotao, Xing, Yanting, Yu, Tianyu, Zhao, Mei, Kakinen, Aleksandr, Faridi, Ava, Parish, Clare L., Ding, Feng, Davis, Thomas P., Ke, Pu Chun and Lin, Sijie (2019). Inhibition of amyloid beta toxicity in zebrafish with a chaperone-gold nanoparticle dual strategy. Nature Communications, 10 (1) 3780, 3780. doi: 10.1038/s41467-019-11762-0

Inhibition of amyloid beta toxicity in zebrafish with a chaperone-gold nanoparticle dual strategy

2019

Journal Article

Amphiphilic surface chemistry of fullerenols is necessary for inhibiting the amyloid aggregation of alpha-synuclein NACore

Sun, Yunxiang, Kakinen, Aleksandr, Zhang, Chi, Yang, Ye, Faridi, Ava, Davis, Thomas P., Cao, Weiguo, Ke, Pu Chun and Ding, Feng (2019). Amphiphilic surface chemistry of fullerenols is necessary for inhibiting the amyloid aggregation of alpha-synuclein NACore. Nanoscale, 11 (24), 11933-11945. doi: 10.1039/c9nr02407g

Amphiphilic surface chemistry of fullerenols is necessary for inhibiting the amyloid aggregation of alpha-synuclein NACore

2019

Journal Article

Mitigation of amyloidosis with nanomaterials

Ke, Pu Chun, Pilkington, Emily H., Sun, Yunxiang, Javed, Ibrahim, Kakinen, Aleksandr, Peng, Guotao, Ding, Feng and Davis, Thomas P. (2019). Mitigation of amyloidosis with nanomaterials. Advanced Materials, 32 (18) 1901690, 1901690. doi: 10.1002/adma.201901690

Mitigation of amyloidosis with nanomaterials

Current funding

  • 2022 - 2026
    Inflammation and chronic infections in the pathogenesis of Alzheimer's disease: the role of amyloid cross-seeding.
    NHMRC Investigator Grants
    Open grant

Availability

Dr Aleksandr Kakinen is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Inflammation and chronic infections in the pathogenesis of Alzheimers disease: the role of amyloid cross-seeding

    Principal Advisor

    Other advisors: Professor Thomas Davis

  • Doctor Philosophy

    Investigating the role of gut-bacteria in neurodegenerative diseases

    Associate Advisor

    Other advisors: Professor Thomas Davis

Enquiries

For media enquiries about Dr Aleksandr Kakinen's areas of expertise, story ideas and help finding experts, contact our Media team:

communications@uq.edu.au