
Overview
Background
Dr. Aleksandr Kakinen is NHMRC Emerging Leadership Fellow at the Australian Institute for Bioengineering and Nanotechnology, the University of Queensland, Australia. He obtained his Ph.D. degree (2014) at Tallinn University of Technology, Estonia, and worked as a postdoctoral fellow (2016–2020) at Monash Institute of Pharmaceutical Sciences, Monash University, Australia. His research interests range from nanomedicine and amyloids diseases to structural biology and nanotoxicology. Dr. Kakinen has published over 50 peer-reviewed articles in high impact factor journals e.g. Chemical Society Reviews, Advanced Materials, Nature Communications, Nano Letters and ACS Nano. In addition to his scientific activities, Aleksandr is also passionate about scientific design and has founded a design studio that specialises in scientific illustrations and biomedical animations.
Availability
- Dr Aleksandr Kakinen is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Tallin Technological University
Research interests
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Neuroscience
Neurodegenerative diseases, amyloid diseases.
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Nanomedicine
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Nanotechnology
Works
Search Professor Aleksandr Kakinen’s works on UQ eSpace
2024
Journal Article
Reverse engineering the Gut-Brain Axis and microbiome-metabolomics for symbiotic/pathogenic balance in neurodegenerative diseases
Munir, Muhammad Usman, Ali, Syed Aoun, Chung, Ka Hang Karen, Kakinen, Aleksandr, Javed, Ibrahim and Davis, Thomas Paul (2024). Reverse engineering the Gut-Brain Axis and microbiome-metabolomics for symbiotic/pathogenic balance in neurodegenerative diseases. Gut Microbes, 16 (1) 2422468, 2422468. doi: 10.1080/19490976.2024.2422468
2024
Journal Article
Brain Targeting Nanomedicines: Pitfalls and Promise
Kakinen, Aleksandr, Jiang, Yuhao, Davis, Thomas, Teesalu, Tambet and Saarma, Mart (2024). Brain Targeting Nanomedicines: Pitfalls and Promise. International Journal of Nanomedicine, Volume 19, 4857-4875. doi: 10.2147/ijn.s454553
2024
Journal Article
Endothelial leakiness elicited by amyloid protein aggregation
Li, Yuhuan, Ni, Nengyi, Lee, Myeongsang, Wei, Wei, Andrikopoulos, Nicholas, Kakinen, Aleksandr, Davis, Thomas P., Song, Yang, Ding, Feng, Leong, David Tai and Ke, Pu Chun (2024). Endothelial leakiness elicited by amyloid protein aggregation. Nature Communications, 15 (1) 613, 1-18. doi: 10.1038/s41467-024-44814-1
2023
Journal Article
Alzheimer's progenitor amyloid‐β targets and dissolves microbial amyloids and impairs biofilm function
Ali, Syed Aoun, Chung, Ka Hang Karen, Forgham, Helen, Olsen, William P., Kakinen, Aleksandr, Balaji, Arunpandian, Otzen, Daniel E., Davis, Thomas Paul and Javed, Ibrahim (2023). Alzheimer's progenitor amyloid‐β targets and dissolves microbial amyloids and impairs biofilm function. Advanced Science, 10 (29) 2301423, e2301423. doi: 10.1002/advs.202301423
2022
Journal Article
Keeping up with the COVID's—Could siRNA‐based antivirals be a part of the answer?
Forgham, Helen, Kakinen, Aleksandr, Qiao, Ruirui and Davis, Thomas P. (2022). Keeping up with the COVID's—Could siRNA‐based antivirals be a part of the answer?. Exploration, 00 (6) 20220012, 20220012. doi: 10.1002/exp.20220012
2022
Journal Article
Graphene quantum dots obstruct the membrane axis of Alzheimer's amyloid beta
Tang, Huayuan, Li, Yuhuan, Kakinen, Aleksandr, Andrikopoulos, Nicholas, Sun, Yunxiang, Kwak, Eunbi, Davis, Thomas P., Ding, Feng and Ke, Pu Chun (2022). Graphene quantum dots obstruct the membrane axis of Alzheimer's amyloid beta. Physical Chemistry Chemical Physics, 24 (1), 86-97. doi: 10.1039/d1cp04246g
2021
Journal Article
Dynamic protein corona of gold nanoparticles with an evolving morphology
Nandakumar, Aparna, Wei, Wei, Siddiqui, Ghizal, Tang, Huayuan, Li, Yuhuan, Kakinen, Aleksandr, Wan, Xulin, Koppel, Kairi, Lin, Sijie, Davis, Thomas P., Leong, David T., Creek, Darren J., Ding, Feng, Song, Yang and Ke, Pu Chun (2021). Dynamic protein corona of gold nanoparticles with an evolving morphology. ACS Applied Materials and Interfaces, 13 (48), 58238-58251. doi: 10.1021/acsami.1c19824
2021
Journal Article
Structure dependent differential modulation of Aβ fibrillization by selenadiazole-based inhibitors
Kalsoom, Umme, Alazmi, Meshari, Farrukh, Hafiz Syed Usama Bin, Chung, Ka Hang Karen, Alshammari, Nawaf, Kakinen, Aleksandr, Chotana, Ghayoor Abbas, Javed, Ibrahim, Davis, Thomas Paul and Saleem, Rahman Shah Zaib (2021). Structure dependent differential modulation of Aβ fibrillization by selenadiazole-based inhibitors. ACS Chemical Neuroscience, 12 (20), 3806-3817. doi: 10.1021/acschemneuro.1c00478
2021
Journal Article
A framework of paracellular transport via nanoparticles‐induced endothelial leakiness
Lee, Myeongsang, Ni, Nengyi, Tang, Huayuan, Li, Yuhuan, Wei, Wei, Kakinen, Aleksandr, Wan, Xulin, Davis, Thomas P., Song, Yang, Leong, David Tai, Ding, Feng and Ke, Pu Chun (2021). A framework of paracellular transport via nanoparticles‐induced endothelial leakiness. Advanced Science, 8 (21) 2102519, e2102519. doi: 10.1002/advs.202102519
2021
Journal Article
Inhibition of amyloid aggregation and toxicity with Janus iron oxide nanoparticles
Andrikopoulos, Nicholas, Song, Zhiyuan, Wan, Xulin, Douek, Alon M., Javed, Ibrahim, Fu, Changkui, Xing, Yanting, Xin, Fangyun, Li, Yuhuan, Kakinen, Aleksandr, Koppel, Kairi, Qiao, Ruirui, Whittaker, Andrew K., Kaslin, Jan, Davis, Thomas P., Song, Yang, Ding, Feng and Ke, Pu Chun (2021). Inhibition of amyloid aggregation and toxicity with Janus iron oxide nanoparticles. Chemistry of Materials, 33 (16) acs.chemmater.1c01947, 6484-6500. doi: 10.1021/acs.chemmater.1c01947
2021
Journal Article
Nanotoxicology and nanomedicine: The Yin and Yang of nano-bio interactions for the new decade
Bondarenko, Olesja, Mortimer, Monika, Kahru, Anne, Feliu, Neus, Javed, Ibrahim, Kakinen, Aleksandr, Lin, Sijie, Xia, Tian, Song, Yang, Davis, Thomas P., Lynch, Iseult, Parak, Wolfgang J., Leong, David Tai, Ke, Pu Chun, Chen, Chunying and Zhao, Yuliang (2021). Nanotoxicology and nanomedicine: The Yin and Yang of nano-bio interactions for the new decade. Nano Today, 39 101184, 101184. doi: 10.1016/j.nantod.2021.101184
2021
Journal Article
Ultrasmall molybdenum disulfide quantum dots cage Alzheimer’s amyloid beta to restore membrane fluidity
Li, Yuhuan, Tang, Huayuan, Zhu, Houjuan, Kakinen, Aleksandr, Wang, Di, Andrikopoulos, Nicholas, Sun, Yunxiang, Nandakumar, Aparna, Kwak, Eunbi, Davis, Thomas P., Leong, David Tai, Ding, Feng and Ke, Pu Chun (2021). Ultrasmall molybdenum disulfide quantum dots cage Alzheimer’s amyloid beta to restore membrane fluidity. ACS Applied Materials and Interfaces, 13 (25) acsami.1c06478, 29936-29948. doi: 10.1021/acsami.1c06478
2021
Journal Article
Spontaneous formation of β-sheet nano-barrels during the early aggregation of Alzheimer’s amyloid beta
Sun, Yunxiang, Kakinen, Aleksandr, Wan, Xulin, Moriarty, Niamh, Hunt, Cameron P.J., Li, Yuhuan, Andrikopoulos, Nicholas, Nandakumar, Aparna, Davis, Thomas P., Parish, Clare L., Song, Yang, Ke, Pu Chun and Ding, Feng (2021). Spontaneous formation of β-sheet nano-barrels during the early aggregation of Alzheimer’s amyloid beta. Nano Today, 38 101125, 101125. doi: 10.1016/j.nantod.2021.101125
2021
Journal Article
In vitro and in vivo models for anti-amyloidosis nanomedicines
Kakinen, Aleksandr, Javed, Ibrahim, Davis, Thomas P. and Ke, Pu Chun (2021). In vitro and in vivo models for anti-amyloidosis nanomedicines. Nanoscale Horizons, 6 (2), 95-119. doi: 10.1039/d0nh00548g
2020
Journal Article
Amyloid aggregation under the lens of liquid–liquid phase separation
Xing, Yanting, Nandakumar, Aparna, Kakinen, Aleksandr, Sun, Yunxiang, Davis, Thomas P., Ke, Pu Chun and Ding, Feng (2020). Amyloid aggregation under the lens of liquid–liquid phase separation. The Journal of Physical Chemistry Letters, 12 (1), 368-378. doi: 10.1021/acs.jpclett.0c02567
2020
Journal Article
The membrane axis of Alzheimer's nanomedicine
Li, Yuhuan, Tang, Huayuan, Andrikopoulos, Nicholas, Javed, Ibrahim, Cecchetto, Luca, Nandakumar, Aparna, Kakinen, Aleksandr, Davis, Thomas P., Ding, Feng and Ke, Pu Chun (2020). The membrane axis of Alzheimer's nanomedicine. Advanced NanoBiomed Research, 1 (1) 2000040, 2000040. doi: 10.1002/anbr.202000040
2020
Journal Article
Human plasma protein corona of Aβ amyloid and its impact on islet amyloid polypeptide cross-seeding
Nandakumar, Aparna, Xing, Yanting, Aranha, Ritchlynn R., Faridi, Ava, Kakinen, Aleksandr, Javed, Ibrahim, Koppel, Kairi, Pilkington, Emily H., Purcell, Anthony Wayne, Davis, Thomas P., Faridi, Pouya, Ding, Feng and Ke, Pu Chun (2020). Human plasma protein corona of Aβ amyloid and its impact on islet amyloid polypeptide cross-seeding. Biomacromolecules, 21 (2), 988-998. doi: 10.1021/acs.biomac.9b01650
2019
Journal Article
Single-Molecular Heteroamyloidosis of Human Islet Amyloid Polypeptide
Kakinen, Aleksandr, Xing, Yanting, Hegoda Arachchi, Nuwan, Javed, Ibrahim, Feng, Lei, Faridi, Ava, Douek, Alon M., Sun, Yunxiang, Kaslin, Jan, Davis, Thomas P., Higgins, Michael J., Ding, Feng and Ke, Pu Chun (2019). Single-Molecular Heteroamyloidosis of Human Islet Amyloid Polypeptide. Nano Letters, 19 (9), 6535-6546. doi: 10.1021/acs.nanolett.9b02771
2019
Journal Article
Inhibition of amyloid beta toxicity in zebrafish with a chaperone-gold nanoparticle dual strategy
Javed, Ibrahim, Peng, Guotao, Xing, Yanting, Yu, Tianyu, Zhao, Mei, Kakinen, Aleksandr, Faridi, Ava, Parish, Clare L., Ding, Feng, Davis, Thomas P., Ke, Pu Chun and Lin, Sijie (2019). Inhibition of amyloid beta toxicity in zebrafish with a chaperone-gold nanoparticle dual strategy. Nature Communications, 10 (1) 3780, 3780. doi: 10.1038/s41467-019-11762-0
2019
Journal Article
Amphiphilic surface chemistry of fullerenols is necessary for inhibiting the amyloid aggregation of alpha-synuclein NACore
Sun, Yunxiang, Kakinen, Aleksandr, Zhang, Chi, Yang, Ye, Faridi, Ava, Davis, Thomas P., Cao, Weiguo, Ke, Pu Chun and Ding, Feng (2019). Amphiphilic surface chemistry of fullerenols is necessary for inhibiting the amyloid aggregation of alpha-synuclein NACore. Nanoscale, 11 (24), 11933-11945. doi: 10.1039/c9nr02407g
Funding
Current funding
Supervision
Availability
- Dr Aleksandr Kakinen is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Inflammation and chronic infections in the pathogenesis of Alzheimers disease: the role of amyloid cross-seeding
Principal Advisor
Other advisors: Professor Thomas Davis
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Doctor Philosophy
Investigating the role of gut-bacteria in neurodegenerative diseases
Associate Advisor
Other advisors: Professor Thomas Davis
Media
Enquiries
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