Overview
Background
Dr. Aleksandr Kakinen is NHMRC Emerging Leadership Fellow at the Australian Institute for Bioengineering and Nanotechnology, the University of Queensland, Australia. He obtained his Ph.D. degree (2014) at Tallinn University of Technology, Estonia, and worked as a postdoctoral fellow (2016–2020) at Monash Institute of Pharmaceutical Sciences, Monash University, Australia. His research interests range from nanomedicine and amyloids diseases to structural biology and nanotoxicology. Dr. Kakinen has published over 50 peer-reviewed articles in high impact factor journals e.g. Chemical Society Reviews, Advanced Materials, Nature Communications, Nano Letters and ACS Nano. In addition to his scientific activities, Aleksandr is also passionate about scientific design and has founded a design studio that specialises in scientific illustrations and biomedical animations.
Availability
- Dr Aleksandr Kakinen is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Tallin Technological University
Research interests
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Neuroscience
Neurodegenerative diseases, amyloid diseases.
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Nanomedicine
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Nanotechnology
Works
Search Professor Aleksandr Kakinen’s works on UQ eSpace
2017
Journal Article
Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation
Ge, Xinwei, Kakinen, Aleksandr, Gurzov, Esteban N., Yang, Wen, Pang, Lokman, Pilkington, Emily H., Govindan-Nedumpully, Praveen, Chen, Pengyu, Separovic, Frances, Davis, Thomas P., Ke, Pu Chun and Ding, Feng (2017). Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation. Chemical Communications, 53 (68), 9394-9397. doi: 10.1039/c7cc04291d
2017
Journal Article
NanoEHS beyond toxicity - focusing on biocorona
Lin, Sijie, Mortimer, Monika, Chen, Ran, Kakinen, Aleksandr, Riviere, Jim E., Davis, Thomas P., Ding, Feng and Ke, Pu Chun (2017). NanoEHS beyond toxicity - focusing on biocorona. Environmental Science-Nano, 4 (7), 1433-1454. doi: 10.1039/c6en00579a
2017
Journal Article
Effects of Protein Corona on IAPP Amyloid Aggregation, Fibril Remodelling, and Cytotoxicity
Pilkington, Emily H., Xing, Yanting, Wang, Bo, Kakinen, Aleksandr, Wang, Miaoyi, Davis, Thomas P., Ding, Feng and Ke, Pu Chun (2017). Effects of Protein Corona on IAPP Amyloid Aggregation, Fibril Remodelling, and Cytotoxicity. Scientific Reports, 7 (1) 2455. doi: 10.1038/s41598-017-02597-0
2017
Journal Article
Differential effects of silver and iron oxide nanoparticles on IAPP amyloid aggregation
Wang, Miaoyi, Kakinen, Aleksandr, Pilkington, Emily H., Davis, Thomas P. and Ke, Pu Chun (2017). Differential effects of silver and iron oxide nanoparticles on IAPP amyloid aggregation. Biomaterials Science, 5 (3), 485-493. doi: 10.1039/c6bm00764c
2017
Conference Publication
Mesoscopic properties and molecular mechanisms of IAPP amyloid inhibition and remodeling with small molecules
Kakinen, Aleksandr, Wang, Bo, Ge, Xinwei, Mezzenga, Raffaele, Davis, Thomas P., Ding, Feng and Chun Ke, Pu (2017). Mesoscopic properties and molecular mechanisms of IAPP amyloid inhibition and remodeling with small molecules. Biophysical Society 61st Annual Meeting, New Orleans, LA United States, 11-15 February 2017. St Louis, MO United States: Cell Press. doi: 10.1016/j.bpj.2016.11.1839
2016
Journal Article
Solubility-driven toxicity of CuO nanoparticles to Caco2 cells and Escherichia coli: effect of sonication energy and test environment
Käkinen, Aleksandr, Kahru, Anne, Nurmsoo, Helen, Kubo, Anna-Liisa and Bondarenko, Olesja M. (2016). Solubility-driven toxicity of CuO nanoparticles to Caco2 cells and Escherichia coli: effect of sonication energy and test environment. Toxicology in Vitro, 36, 172-179. doi: 10.1016/j.tiv.2016.08.004
2016
Journal Article
Inhibition of hIAPP amyloid aggregation and pancreatic beta-cell toxicity by OH-terminated PAMAM dendrimer
Gurzov, Esteban N., Wang, Bo, Pilkington, Emily H., Chen, Pengyu, Kakinen, Aleksandr, Stanley, William J., Litwak, Sara A., Hanssen, Eric G., Davis, Thomas P., Ding, Feng and Ke, Pu Chun (2016). Inhibition of hIAPP amyloid aggregation and pancreatic beta-cell toxicity by OH-terminated PAMAM dendrimer. Small, 12 (12), 1615-1626. doi: 10.1002/smll.201502317
2016
Journal Article
Pancreatic beta-Cell Membrane Fluidity and Toxicity Induced by Human Islet Amyloid Polypeptide Species
Pilkington, Emily H., Gurzov, Esteban N., Kakinen, Aleksandr, Litwak, Sara A., Stanley, William J., Davis, Thomas P. and Ke, Pu Chun (2016). Pancreatic beta-Cell Membrane Fluidity and Toxicity Induced by Human Islet Amyloid Polypeptide Species. Scientific Reports, 6 (1) 21274. doi: 10.1038/srep21274
2016
Journal Article
An interlaboratory comparison of nanosilver characterisation and hazard identification: harmonising techniques for high quality data
Jemec, Anita, Kahru, Anne, Potthoff, Annegret, Drobne, Damjana, Heinlaan, Margit, Böhme, Steffi, Geppert, Mark, Novak, Sara, Schirmer, Kristin, Rekulapally, Rohit, Singh, Shashi, Aruoja, Villem, Sihtmäe, Mariliis, Juganson, Katre, Käkinen, Aleksandr and Kühnel, Dana (2016). An interlaboratory comparison of nanosilver characterisation and hazard identification: harmonising techniques for high quality data. Environment International, 87, 20-32. doi: 10.1016/j.envint.2015.10.014
2016
Journal Article
Stabilizing off-pathway oligomers by polyphenol nanoassemblies for IAPP aggregation inhibition
Nedumpully-Govindan, Praveen, Kakinen, Aleksandr, Pilkington, Emily H., Davis, Thomas P., Ke, Pu Chun and Ding, Feng (2016). Stabilizing off-pathway oligomers by polyphenol nanoassemblies for IAPP aggregation inhibition. Scientific Reports, 6 (1) 19463. doi: 10.1038/srep19463
2016
Journal Article
Synthesis and in vitro properties of iron oxide nanoparticles grafted with brushed phosphorylcholine and polyethylene glycol
Blin, Thomas, Kakinen, Aleksandr, Pilkington, Emily H., Ivask, Angela, Ding, Feng, Quinn, John F., Whittaker, Michael R., Ke, Pu Chun and Davis, Thomas P. (2016). Synthesis and in vitro properties of iron oxide nanoparticles grafted with brushed phosphorylcholine and polyethylene glycol. Polymer Chemistry, 7 (10), 1931-1944. doi: 10.1039/c5py02024g
2016
Journal Article
Brushed polyethylene glycol and phosphorylcholine for grafting nanoparticles against protein binding
Wang, Bo, Blin, Thomas, Kakinen, Aleksandr, Ge, Xinwei, Pilkington, Emily H., Quinn, John F., Whittaker, Michael R., Davis, Thomas P., Ke, Pu Chun and Ding, Feng (2016). Brushed polyethylene glycol and phosphorylcholine for grafting nanoparticles against protein binding. Polymer Chemistry, 7 (45), 6875-6879. doi: 10.1039/c6py01480a
2015
Journal Article
Dissolution of CuO nanoparticles and their in vitro toxicity to Caco-2 cells and bacteria Escherichia coli depends on CuO ultrasonication protocol
Bondarenko, O., Käkinen, A., Nurmsoo, H. and Kahru, A. (2015). Dissolution of CuO nanoparticles and their in vitro toxicity to Caco-2 cells and bacteria Escherichia coli depends on CuO ultrasonication protocol. Toxicology Letters, 238 (2), S210-S210. doi: 10.1016/j.toxlet.2015.08.624
2015
Journal Article
Toxicity of 11 metal oxide nanoparticles to three mammalian cell types in vitro
Ivask, Angela, Titma, Tiina, Visnapuu, Meeri, Vija, Heiki, Kaekinen, Aleksandr, Sihtmaee, Mariliis, Pokhrel, Suman, Maedler, Lutz, Heinlaan, Margit, Kisand, Vambola, Shimmo, Ruth and Kahru, Anne (2015). Toxicity of 11 metal oxide nanoparticles to three mammalian cell types in vitro. Current Topics in Medicinal Chemistry, 15 (18), 1914-1929. doi: 10.2174/1568026615666150506150109
2014
Journal Article
Size-dependent toxicity of silver nanoparticles to bacteria, yeast, algae, crustaceans and mammalian cells in vitro
Ivask, Angela, Kurvet, Imbi, Kasemets, Kaja, Blinova, Irina, Aruoja, Villem, Suppi, Sandra, Vija, Heiki, Kaekinen, Aleksandr, Titma, Tiina, Heinlaan, Margit, Visnapuu, Meeri, Koller, Dagmar, Kisand, Vambola and Kahru, Anne (2014). Size-dependent toxicity of silver nanoparticles to bacteria, yeast, algae, crustaceans and mammalian cells in vitro. PLoS One, 9 (7) e102108. doi: 10.1371/journal.pone.0102108
2014
Journal Article
Selective performance of sol-gel synthesised titanium dioxide photocatalysts in aqueous oxidation of various-type organic pollutants
Klauson, Deniss, Budarnaja, Olga, Stepanova, Kristina, Krichevskaya, Marina, Dedova, Tatjana, Käkinen, Aleksandr and Preis, Sergei (2014). Selective performance of sol-gel synthesised titanium dioxide photocatalysts in aqueous oxidation of various-type organic pollutants. Kinetics and Catalysis, 55 (1), 47-55. doi: 10.1134/s0023158414010030
2013
Journal Article
Aqueous photocatalytic oxidation of prednisolone
Klauson, Deniss, Pilnik-Sudareva, Jana, Pronina, Natalja, Budarnaja, Olga, Krichevskaya, Marina, Käkinen, Aleksandr, Juganson, Katre and Preis, Sergei (2013). Aqueous photocatalytic oxidation of prednisolone. Central European Journal of Chemistry, 11 (10), 1620-1633. doi: 10.2478/s11532-013-0290-8
2013
Journal Article
Interaction of firefly luciferase and silver nanoparticles and its impact on enzyme activity
Kaekinen, Aleksandr, Ding, Feng, Chen, Pengyu, Mortimer, Monika, Kahru, Anne and Ke, Pu Chun (2013). Interaction of firefly luciferase and silver nanoparticles and its impact on enzyme activity. Nanotechnology, 24 (34) 345101. doi: 10.1088/0957-4484/24/34/345101
2013
Conference Publication
Biological effects of nanoparticles of silver, gold, TiO2 and nanoporous silica to selected invertebrate species and bacteria: FP7 project NanoValid
Bondarenko, Olesja, Ivask, Angela, Kaekinen, Aleksandr, Aruoja, Villem, Blinova, Irina, Juganson, Katre, Kasemets, Kaja, Kuennis-Beres, Kai, Kurvet, Imbi, Mortimer, Monika, Sihtmaee, Mariliis and Kahru, Anne (2013). Biological effects of nanoparticles of silver, gold, TiO2 and nanoporous silica to selected invertebrate species and bacteria: FP7 project NanoValid. 49th Congress of the European Societies of Toxicology (EUROTOX), Interlaken, Switzerland, 1-4 September 2013. Shannon, Ireland: Elsevier . doi: 10.1016/j.toxlet.2013.05.146
2013
Journal Article
Competitive binding of natural amphiphiles with graphene derivatives
Radic, Slaven, Geitner, Nicholas K., Podila, Ramakrishna, Kaekinen, Aleksandr, Chen, Pengyu, Ke, Pu Chun and Ding, Feng (2013). Competitive binding of natural amphiphiles with graphene derivatives. Scientific Reports, 3 (1) 2273. doi: 10.1038/srep02273
Funding
Current funding
Supervision
Availability
- Dr Aleksandr Kakinen is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Inflammation and chronic infections in the pathogenesis of Alzheimers disease: the role of amyloid cross-seeding
Principal Advisor
Other advisors: Professor Thomas Davis
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Doctor Philosophy
Investigating the role of gut-bacteria in neurodegenerative diseases
Associate Advisor
Other advisors: Professor Thomas Davis
Media
Enquiries
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