
Overview
Background
I am a Research Fellow in Bioinformatics, holding a joint position with QBI the Bredy group (50%) and IMB the Palpant group (50%). With over 15 years of experience in the bioinformatics/NGS field, my journey began with the greenfield development of three NGS platforms: 454, Illumina, and SOLiD. This experience has equipped me with extensive expertise in bioinformatic analysis, particularly in analyzing a variety of NGS data types. As the leader of the bioinformatics core facility at QBI from 2012 to 2022, my role was primarily focused on providing bioinformatics services. However, I have also been actively engaged in custom programming and analysis for numerous projects, allowing me to make significant intellectual contributions and deepen my involvement in research studies. Despite the typical service-oriented position of bioinformaticians, my publication record is notable, featuring over 40 peer-reviewed publications, with me serving as the first, co-first, or last author on 16 of them. Since 2019, my work has garnered 1,525 citations (as per Google Scholar, as of 12 Jan 2024), with 41.2% of my publications ranking in the top 10% of journals based on the CiteScore Percentile Source from SciVal. My contributions to bioinformatics are showcased in prestigious journals, with notable examples including lncRNA capture sequencing and ATAC-seq data analysis (Nature Communications, 2023) and (Cell Reports, 2022), de novo transcriptome assembly (Development, 2022), noncanonical structure Z-DNA analysis (Nature Neuroscience, 2020), DNA modification m6dA data analysis (Nature Neuroscience, 2019), whole-exome sequencing data analysis (Genome Medicine, 2017), and cross-ethnic meta-analysis (Nature Communications, 2017).
Availability
- Dr Qiongyi Zhao is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Engineering, Shanghai Jiao Tong University
- Doctoral Diploma of Science (Advanced), University of the Chinese Academy of Science
Works
Search Professor Qiongyi Zhao’s works on UQ eSpace
2019
Journal Article
Monozygotic twins and triplets discordant for amyotrophic lateral sclerosis display differential methylation and gene expression
Tarr, Ingrid S., McCann, Emily P., Benyamin, Beben, Peters, Timothy J., Twine, Natalie A., Zhang, Katharine Y., Zhao, Qiongyi, Zhang, Zong-Hong, Rowe, Dominic B., Nicholson, Garth A., Bauer, Denis, Clark, Susan J., Blair, Ian P. and Williams, Kelly L. (2019). Monozygotic twins and triplets discordant for amyotrophic lateral sclerosis display differential methylation and gene expression. Scientific Reports, 9 (1) 8254, 8254. doi: 10.1038/s41598-019-44765-4
2019
Journal Article
The DNA modification N6-methyl-2’-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction
Li, Xiang, Zhao, Qiongyi, Wei, Wei, Lin, Quan, Magnan, Christophe, Emami, Michael R., Wearick-Silva, Luis E., Viola, Thiago W., Marshall, Paul R., Yin, Jiayu, Madugalle, Sachithrani U., Wang, Ziqi, Nainar, Sarah, Vågbø, Cathrine Broberg, Leighton, Laura J., Zajaczkowski, Esmi L., Ke, Ke, Grassi-Oliveira, Rodrigo, Bjørås, Magnar, Baldi, Pierre F., Spitale, Robert C. and Bredy, Timothy W. (2019). The DNA modification N6-methyl-2’-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction. Nature Neuroscience, 22 (4), 534-544. doi: 10.1038/s41593-019-0339-x
2018
Journal Article
Bioorthogonal metabolic labeling of nascent RNA in neurons improves the sensitivity of transcriptome-wide profiling
Zajaczkowski, Esmi L., Zhao, Qiong-Yi, Zhang, Zong Hong, Li, Xiang, Wei, Wei, Marshall, Paul R., Leighton, Laura J., Nainar, Sarah, Feng, Chao, Spitale, Robert C. and Bredy, Timothy W. (2018). Bioorthogonal metabolic labeling of nascent RNA in neurons improves the sensitivity of transcriptome-wide profiling. ACS Chemical Neuroscience, 9 (7), 1858-1865. doi: 10.1021/acschemneuro.8b00197
2017
Journal Article
A Functional Role for the Epigenetic Regulator ING1 in Activity-induced Gene Expression in Primary Cortical Neurons
Leighton, Laura J., Zhao, Qiongyi, Li, Xiang, Dai, Chuanyang, Marshall, Paul R., Liu, Sha, Wang, Yi, Zajaczkowski, Esmi L., Khandelwal, Nitin, Kumar, Arvind, Bredy, Timothy W. and Wei, Wei (2017). A Functional Role for the Epigenetic Regulator ING1 in Activity-induced Gene Expression in Primary Cortical Neurons. Neuroscience, 369, 248-260. doi: 10.1016/j.neuroscience.2017.11.018
2017
Journal Article
Whole-exome sequencing in amyotrophic lateral sclerosis suggests NEK1 is a risk gene in Chinese
Gratten, Jacob, Zhao, Qiongyi, Benyamin, Beben, Garton, Fleur, He, Ji, Leo, Paul J., Mangelsdorf, Marie, Anderson, Lisa, Zhang, Zong-Hong, Chen, Lu, Chen, Xiang-Ding, Cremin, Katie, Deng, Hong-Weng, Edson, Janette, Han, Ying-Ying, Harris, Jessica, Henders, Anjali K., Jin, Zi-Bing, Li, Zhongshan, Lin, Yong, Liu, Xiaolu, Marshall, Mhairi, Mowry, Bryan J., Ran, Shu, Reutens, David C., Song, Sharon, Tan, Li-Jun, Tang, Lu, Wallace, Robyn H. ... Fan, Dongsheng (2017). Whole-exome sequencing in amyotrophic lateral sclerosis suggests NEK1 is a risk gene in Chinese. Genome Medicine, 9 (97) 97, 97. doi: 10.1186/s13073-017-0487-0
2017
Journal Article
Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis
Benyamin, Beben, He, Ji, Zhao, Qiongyi, Gratten, Jacob, Garton, Fleur, Leo, Paul J., Liu, Zhijun, Mangelsdorf, Marie, Al-Chalabi, Ammar, Anderson, Lisa, Butler, Timothy J., Chen, Lu, Chen, Xiang-Ding, Cremin, Katie, Deng, Hong-Weng, Devine, Matthew, Edson, Janette, Fifita, Jennifer A., Furlong, Sarah, Han, Ying-Ying, Harris, Jessica, Henders, Anjali K., Jeffree, Rosalind L., Jin, Zi-Bing, Li, Zhongshan, Li, Ting, Li, Mengmeng, Lin, Yong, Liu, Xiaolu ... Fan, Dongsheng (2017). Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis. Nature Communications, 8 (1) 611, 611. doi: 10.1038/s41467-017-00471-1
2017
Journal Article
Whole exome sequencing and DNA methylation analysis in a clinical amyotrophic lateral sclerosis cohort
Garton, Fleur C., Benyamin, Beben, Zhao, Qiongyi, Liu, Zhijun, Gratten, Jacob, Henders, Anjali K., Zhang, Zong-Hong, Edson, Janette, Furlong, Sarah, Morgan, Sarah, Heggie, Susan, Thorpe, Kathryn, Pfluger, Casey, Mather, Karen A., Sachdev, Perminder S., McRae, Allan F., Robinson, Matthew R., Shah, Sonia, Visscher, Peter M., Mangelsdorf, Marie, Henderson, Robert D., Wray, Naomi R. and McCombe, Pamela A. (2017). Whole exome sequencing and DNA methylation analysis in a clinical amyotrophic lateral sclerosis cohort. Molecular Genetics and Genomic Medicine, 5 (4), 418-428. doi: 10.1002/mgg3.302
2016
Other Outputs
DEAR-O: Differential Expression Analysis based on RNA-seq data - Online
Zhang, Zong-Hong, Wray, Naomi R. and Zhao, Qiong-Yi (2016). DEAR-O: Differential Expression Analysis based on RNA-seq data - Online. doi: 10.1101/069807
2016
Journal Article
Experience-dependent accumulation of N6-methyladenosine in the prefrontal cortex is associated with memory processes in mice
Widagdo, Jocelyn, Zhao, Qiong-Yi, Kempen, Marie-Jeanne, Tan, Men Chee, Ratnu, Vikram S., Wei, Wei, Leighton, Laura, Spadaro, Paola A., Edson, Janette, Anggono, Victor and Bredy, Timothy W. (2016). Experience-dependent accumulation of N6-methyladenosine in the prefrontal cortex is associated with memory processes in mice. Journal of Neuroscience, 36 (25), 6771-6777. doi: 10.1523/JNEUROSCI.4053-15.2016
2016
Journal Article
De novo assembly of transcriptome from next-generation sequencing data
Li, Xuan, Kong, Yimeng, Zhao, Qiong-Yi, Li, Yuan-Yuan and Hao, Pei (2016). De novo assembly of transcriptome from next-generation sequencing data. Quantitative Biology, 4 (2), 94-105. doi: 10.1007/s40484-016-0069-y
2016
Journal Article
Mapping and differential expression analysis from short-read RNA-Seq data in model organisms
Zhao, Qiong-Yi, Gratten, Jacob, Restaudi, Restuadi and Li, Xuan (2016). Mapping and differential expression analysis from short-read RNA-Seq data in model organisms. Quantitative Biology, 4 (1), 22-35. doi: 10.1007/s40484-016-0060-7
2016
Journal Article
Rare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder: a next-generation sequencing study
Hawi, Z., Cummins, T.D.R., Tong, J., Arcos-Burgos, M., Zhao, Q., Matthews, N., Newman, D. P., Johnson, B., Vance, A., Heussler, H. S., Levy, F., Easteal, S., Wray, N. R., Kenny, E., Morris, D., Kent, L., Gill, M. and Bellgrove, M. A. (2016). Rare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder: a next-generation sequencing study. Molecular Psychiatry, 22 (4), 580-584. doi: 10.1038/mp.2016.117
2015
Journal Article
Persistent variations in neuronal DNA methylation following cocaine self-administration and protracted abstinence in mice
Baker-Andresen, Danay, Zhao, Qiongyi, Li, Xiang, Jupp, Bianca, Chesworth, Rose, Lawrence, Andrew J. and Bredy, Timothy (2015). Persistent variations in neuronal DNA methylation following cocaine self-administration and protracted abstinence in mice. Neuroepigenetics, 4, 1-11. doi: 10.1016/j.nepig.2015.10.001
2015
Journal Article
Global transcriptome and gene regulation network for secondary metabolite biosynthesis of tea plant (Camellia sinensis)
Li, Chun-Fang, Zhu, Yan, Yu, Yao, Zhao, Qiong-Yi, Wang, Sheng-Jun, Wang, Xin-Chao, Yao, Ming-Zhe, Luo, Da, Li, Xuan, Chen, Liang and Yang, Ya-Jun (2015). Global transcriptome and gene regulation network for secondary metabolite biosynthesis of tea plant (Camellia sinensis). BMC Genomics, 16 (560) 560. doi: 10.1186/s12864-015-1773-0
2015
Journal Article
Purification of neural precursor cells reveals the presence of distinct, stimulus-specific subpopulations of quiescent precursors in the adult mouse hippocampus
Jhaveri, Dhanisha J., O'Keeffe, Imogen, Robinson, Gregory J., Zhao, Qiong-Yi, Zhang, Zong Hong, Nink, Virginia, Narayanan, Ramesh K., Osborne, Geoffrey W., Wray, Naomi R. and Bartlett, Perry F. (2015). Purification of neural precursor cells reveals the presence of distinct, stimulus-specific subpopulations of quiescent precursors in the adult mouse hippocampus. Journal of Neuroscience, 35 (21), 8132-8144. doi: 10.1523/JNEUROSCI.0504-15.2015
2015
Conference Publication
Exploring the role of histone demethylase, UTX, in mediating sex differences in fear-related learning and memory
Ratnu, V., Li, X., Emami, M., Zhao, Q. -Y. and Bredy, T. (2015). Exploring the role of histone demethylase, UTX, in mediating sex differences in fear-related learning and memory. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13188
2015
Conference Publication
Epitranscriptomic mechanisms of memory stability
Bredy, T., Widagdo, J. and Zhao, Q.-Y. (2015). Epitranscriptomic mechanisms of memory stability. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13185
2015
Journal Article
New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis
Lee, S. Hong, Byrne, Enda M., Hultman, Christina M., Kahler, Anna, Vinkhuyzen, Anna A. E., Ripke, Stephan, Andreassen, Ole A., Frisell, Thomas, Gusev, Alexander, Hu, Xinli, Karlsson, Robert, Mantzioris, Vasilis X., McGrath, John J., Mehta, Divya, Stahl, Eli A., Zhao, Qiongyi, Kendler, Kenneth S., Sullivan, Patrick F., Price, Alkes L., O'Donovan, Michael, Okada, Yukinori, Mowry, Bryan J., Raychaudhuri, Soumya, Wray, Naomi R., Schizophrenia Working Group of the Psychiatric Genomics Consortium, Rheumatoid Arthritis Consortium International and Visscher, Peter M . (2015). New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis. International Journal of Epidemiology, 44 (5) dyv136, 1-16. doi: 10.1093/ije/dyv136
2015
Conference Publication
Activity-dependent RNA methylation in learning and memory
Widagdo, J., Zhao, Q. -Y., Anggono, V. and Bredy, T. (2015). Activity-dependent RNA methylation in learning and memory. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13188
2014
Journal Article
Methyl CpG Binding Domain Ultra-Sequencing: a novel method for identifying inter-individual and cell-type-specific variation in DNA methylation
Li, X., Baker-Andresen, D., Zhao, Q., Marshall, V. and Bredy, T. W. (2014). Methyl CpG Binding Domain Ultra-Sequencing: a novel method for identifying inter-individual and cell-type-specific variation in DNA methylation. Genes, Brain and Behavior, 13 (7), 721-731. doi: 10.1111/gbb.12150
Funding
Past funding
Supervision
Availability
- Dr Qiongyi Zhao is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Exploring the role of chromatin associated RNAs and trans splicing in learning and memory
Associate Advisor
Other advisors: Professor Timothy Bredy
Completed supervision
-
2023
Master Philosophy
Long Noncoding RNAs: Needles or Straw in the Haystack?
Associate Advisor
Other advisors: Professor Timothy Bredy
Media
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