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2022

Journal Article

Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection

De Oliveira, David M. P., Forde, Brian M., Phan, Minh-Duy, Steiner, Bernhard, Zhang, Bing, Zuegg, Johannes, El-deeb, Ibrahim M., Li, Gen, Keller, Nadia, Brouwer, Stephan, Harbison-Price, Nichaela, Cork, Amanda J., Bauer, Michelle J., Alquethamy, Saleh F., Beatson, Scott A., Roberts, Jason A., Paterson, David L., McEwan, Alastair G., Blaskovich, Mark A. T., Schembri, Mark A., McDevitt, Christopher A., von Itzstein, Mark and Walker, Mark J. (2022). Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection. mBio, 13 (1) e03517, e0351721. doi: 10.1128/mbio.03517-21

Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection

2021

Journal Article

Loss of YhcB results in dysregulation of coordinated peptidoglycan, LPS and phospholipid synthesis during Escherichia coli cell growth

Goodall, Emily C. A., Isom, Georgia L., Rooke, Jessica L., Pullela, Karthik, Icke, Christopher, Yang, Zihao, Boelter, Gabriela, Jones, Alun, Warner, Isabel, Da Costa, Rochelle, Zhang, Bing, Rae, James, Tan, Wee Boon, Winkle, Matthias, Delhaye, Antoine, Heinz, Eva, Collet, Jean-Francois, Cunningham, Adam F., Blaskovich, Mark A., Parton, Robert G., Cole, Jeff A., Banzhaf, Manuel, Chng, Shu-Sin, Vollmer, Waldemar, Bryant, Jack A. and Henderson, Ian R. (2021). Loss of YhcB results in dysregulation of coordinated peptidoglycan, LPS and phospholipid synthesis during Escherichia coli cell growth. PLoS Genetics, 17 (12) e1009586, 1-40. doi: 10.1371/journal.pgen.1009586

Loss of YhcB results in dysregulation of coordinated peptidoglycan, LPS and phospholipid synthesis during Escherichia coli cell growth

2021

Journal Article

Biostimulation of bacteria in liquid culture for identification of new antimicrobial compounds

Mirzaee, Hooman, Ariens, Emily, Blaskovich, Mark A. T., Clark, Richard J. and Schenk, Peer M. (2021). Biostimulation of bacteria in liquid culture for identification of new antimicrobial compounds. Pharmaceuticals, 14 (12) 1232, 1232. doi: 10.3390/ph14121232

Biostimulation of bacteria in liquid culture for identification of new antimicrobial compounds

2021

Journal Article

CryoEM structure of the outer membrane secretin channel pIV from the f1 filamentous bacteriophage

Conners, Rebecca, McLaren, Mathew, Łapińska, Urszula, Sanders, Kelly, Stone, M. Rhia L., Blaskovich, Mark A. T., Pagliara, Stefano, Daum, Bertram, Rakonjac, Jasna and Gold, Vicki A. M. (2021). CryoEM structure of the outer membrane secretin channel pIV from the f1 filamentous bacteriophage. Nature Communications, 12 (1) 6316, 6316. doi: 10.1038/s41467-021-26610-3

CryoEM structure of the outer membrane secretin channel pIV from the f1 filamentous bacteriophage

2021

Journal Article

Instructive analysis of engineered carbon materials for potential application in water and wastewater treatment

Jain, Marut, Khan, Sadaf Aiman, Pandey, Ashish, Pant, Kamal Kishore, Ziora, Zyta Maria and Blaskovich, Mark A.T. (2021). Instructive analysis of engineered carbon materials for potential application in water and wastewater treatment. Science of The Total Environment, 793 148583, 1-19. doi: 10.1016/j.scitotenv.2021.148583

Instructive analysis of engineered carbon materials for potential application in water and wastewater treatment

2021

Journal Article

Design, synthesis and screening of a drug discovery library based on an Eremophila-derived serrulatane scaffold

Zhang, Chen, Lum, Kah Yean, Taki, Aya C., Gasser, Robin B., Byrne, Joseph J., Wang, Tao, Blaskovich, Mark A.T., Register, Emery T., Montaner, Luis J., Tietjen, Ian and Davis, Rohan A. (2021). Design, synthesis and screening of a drug discovery library based on an Eremophila-derived serrulatane scaffold. Phytochemistry, 190 112887, 1-10. doi: 10.1016/j.phytochem.2021.112887

Design, synthesis and screening of a drug discovery library based on an Eremophila-derived serrulatane scaffold

2021

Journal Article

Serum complement activation by C4BP-IgM fusion protein can restore susceptibility to antibiotics in Neisseria gonorrhoeae

Bettoni, Serena, Maziarz, Karolina, Stone, M. Rhia L., Blaskovich, Mark A. T., Potempa, Jan, Bazzo, Maria Luiza, Unemo, Magnus, Ram, Sanjay and Blom, Anna M. (2021). Serum complement activation by C4BP-IgM fusion protein can restore susceptibility to antibiotics in Neisseria gonorrhoeae. Frontiers in Immunology, 12 726801, 1-15. doi: 10.3389/fimmu.2021.726801

Serum complement activation by C4BP-IgM fusion protein can restore susceptibility to antibiotics in Neisseria gonorrhoeae

2021

Journal Article

Mesoporous silica nanoparticles improve oral delivery of antitubercular bicyclic nitroimidazoles

Ang, Chee Wei, Tan, Lendl, Qu, Zhi, West, Nicholas P., Cooper, Matthew A., Popat, Amirali and Blaskovich, Mark A.T. (2021). Mesoporous silica nanoparticles improve oral delivery of antitubercular bicyclic nitroimidazoles. ACS Biomaterials Science and Engineering, 8 (10) acsbiomaterials.1c00807, 4196-4206. doi: 10.1021/acsbiomaterials.1c00807

Mesoporous silica nanoparticles improve oral delivery of antitubercular bicyclic nitroimidazoles

2021

Journal Article

Antibiotic alternatives special issue

Blaskovich, Mark A. T. (2021). Antibiotic alternatives special issue. ACS Infectious Diseases, 7 (8), 2025-2026. doi: 10.1021/acsinfecdis.1c00388

Antibiotic alternatives special issue

2021

Journal Article

Targeted protein degradation: the new frontier of antimicrobial discovery?

Powell, Matthew, Blaskovich, Mark A. T. and Hansford, Karl A. (2021). Targeted protein degradation: the new frontier of antimicrobial discovery?. ACS Infectious Diseases, 7 (8) acsinfecdis.1c00203, 2050-2067. doi: 10.1021/acsinfecdis.1c00203

Targeted protein degradation: the new frontier of antimicrobial discovery?

2021

Journal Article

Antimicrobial screening of a historical collection of over 140 000 small molecules

Semenov, Victor V., Raihstat, Mikhail M., Konyushkin, Leonid D., Semenov, Roman V., Blaskovich, Mark A. T., Zuegg, Johannes, Elliott, Alysha G., Hansford, Karl A. and Cooper, Matthew A. (2021). Antimicrobial screening of a historical collection of over 140 000 small molecules. Mendeleev Communications, 31 (4), 484-487. doi: 10.1016/j.mencom.2021.07.015

Antimicrobial screening of a historical collection of over 140 000 small molecules

2021

Journal Article

The antimicrobial resistance crisis: an inadvertent, unfortunate but nevertheless informative experiment in evolutionary biology

Michael, Carolyn A., Gillings, Michael R., Blaskovich, Mark A. T. and Franks, Ashley E. (2021). The antimicrobial resistance crisis: an inadvertent, unfortunate but nevertheless informative experiment in evolutionary biology. Frontiers in Ecology and Evolution, 9 692674. doi: 10.3389/fevo.2021.692674

The antimicrobial resistance crisis: an inadvertent, unfortunate but nevertheless informative experiment in evolutionary biology

2021

Journal Article

Chemical synthesis of TFF3 reveals novel mechanistic insights and a gut-stable metabolite

Braga Emidio, Nayara, Meli, Rajeshwari, Tran, Hue N. T., Baik, Hayeon, Morisset-Lopez, Séverine, Elliott, Alysha G., Blaskovich, Mark A. T., Spiller, Sabrina, Beck-Sickinger, Annette G., Schroeder, Christina I. and Muttenthaler, Markus (2021). Chemical synthesis of TFF3 reveals novel mechanistic insights and a gut-stable metabolite. Journal of Medicinal Chemistry, 64 (13) acs.jmedchem.1c00767, 9484-9495. doi: 10.1021/acs.jmedchem.1c00767

Chemical synthesis of TFF3 reveals novel mechanistic insights and a gut-stable metabolite

2021

Journal Article

There is no market for new antibiotics: this allows an open approach to research and development

Klug, Dana M., Idiris, Fahima I. M., Blaskovich, Mark A. T., von Delft, Frank, Dowson, Christopher G., Kirchhelle, Claas, Roberts, Adam P., Singer, Andrew C. and Todd, Matthew H. (2021). There is no market for new antibiotics: this allows an open approach to research and development. Wellcome Open Research, 6 146, 146. doi: 10.12688/wellcomeopenres.16847.1

There is no market for new antibiotics: this allows an open approach to research and development

2021

Journal Article

Virtual Issue: Anti-infective Discovery Down Under

Blaskovich, Mark (2021). Virtual Issue: Anti-infective Discovery Down Under. ACS Infectious Diseases, 7 (6), 1555-1557. doi: 10.1021/acsinfecdis.1c00196

Virtual Issue: Anti-infective Discovery Down Under

2021

Journal Article

In Vitro activity of vancapticin MCC5145 against methicillin-resistant Staphylococcus aureus from periprosthetic joint infection

Cho, Hye-Kyung, Karau, Melissa J., Greenwood-Quaintance, Kerryl E., Hansford, Karl A., Cooper, Matthew A., Blaskovich, Mark A. T. and Patel, Robin (2021). In Vitro activity of vancapticin MCC5145 against methicillin-resistant Staphylococcus aureus from periprosthetic joint infection. Antimicrobial Agents and Chemotherapy, 65 (5) e02443-20. doi: 10.1128/aac.02443-20

In Vitro activity of vancapticin MCC5145 against methicillin-resistant Staphylococcus aureus from periprosthetic joint infection

2021

Journal Article

Antimicrobial and anticancer properties of synthetic peptides derived from the wasp Parachartergus fraternus

Muller, Jessica A. I., Lawrence, Nicole, Chan, Lai Yue, Harvey, Peta J., Elliott, Alysha G., Blaskovich, Mark A. T., Gonçalves, Jacqueline C., Galante, Priscilla, Mortari, Marcia R., Toffoli-Kadri, Mônica C., Koehbach, Johannes and Craik, David (2021). Antimicrobial and anticancer properties of synthetic peptides derived from the wasp Parachartergus fraternus. Chembiochem , 22 (8) cbic.202000716, 1415-1423. doi: 10.1002/cbic.202000716

Antimicrobial and anticancer properties of synthetic peptides derived from the wasp Parachartergus fraternus

2021

Journal Article

Bio-potency and molecular docking studies of isolated compounds from Grewia optiva J.R. Drumm. ex Burret

Ul Bari, Wasim, Ur Rehman, Najeeb, Khan, Ajmal, Ahsan Halim, Sobia, Yuan, Ye, Blaskovich, Mark A.T., Ziora, Zyta M., Zahoor, Muhammad, Naz, Sumaira, Ullah, Riaz, Alotaibi, Amal and Al-Harrasi, Ahmed (2021). Bio-potency and molecular docking studies of isolated compounds from Grewia optiva J.R. Drumm. ex Burret. Molecules, 26 (7) 2019, 2019. doi: 10.3390/molecules26072019

Bio-potency and molecular docking studies of isolated compounds from Grewia optiva J.R. Drumm. ex Burret

2021

Journal Article

Supercritical carbon dioxide assisted complexation of benznidazole: γ-cyclodextrin for improved dissolution

Ndayishimiye, John, Popat, Amirali, Kumeria, Tushar, Blaskovich, Mark A.T. and Falconer, James Robert (2021). Supercritical carbon dioxide assisted complexation of benznidazole: γ-cyclodextrin for improved dissolution. International Journal of Pharmaceutics, 596 120240, 120240. doi: 10.1016/j.ijpharm.2021.120240

Supercritical carbon dioxide assisted complexation of benznidazole: γ-cyclodextrin for improved dissolution

2021

Journal Article

Nontoxic cobalt(III) schiff base complexes with broad‐spectrum antifungal activity

Frei, Angelo, King, A. Paden, Lowe, Gabrielle J., Cain, Amy K., Short, Francesca L., Dinh, Hue, Elliott, Alysha G., Zuegg, Johannes, Wilson, Justin J. and Blaskovich, Mark A. T. (2021). Nontoxic cobalt(III) schiff base complexes with broad‐spectrum antifungal activity. Chemistry – A European Journal, 27 (6), 2021-2029. doi: 10.1002/chem.202003545

Nontoxic cobalt(III) schiff base complexes with broad‐spectrum antifungal activity