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Featured

2020

Journal Article

How to stimulate and facilitate early stage antibiotic discovery

Zuegg, Johannes, Hansford, Karl A., Elliott, Alysha G., Cooper, Matthew A. and Blaskovich, Mark A. T. (2020). How to stimulate and facilitate early stage antibiotic discovery. ACS Infectious Diseases, 6 (6), 1302-1304. doi: 10.1021/acsinfecdis.0c00163

How to stimulate and facilitate early stage antibiotic discovery

Featured

2020

Journal Article

Metal complexes as a promising source for new antibiotics

Frei, Angelo, Zuegg, Johannes, Elliott, Alysha G., Baker, Murray V., Braese, Stefan, Brown, Christopher, Chen, Feng, Dowson, Christopher Gerard, Dujardin, Gilles, Jung, Nicole, King, A. Paden, Mansour, Ahmed Moustafa, Massi, Massimiliano, Moat, John, Mohamed, Heba A., Renfrew, Anna, Rutledge, Peter, Sadler, Peter J., Todd, Matthew Houghton, Willans, Charlotte E., Wilson, Justin Jeff, Cooper, Matthew Allister and Blaskovich, Mark (2020). Metal complexes as a promising source for new antibiotics. Chemical Science, 11 (10), 2627-2639. doi: 10.1039/c9sc06460e

Metal complexes as a promising source for new antibiotics

2019

Journal Article

The diminished antimicrobial pipeline

Blaskovich, Mark A.T. (2019). The diminished antimicrobial pipeline. Microbiology Australia, 40 (2), 92-96. doi: 10.1071/MA19025

The diminished antimicrobial pipeline

Featured

2019

Journal Article

Fluoroquinolone-derived fluorescent probes for studies of bacterial penetration and efflux

Stone, M. Rhia L., Masi, Muriel, Phetsang, Wanida, Pagès, Jean-Marie, Cooper, Matthew A. and Blaskovich, Mark A. T. (2019). Fluoroquinolone-derived fluorescent probes for studies of bacterial penetration and efflux. MedChemComm, 10 (6), 901-906. doi: 10.1039/c9md00124g

Fluoroquinolone-derived fluorescent probes for studies of bacterial penetration and efflux

Featured

2018

Journal Article

Can octapeptin antibiotics combat extensively drug-resistant (XDR) bacteria?

Blaskovich, Mark A. T., Pitt, Miranda E., Elliott, Alysha G. and Cooper, Matthew A. (2018). Can octapeptin antibiotics combat extensively drug-resistant (XDR) bacteria?. Expert Review of Anti-infective Therapy, 16 (6), 485-499. doi: 10.1080/14787210.2018.1483240

Can octapeptin antibiotics combat extensively drug-resistant (XDR) bacteria?

2018

Journal Article

Fluorescent Antibiotics: New Research Tools to Fight Antibiotic Resistance

Stone, M Rhia L., Butler, Mark S., Phetsang, Wanida, Cooper, Matthew A. and Blaskovich, Mark A. T. (2018). Fluorescent Antibiotics: New Research Tools to Fight Antibiotic Resistance. Trends in Biotechnology, 36 (5), 523-536. doi: 10.1016/j.tibtech.2018.01.004

Fluorescent Antibiotics: New Research Tools to Fight Antibiotic Resistance

Featured

2018

Journal Article

Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria

Velkov, Tony, Gallardo-Godoy, Alejandra, Swarbrick, James D., Blaskovich, Mark A. T., Elliott, Alysha G., Han, Meiling, Thompson, Philip E., Roberts, Kade D., Huang, Johnny X., Becker, Bernd, Butler, Mark S., Lash, Lawrence H., Henriques, Sónia Troeira, Nation, Roger L., Sivanesan, Sivashangarie, Sani, Marc-Antoine, Separovic, Frances, Mertens, Haydyn, Bulach, Dieter, Seemann, Torsten, Owen, Jeremy, Li, Jian and Cooper, Matthew A. (2018). Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria. Cell Chemical Biology, 25 (4), 380-391.e5. doi: 10.1016/j.chembiol.2018.01.005

Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria

Featured

2018

Journal Article

Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria

Blaskovich, Mark A T, Hansford, Karl A., Gong, Yujing, Butler, Mark S., Muldoon, Craig, Huang, Johnny X., Ramu, Soumya, Silva, Alberto B., Cheng, Mu, Kavanagh, Angela M., Ziora, Zyta, Premraj, Rajaratnam, Lindahl, Fredrik, Bradford, Tanya A., Lee, June C., Karoli, Tomislav, Pelingon, Ruby, Edwards, David J., Amado, Maite, Elliott, Alysha G, Phetsang, Wanida, Daud, Noor Huda, Deecke, Johan E, Sidjabat, Hanna E, Ramaologa, Sefetogi, Zuegg, Johannes, Betley, Jason R, Beevers, Andrew P G, Smith, Richard A G ... Cooper, Matthew A. (2018). Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria. Nature Communications, 9 (1) 02123, 22. doi: 10.1038/s41467-017-02123-w

Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria

Featured

2016

Journal Article

Unusual amino acids in medicinal chemistry

Blaskovich, Mark A. T. (2016). Unusual amino acids in medicinal chemistry. Journal of Medicinal Chemistry, 59 (24), 10807-10836. doi: 10.1021/acs.jmedchem.6b00319

Unusual amino acids in medicinal chemistry

Featured

2016

Journal Article

Antibiotics in the clinical pipeline at the end of 2015

Butler, Mark S., Blaskovich, Mark A. T. and Cooper, Matthew A. (2016). Antibiotics in the clinical pipeline at the end of 2015. The Journal of Antibiotics, 70 (1), 1-22. doi: 10.1038/ja.2016.72

Antibiotics in the clinical pipeline at the end of 2015

Featured

2016

Journal Article

Fluorescent trimethoprim conjugate probes to assess drug accumulation in wild type and mutant Escherichia coli

Phetsang, Wanida, Pelingon, Ruby, Butler, Mark S., KC, Sanjaya, Pitt, Miranda, Kaeslin, Geraldine, Cooper, Matthew A. and Blaskovich, Mark A. T. (2016). Fluorescent trimethoprim conjugate probes to assess drug accumulation in wild type and mutant Escherichia coli. ACS Infectious Diseases, 2 (10), 688-701. doi: 10.1021/acsinfecdis.6b00080

Fluorescent trimethoprim conjugate probes to assess drug accumulation in wild type and mutant Escherichia coli

Featured

2010

Book

Handbook on syntheses of amino acids : General routes for the syntheses of amino acids

Blaskovich, Mark A (2010). Handbook on syntheses of amino acids : General routes for the syntheses of amino acids. First ed. New York , NY, U.S.A.: Oxford University Press; American Chemical Society.

Handbook on syntheses of amino acids : General routes for the syntheses of amino acids

2025

Journal Article

Recent developments in cyclin-dependent kinase (CDK) PROTAC in cancer therapy

Nandi, Arijit, Das, Anwesha, Stone, M. Rhia L. and Blaskovich, Mark A. T. (2025). Recent developments in cyclin-dependent kinase (CDK) PROTAC in cancer therapy. ACS Medicinal Chemistry Letters, 16 (12), 2373-2384. doi: 10.1021/acsmedchemlett.5c00462

Recent developments in cyclin-dependent kinase (CDK) PROTAC in cancer therapy

2025

Journal Article

Hyperforin potentiates polymyxin B against multidrug-resistant Gram-negative pathogens via membrane disruption, biofilm eradication, and oxidative stress

Hussein, Maytham, Crawford, Simon, Baker, Mark, Floyd, Holly, Allobawi, Rafah, Blaskovich, Mark A. T., Rao, Gauri G., Zuegg, Johannes, Li, Jian and Velkov, Tony (2025). Hyperforin potentiates polymyxin B against multidrug-resistant Gram-negative pathogens via membrane disruption, biofilm eradication, and oxidative stress. Antimicrobial Agents and Chemotherapy, 69 (12) e01007-25, e0100725. doi: 10.1128/aac.01007-25

Hyperforin potentiates polymyxin B against multidrug-resistant Gram-negative pathogens via membrane disruption, biofilm eradication, and oxidative stress

2025

Journal Article

Seeing the Unseen: Imaging Bacterial Infections

Stone, Magali, Ramu, Soumya, Bhalla, Rajiv, Mardon, Karine and Blaskovich, Mark (2025). Seeing the Unseen: Imaging Bacterial Infections. Nuclear Medicine and Biology, 150-151 109403, 109403. doi: 10.1016/j.nucmedbio.2025.109403

Seeing the Unseen: Imaging Bacterial Infections

2025

Journal Article

A Comparative Review of the Pharmacology of Dalbavancin and Oritavancin for Gram-Positive Infections: Birds of a Feather or Apples and Oranges?

Hussein, Maytham, Barclay, James, Baker, Mark, Wu, Yuezhou, Thombare, Varsha J., Patil, Nitin, Murthy, Ananya B., Sharma, Rajnikant, Rao, Gauri G., Blaskovich, Mark A. T., Li, Jian and Velkov, Tony (2025). A Comparative Review of the Pharmacology of Dalbavancin and Oritavancin for Gram-Positive Infections: Birds of a Feather or Apples and Oranges?. Infectious Diseases and Therapy, 14 (10), 2221-2246. doi: 10.1007/s40121-025-01215-1

A Comparative Review of the Pharmacology of Dalbavancin and Oritavancin for Gram-Positive Infections: Birds of a Feather or Apples and Oranges?

2025

Journal Article

Loss of cardiolipin and porins bypasses the essentiality of the sigma E cell envelope stress response in Escherichia coli

Yang, Zihao, Goodall, Emily C. A., Zhang, Bing, Torres, Von V. L., Rooke, Jessica L., Pullela, Karthik, Da Costa, Rochelle M., Icke, Christopher, Blaskovich, Mark A.T., Legood, Simon, Cunningham, Adam F., Vollmer, Waldemar, Bryant, Jack A. and Henderson, Ian R. (2025). Loss of cardiolipin and porins bypasses the essentiality of the sigma E cell envelope stress response in Escherichia coli. mBio, 16 (9) e01613-25, e0161325. doi: 10.1128/mbio.01613-25

Loss of cardiolipin and porins bypasses the essentiality of the sigma E cell envelope stress response in Escherichia coli

2025

Journal Article

RhoA and Rac1 as mechanotransduction mediators in colorectal cancer

Yadav, Sharda, K. C., Sanjaya, Blaskovich, Mark A. T., Lu, Cu‐tai, Lam, Alfred K and Nguyen, Nam‐Trung (2025). RhoA and Rac1 as mechanotransduction mediators in colorectal cancer. Advanced Biology, 9 (8) 2400626, 1-13. doi: 10.1002/adbi.202400626

RhoA and Rac1 as mechanotransduction mediators in colorectal cancer

2025

Journal Article

Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides

Lee, Ka Kiu, Łapińska, Urszula, Tolle, Giulia, Micaletto, Maureen, Zhang, Bing, Phetsang, Wanida, Verderosa, Anthony D, Invergo, Brandon M, Westley, Joseph, Bebes, Attila, Yuecel, Raif, O'Neill, Paul A, Farbos, Audrey, Jeffries, Aaron R, van Houte, Stineke, Caboni, Pierluigi, Blaskovich, Mark AT, Housden, Benjamin E, Tsaneva-Atanasova, Krasimira and Pagliara, Stefano (2025). Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides. eLife, 13. doi: 10.7554/elife.99752.4

Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides

2025

Journal Article

Nanoparticle based antigen detection of norovirus in human faecal samples: A proof-of-concept study

Pandey, Rishi, Gyawali, Pradip, Blaskovich, Mark A.T. and Sanjaya, K.C. (2025). Nanoparticle based antigen detection of norovirus in human faecal samples: A proof-of-concept study. Environmental Nanotechnology, Monitoring & Management, 23 101064, 1-7. doi: 10.1016/j.enmm.2025.101064

Nanoparticle based antigen detection of norovirus in human faecal samples: A proof-of-concept study