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2025

Journal Article

Mental health and sleep correlates of self-reported outdoor daylight exposure in over 13,000 adults with depression

Crouse, Jacob J., Park, Shin Ho, Mitchell, Brittany L., Byrne, Enda M., Medland, Sarah E., Lin, Tian, Scott, Jan, de Haan, Zsofi, Tonini, Emiliana, Iorfino, Frank, Wray, Naomi R., Martin, Nicholas G. and Hickie, Ian B. (2025). Mental health and sleep correlates of self-reported outdoor daylight exposure in over 13,000 adults with depression. European Psychiatry, 68 (1) e41, 1-34. doi: 10.1192/j.eurpsy.2025.20

Mental health and sleep correlates of self-reported outdoor daylight exposure in over 13,000 adults with depression

2025

Journal Article

Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies

Adams, Mark J., Streit, Fabian, Meng, Xiangrui, Awasthi, Swapnil, Adey, Brett N., Choi, Karmel W., Chundru, V. Kartik, Coleman, Jonathan R.I., Ferwerda, Bart, Foo, Jerome C., Gerring, Zachary F., Giannakopoulou, Olga, Gupta, Priya, Hall, Alisha S.M., Harder, Arvid, Howard, David M., Hübel, Christopher, Kwong, Alex S.F., Levey, Daniel F., Mitchell, Brittany L., Ni, Guiyan, Ota, Vanessa K., Pain, Oliver, Pathak, Gita A., Schulte, Eva C., Shen, Xueyi, Thorp, Jackson G., Walker, Alicia, Yao, Shuyang ... McIntosh, Andrew M. (2025). Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies. Cell, 188 (3), 640-652.e9. doi: 10.1016/j.cell.2024.12.002

Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies

2024

Journal Article

The effect of polygenic liability to mental disorders on COVID-19 outcomes in people with depression: the mediating role of anxiety

Monistrol-Mula, Anna, Felez-Nobrega, Mireia, Byrne, Enda M., Lind, Penelope A., Hickie, Ian B., Martin, Nicholas G., Medland, Sarah E., Colodro-Conde, Lucía and Mitchell, Brittany L. (2024). The effect of polygenic liability to mental disorders on COVID-19 outcomes in people with depression: the mediating role of anxiety. Psychological Medicine, 54 (15), 4140-4149. doi: 10.1017/s0033291724001983

The effect of polygenic liability to mental disorders on COVID-19 outcomes in people with depression: the mediating role of anxiety

2024

Journal Article

Development and temporal validation of a clinical prediction model of transition to psychosis in individuals at ultra-high risk in the UHR 1000+ cohort

Hartmann, Simon, Dwyer, Dominic, Cavve, Blake, Byrne, Enda M., Scott, Isabelle, Gao, Caroline, Wannan, Cassandra, Yuen, Hok Pan, Hartmann, Jessica, Lin, Ashleigh, Wood, Stephen J., Wigman, Johanna T.W., Middeldorp, Christel M., Thompson, Andrew, Amminger, Paul, Schlögelhofer, Monika, Riecher-Rössler, Anita, Chen, Eric Y.H., Hickie, Ian B., Phillips, Lisa J., Schäfer, Miriam R., Mossaheb, Nilufar, Smesny, Stefan, Berger, Gregor, de Haan, Lieuwe, Nordentoft, Merete, Verma, Swapna, Nieman, Dorien H., McGorry, Patrick D. ... Nelson, Barnaby (2024). Development and temporal validation of a clinical prediction model of transition to psychosis in individuals at ultra-high risk in the UHR 1000+ cohort. World Psychiatry, 23 (3), 400-410. doi: 10.1002/wps.21240

Development and temporal validation of a clinical prediction model of transition to psychosis in individuals at ultra-high risk in the UHR 1000+ cohort

2024

Journal Article

Genome-wide meta-analysis of ascertainment and symptom structures of major depression in case-enriched and community cohorts

Adams, Mark J., Thorp, Jackson G., Jermy, Bradley S., Kwong, Alex S. F., Kõiv, Kadri, Grotzinger, Andrew D., Nivard, Michel G., Marshall, Sally, Milaneschi, Yuri, Baune, Bernhard T., Müller-Myhsok, Bertram, Penninx, Brenda W. J. H., Boomsma, Dorret I., Levinson, Douglas F., Breen, Gerome, Pistis, Giorgio, Grabe, Hans J., Tiemeier, Henning, Berger, Klaus, Rietschel, Marcella, Magnusson, Patrik K., Uher, Rudolf, Hamilton, Steven P., Lucae, Susanne, Lehto, Kelli, Li, Qingqin S., Byrne, Enda M., Hickie, Ian B., Martin, Nicholas G. ... Derks, Eske M. (2024). Genome-wide meta-analysis of ascertainment and symptom structures of major depression in case-enriched and community cohorts. Psychological Medicine, 54 (12), 3459-3468. doi: 10.1017/s0033291724001880

Genome-wide meta-analysis of ascertainment and symptom structures of major depression in case-enriched and community cohorts

2024

Journal Article

Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression

Crouse, Jacob J., Park, Shin Ho, Byrne, Enda M., Mitchell, Brittany L., Scott, Jan, Medland, Sarah E., Lin, Tian, Wray, Naomi R., Martin, Nicholas G. and Hickie, Ian B. (2024). Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression. Molecular Psychiatry, 29 (9), 2765-2773. doi: 10.1038/s41380-024-02492-x

Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression

2024

Journal Article

Markers of positive affect and brain state synchrony discriminate melancholic from non-melancholic depression using naturalistic stimuli

Mosley, Philip E., van der Meer, Johan N., Hamilton, Lachlan H. W., Fripp, Jurgen, Parker, Stephen, Jeganathan, Jayson, Breakspear, Michael, Parker, Richard, Holland, Rebecca, Mitchell, Brittany L., Byrne, Enda, Hickie, Ian B., Medland, Sarah E., Martin, Nicholas G. and Cocchi, Luca (2024). Markers of positive affect and brain state synchrony discriminate melancholic from non-melancholic depression using naturalistic stimuli. Molecular Psychiatry, 30 (3), 848-860. doi: 10.1038/s41380-024-02699-y

Markers of positive affect and brain state synchrony discriminate melancholic from non-melancholic depression using naturalistic stimuli

2024

Journal Article

Combining clinical with cognitive or magnetic resonance imaging data for predicting transition to psychosis in ultra high-risk patients: data from the PACE 400 cohort

Hartmann, Simon, Cearns, Micah, Pantelis, Christos, Dwyer, Dominic, Cavve, Blake, Byrne, Enda, Scott, Isabelle, Yuen, Hok Pan, Gao, Caroline, Allott, Kelly, Lin, Ashleigh, Wood, Stephen J., Wigman, Johanna T.W., Amminger, G. Paul, McGorry, Patrick D., Yung, Alison R., Nelson, Barnaby and Clark, Scott R. (2024). Combining clinical with cognitive or magnetic resonance imaging data for predicting transition to psychosis in ultra high-risk patients: data from the PACE 400 cohort. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 9 (4), 417-428. doi: 10.1016/j.bpsc.2023.11.009

Combining clinical with cognitive or magnetic resonance imaging data for predicting transition to psychosis in ultra high-risk patients: data from the PACE 400 cohort

2024

Journal Article

Comprehensive sex-stratified genetic analysis of 28 blood biomarkers and depression reveals a significant association between depression and low levels of total protein in females

Kiewa, Jacqueline, Meltzer-Brody, Samantha, Milgrom, Jeannette, Guintivano, Jerry, Hickie, Ian B., Whiteman, David C., Olsen, Catherine M., Medland, Sarah E., Martin, Nicholas G., Wray, Naomi R. and Byrne, Enda M. (2024). Comprehensive sex-stratified genetic analysis of 28 blood biomarkers and depression reveals a significant association between depression and low levels of total protein in females. Complex Psychiatry, 10 (1-4), 19-34. doi: 10.1159/000538058

Comprehensive sex-stratified genetic analysis of 28 blood biomarkers and depression reveals a significant association between depression and low levels of total protein in females

2024

Journal Article

Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference

Meng, Xiangrui, Navoly, Georgina, Giannakopoulou, Olga, Levey, Daniel F., Koller, Dora, Pathak, Gita A., Koen, Nastassja, Lin, Kuang, Adams, Mark J., Renteria, Miguel E., Feng, Yanzhe, Gaziano, J. Michael, Stein, Dan J., Zar, Heather J., Campbell, Megan L., van Heel, David A., Trivedi, Bhavi, Finer, Sarah, McQuillin, Andrew, Bass, Nick, Chundru, V. Kartik, Martin, Hilary C., Huang, Qin Qin, Valkovskaya, Maria, Chu, Chia-Yi, Kanjira, Susan, Kuo, Po-Hsiu, Chen, Hsi-Chung, Tsai, Shih-Jen ... BioBank Japan Project (2024). Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference. Nature Genetics, 56 (2), 222-233. doi: 10.1038/s41588-023-01596-4

Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference

2024

Journal Article

Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference

Meng, Xiangrui, Navoly, Georgina, Giannakopoulou, Olga, Levey, Daniel F., Koller, Dora, Pathak, Gita A., Koen, Nastassja, Lin, Kuang, Adams, Mark J., Rentería, Miguel E., Feng, Yanzhe, Gaziano, J. Michael, Stein, Dan J., Zar, Heather J., Campbell, Megan L., van Heel, David A., Trivedi, Bhavi, Finer, Sarah, McQuillin, Andrew, Bass, Nick, Chundru, V. Kartik, Martin, Hilary C., Huang, Qin Qin, Valkovskaya, Maria, Chu, Chia-Yi, Kanjira, Susan, Kuo, Po-Hsiu, Chen, Hsi-Chung, Tsai, Shih-Jen ... BioBank Japan Project (2024). Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference. Nature Genetics, 56 (2), 222-233. doi: 10.1038/s41588-023-01596-4

Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference

2024

Journal Article

Changes in sleep patterns in people with a history of depression during the COVID-19 pandemic: a natural experiment

Shin, Mirim, Crouse, Jacob J., Byrne, Enda M., Mitchell, Brittany L., Lind, Penelope, Parker, Richard, Tonini, Emiliana, Carpenter, Joanne S., Wray, Naomi R., Colodro-Conde, Lucia, Medland, Sarah E. and Hickie, Ian B. (2024). Changes in sleep patterns in people with a history of depression during the COVID-19 pandemic: a natural experiment. BMJ Mental Health, 27 (1) e301067, e301067. doi: 10.1136/bmjment-2024-301067

Changes in sleep patterns in people with a history of depression during the COVID-19 pandemic: a natural experiment

2024

Journal Article

Evening chronotypes with depression report poorer outcomes of SSRIs: A survey-based study of self-ratings

Crouse, Jacob J., Park, Shin Ho, Byrne, Enda M., Mitchell, Brittany L., Chan, Karina, Scott, Jan, Medland, Sarah E., Martin, Nicholas G., Wray, Naomi R. and Hickie, Ian B. (2024). Evening chronotypes with depression report poorer outcomes of SSRIs: A survey-based study of self-ratings. Biological Psychiatry, 96 (1), 4-14. doi: 10.1016/j.biopsych.2023.12.023

Evening chronotypes with depression report poorer outcomes of SSRIs: A survey-based study of self-ratings

2023

Journal Article

Meta-analyses of genome-wide association studies for postpartum depression

Guintivano, Jerry, Byrne, Enda M., Kiewa, Jacqueline, Yao, Shuyang, Bauer, Anna E., Aberg, Karolina A., Adams, Mark J., Campbell, Archie, Campbell, Megan L., Choi, Karmel W., Corfield, Elizabeth C., Havdahl, Alexandra, Hucks, Donald, Koen, Nastassja, Lu, Yi, Maegbaek, Merete L., Mullaer, Jimmy, Peterson, Roseann E., Raffield, Laura M., Sallis, Hannah M., Sealock, Julia M., Walker, Alicia, Watson, Hunna J., Xiong, Ying, Yang, Jessica M. K., Anney, Richard J. L., Gordon-Smith, Katherine, Hubbard, Leon, Jones, Lisa A. ... Sullivan, Patrick (2023). Meta-analyses of genome-wide association studies for postpartum depression. American Journal of Psychiatry, 180 (12), 884-895. doi: 10.1176/appi.ajp.20230053

Meta-analyses of genome-wide association studies for postpartum depression

2023

Journal Article

Discontinuation of antidepressant treatment: a retrospective cohort study on more than 20,000 participants

Garcia-Marin, Luis M., Mulcahy, Aoibhe, Byrne, Enda M., Medland, Sarah E., Wray, Naomi R., Chafota, Freddy, Lind, Penelope A., Martin, Nicholas G., Hickie, Ian B., Rentería, Miguel E. and Campos, Adrian I. (2023). Discontinuation of antidepressant treatment: a retrospective cohort study on more than 20,000 participants. Annals of General Psychiatry, 22 (1) 49, 1-8. doi: 10.1186/s12991-023-00480-z

Discontinuation of antidepressant treatment: a retrospective cohort study on more than 20,000 participants

2023

Journal Article

Using electronic health record data to predict future self‐harm or suicidal ideation in young people treated by child and youth mental health services

Tennakoon, Gayani, Byrne, Enda M., Vaithianathan, Rhema and Middeldorp, Christel M. (2023). Using electronic health record data to predict future self‐harm or suicidal ideation in young people treated by child and youth mental health services. Suicide and Life-Threatening Behavior, 53 (5), 853-869. doi: 10.1111/sltb.12988

Using electronic health record data to predict future self‐harm or suicidal ideation in young people treated by child and youth mental health services

2023

Journal Article

GWAS meta-analysis of suicide attempt: identification of 12 genome-wide significant loci and implication of genetic risks for specific health factors

Docherty, Anna R., Mullins, Niamh, Ashley-Koch, Allison E., Qin, Xuejun, Coleman, Jonathan R.I., Shabalin, Andrey, Kang, JooEun, Murnyak, Balasz, Wendt, Frank, Adams, Mark, Campos, Adrian I., DiBlasi, Emily, Fullerton, Janice M., Kranzler, Henry R., Bakian, Amanda V., Monson, Eric T., Rentería, Miguel E., Walss-Bass, Consuelo, Andreassen, Ole A., Behera, Chittaranjan, Bulik, Cynthia M., Edenberg, Howard J., Kessler, Ronald C., Mann, J. John, Nurnberger, John I., Pistis, Giorgio, Streit, Fabian, Ursano, Robert J., Polimanti, Renato ... German Borderline Genomics Consortium (2023). GWAS meta-analysis of suicide attempt: identification of 12 genome-wide significant loci and implication of genetic risks for specific health factors. American Journal of Psychiatry, 180 (10), 723-738. doi: 10.1176/appi.ajp.21121266

GWAS meta-analysis of suicide attempt: identification of 12 genome-wide significant loci and implication of genetic risks for specific health factors

2023

Journal Article

A common genetic factor underlies genetic risk for gynaecological and reproductive disorders and is correlated with risk to depression

Kiewa, Jacqueline, Mortlock, Sally, Meltzer-Brody, Samantha, Middeldorp, Christel, Wray, Naomi R. and Byrne, Enda M. (2023). A common genetic factor underlies genetic risk for gynaecological and reproductive disorders and is correlated with risk to depression. Neuroendocrinology, 113 (10), 1059-1075. doi: 10.1159/000533413

A common genetic factor underlies genetic risk for gynaecological and reproductive disorders and is correlated with risk to depression

2023

Journal Article

The association between trauma exposure, polygenic risk and individual depression symptoms

Thorp, Jackson G., Gerring, Zachary F., Colodro-Conde, Lucía, Byrne, Enda M., Medland, Sarah E., Middeldorp, Christel M. and Derks, Eske M. (2023). The association between trauma exposure, polygenic risk and individual depression symptoms. Psychiatry Research, 321 115101, 1-8. doi: 10.1016/j.psychres.2023.115101

The association between trauma exposure, polygenic risk and individual depression symptoms

2023

Journal Article

Polygenic risk scores and the prediction of onset of mood and psychotic disorders in adolescents and young adults

Scott, Jan, Crouse, Jacob J., Medland, Sarah, Byrne, Enda, Iorfino, Frank, Mitchell, Brittany, Gillespie, Nathan A., Martin, Nicholas, Wray, Naomi and Hickie, Ian B. (2023). Polygenic risk scores and the prediction of onset of mood and psychotic disorders in adolescents and young adults. Early Intervention in Psychiatry, 18 (6), 397-405. doi: 10.1111/eip.13472

Polygenic risk scores and the prediction of onset of mood and psychotic disorders in adolescents and young adults