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2006 Journal Article Direct electrochemistry of human and rat NADPH cytochrome P450 reductaseShukla, Alka, Gillam, Elizabeth M. J. and Bernhardt, Paul V. (2006). Direct electrochemistry of human and rat NADPH cytochrome P450 reductase. Electrochemistry Communications, 8 (12), 1845-1849. doi: 10.1016/j.elecom.2006.08.020 |
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2006 Journal Article STAR: predicting recombination sites from amino acid sequenceBauer, Denis C., Boden, Mikael, Thier, Ricarda and Gillam, Elizabeth M. (2006). STAR: predicting recombination sites from amino acid sequence. BMC Bioinformatics, 7 (437) 437, 437. doi: 10.1186/1471-2105-7-437 |
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2006 Journal Article Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolitesAvent, Kathryn M., DeVoss, J. J. and Gillam, Elizabeth M. J. (2006). Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites. Chemical Research In Toxicology, 19 (7), 914-920. doi: 10.1021/tx0600090 |
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2006 Journal Article An evaluation of potential mechanism-based inactivation of human drug metabolizing cytochromes P450 by monoamine oxidase inhibitors, including isoniazidPolasek, TM, Elliot, DJ, Somogyi, AA, Gillam, EMJ, Lewis, BC and Miners, JO (2006). An evaluation of potential mechanism-based inactivation of human drug metabolizing cytochromes P450 by monoamine oxidase inhibitors, including isoniazid. British Journal of Clinical Pharmacology, 61 (5), 570-584. doi: 10.1111/j.1365-2125.2006.02627.x |
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2005 Journal Article Cytochrome P450 enzyme-mediated degradation of Echinacea alkylamides in human liver microsomesMatthias, A., Gillam, E. M. J., Penman, K. G., Matovic, N. J., Bone, K. M., De Voss, J. J. and Lehmann, R. P. (2005). Cytochrome P450 enzyme-mediated degradation of Echinacea alkylamides in human liver microsomes. Chemico-biological Interactions, 155 (1-2), 62-70. doi: 10.1016/j.cbi.2005.04.003 |
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2005 Journal Article Direct electrochemistry of enzymes from the cytochrome P4502C familyShukla, Alka, Gillam, Elizabeth M., Mitchell, Deanne J. and Bernhardt, Paul V. (2005). Direct electrochemistry of enzymes from the cytochrome P4502C family. Electrochemistry Communications, 7 (4), 437-442. doi: 10.1016/j.elecom.2005.02.021 |
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2005 Journal Article Exploring the potential of xenobiotic-metabolising enzymes as biocatalysts: Evolving designer catalysts from polyfunctional cytochrome P450 enzymesGillam, Elizabeth M. J. (2005). Exploring the potential of xenobiotic-metabolising enzymes as biocatalysts: Evolving designer catalysts from polyfunctional cytochrome P450 enzymes. Clinical and Experimental Pharmacology and Physiology, 32 (3), 147-152. doi: 10.1111/j.1440-1681.2005.04165.x |
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2005 Journal Article Modified nicotine metabolism in transgenic tobacco plants expressing the human cytochrome P450 2A6 cDNADueckershoff, K., Unger, M., Frank, A., Gillam, E. M. J., Guengerich, F. P. and Warzecha, H. (2005). Modified nicotine metabolism in transgenic tobacco plants expressing the human cytochrome P450 2A6 cDNA. Febs Letters, 579 (11), 2480-2484. doi: 10.1016/j.febslet.2005.02.082 |
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2005 Journal Article Characterization of the human cytochrome P450 forms involved in metabolism of tamoxifen to its alpha-hydroxy and alpha,4-dihydroxy derivativesNotley, LM, Crewe, KH, Taylor, PJ, Lennard, MS and Gillam, EMJ (2005). Characterization of the human cytochrome P450 forms involved in metabolism of tamoxifen to its alpha-hydroxy and alpha,4-dihydroxy derivatives. Chemical Research In Toxicology, 18 (10), 1611-1618. doi: 10.1021/tx050140s |
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2005 Journal Article P4502C18 catalyzes the metabolic bioactivation of phenytoinKinobe, Robert T., Parkinson, Oliver T., Mitchell, Deanne J. and Gillam, Elizabeth M. J. (2005). P4502C18 catalyzes the metabolic bioactivation of phenytoin. Chemical Research In Toxicology, 18 (12), 1868-1875. doi: 10.1021/tx050181o |
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2005 Journal Article Functional characterisation of an engineered multidomain human P450 E1 by molecular LegoFairhead, M., Giannini, S., Gillam, E. M. J. and Gilardi, G. (2005). Functional characterisation of an engineered multidomain human P450 E1 by molecular Lego. Journal of Biological Inorganic Chemistry, 10 (8), 842-853. doi: 10.1007/s00775-005-0033-1 |
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2004 Journal Article Assessment of arginine 97 and lysine 72 as determinants of substrate specificity in cytochrome P450 2C9 (CYP2C9)Davies, C., Witham, K., Scott, J. R., Pearson, A., De Voss, J. J., Graham, S. E. and Gillam, E. M. J. (2004). Assessment of arginine 97 and lysine 72 as determinants of substrate specificity in cytochrome P450 2C9 (CYP2C9). Drug Metabolism and Disposition, 32 (4), 431-436. doi: 10.1124/dmd.32.4.431 |
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2003 Journal Article Rabbit CYP4B1 engineered for high-level expression in Escherichia coli: ligand stabilization and processing of the N-terminus and heme prosthetic groupCheesman, Matthew J., Baer, Brian R., Zheng, Yi-Min, Gillam, Elizabeth M. J. and Rettie, Allan E. (2003). Rabbit CYP4B1 engineered for high-level expression in Escherichia coli: ligand stabilization and processing of the N-terminus and heme prosthetic group. Archives of Biochemistry And Biophysics, 416 (1), 17-24. doi: 10.1016/S0003-9861(03)00278-9 |
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2003 Journal Article Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysisGuengerich, F. Peter, Hanna, Imad H., Martin, Martha V. and Gillam, Elizabeth M. J. (2003). Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis. Biochemistry, 42 (5), 1245-1253. doi: 10.1021/bi027085w |
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2003 Journal Article Molecular modelling of human CYP1B1 substrate interactions and investigation of allelic variant effects on metabolismLewis, DFV, Gillam, EMJ, Everett, SA and Shimada, T (2003). Molecular modelling of human CYP1B1 substrate interactions and investigation of allelic variant effects on metabolism. Chemico-biological Interactions, 145 (3), 281-295. doi: 10.1016/S0009-2797(03)00021-8 |
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2003 Journal Article Evaluation of recombinant cytochromes P450 activity in metabolic pathways - ResponseGillam, EMJ and Lennard, MS (2003). Evaluation of recombinant cytochromes P450 activity in metabolic pathways - Response. Drug Metabolism and Disposition, 31 (1), 146-146. |
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2002 Journal Article DNA–protein adducts: hijacking one repair process to examine anotherGillam, E. M. J. (2002). DNA–protein adducts: hijacking one repair process to examine another. Trends in Pharmacolgical Sciences, 23 (5), 210-210. doi: 10.1016/S0165-6147(02)02033-3 |
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2002 Journal Article Use of heterologously-expressed cytochomre P450 and glutathione transferase enzymes in toxicity assaysGuengerich, F. P., Wheeler, J. B., Chun, Y. J., Kim, D., Shimada, T., Aryal, P., Oda, Y. and Gillam, E. M. J. (2002). Use of heterologously-expressed cytochomre P450 and glutathione transferase enzymes in toxicity assays. Toxicology, 181-182, 261-264. doi: 10.1016/S0300-483X(02)00293-7 |
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2002 Journal Article Bioactivation of tamoxifen by recombinant human cytochrome P450 enzymesNotely, Lisa M., de Wolf, Cornelia J. F., Wunsch, Rebecca M., Lancaster, Roy G. and Gillam, Elizabeth M. J. (2002). Bioactivation of tamoxifen by recombinant human cytochrome P450 enzymes. Chemical Research in Toxicology, 15 (5), 614-622. doi: 10.1021/tx0100439 |
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2002 Journal Article S-SXR-RMs? Selective SXR response modulators - the future of designer drug interactions?Gillam, E. M. J. (2002). S-SXR-RMs? Selective SXR response modulators - the future of designer drug interactions?. Trends in Pharmacological Sciences, 23 (8), 355-355. doi: 10.1016/s0165-6147(02)02092-8 |
