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2002 Journal Article Bioactivation of tamoxifen by recombinant human cytochrome P450 enzymesNotely, Lisa M., de Wolf, Cornelia J. F., Wunsch, Rebecca M., Lancaster, Roy G. and Gillam, Elizabeth M. J. (2002). Bioactivation of tamoxifen by recombinant human cytochrome P450 enzymes. Chemical Research in Toxicology, 15 (5), 614-622. doi: 10.1021/tx0100439 |
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2002 Journal Article S-SXR-RMs? Selective SXR response modulators - the future of designer drug interactions?Gillam, E. M. J. (2002). S-SXR-RMs? Selective SXR response modulators - the future of designer drug interactions?. Trends in Pharmacological Sciences, 23 (8), 355-355. doi: 10.1016/s0165-6147(02)02092-8 |
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2002 Journal Article Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: Formation of the 4-hydroxy, 4′-hydroxy andN-desmethyl metabolites and isomerization oftrans-4-hydroxytamoxifenCrewe, H. K., Notley, L. M., Wunsch, R. M., Lennard, M. S. and Gillam, E. M. J. (2002). Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: Formation of the 4-hydroxy, 4′-hydroxy andN-desmethyl metabolites and isomerization oftrans-4-hydroxytamoxifen. Drug Metabolism and Disposition, 30 (8), 869-874. doi: 10.1124/dmd.30.8.869 |
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2002 Journal Article Coordinating clearance - the many phases of PXR!Gillam, E. M. J. (2002). Coordinating clearance - the many phases of PXR!. Trends in Pharmacological Sciences, 23 (12), 548-549. doi: 10.1016/s0165-6147(02)02158-2 |
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2001 Journal Article The dark side of a 'detoxification' mechanismGillam, E. M. J. (2001). The dark side of a 'detoxification' mechanism. TRENDS in Pharmacological Sciences, 22 (1), 11-11. doi: 10.1016/s0165-6147(00)01601-1 |
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2001 Journal Article Metabolic activation of heterocyclic amines and other procarcinogens in Salmonella typhimurium umu tester strains expressing human cytochrome P4501A1, 1A2, 1B1, 2C9, 2D6, 2E1, and 3A4 and human NADPH-P450 reductase and bacterial O-acetyltransferaseOda, Y, Aryal, P, Terashita, T, Gillam, EMJ, Guengerich, FP and Shimada, T (2001). Metabolic activation of heterocyclic amines and other procarcinogens in Salmonella typhimurium umu tester strains expressing human cytochrome P4501A1, 1A2, 1B1, 2C9, 2D6, 2E1, and 3A4 and human NADPH-P450 reductase and bacterial O-acetyltransferase. Mutation Research-genetic Toxicology And Environmental Mutagenesis, 492 (1-2), 81-90. doi: 10.1016/S1383-5718(01)00154-1 |
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2001 Journal Article Hang onto your haem....what's happened to CYP4A?Gillam, E. M. J. (2001). Hang onto your haem....what's happened to CYP4A?. TRENDS in Pharmacological Sciences, 22 (5), 220-220. doi: 10.1016/s0165-6147(00)01709-0 |
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2001 Journal Article Exploiting the versatility of human cytochrome P450 enzymes: The promise of blue roses from biotechnologyGillam, EMJ and Guengerich, FP (2001). Exploiting the versatility of human cytochrome P450 enzymes: The promise of blue roses from biotechnology. Iubmb Life, 52 (6), 271-277. doi: 10.1080/152165401317291110 |
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2001 Journal Article Specificity of 17 beta-oestradiol and benzo[a] pyrene oxidation by polymorphic human cytochrome P4501B1 variants substituted at residues 48, 119 and 432Shimada, T, Watanabe, J, Inoue, K, Guengerich, FP and Gillam, EMJ (2001). Specificity of 17 beta-oestradiol and benzo[a] pyrene oxidation by polymorphic human cytochrome P4501B1 variants substituted at residues 48, 119 and 432. Xenobiotica, 31 (3), 163-176. doi: 10.1080/00498250110043490 |
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2001 Journal Article The PXR ligand-binding domain: How to be picky and promiscuous at the same timeGillam, E. M. J. (2001). The PXR ligand-binding domain: How to be picky and promiscuous at the same time. TRENDS in Pharmacological Sciences, 22 (9), 448-448. doi: 10.1016/S0165-6147(00)01847-2 |
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2001 Journal Article Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P4501B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009Shimada, T, Oda, Y, Gillam, EMJ, Guengerich, FP and Inoue, K (2001). Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P4501B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009. Drug Metabolism And Disposition, 29 (9), 1176-1182. |
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2000 Journal Article Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: Roles of cytochromes P450 2C9, 2C19, and 3A4Komatsu, T., Yamazaki, H., Asahi, S., Gillam, E. M. J., Guengerich, F. P., Nakajima, M. and Yokoi, T. (2000). Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: Roles of cytochromes P450 2C9, 2C19, and 3A4. Drug Metabolism and Disposition, 28 (11), 1361-1368. |
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2000 Journal Article Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: roles of cytochromes P450 2C9, 2C19, and 3A4Komatsu, T., Yamazaki, H., Asahi, S., Gillam, E. M., Guengerich, F. P., Nakajima, M. and Yokoi, T. (2000). Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: roles of cytochromes P450 2C9, 2C19, and 3A4. Drug Metabolism and Disposition, 28 (11), 1361-1368. |
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2000 Journal Article Roles of NADPH-P450 reductase in the O-Deethylation of 7-Ethoxycoumarin by recombinant human cytochrome P450 1B1 variants in Escherichia coliShimada, Tsutomu, Tsumura, Fujiko, Gillam, Elizabeth M. J., Guengerich, F. Peter and Inoue, Kiyoshi (2000). Roles of NADPH-P450 reductase in the O-Deethylation of 7-Ethoxycoumarin by recombinant human cytochrome P450 1B1 variants in Escherichia coli. Protein Expression and Purification, 20 (1), 73-80. doi: 10.1006/prep.2000.1302 |
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2000 Journal Article Phenytoin metabolism by human cytochrome P450: Involvement of P450 3A and 2C Fprms in secondary metabolism and drug-protein adduct formationCuttle, L., Munns, A., Hogg, N., Scott, J. R., Hooper, W. D., Dickinson, R. G. and Gillam, E. M. J. (2000). Phenytoin metabolism by human cytochrome P450: Involvement of P450 3A and 2C Fprms in secondary metabolism and drug-protein adduct formation. Drug Metabolism and Disposition, 28 (8), 945-950. |
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2000 Journal Article Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancerWatanabe, J., Shimada, T., Gillam, E. M. J., Ikuta, T., Suemasu, K., Higashi, Y., Gotoh, O. and Kawajiri, K. (2000). Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer. Pharmacogenetics, 10 (1), 25-33. doi: 10.1097/00008571-200002000-00004 |
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2000 Journal Article Oxidation of Indole by Cytochrome P450 EnzymesGillam, E. M. J., Notley, L. M., Cai, H. L., De Voss, J. J. and Guengerich, F. P. (2000). Oxidation of Indole by Cytochrome P450 Enzymes. Biochemistry, 39 (45), 13817-13824. doi: 10.1021/bi001229u |
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2000 Journal Article Transgenic xenosensors: humanizing miceGillam, E. M. J. (2000). Transgenic xenosensors: humanizing mice. Trends in Pharmacological Sciences, 21 (9), 330-331. doi: 10.1016/S0165-6147(00)01532-7 |
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2000 Journal Article What makes P450s work? Searches for answers with known and new P450s*Guengerich, F. P., Parikh, A., Yun, C., Kim, D., Nakamura, K., Notley, L. and Gillam, E. M. J. (2000). What makes P450s work? Searches for answers with known and new P450s*. Drug Metabolism Reviews, 32 (3-4), 267-281. doi: 10.1081/DMR-100102334 |
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1999 Journal Article Enhancement of cytochrome P-450 3A4 catalytic activities by cytochrome b(5) in bacterial membranesYamazaki, H, Nakajima, M, Nakamura, M, Asahi, S, Shimada, N, Gillam, EMJ, Guengerich, FP, Shimada, T and Yokoi, T (1999). Enhancement of cytochrome P-450 3A4 catalytic activities by cytochrome b(5) in bacterial membranes. Drug Metabolism and Disposition, 27 (9), 999-1004. |
