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2019 Journal Article The GMC superfamily of oxidoreductases revisited: analysis and evolution of fungal GMC oxidoreductasesSützl, Leander, Foley, Gabriel, Gillam, Elizabeth M J, Bodén, Mikael and Haltrich, Dietmar (2019). The GMC superfamily of oxidoreductases revisited: analysis and evolution of fungal GMC oxidoreductases. Biotechnology for Biofuels, 12 (1) 118, 118. doi: 10.1186/s13068-019-1457-0 |
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2019 Journal Article Engineering thermostable CYP2D enzymes for biocatalysis using combinatorial libraries of ancestors for directed evolution (CLADE)Gumulya, Yosephine, Huang, Weiliang, D'Cunha, Stephlina A., Richards, Katelyn E., Thomson, Raine E.S., Hunter, Dominic J.B., Baek, Jong-Min, Harris, Kurt L., Boden, Mikael, De Voss, James J., Hayes, Martin A., Isin, Emre M., Andersson, Shalini, Jurva, Ulrik and Gillam, Elizabeth (2019). Engineering thermostable CYP2D enzymes for biocatalysis using combinatorial libraries of ancestors for directed evolution (CLADE). ChemCatChem, 11 (2) cctc.201801644, 841-850. doi: 10.1002/cctc.201801644 |
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2018 Journal Article Engineering highly functional thermostable proteins using ancestral sequence reconstructionGumulya, Yosephin, Baek, Jong-Min, Wun, Shun-Jie, Thomson, Raine E. S., Harris, Kurt L., Hunter, Dominic J. B., Behrendorff, James B. Y. H., Kulig, Justyna, Zheng, Shan, Wu, Xueming, Wu, Bin, Stok, Jeanette E., De Voss, James J., Schenk, Gerhard, Jurva, Ulrik, Andersson, Shalini, Isin, Emre M., Bodén, Mikael, Guddat, Luke and Gillam, Elizabeth M. J. (2018). Engineering highly functional thermostable proteins using ancestral sequence reconstruction. Nature Catalysis, 1 (11), 878-888. doi: 10.1038/s41929-018-0159-5 |
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2018 Journal Article Determinants of thermostability in the cytochrome P450 foldHarris, Kurt L., Thomson, Raine E. S., Strohmaier, Silja J., Gumulya, Yosephine and Gillam, Elizabeth M. J. (2018). Determinants of thermostability in the cytochrome P450 fold. Biochimica et Biophysica Acta - Proteins and Proteomics, 1866 (1), 97-115. doi: 10.1016/j.bbapap.2017.08.003 |
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2017 Journal Article Recombinant expression and characterization of Lucilia cuprina CYP6G3: Activity and binding properties toward multiple pesticidesTraylor, Matthew J., Baek, Jong-Min, Richards, Katelyn E., Fusetto, Roberto, Huang, W., Josh, Peter, Chen, Zhenzhong, Bollapragada, Padma, O'Hair, Richard A.J., Batterham, Phillip and Gillam, Elizabeth M.J. (2017). Recombinant expression and characterization of Lucilia cuprina CYP6G3: Activity and binding properties toward multiple pesticides. Insect Biochemistry and Molecular Biology, 90, 14-22. doi: 10.1016/j.ibmb.2017.09.004 |
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2017 Journal Article Prospects for applying synthetic biology to toxicology: future opportunities and current limitations for the repurposing of cytochrome P450 systemsBehrendorff, James B. Y. H. and Gillam, Elizabeth M. J. (2017). Prospects for applying synthetic biology to toxicology: future opportunities and current limitations for the repurposing of cytochrome P450 systems. Chemical Research in Toxicology, 30 (1), 453-468. doi: 10.1021/acs.chemrestox.6b00396 |
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2016 Journal Article Exploring the past and the future of protein evolution with ancestral sequence reconstruction: the 'retro' approach to protein engineeringGumulya, Yosephine and Gillam, Elizabeth M. J. (2016). Exploring the past and the future of protein evolution with ancestral sequence reconstruction: the 'retro' approach to protein engineering. Biochemical Journal, 474 (1), 1-19. doi: 10.1042/BCJ20160507 |
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2016 Journal Article Identification, synthesis, and biological evaluation of the major human metabolite of NLRP3 inflammasome inhibitor MCC950Salla, Manohar, Butler, Mark S., Pelingon, Ruby, Kaeslin, Geraldine, Croker, Daniel E., Reid, Janet C., Baek, Jong-Min, Bernhardt, Paul V., Gillam, Elizabeth M. J., Cooper, Matthew A. and Robertson, Avril A. B. (2016). Identification, synthesis, and biological evaluation of the major human metabolite of NLRP3 inflammasome inhibitor MCC950. ACS Medicinal Chemistry Letters, 7 (12), 1034-1038. doi: 10.1021/acsmedchemlett.6b00198 |
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2016 Journal Article Emerging roles for brain drug-metabolizing cytochrome P450 enzymes in neuropsychiatric conditions and responses to drugsToselli, Francesca, Dodd, Peter R. and Gillam, Elizabeth M. J. (2016). Emerging roles for brain drug-metabolizing cytochrome P450 enzymes in neuropsychiatric conditions and responses to drugs. Drug Metabolism Reviews, 48 (3), 379-404. doi: 10.1080/03602532.2016.1221960 |
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2016 Journal Article ReX: A suite of computational tools for the design, visualization, and analysis of chimeric protein librariesHuang, Weiliang, Johnston, Wayne A., Boden, Mikael and Gillam, Elizabeth M.J. (2016). ReX: A suite of computational tools for the design, visualization, and analysis of chimeric protein libraries. BioTechniques, 60 (2), 91-94. doi: 10.2144/000114381 |
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2016 Journal Article In vitro metabolism of the anti-inflammatory clerodane diterpenoid polyandric acid A and its hydrolysis product by human liver microsomes and recombinant cytochrome P450 and UDP-glucuronosyltransferase enzymesBendikov, Matthew Y., Miners, John O., Simpson, Bradley S., Elliot, David J., Semple, Susan J., Claudie, David J., McKinnon, Ross A., Gillam, Elizabeth M. and Sykes, Matthew J. (2016). In vitro metabolism of the anti-inflammatory clerodane diterpenoid polyandric acid A and its hydrolysis product by human liver microsomes and recombinant cytochrome P450 and UDP-glucuronosyltransferase enzymes. Xenobiotica, 47 (6), 1-9. doi: 10.1080/00498254.2016.1203041 |
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2015 Journal Article Gene expression profiling of cytochromes P450, ABC transporters and their principal transcription factors in the amygdala and prefrontal cortex of alcoholics, smokers and drug-free controls by qRT-PCRToselli, Francesca, de Waziers, Isabelle, Dutheil, Mary, Vincent, Marc, Wilce, Peter A., Dodd, Peter R., Beaune, Philippe, Loriot, Marie-Anne and Gillam, Elizabeth M. J. (2015). Gene expression profiling of cytochromes P450, ABC transporters and their principal transcription factors in the amygdala and prefrontal cortex of alcoholics, smokers and drug-free controls by qRT-PCR. Xenobiotica, 45 (12), 1129-1137. doi: 10.3109/00498254.2015.1040102 |
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2015 Journal Article Expression of CYP2E1 and CYP2U1 proteins in amygdala and prefrontal cortex: influence of alcoholism and smokingToselli, Francesca, Depaz, Iris M. Booth, Worrall, Simon, Etheridge, Naomi, Dodd, Peter R., Wilce, Peter A. and Gillam, Elizabeth M. J. (2015). Expression of CYP2E1 and CYP2U1 proteins in amygdala and prefrontal cortex: influence of alcoholism and smoking. Alcoholism: Clinical and Experimental Research, 39 (5), 790-797. doi: 10.1111/acer.12697 |
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2015 Journal Article Directed evolution of cytochrome P450 enzymes for biocatalysis: exploiting the catalytic versatility of enzymes with relaxed substrate specificityBehrendorff, James B. Y. H, Huang, Weiliang and Gillam, Elizabeth M. J (2015). Directed evolution of cytochrome P450 enzymes for biocatalysis: exploiting the catalytic versatility of enzymes with relaxed substrate specificity. Biochemical Journal, 467 (1), 1-15. doi: 10.1042/BJ20141493 |
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2015 Journal Article Differential expression of cytochrome P450 enzymes from the CYP2C subfamily in the human brainBooth Depaz, Iris M., Toselli, Francesca, Wilce, Peter A. and Gillam, Elizabeth M. J. (2015). Differential expression of cytochrome P450 enzymes from the CYP2C subfamily in the human brain. Drug Metabolism and Disposition, 43 (3), 353-357. doi: 10.1124/dmd.114.061242 |
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2014 Journal Article Restriction Enzyme-Mediated DNA Family ShufflingBehrendorff, James B. Y. H, Johnston, Wayne A. and Gillam, Elizabeth M. J (2014). Restriction Enzyme-Mediated DNA Family Shuffling. Methods in Molecular Biology, 1179, 175-187. doi: 10.1007/978-1-4939-1053-3_12 |
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2014 Journal Article PrefaceGillam, Elizabeth M.J., Copp, Janine N. and Ackerley, David F. (2014). Preface. Methods in Molecular Biology, 1179. |
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2013 Journal Article The evolution of cytochrome P450 enzymes as biocatalysts in drug discovery and developmentGillam, Elizabeth M. J. and Hayes, Martin A. (2013). The evolution of cytochrome P450 enzymes as biocatalysts in drug discovery and development. Current Topics in Medicinal Chemistry, 13 (18), 2254-2280. doi: 10.2174/15680266113136660158 |
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2013 Journal Article Differential expression of human cytochrome P450 enzymes from the CYP3A subfamily in the brains of alcoholic subjects and drug-free controlsDepaz, Iris M. Booth, Toselli, Francesca, Wilce, Peter A. and Gillam, Elizabeth M. J. (2013). Differential expression of human cytochrome P450 enzymes from the CYP3A subfamily in the brains of alcoholic subjects and drug-free controls. Drug Metabolism and Disposition, 41 (6), 1187-1194. doi: 10.1124/dmd.113.051359 |
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2013 Journal Article Soluble and membrane-bound Drosophila melanogaster CYP6G1 expressed in Escherichia coli: purification, activity, and binding properties toward multiple pesticidesCheesman, Matthew J., Traylor, Matthew. J., Hilton, Margaret E., Richards, Katelyn E., Taylor, Matthew C., Daborn, Philip J., Russell, Robyn J., Gillam, Elizabeth M. J. and Oakeshott, John G. (2013). Soluble and membrane-bound Drosophila melanogaster CYP6G1 expressed in Escherichia coli: purification, activity, and binding properties toward multiple pesticides. Insect Biochemistry and Molecular Biology, 43 (5), 455-465. doi: 10.1016/j.ibmb.2013.02.003 |
