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2016 Journal Article Characterization and structural analysis of a potent anticoagulant phospholipase A2 from Pseudechis australis snake venomDu, Qianyun Sharon, Trabi, Manuela, Richards, Renee Stirling, Mirtschin, Peter, Madaras, Frank, Nouwens, Amanda, Zhao, Kong-Nan, De Jersey, John, Lavin, Martin F., Guddat, Luke W. and Masci, Paul P. (2016). Characterization and structural analysis of a potent anticoagulant phospholipase A2 from Pseudechis australis snake venom. Toxicon, 111, 37-49. doi: 10.1016/j.toxicon.2015.12.017 |
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2016 Journal Article Commercial herbicides can trigger the oxidative inactivation of acetohydroxyacid synthaseLonhienne, Thierry, Nouwens, Amanda, Williams, Craig M., Fraser, James A., Lee, Yu-Ting, West, Nicholas P. and Guddat, Luke W. (2016). Commercial herbicides can trigger the oxidative inactivation of acetohydroxyacid synthase. Angewandte Chemie, 128 (13), 4319-4323. doi: 10.1002/ange.201511985 |
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2016 Journal Article Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution: A potential target for anti-tuberculosis drug discoveryYou, Lv, Kandale, Ajit, Wun, Shun Jie, McGeary, Ross P., Williams, Simon J., Kobe, Bostjan, Sieber, Volker, Schembri, Mark A., Schenk, Gerhard and Guddat, Luke W. (2016). Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution: A potential target for anti-tuberculosis drug discovery. Febs Journal, 283 (7), 1184-1196. doi: 10.1111/febs.13672 |
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2016 Journal Article Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid SynthaseLonhienne, Thierry, Nouwens, Amanda, Williams, Craig M., Fraser, James A., Lee, Yu-Ting, West, Nicholas P. and Guddat, Luke W. (2016). Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase. Angewandte Chemie - International Edition, 55 (13), 4247-4251. doi: 10.1002/anie.201511985 |
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2015 Journal Article Synthesis and evaluation of novel acyclic nucleoside phosphonates as inhibitors of Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferasesKaiser, Martin M., Hocková, Dana, Wang, Tzu-Hsuan, Dračínský, Martin, Poštová-Slavětínská, Lenka, Procházková, Eliška, Edstein, Michael D., Chavchich, Marina, Keough, Dianne T., Guddat, Luke W. and Janeba, Zlatko (2015). Synthesis and evaluation of novel acyclic nucleoside phosphonates as inhibitors of Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases. ChemMedChem, 10 (10), 1707-1723. doi: 10.1002/cmdc.201500322 |
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2015 Journal Article Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferasesHockova, Dana, Janeba, Zlatko, Naesens, Lieve, Edstein, Michael D., Chavchich, Marina, Keough, Dianne T. and Guddat, Luke W. (2015). Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases. Bioorganic and Medicinal Chemistry, 23 (17), 5502-5510. doi: 10.1016/j.bmc.2015.07.038 |
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2015 Journal Article First crystal structures of mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase: complexes with GMP and pyrophosphate and with acyclic nucleoside phosphonates ehose prodrugs have antituberculosis activityEng, Wai Soon, Hockova, Dana, Spacek, Petr, Janeba, Zlatko, West, Nicholas P., Woods, Kyra, Naesens, Lieve M. J., Keough, Dianne T. and Guddat, Luke W. (2015). First crystal structures of mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase: complexes with GMP and pyrophosphate and with acyclic nucleoside phosphonates ehose prodrugs have antituberculosis activity. Journal of Medicinal Chemistry, 58 (11), 4822-4838. doi: 10.1021/acs.jmedchem.5b00611 |
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2015 Journal Article Synthesis, conformational studies, and biological properties of phosphonomethoxyethyl derivatives of nucleobases with a locked conformation via a pyrrolidine ringPohl, Radek, Slavetinska, Lenka Postova, Eng, Wai Soon, Keough, Dianne T., Guddat, Luke W. and Rejman, Dominik (2015). Synthesis, conformational studies, and biological properties of phosphonomethoxyethyl derivatives of nucleobases with a locked conformation via a pyrrolidine ring. Organic and Biomolecular Chemistry, 13 (16), 4693-4705. doi: 10.1039/c5ob00097a |
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2015 Journal Article Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agentsKeough, Dianne T., Hockova, Dana, Janeba, Zlatko, Wang, Tzu-Hsuan, Naesens, Lieve, Edstein, Michael D., Chavchich, Marina and Guddat, Luke W. (2015). Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents. Journal of Medicinal Chemistry, 58 (2), 827-846. doi: 10.1021/jm501416t |
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2014 Journal Article The applications of binuclear metallohydrolases in medicine: recent advances in the design and development of novel drug leads for purple acid phosphatases, metallo-beta-lactamases and arginasesMcGeary, Ross P., Schenk, Gerhard and Guddat, Luke W. (2014). The applications of binuclear metallohydrolases in medicine: recent advances in the design and development of novel drug leads for purple acid phosphatases, metallo-beta-lactamases and arginases. European Journal of Medicinal Chemistry, 76, 132-144. doi: 10.1016/j.ejmech.2014.02.008 |
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2014 Journal Article Determination of the catalytic activity of binuclear metallohydrolases using isothermal titration calorimetryPedroso, Marcelo M., Ely, Fernanda, Lonhienne, Thierry, Gahan, Lawrence R., Ollis, David L., Guddat, Luke W. and Schenk, Gerhard (2014). Determination of the catalytic activity of binuclear metallohydrolases using isothermal titration calorimetry. Journal of Biological Inorganic Chemistry, 19 (3), 389-398. doi: 10.1007/s00775-013-1079-0 |
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2014 Journal Article International Year of CrystallographyBatten, Stuart R., Kobe, Bostjan and Guddat, Luke (2014). International Year of Crystallography. Australian Journal of Chemistry, 67 (12), 1718-1719. doi: 10.1071/CH14557 |
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2013 Journal Article Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir)Naesens, Lieve, Guddat, Luke W., Keough, Dianne T., van Kuilenburg, André B. P., Meijer, Judith, Vande Voorde, Johan and Balzarini, Jan (2013). Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir). Molecular Pharmacology, 84 (4), 615-629. doi: 10.1124/mol.113.087247 |
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2013 Journal Article Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agentsKeough, Dianne T., Hocková, Dana, Rejman, Dominik, Spaček, Petr, Vrbková, Silvie, Krečmerová, Marcela, Eng, Wai Soon, Jans, Harmen, West, Nicholas P., Naesens, Lieve M. J., de Jersey, John and Guddat, Luke W. (2013). Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents. Journal of Medicinal Chemistry, 56 (17), 6967-6984. doi: 10.1021/jm400779n |
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2013 Journal Article The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferasesBaszczynski, Ondrej, Hockova, Dana, Janeba, Zlatko, Holy, Antonin, Jansa, Petr, Dracinsky, Martin, Keough, Dianne T. and Guddat, Luke W. (2013). The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. European Journal of Medicinal Chemistry, 67, 81-89. doi: 10.1016/j.ejmech.2013.06.032 |
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2013 Journal Article Acetohydroxyacid synthase: A target for antimicrobial drug discoveryPue, Nason and Guddat, Luke W. (2013). Acetohydroxyacid synthase: A target for antimicrobial drug discovery. Current Pharmaceutical Design, 19 (5), 1-17. doi: 10.2174/13816128113199990009 |
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2013 Journal Article Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activityKeough, Dianne T., Špaček, Petr, Hocková, Dana, Tichý, Tomáš, Vrbková, Silvie, Slavětínská, Lenka, Janeba, Zlatko, Naesens, Lieve, Edstein, Michael D., Chavchich, Marina, Wang, Tzu-Hsuan, de Jersey, John and Guddat, Luke W. (2013). Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity. Journal of Medicinal Chemistry, 56 (6), 2513-2526. doi: 10.1021/jm301893b |
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2013 Journal Article Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthaseLee, Yu-Ting, Cui, Chang-Jun, Chow, Eve W. L., Pue, Nason, Lonhienne, Thierry, Wang, Jian-Guo, Fraser, James A. and Guddat, Luke W. (2013). Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase. Journal of Medicinal Chemistry, 56 (1), 210-219. doi: 10.1021/jm301501k |
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2013 Journal Article The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snakeMillers, Emma-Karin I., Johnson, Lambro A., Birrell, Geoff W., Masci, Paul P., Lavin, Martin F., de Jersey, John and Guddat, Luke W. (2013). The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake. PLoS One, 8 (1) e54104, e54104.1-e54104.12. doi: 10.1371/journal.pone.0054104 |
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2012 Journal Article Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeuticsFeder, Daniel, Hussein, Waleed M., Clayton, Daniel J., Kan, Meng-Wei, Schenk, Gerhard, McGeary, Ross P. and Guddat, Luke W. (2012). Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chemical Biology and Drug Design, 80 (5), 665-674. doi: 10.1111/cbdd.12001 |
