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2017 Journal Article Acyclic nucleoside phosphonates containing 9-deazahypoxanthine and a five-membered heterocycle as selective inhibitors of plasmodial 6-oxopurine phosphoribosyltransferasesKaiser, Martin Maxmilian, Baszczynski, Ondrej, Hockova, Dana, Postova-Slavetinska, Lenka, Dracinsky, Martin, Keough, Dianne T., Guddat, Luke W. and Janeba, Zlatko (2017). Acyclic nucleoside phosphonates containing 9-deazahypoxanthine and a five-membered heterocycle as selective inhibitors of plasmodial 6-oxopurine phosphoribosyltransferases. ChemMedChem, 12 (14), 1133-1141. doi: 10.1002/cmdc.201700293 |
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2017 Journal Article High resolution crystal structure of a fluoride-inhibited organophosphate-degrading metallohydrolaseSelleck, Christopher , Guddat, Luke W., Ollis, David L., Schenk, Gerhard and Pedroso, Marcelo Monteiro (2017). High resolution crystal structure of a fluoride-inhibited organophosphate-degrading metallohydrolase. Journal of Inorganic Biochemistry, 177, 287-290. doi: 10.1016/j.jinorgbio.2017.06.013 |
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2017 Journal Article Synthesis and evaluation of symmetric acyclic nucleoside bisphosphonates as inhibitors of the Plasmodium falciparum, Plasmodium vivax and human 6-oxopurine phosphoribosyltransferases and the antimalarial activity of their prodrugsSpacek, Petr, Keough, Dianne T., Chavchich, Marina, Dracinsky, Martin, Janeba, Zlatko, Naesens, Lieve, Edstein, Michael D., Guddat, Luke W. and Hockova, Dana (2017). Synthesis and evaluation of symmetric acyclic nucleoside bisphosphonates as inhibitors of the Plasmodium falciparum, Plasmodium vivax and human 6-oxopurine phosphoribosyltransferases and the antimalarial activity of their prodrugs. Bioorganic & Medicinal Chemistry, 25 (15), 4008-4030. doi: 10.1016/j.bmc.2017.05.048 |
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2017 Journal Article Crystal structure of plant acetohydroxyacid synthase, the target for several commercial herbicidesGarcia, Mario Daniel, Wang, Jian-Guo, Lonhienne, Thierry and Guddat, Luke William (2017). Crystal structure of plant acetohydroxyacid synthase, the target for several commercial herbicides. The FEBS Journal, 284 (13), 2037-2051. doi: 10.1111/febs.14102 |
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2017 Journal Article Oligomeric state of hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosisEng, Wai Soon, Keough, Dianne T., Hockova, Dana, Winzor, Donald J. and Guddat, Luke W. (2017). Oligomeric state of hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis. Biochimie, 135, 6-14. doi: 10.1016/j.biochi.2016.12.020 |
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2017 Journal Article The role of a FAD cofactor in the regulation of acetohydroxyacid synthase by redox signaling moleculesLonhienne, Thierry, Garcia, Mario D. and Guddat, Luke W. (2017). The role of a FAD cofactor in the regulation of acetohydroxyacid synthase by redox signaling molecules. Journal of Biological Chemistry, 292 (12), 5101-5109. doi: 10.1074/jbc.M116.773242 |
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2017 Journal Article Visualization of the reaction trajectory and transition state in a hydrolytic reaction catalyzed by a metalloenzymeSelleck, Christopher, Clayton, Daniel, Gahan, Lawrence R., Mitic, Nataša, McGeary, Ross P., Pedroso, Marcelo Monteiro, Guddat, Luke W. and Schenk, Gerhard (2017). Visualization of the reaction trajectory and transition state in a hydrolytic reaction catalyzed by a metalloenzyme. Chemistry: A European Journal, 23 (20), 4778-4781. doi: 10.1002/chem.201700866 |
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2017 Journal Article Novel nucleotide analogues bearing (1H-1,2,3-triazol-4-yl)phosphonic acid moiety as inhibitors of Plasmodium and human 6-oxopurine phosphoribosyltransferasesLukáč, Miloš, Hocková, Dana, Keough, Dianne T., Guddat, Luke W. and Janeba, Zlatko (2017). Novel nucleotide analogues bearing (1H-1,2,3-triazol-4-yl)phosphonic acid moiety as inhibitors of Plasmodium and human 6-oxopurine phosphoribosyltransferases. Tetrahedron, 73 (6), 692-702. doi: 10.1016/j.tet.2016.12.046 |
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2017 Journal Article The 2.0 Å X-ray structure for yeast acetohydroxyacid synthase provides new insights into its cofactor and quaternary structure requirementsLonhienne, Thierry, Garcia, Mario D., Fraser, James A., Williams, Craig M. and Guddat, Luke W. (2017). The 2.0 Å X-ray structure for yeast acetohydroxyacid synthase provides new insights into its cofactor and quaternary structure requirements. PLoS One, 12 (2) e0171443, e0171443.1-e0171443.13. doi: 10.1371/journal.pone.0171443 |
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2017 Journal Article Comprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide familiesGarcia, Mario D., Nouwens, Amanda, Lonhienne, Thierry G. and Guddat, Luke W. (2017). Comprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide families. Proceedings of the National Academy of Sciences, 114 (7), E1091-E1100. doi: 10.1073/pnas.1616142114 |
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2017 Journal Article Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) PhosphoribosyltransferaseŠpaček, Petr, Keough, Dianne T., Chavchich, Marina, Dračínský, Martin, Janeba, Zlatko, Naesens, Lieve, Edstein, Michael D., Guddat, Luke W. and Hocková, Dana (2017). Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase. Journal of Medicinal Chemistry, 60 (17), 7539-7554. doi: 10.1021/acs.jmedchem.7b00926 |
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2016 Journal Article AIM-1: an antibiotic-degrading metallohydrolase that displays mechanistic flexibilitySelleck, Christopher, Larrabee James A., Harmer, Jeffrey, Guddat, Luke W., Mitić, Natasa, Helweh, Waleed, Ollis, David L., Craig, Whitney R., Tierney, David L., Monteiro Pedroso, Marcelo and Schenk, Gerhard (2016). AIM-1: an antibiotic-degrading metallohydrolase that displays mechanistic flexibility. Chemistry, 22 (49), 17704-17714. doi: 10.1002/chem.201602762 |
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2016 Journal Article Crystal structures of acyclic nucleoside phosphonates in complex with Escherichia coli hypoxanthine phosphoribosyltransferaseEng, Wai Soon, Hocková, Dana, Špaček, Petr, Baszczyňski, Ondřej, Janeba, Zlatko, Naesens, Lieve, Keough, Dianne T. and Guddat, Luke W. (2016). Crystal structures of acyclic nucleoside phosphonates in complex with Escherichia coli hypoxanthine phosphoribosyltransferase. ChemistrySelect, 1 (19), 6267-6276. doi: 10.1002/slct.201601679 |
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2016 Journal Article Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferaseTeran, David, Hockova, Dana, Cesnek, Micha, Zikova, Alena, Naesens, Lieve, Keough, Dianne T. and Guddat, Luke W. (2016). Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase. Scientific Reports, 6 (1) 35894, 35894. doi: 10.1038/srep35894 |
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2016 Journal Article New strategies to combat tuberculosisSchenk, Gerhard and Guddat, Luke W. (2016). New strategies to combat tuberculosis. Australasian Biotechnology, 26 (3), 52-53. |
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2016 Journal Article Metal ions play an essential catalytic role in the mechanism of ketol-acid reductoisomeraseTadrowski, Sonya, Pedroso, Marcelo M., Sieber, Volker, Larrabee, James A., Guddat, Luke W. and Schenk, Gerhard (2016). Metal ions play an essential catalytic role in the mechanism of ketol-acid reductoisomerase. Chemistry, 22 (22), 7427-7436. doi: 10.1002/chem.201600620 |
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2016 Journal Article Characterization and structural analysis of a potent anticoagulant phospholipase A2 from Pseudechis australis snake venomDu, Qianyun Sharon, Trabi, Manuela, Richards, Renee Stirling, Mirtschin, Peter, Madaras, Frank, Nouwens, Amanda, Zhao, Kong-Nan, De Jersey, John, Lavin, Martin F., Guddat, Luke W. and Masci, Paul P. (2016). Characterization and structural analysis of a potent anticoagulant phospholipase A2 from Pseudechis australis snake venom. Toxicon, 111, 37-49. doi: 10.1016/j.toxicon.2015.12.017 |
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2016 Journal Article Commercial herbicides can trigger the oxidative inactivation of acetohydroxyacid synthaseLonhienne, Thierry, Nouwens, Amanda, Williams, Craig M., Fraser, James A., Lee, Yu-Ting, West, Nicholas P. and Guddat, Luke W. (2016). Commercial herbicides can trigger the oxidative inactivation of acetohydroxyacid synthase. Angewandte Chemie, 128 (13), 4319-4323. doi: 10.1002/ange.201511985 |
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2016 Journal Article Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution: A potential target for anti-tuberculosis drug discoveryYou, Lv, Kandale, Ajit, Wun, Shun Jie, McGeary, Ross P., Williams, Simon J., Kobe, Bostjan, Sieber, Volker, Schembri, Mark A., Schenk, Gerhard and Guddat, Luke W. (2016). Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution: A potential target for anti-tuberculosis drug discovery. Febs Journal, 283 (7), 1184-1196. doi: 10.1111/febs.13672 |
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2016 Journal Article Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid SynthaseLonhienne, Thierry, Nouwens, Amanda, Williams, Craig M., Fraser, James A., Lee, Yu-Ting, West, Nicholas P. and Guddat, Luke W. (2016). Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase. Angewandte Chemie - International Edition, 55 (13), 4247-4251. doi: 10.1002/anie.201511985 |
