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2015

Journal Article

Cytokines in graft-versus-host disease

Henden, Andrea S. and Hill, Geoffrey R. (2015). Cytokines in graft-versus-host disease. Journal of Immunology, 194 (10), 4604-4612. doi: 10.4049/jimmunol.1500117

Cytokines in graft-versus-host disease

2015

Journal Article

Autophagy is required for stem cell mobilization by G-CSF

Leveque-El Mouttie, Lucie, Vu, Therese, Lineburg, Katie E., Kuns, Rachel D., Bagger, Frederik O., Teal, Bianca E., Lor, Mary, Boyle, Glen M., Bruedigam, Claudia, Mintern, Justine D., Hill, Geoffrey R., MacDonald, Kelli P. A. and Lane, Steven W. (2015). Autophagy is required for stem cell mobilization by G-CSF. Blood, 125 (19), 2933-2936. doi: 10.1182/blood-2014-03-562660

Autophagy is required for stem cell mobilization by G-CSF

2015

Journal Article

NK cells require IL-28R for optimal in vivo activity

Souza-Fonseca-Guimaraes, Fernando, Young, Arabella, Mittal, Deepak, Martinet, Ludovic, Bruedigam, Claudia, Takeda, Kazuyoshi, Andoniou, Christopher E., Degli-Esposti, Mariapia A., Hill, Geoffrey R. and Smyth, Mark J. (2015). NK cells require IL-28R for optimal in vivo activity. Proceedings of the National Academy of Sciences of the United States of America, 112 (18), E2376-E2384. doi: 10.1073/pnas.1424241112

NK cells require IL-28R for optimal in vivo activity

2015

Journal Article

Immunosurveillance and therapy of multiple myeloma are CD226 dependent

Guillerey, Camille, de Andrade, Lucas Ferrari, Vuckovic, Slavica, Miles, Kim, Ngiow, Shin Foong, Yong, Michelle C. R., Teng, Michele W. L., Colonna, Marco, Ritchie, David S., Chesi, Martha, Bergsagel, P. Leif, Hill, Geoffrey R., Smyth, Mark J. and Martinet, Ludovic (2015). Immunosurveillance and therapy of multiple myeloma are CD226 dependent. Journal of Clinical Investigation, 125 (5), 2077-2089. doi: 10.1172/JCI77181

Immunosurveillance and therapy of multiple myeloma are CD226 dependent

Featured

2015

Journal Article

Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation

Varelias, Antiopi, Gartlan, Kate H., Kreijveld, Ellen, Olver, Stuart D., Lor, Mary, Kuns, Rachel D., Lineburg, Katie E., Teal, Bianca E., Raffelt, Neil C., Cheong, Melody, Alexander, Kylie A., Koyama, Motoko, Markey, Kate A., Sturgeon, Elise, Leach, Justine, Reddy, Pavan, Kennedy, Glen A., Yanik, Gregory A., Blazar, Bruce R., Tey, Siok-Keen, Clouston, Andrew D., MacDonald, Kelli P. A., Cooke, Kenneth R. and Hill, Geoffrey R. (2015). Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation. Blood, 125 (15), 2435-2444. doi: 10.1182/blood-2014-07-590232

Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation

2015

Journal Article

CD3 bright signals on γδ T cells identify IL-17A-producing Vγ6Vδ1+T cells

Paget, C., Chow, M. T., Gherardin, N. A., Beavis, P. A., Uldrich, A. P., Duret, H., Hassane, M., Souza-Fonseca-Guimaraes, F., Mogilenko, D. A., Staumont-Salle, D., Escalante, N. K., Hill, G. R., Neeson, P., Ritchie, D. S., Dombrowicz, D., Mallevaey, T., Trottein, F., Belz, G. T., Godfrey, D. I. and Smyth, M. J. (2015). CD3 bright signals on γδ T cells identify IL-17A-producing Vγ6Vδ1+T cells. Immunology and Cell Biology, 93 (2), 198-212. doi: 10.1038/icb.2014.94

CD3 bright signals on γδ T cells identify IL-17A-producing Vγ6Vδ1+T cells

2015

Journal Article

Autophagy and haematopoietic stem cell transplantation

Leveque, Lucie, Le Texier, Laetitia, Lineburg, Katie E., Hill, Geoffrey R. and MacDonald, Kelli P. A. (2015). Autophagy and haematopoietic stem cell transplantation. Immunology and Cell Biology, 93 (1), 43-50. doi: 10.1038/icb.2014.95

Autophagy and haematopoietic stem cell transplantation

2015

Journal Article

Post transplant CMV-specific T-cell immune reconstitution in the absence of global T-cell immunity is associated with a high risk of subsequent virus reactivation

Tey, S.-K., Davenport, M. P., Hill, G. R., Kennedy, G. A., Durrant, S. T., Khanna, R. and Cromer, D. (2015). Post transplant CMV-specific T-cell immune reconstitution in the absence of global T-cell immunity is associated with a high risk of subsequent virus reactivation. Bone Marrow Transplantation, 50 (2), 315-316. doi: 10.1038/bmt.2014.265

Post transplant CMV-specific T-cell immune reconstitution in the absence of global T-cell immunity is associated with a high risk of subsequent virus reactivation

2015

Journal Article

α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice

Uryu, Hidetaka, Hashimoto, Daigo, Kato, Koji, Hayase, Eiko, Matsuoka, Satomi, Ogasawara, Reiki, Takahashi, Shuichiro, Maeda, Yoshinobu, Iwasaki, Hiromi, Miyamoto, Toshihiro, Saijo, Shinobu, Iwakura, Yoichiro, Hill, Geoffrey R., Akashi, Koichi and Teshima, Takanori (2015). α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice. Blood, 125 (19), 3014-3023. doi: 10.1182/blood-2014-12-615781

α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice

2015

Journal Article

Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation

Ullah, Md Ashik, Revez, Joana A., Loh, Zhixuan, Simpson, Jennifer, Zhang, Vivian, Bain, Lisa, Varelias, Antiopi, Rose-John, Stefan, Blumenthal, Antje, Smyth, Mark J., Hill, Geoffrey R., Sukkar, Manuel A. R, Ferreira M. A. R. and Phipps, Simon (2015). Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation. Journal of Allergy and Clinical Immunology, 136 (4), 1065-1073. doi: 10.1016/j.jaci.2015.02.032

Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation

2014

Journal Article

Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy

Bruedigam, C., Bagger, F.O., Heidel, F.H., Paine, Kuhn C., Guignes, S., Song, A., Austin, R., Vu, T., Lee, E., Riyat, S., Moore, A.S., Lock, R.B., Bullinger, L., Hill, G.R., Armstrong, S.A., Williams, D.A. and Lane, S.W. (2014). Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy. Cell Stem Cell, 15 (6), 775-790. doi: 10.1016/j.stem.2014.11.010

Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy

Featured

2014

Journal Article

Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial

Kennedy, Glen A., Varelias, Antiopi, Vuckovic, Slavica, Le Texier, Laetitia, Gartlan, Kate H., Zhang, Ping, Thomas, Gethin, Anderson, Lisa, Boyle, Glen, Cloonan, Nicole, Leach, Justine, Sturgeon, Elise, Avery, Judy, Olver, Stuart D., Lor, Mary, Misra, Ashish K., Hutchins, Cheryl, Morton, A. James, Durrant, Simon T. S., Subramoniapillai, Elango, Butler, Jason P., Curley, Cameron I., MacDonald, Kelli P. A., Tey, Siok-Keen and Hill, Geoffrey R. (2014). Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial. The Lancet Oncology, 15 (13), 1451-1459. doi: 10.1016/S1470-2045(14)71017-4

Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial

2014

Journal Article

Ibrutinib treatment ameliorates murine chronic graft-versus-host disease

Dubovsky, Jason A., Flynn, Ryan, Du, Jing, Harrington, Bonnie K., Zhong, Yiming, Kaffenberger, Benjamin, Yang, Carrie, Towns, William H., Lehman, Amy, Johnson, Amy J., Muthusamy, Natarajan, Devine, Steven M., Jaglowski, Samantha, Serody, Jonathan S., Murphy, William J., Munn, David H., Luznik, Leo, Hill, Geoffrey R., Wong, Henry K., MacDonald, Kelli K. P., Maillard, Ivan, Koreth, John, Elias, Laurence, Cutler, Corey, Soiffer, Robert J., Antin, Joseph H., Ritz, Jerome, Panoskaltsis-Mortari, Angela, Byrd, John C. and Blazar, Bruce R. (2014). Ibrutinib treatment ameliorates murine chronic graft-versus-host disease. Journal of Clinical Investigation, 124 (11), 4867-4876. doi: 10.1172/JCI75328

Ibrutinib treatment ameliorates murine chronic graft-versus-host disease

2014

Journal Article

TRAIL+ NK Cells Control CD4+ T Cell Responses during Chronic Viral Infection to Limit Autoimmunity

Schuster, Iona S., Wikstrom, Matthew E., Brizard, Geraldine, Coudert, Jerome D., Estcourt, Marie J., Manzur, Mitali, O'Reilly, Lorraine A., Smyth, Mark J., Trapani, Joseph A., Hill, Geoffrey R., Andoniou, Christopher E. and Degli-Esposti, Mariapia A. (2014). TRAIL+ NK Cells Control CD4+ T Cell Responses during Chronic Viral Infection to Limit Autoimmunity. Immunity, 41 (4), 646-656. doi: 10.1016/j.immuni.2014.09.013

TRAIL+ NK Cells Control CD4+ T Cell Responses during Chronic Viral Infection to Limit Autoimmunity

2014

Journal Article

Reduced mucosal associated invariant T-cells are associated with increased disease severity and Pseudomonas aeruginosa infection in cystic fibrosis

Smith, Daniel J., Hill, Geoffrey R., Bell, Scott C. and Reid, David W. (2014). Reduced mucosal associated invariant T-cells are associated with increased disease severity and Pseudomonas aeruginosa infection in cystic fibrosis. PLoS ONE, 9 (10) e109891, 1-8. doi: 10.1371/journal.pone.0109891

Reduced mucosal associated invariant T-cells are associated with increased disease severity and Pseudomonas aeruginosa infection in cystic fibrosis

2014

Journal Article

CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease

Alexander K.A., Flynn R., Lineburg K.E., Kuns R.D., Teal B.E., Olver S.D., Lor M., Raffelt N.C., Koyama M., Leveque L., Le Texier L., Melino M., Markey K.A., Varelias A., Engwerda C., Serody J.S., Janela B., Ginhoux F., Clouston A.D., Blazar B.R., Hill G.R. and MacDonald K.P.A. (2014). CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease. Journal of Clinical Investigation, 124 (10), 4266-4280. doi: 10.1172/JCI75935

CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease

2014

Journal Article

The biology of graft-versus-host disease: experimental systems instructing clinical practice

Markey, Kate A., MacDonald, Kelli P. A. and Hill, Geoffrey R. (2014). The biology of graft-versus-host disease: experimental systems instructing clinical practice. Blood, 124 (3), 354-362. doi: 10.1182/blood-2014-02-514745

The biology of graft-versus-host disease: experimental systems instructing clinical practice

2014

Journal Article

Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

Flynn, Ryan, Du, Jing, Veenstra, Rachelle G., Reichenbach, Dawn K., Panoskaltsis-Mortari, Angela, Taylor, Patricia A., Freeman, Gordon J., Serody, Jonathan S., Murphy, William J., Munn, David H., Sarantopoulos, Stefanie, Luznik, Leo, Maillard, Ivan, Koreth, John, Cutler, Corey, Soiffer, Robert J., Antin, Joseph H., Ritz, Jerome, Dubovsky, Jason A., Byrd, John C., MacDonald, Kelli P., Hill, Geoff R. and Blazar, Bruce R. (2014). Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans. Blood, 123 (25), 3988-3998. doi: 10.1182/blood-2014-03-562231

Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

2014

Journal Article

Type I IFN signaling in CD8-DCs impairs Th1-dependent malaria immunity

Haque, Ashraful, Best, Shannon E., De Oca, Marcela Montes, James, Kylie R., Ammerdorffer, Anne, Edwards, Chelsea L., De Labastida Rivera, Fabian, Amante, Fiona H., Bunn, Patrick T., Sheel, Meru, Sebina, Ismail, Koyama, Motoko, Varelias, Antiopi, Hertzog, Paul J., Kalinke, Ulrich, Gun, Sin Yee, Renia, Laurent, Ruedl, Christiane, MacDonald, Kelli P.A., Hill, Geoffrey R. and Engwerda, Christian R. (2014). Type I IFN signaling in CD8-DCs impairs Th1-dependent malaria immunity. Journal of Clinical Investigation, 124 (6), 2483-2496. doi: 10.1172/JCI70698

Type I IFN signaling in CD8-DCs impairs Th1-dependent malaria immunity

2014

Journal Article

Cross-dressing by donor dendritic cells after allogeneic bone marrow transplantation contributes to formation of the immunological synapse and maximizes responses to indirectly presented antigen

Markey, Kate A., Koyama, Motoko, Gartlan, Kate H., Leveque, Lucie, Kuns, Rachel D., Lineburg, Katie E., Teal, Bianca E., MacDonald, Kelli P. A. and Hill, Geoffrey R. (2014). Cross-dressing by donor dendritic cells after allogeneic bone marrow transplantation contributes to formation of the immunological synapse and maximizes responses to indirectly presented antigen. Journal of Immunology, 192 (11), 5426-5433. doi: 10.4049/jimmunol.1302490

Cross-dressing by donor dendritic cells after allogeneic bone marrow transplantation contributes to formation of the immunological synapse and maximizes responses to indirectly presented antigen