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2014 Journal Article Carvedilol induces greater control of β2- than β1-adrenoceptor-mediated inotropic and lusitropic effects by PDE3, while PDE4 has no effect in human failing myocardiumMolenaar, Peter, Christ, Torsten, Berk, Emanuel, Engel, Andreas, Gillette, Katherine T., Galindo-Tovar, Alejandro, Ravens, Ursula and Kaumann, Alberto J. (2014). Carvedilol induces greater control of β2- than β1-adrenoceptor-mediated inotropic and lusitropic effects by PDE3, while PDE4 has no effect in human failing myocardium. Naunyn-Schmiedeberg's Archives of Pharmacology, 387 (7), 629-640. doi: 10.1007/s00210-014-0974-4 |
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2013 Journal Article Chronic activation of the low affinity site of beta(1)-adrenoceptors stimulates haemodynamics but exacerbates pressure-overload cardiac remodellingKiriazis, Helen, Tugiono, Niquita, Xu, Qi, Gao, Xiao-Ming, Jennings, Nicole L., Ming, Ziqui, Su, Yidan, Klenowski, Paul, Summers, Roger J., Kaumann, Alberto, Molenaar, Peter and Du, Xiao-Jun (2013). Chronic activation of the low affinity site of beta(1)-adrenoceptors stimulates haemodynamics but exacerbates pressure-overload cardiac remodelling. British Journal of Pharmacology, 170 (2), 352-365. doi: 10.1111/bph.12272 |
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2013 Journal Article PDE3, but not PDE4, reduces beta 1- and beta 2-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patientsMolenaar, Peter, Christ, Torsten, Hussain, Rizwan I., Engel, Andreas, Berk, Emanuel, Gillette, Katherine T., Chen, Lu, Galindo-Tovar, Alejandro, Krobert, Kurt A., Ravens, Ursula, Levy, Finn Olav and Kaumann, Alberto J. (2013). PDE3, but not PDE4, reduces beta 1- and beta 2-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients. British Journal of Pharmacology, 169 (3), 528-538. doi: 10.1111/bph.12167 |
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2013 Journal Article Expression, Regulation and Putative Nutrient-Sensing Function of Taste GPCRs in the HeartFoster, Simon R., Porrello, Enzo R., Purdue, Brooke, Chan, Hsiu-Wen, Voigt, Anja, Frenzel, Sabine, Hannan, Ross D., Moritz, Karen M., Simmons, David G., Molenaar, Peter, Roura, Eugeni, Boehm, Ulrich, Meyerhof, Wolfgang and Thomas, Walter G. (2013). Expression, Regulation and Putative Nutrient-Sensing Function of Taste GPCRs in the Heart. PLoS ONE, 8 (5) e64579, e64579-1-e64579-10. doi: 10.1371/journal.pone.0064579 |
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2011 Journal Article Computer three-dimensional anatomical reconstruction of the human sinus node and a novel paranodal areaChandler, Natalie, Aslanidi, Oleg, Buckley, David, Inada, Shin, Birchall, Steven, Atkinson, Andrew, Kirk, Danielle, Monfredi, Oliver, Molenaar, Peter, Anderson, Robert, Sharma, Vinod, Sigg, Daniel, Zhang, Henggui, Boyett, Mark and Dobrzynski, Halina (2011). Computer three-dimensional anatomical reconstruction of the human sinus node and a novel paranodal area. Anatomical Record, 294 (6), 970-979. doi: 10.1002/ar.21379 |
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2011 Journal Article Molecular architecture of the human specialised atrioventricular conduction axisGreener, I. D., Monfredi, O., Inada, S., Chandler, N. J, Tellez, J.O., Atkinson, A., Taube, M. A., Billeter, R., Anderson, R. H., Efimov, I. R., Molenaar, P., Sigg, D. C., Sharma, V., Boyett, M. R. and Dobrzynski, H. (2011). Molecular architecture of the human specialised atrioventricular conduction axis. Journal of Molecular and Cellular Cardiology, 50 (4), 642-651. doi: 10.1016/j.yjmcc.2010.12.017 |
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2011 Journal Article Human atrial β 1L-adrenoceptor but not β 3- adrenoceptor activation increases force and Ca 2+ current at physiological temperatureChrist, Torsten, Molenaar, Peter, Klenowski, Paul M., Ravens, Ursula and Kaumann, Alberto J. (2011). Human atrial β 1L-adrenoceptor but not β 3- adrenoceptor activation increases force and Ca 2+ current at physiological temperature. British Journal of Pharmacology, 162 (4), 823-839. doi: 10.1111/j.1476-5381.2010.00996.x |
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2009 Journal Article P2 purinergic receptor mRNA in rat and human sinoatrial node and other heart regionsMusa, Hanny, Tellez, James O., Chandler, Natalie J., Greener, Ian D., Maczewski, Michał, Mackiewicz, Urszula, Beresewicz, Andrzej, Molenaar, Peter, Boyett, Mark R. and Dobrzynski, Halina (2009). P2 purinergic receptor mRNA in rat and human sinoatrial node and other heart regions. Naunyn-Schmiedeberg's Archives of Pharmacology, 379 (6), 541-549. doi: 10.1007/s00210-009-0403-2 |
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2009 Journal Article Molecular Architecture of the Human Sinus Node Insights Into the Function of the Cardiac PacemakerChandler, Natalie J., Greener, Ian D., Tellez, James O., Inada, Shin, Musa, Hanny, Molenaar, Peter, DiFrancesco, Dario, Baruscotti, Mirko, Longhi, Renato, Anderson, Robert H., Billeter, Rudolf, Sharma, Vinod, Sigg, Daniel C., Boyett, Mark R. and Dobrzynski, Halina (2009). Molecular Architecture of the Human Sinus Node Insights Into the Function of the Cardiac Pacemaker. Circulation, 119 (12), 1562-1575. doi: 10.1161/CIRCULATIONAHA.108.804369 |
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2008 Journal Article The low-affinity site of the β1-adrenoceptor and its relevance to cardiovascular pharmacologyKaumann, Alberto J. and Molenaar, Peter (2008). The low-affinity site of the β1-adrenoceptor and its relevance to cardiovascular pharmacology. Pharmacology and Therapeutics, 118 (3), 303-336. doi: 10.1016/j.pharmthera.2008.03.009 |
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2007 Journal Article Arg389Gly-beta(1)-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilolCheng lu, Meyers, Deborah, Javorsky, George, Bursto, Darryl, Lolekha, Pakorn, Lucas, Margaret, Semmler, Annalese B. T., Savarimuthu, Santiyagu M., Fong, Kwun M., Yang, Ian A., Atherton, John, Galbraith, Andrew J., Parsonage, William A. and Molenaar, Peter (2007). Arg389Gly-beta(1)-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilol. Pharmacogenetics And Genomics, 17 (11), 941-949. doi: 10.1097/FPC.0b013e3282ef7354 |
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2007 Journal Article beta(2)-adrenoceptor polymorphisms and obstructive airway diseases: Important issues of study designYang, Ian A., Ng, Taria, Molenaar, Peter and Fong, Kwun M. (2007). beta(2)-adrenoceptor polymorphisms and obstructive airway diseases: Important issues of study design. Clinical And Experimental Pharmacology and Physiology, 34 (10), 1029-1036. doi: 10.1111/j.1440-1681.2007.04731.x |
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2007 Journal Article Human heart beta-adrenoceptors: beta(1)-adrenoceptor diversification through 'affinity states' and polymorphismMolenaar, P., Chen, L., Semmler, A. B. T., Parsonage, W. A. and Kaumann, A. J. (2007). Human heart beta-adrenoceptors: beta(1)-adrenoceptor diversification through 'affinity states' and polymorphism. Clinical And Experimental Pharmacology And Physiology, 34 (10), 1020-1028. doi: 10.1111/j.1440-1681.2007.04730.x |
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2007 Journal Article The effects of both noradrenaline and CGP12177, mediated through human beta(1)-adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cellsKaumann, Alberto, Semmler, Annalese B. T. and Molenaar, Peter (2007). The effects of both noradrenaline and CGP12177, mediated through human beta(1)-adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cells. Naunyn-schmiedebergs Archives of Pharmacology, 375 (2), 123-131. doi: 10.1007/s00210-007-0140-3 |
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2007 Journal Article (-)Adrenaline elicits positive inotropic,lusitropic, and biochemical effects through ß2-adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consisten with Gs coupling but not with Gi coupling.Molenaar, P., Savarimuthu, S. M., Sarsero, D., Chen, L., Semmler, A. B. T., Carle, A., Yang, I., Bartel, S., Vetter, D., Beyerdorfer, I., Krause,E-G. and Kaumann, A. J. (2007). (-)Adrenaline elicits positive inotropic,lusitropic, and biochemical effects through ß2-adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consisten with Gs coupling but not with Gi coupling.. Naunyn-Schmiedeberg's Archives of Pharmocolgy, 375 (1), 11-28. doi: 10.1007/s00210-007-0138-x |
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2006 Journal Article Carvedilol blocks beta(2)- more than beta(1)-adrenoceptors in human heartMolenaar, Peter, Christ, Torsten, Ravens, Ursula and Kaumann, Alberto (2006). Carvedilol blocks beta(2)- more than beta(1)-adrenoceptors in human heart. Cardiovascular Research, 69 (1), 128-139. doi: 10.1016/j.cardiores.2005.08.024 |
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2006 Journal Article Cardiac implications for the use of beta(2)-adrenoceptor agonists for the management of muscle wastingMolenaar, Peter, Chen, Lu and Parsonage, William A. (2006). Cardiac implications for the use of beta(2)-adrenoceptor agonists for the management of muscle wasting. British Journal of Pharmacology, 147 (6), 583-586. doi: 10.1038/sj.bjp.0706670 |
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2005 Journal Article Fundamental considerations of beta-adrenoceptor subtypes in human heart failureMolenaar, P and Parsonage, WA (2005). Fundamental considerations of beta-adrenoceptor subtypes in human heart failure. Trends In Pharmacological Sciences, 26 (7), 368-375. doi: 10.1016/j.tips.2005.05.005 |
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2005 Journal Article Cardiovascular actions of the venom from the Irukandji (Carukia barnesi) jellyfish: Effects in human, rat and guinea-pig tissues in vitro and in pigs in vivoWinkel, KD, Tibballs, J, Molenaar, P, Lambert, G, Coles, P, Ross-Smith, M, Wiltshire, C, Fenner, PJ, Gershwin, LA, Hawdon, GM, Wright, CE and Angus, JA (2005). Cardiovascular actions of the venom from the Irukandji (Carukia barnesi) jellyfish: Effects in human, rat and guinea-pig tissues in vitro and in pigs in vivo. Clinical And Experimental Pharmacology And Physiology, 32 (9), 777-788. doi: 10.1111/j.1440-1681.2005.04258.x |
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2005 Journal Article Activation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin IILi, J., Wang, J. C., Russell, F. D. and Molenaar, P. (2005). Activation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin II. British Journal of Pharmacology, 145 (4), 432-440. doi: 10.1038/sj.bjp.0706217 |
