|
2008 Journal Article Role of Nonstructural Protein NS2A in Flavivirus AssemblyLeung, Jason Y., Pijlman, Gorben P., Kondratieva, Natasha, Hyde, Jennifer, Mackenzie, Jason M. and Khromykh, Alexander A. (2008). Role of Nonstructural Protein NS2A in Flavivirus Assembly. Journal of Virology, 82 (10), 4731-4741. doi: 10.1128/JVI.00002-08 |
|
2008 Journal Article Evaluation of recombinant Kunjin replicon SIV vaccines for protective efficacy in macaquesKent, Stephen J., De Rose, Robert, Mokhonov, Vlad V., Mokhonova, Ekaterina I., Fernandez, Caroline S., Alcantara, Sheilajen, Rollman, Erik, Mason, Rosemarie D., Loh, Liyen, Peut, Viv, Reece, Jeanette C., Wang, Xiang Ju, Wilson, Kim M., Suhrbier, Andreas and Khromykh, Alexander (2008). Evaluation of recombinant Kunjin replicon SIV vaccines for protective efficacy in macaques. Virology, 374 (2), 528-534. doi: 10.1016/j.virol.2008.01.006 |
|
2008 Journal Article Single-round infectious particles enhance immunogenicity of a DNA vaccine against West Nile virusChang, David C., Liu, Wen J., Anraku, Itaru, Clark, David C., Pollitt, Christopher C., Suhrbier, Andreas, Hall, Roy A. and Khromykh, Alexander A. (2008). Single-round infectious particles enhance immunogenicity of a DNA vaccine against West Nile virus. Nature Biotechnology, 26 (5), 571-577. doi: 10.1038/nbt1400 |
|
2007 Journal Article Drug evaluation: ChimeriVax-West Nile vaccineHall, RA and Khromykh, AA (2007). Drug evaluation: ChimeriVax-West Nile vaccine. Current Opinion In Molecular Therapeutics, 9 (5), 498-504. |
|
2007 Journal Article Cholesterol Manipulation by West Nile Virus Perturbs the Cellular Immune ResponseMackenzie, Jason M., Khromykh, Alexander and Parton, Robert G. (2007). Cholesterol Manipulation by West Nile Virus Perturbs the Cellular Immune Response. Cell Host and Microbe, 2 (4), 229-239. doi: 10.1016/j.chom.2007.09.003 |
|
2007 Journal Article Construction and biological characterization of artificial recombinants between a wild type flavivirus (Kunjin) and a live chimeric flavivirus vaccine (ChimeriVax-JE)Pugachev, KV, Schwaiger, J, Brown, N, Zhang, ZX, Catalan, J, Mitchell, FS, Ocran, SW, Rumyantsev, AA, Khromykh, AA, Monath, TP and Guirakhoo, F (2007). Construction and biological characterization of artificial recombinants between a wild type flavivirus (Kunjin) and a live chimeric flavivirus vaccine (ChimeriVax-JE). Vaccine, 25 (37-38), 6661-6671. doi: 10.1016/j.vaccine.2007.07.016 |
|
2007 Journal Article West Nile virus-induced cytoplasmic membrane structures provide partial protection against the interferon-induced antiviral MxA proteinHoenen, A., Liu, W., Kochs, G., Khromykh, A. and Mackenzie, J. (2007). West Nile virus-induced cytoplasmic membrane structures provide partial protection against the interferon-induced antiviral MxA protein. Journal of General Virology, 88 (11), 3013-3017. doi: 10.1099/vir.0.83125-0 |
|
2007 Journal Article Crystal structure and activity of Kunjin virus NS3 helicase; Protease and helicase domain assembly in the full length NS3 proteinMastrangelo, E, Milani, M, Bollati, M, Selisko, B, Peyrane, F, Pandini, V, Sorrentino, G, Canard, B, Konarev, PV, Svergun, DI, de Lamballerie, X, Coutard, B, Khromykh, AA and Bolognesi, M (2007). Crystal structure and activity of Kunjin virus NS3 helicase; Protease and helicase domain assembly in the full length NS3 protein. Journal of Molecular Biology, 372 (2), 444-455. doi: 10.1016/j.jmb.2007.06.055 |
|
2007 Journal Article Crystal structure of the RNA polymerase domain of the West Nile Virus non-structural protein 5Malet, H., Egloff, M., Selisko, B., Butcher, R., Wright, P., Roberts, M., Gruez, A., Sulzenbacher, G., Vonrhein, C., Bricogne, G., Mackenzie, J., Khromykh, A., Davidson, A. and Canard, B. (2007). Crystal structure of the RNA polymerase domain of the West Nile Virus non-structural protein 5. The Journal of Biological Chemistry, 282 (14), 10678-10689. doi: 10.1074/jbc.M607273200 |
|
2007 Journal Article Using a bioaerosol personal sampler in combination with real-time PCR analysis for rapid detection of airborne virusesPyankov, O. V., Agranovski, I. E., Pyankova, O., Mokhonova, E., Mokhonov, V., Safatov, A. S. and Khromykh, A. A. (2007). Using a bioaerosol personal sampler in combination with real-time PCR analysis for rapid detection of airborne viruses. Environmental Microbiology, 9 (4), 992-1000. doi: 10.1111/j.1462-2920.2006.01226.x |
|
2006 Journal Article Translation of the flavivirus Kunjin NS3 gene in cis but not its RNA sequence or secondary structure is essential for efficient RNA packagingPijlman, Gorben P., Kondratieva, Natasha and Khromykh, Alexander A. (2006). Translation of the flavivirus Kunjin NS3 gene in cis but not its RNA sequence or secondary structure is essential for efficient RNA packaging. Journal of Virology, 80 (22), 11255-11264. doi: 10.1128/JVI.01559-06 |
|
2006 Journal Article Ebola virus glycoprotein GP is not cytotoxic when expressed constitutively at a moderate levelAlazard-Dany, N., Volchkova, V., Reynard, O., Carbonnelle, C., Dolnik, O., Ottmann, M., Khromykh, A. and Volchkov, V. E. (2006). Ebola virus glycoprotein GP is not cytotoxic when expressed constitutively at a moderate level. Journal of General Virology, 87 (5), 1247-1257. doi: 10.1099/vir.0.81361-0 |
|
2006 Journal Article Regulated Cleavages at the West Nile Virus NS4A-2K-NS4B Junctions Play a Major Role in Rearranging Cytoplasmic Membranes and Golgi Trafficking of the NS4A ProteinRoosendaal, Jojanneke, Westaway, Edwin G., Khromykh, Alexander and Mackenzie, Jason M. (2006). Regulated Cleavages at the West Nile Virus NS4A-2K-NS4B Junctions Play a Major Role in Rearranging Cytoplasmic Membranes and Golgi Trafficking of the NS4A Protein. Journal of Virology, 80 (9), 4623-4632. doi: 10.1128/JVI.80.9.4623-4632.2006 |
|
2006 Journal Article A single amino acid substitution in the west nile virus nonstructural protein NS2A disables its ability to inhibit alpha/beta interferon induction and attenuates virus virulence in miceLiu, Wen Jun, Wang, Xiang Ju, Clark, David C., Lobigs, Mario, Hall, Roy A. and Khromykh, Alexander A. (2006). A single amino acid substitution in the west nile virus nonstructural protein NS2A disables its ability to inhibit alpha/beta interferon induction and attenuates virus virulence in mice. Journal of Virology, 80 (5), 2396-2404. doi: 10.1128/JVI.80.5.2396-2404.2006 |
|
2006 Journal Article Kunjin virus replicons: an RNA-based, non-cytopathic viral vector system for protein production, vaccine and gene therapy applicationsPijlman, Gorben P., Suhrbier, Andreas and Khromykh, Alexander A. (2006). Kunjin virus replicons: an RNA-based, non-cytopathic viral vector system for protein production, vaccine and gene therapy applications. Expert Opinion On Biological Therapy, 6 (2), 135-145. doi: 10.1517/14712598.6.2.135 |
|
2006 Journal Article Comparative mechanistic studies of de novo RNA synthesis by flavivirus RNA-dependent RNA polymerasesSelisko, B., Dutartre, H., Guillemot, J. C., Debarnot, C., Benarroch, D., Khromykh, A., Despres, P., Egloff, M. P. and Canard, B. (2006). Comparative mechanistic studies of de novo RNA synthesis by flavivirus RNA-dependent RNA polymerases. Virology, 351 (1), 145-158. doi: 10.1016/j.virol.2006.03.026 |
|
2006 Journal Article Preliminary crystallographic characterization of an RNA helicase from Kunjin virusMastrangelo, Eloise, Bollati, Michela, Milani, Mario, Brisbarre, Nadege, de Lamballerie, Xavier, Coutard, Bruno, Canard, Bruno, Khromykh, Alexander and Bolognesi, Martino (2006). Preliminary crystallographic characterization of an RNA helicase from Kunjin virus. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 62 (9), 876-879. doi: 10.1107/S1744309106028776 |
|
2005 Journal Article Inhibition of interferon signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteinsLiu, Wen Jun, Wang, Xiang Ju, Mokhonov, Vladislav V., Shi, Pei-Yong, Randall, Richard and Khromykh, Alexander A. (2005). Inhibition of interferon signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteins. Journal of Virology, 79 (3), 1934-1942. doi: 10.1128/JVI.79.3.1934-1942.2005 |
|
2005 Journal Article Semliki Forest virus and Kunjin virus RNA replicons elicit comparable cellular immunity but distinct humoral immunityTannis, Laura Lee, Gauthier, Andree, Evelegh, Carole, Parsons, Robin, Nyholt, Dana, Khromykh, Alexander and Brarnson, Jonathan L. (2005). Semliki Forest virus and Kunjin virus RNA replicons elicit comparable cellular immunity but distinct humoral immunity. Vaccine, 23 (33), 4189-4194. doi: 10.1016/j.vaccine.2005.04.005 |
|
2004 Journal Article Analysis of adaptive mutations in Kunjin virus replicon RNA reveals a novel role for the flavivirus nonstructural protein NS2A in inhibition of beta interferon promoter-driven transcriptionLiu, Wen Jun, Chen, Hua Bo, Xiang, Ju Wang, Huang, Hester and Khromykh, Alexander A. (2004). Analysis of adaptive mutations in Kunjin virus replicon RNA reveals a novel role for the flavivirus nonstructural protein NS2A in inhibition of beta interferon promoter-driven transcription. Journal of Virology, 78 (22), 12225-12235. doi: 10.1128/JVI.78.22.12225-12235.2004 |
