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2025 Journal Article Insect-specific virus platforms for arbovirus vaccine developmentHall, Roy A., Nguyen, Wilson, Khromykh, Alexander A. and Suhrbier, Andreas (2025). Insect-specific virus platforms for arbovirus vaccine development. Frontiers in Immunology, 16 1521104. doi: 10.3389/fimmu.2025.1521104 |
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2025 Journal Article Skin patch delivery of a SARS-CoV-2 Spike DNA vaccine produces broad neutralising antibody responsesMcMillan, Christopher L.D., Corner, Andrea V., Wijesundara, Danushka K., Choo, Jovin J.Y., Pittayakhajonwut, Daraporn, Poredi, Indrajeet, Parry, Rhys H., Bindra, Guneet K., Bruce, Kimberley, Khromykh, Alexander A., Fernando, Germain J.P., Dapremont, Laurent, Young, Paul R. and Muller, David A. (2025). Skin patch delivery of a SARS-CoV-2 Spike DNA vaccine produces broad neutralising antibody responses. Heliyon, 11 (4) e42533, e42533. doi: 10.1016/j.heliyon.2025.e42533 |
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2025 Journal Article The PAZ domain of Aedes aegypti Dicer 2 is critical for accurate and high-fidelity size determination of virus-derived small interfering RNAsReuter, Melinda, Parry, Rhys H., McDonald, Melanie, Gestuveo, Rommel J., Arif, Rozeena, Khromykh, Alexander A., Brennan, Benjamin, Varjak, Margus, Castello, Alfredo, Redecke, Lars, Schnettler, Esther and Kohl, Alain (2025). The PAZ domain of Aedes aegypti Dicer 2 is critical for accurate and high-fidelity size determination of virus-derived small interfering RNAs. RNA, 31 (5), rna.080149.124-5. doi: 10.1261/rna.080149.124 |
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2025 Journal Article Evolution of Zika virus in <i>Rag1</i>-deficient mice selects for unique envelope glycosylation motif mutants that show enhanced replication fitnessNakayama, Eri, Tang, Bing, Stewart, Romal, Cox, Abigail L, Yan, Kexin, Bishop, Cameron R, Dumenil, Troy, Nguyen, Wilson, Slonchak, Andrii, Sng, Julian, Khromykh, Alexander A, Lutzky, Viviana P, Rawle, Daniel J and Suhrbier, Andreas (2025). Evolution of Zika virus in Rag1-deficient mice selects for unique envelope glycosylation motif mutants that show enhanced replication fitness. Virus Evolution, 11 (1) veaf021. doi: 10.1093/ve/veaf021 |
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2024 Journal Article The flavivirus Non-Structural Protein 5 (NS5): structure, functions, and targeting for development of vaccines and therapeuticsGoh, Jarvis Z. H., De Hayr, Lachlan, Khromykh, Alexander A. and Slonchak, Andrii (2024). The flavivirus Non-Structural Protein 5 (NS5): structure, functions, and targeting for development of vaccines and therapeutics. Vaccines, 12 (8) 865, 865. doi: 10.3390/vaccines12080865 |
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2024 Journal Article Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2Shaker, Mohammed R., Slonchak, Andrii, Al-Mhanawi, Bahaa, Morrison, Sean D., Sng, Julian D.J., Cooper-White, Justin, Khromykh, Alexander A. and Wolvetang, Ernst J. (2024). Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2. Science Advances, 10 (23) eadj4735, 1-23. doi: 10.1126/sciadv.adj4735 |
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2024 Journal Article Xinyang flavivirus, from Haemaphysalis flava ticks in Henan Province, China, defines a basal, likely tick-only Orthoflavivirus cladeWang, Lan-Lan, Cheng, Qia, Newton, Natalee D., Wolfinger, Michael T., Morgan, Mahali S., Slonchak, Andrii, Khromykh, Alexander A., Cheng, Tian-Yin and Parry, Rhys H. (2024). Xinyang flavivirus, from Haemaphysalis flava ticks in Henan Province, China, defines a basal, likely tick-only Orthoflavivirus clade. Journal of General Virology, 105 (5) 001991, 1-13. doi: 10.1099/jgv.0.001991 |
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2024 Journal Article Residue K28 of Zika Virus NS5 Protein Is Implicated in Virus Replication and Antagonism of STAT2Peng, Nias Y. G., Sng, Julian D. J., Setoh, Yin Xiang and Khromykh, Alexander A. (2024). Residue K28 of Zika Virus NS5 Protein Is Implicated in Virus Replication and Antagonism of STAT2. Microorganisms, 12 (4) 660, 1-15. doi: 10.3390/microorganisms12040660 |
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2024 Journal Article Enhancement of cellular immunity following needle-free vaccination of mice with SARS-CoV-2 spike proteinMcMillan, Christopher L. D., Wijesundara, Danushka K., Choo, Jovin J. Y., Amarilla, Alberto A., Modhiran, Naphak, Fernando, Germain J. P., Khromykh, Alexander A., Watterson, Daniel, Young, Paul R. and Muller, David A. (2024). Enhancement of cellular immunity following needle-free vaccination of mice with SARS-CoV-2 spike protein. Journal of General Virology, 105 (1) 001947, 1-6. doi: 10.1099/jgv.0.001947 |
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2023 Journal Article A novel tamanavirus (Flaviviridae) of the European common frog (Rana temporaria) from the UKParry, Rhys H., Slonchak, Andrii, Campbell, Lewis J., Newton, Natalee D., Debat, Humberto J., Gifford, Robert J. and Khromykh, Alexander A. (2023). A novel tamanavirus (Flaviviridae) of the European common frog (Rana temporaria) from the UK. Journal of General Virology, 104 (12) 001927, 1-12. doi: 10.1099/jgv.0.001927 |
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2023 Journal Article The role of N-glycosylation in spike antigenicity for the SARS-CoV-2 gamma variantPegg, Cassandra L., Modhiran, Naphak, Parry, Rhys H., Liang, Benjamin, Amarilla, Alberto A., Khromykh, Alexander A., Burr, Lucy, Young, Paul R., Chappell, Keith, Schulz, Benjamin L. and Watterson, Daniel (2023). The role of N-glycosylation in spike antigenicity for the SARS-CoV-2 gamma variant. Glycobiology, 34 (2) cwad097, 1-13. doi: 10.1093/glycob/cwad097 |
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2023 Journal Article SARS-CoV-2 omicron BA.5 and XBB variants have increased neurotropic potential over BA.1 in K18-hACE2 mice and human brain organoidsStewart, Romal, Yan, Kexin, Ellis, Sevannah A., Bishop, Cameron R., Dumenil, Troy, Tang, Bing, Nguyen, Wilson, Larcher, Thibaut, Parry, Rhys, Sng, Julian De Jun, Khromykh, Alexander A., Sullivan, Robert K. P., Lor, Mary, Meunier, Frédéric A., Rawle, Daniel J. and Suhrbier, Andreas (2023). SARS-CoV-2 omicron BA.5 and XBB variants have increased neurotropic potential over BA.1 in K18-hACE2 mice and human brain organoids. Frontiers in Microbiology, 14 1320856, 1-18. doi: 10.3389/fmicb.2023.1320856 |
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2023 Journal Article Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathologyAguado, Julio, Amarilla, Alberto A., Taherian Fard, Atefeh, Albornoz, Eduardo A., Tyshkovskiy, Alexander, Schwabenland, Marius, Chaggar, Harman K., Modhiran, Naphak, Gómez-Inclán, Cecilia, Javed, Ibrahim, Baradar, Alireza A., Liang, Benjamin, Peng, Lianli, Dharmaratne, Malindrie, Pietrogrande, Giovanni, Padmanabhan, Pranesh, Freney, Morgan E., Parry, Rhys, Sng, Julian D. J., Isaacs, Ariel, Khromykh, Alexander A., Valenzuela Nieto, Guillermo, Rojas-Fernandez, Alejandro, Davis, Thomas P., Prinz, Marco, Bengsch, Bertram, Gladyshev, Vadim N., Woodruff, Trent M., Mar, Jessica C. ... Wolvetang, Ernst J. (2023). Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology. Nature Aging, 3 (12), 1561-1575. doi: 10.1038/s43587-023-00519-6 |
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2023 Journal Article A nanobody recognizes a unique conserved epitope and potently neutralizes against the SARS-CoV-2 omicron variantsModhiran, Naphak, Lauer, Simon Malte, Amarilla, Alberto A., Hewins, Peter, Lopes van den Broek, Sara Irene, Low, Yu Shang, Thakur, Nazia, Liang, Benjamin, Nieto, Guillermo Valenzuela, Jung, James, Paramitha, Devina, Isaacs, Ariel, Sng, Julian D. J., Song, David, Jørgensen, Jesper Tranekjær, Cheuquemilla, Yorka, Bürger, Jörg, Andersen, Ida Vang, Himelreichs, Johanna, Jara, Ronald, MacLoughlin, Ronan, Miranda-Chacon, Zaray, Chana-Cuevas, Pedro, Kramer, Vasko, Spahn, Christian M. T., Mielke, Thorsten, Khromykh, Alexander A., Munro, Trent, Jones, Martina L. ... Watterson, Daniel (2023). A nanobody recognizes a unique conserved epitope and potently neutralizes against the SARS-CoV-2 omicron variants. iScience, 26 (7) 107085, 107085. doi: 10.1016/j.isci.2023.107085 |
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2023 Journal Article Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2Shaker, Mohammed R., Slonchak, Andrii, Al-mhanawi, Bahaa, Morrison, Sean D., Sng, Julian D. J., Cooper-White, Justin, Khromykh, Alexander A. and Wolvetang, Ernst J. (2023). Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2. bioRxiv, 10 (23) eadj4735, eadj4735. doi: 10.1101/2023.06.12.544552 |
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2023 Journal Article Noncoding RNA of Zika virus affects interplay between Wnt-signaling and pro-apoptotic pathways in the developing brain tissueSlonchak, Andrii, Chaggar, Harman, Aguado, Julio, Wolvetang, Ernst and Khromykh, Alexander A. (2023). Noncoding RNA of Zika virus affects interplay between Wnt-signaling and pro-apoptotic pathways in the developing brain tissue. Viruses, 15 (5) 1062, 1062. doi: 10.3390/v15051062 |
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2023 Journal Article Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”Speck, Peter, Mackenzie, Jason, Bull, Rowena A., Slobedman, Barry, Drummer, Heidi, Fraser, Johanna, Herrero, Lara, Helbig, Karla, Londrigan, Sarah, Moseley, Gregory, Prow, Natalie, Hansman, Grant, Edwards, Robert, Ahlenstiel, Chantelle, Abendroth, Allison, Tscharke, David, Hobson-Peters, Jody, Kriiger-Loterio, Robson, Parry, Rhys, Marsh, Glenn, Harding, Emma, Jacques, David A., Gartner, Matthew J., Lee, Wen Shi, McAuley, Julie, Vaz, Paola, Sainsbury, Frank, Tate, Michelle D., Sinclair, Jane ... Young, Paul (2023). Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”. Journal of Virology, 97 (5), e0045123. doi: 10.1128/jvi.00451-23 |
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2023 Journal Article Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”Speck, Peter, Mackenzie, Jason, Bull, Rowena A., Slobedman, Barry, Drummer, Heidi, Fraser, Johanna, Herrero, Lara, Helbig, Karla, Londrigan, Sarah, Moseley, Gregory, Prow, Natalie, Hansman, Grant, Edwards, Robert, Ahlenstiel, Chantelle, Abendroth, Allison, Tscharke, David, Hobson-Peters, Jody, Kriiger-Loterio, Robson, Parry, Rhys, Marsh, Glenn, Harding, Emma, Jacques, David A., Gartner, Matthew J., Lee, Wen Shi, McAuley, Julie, Vaz, Paola, Sainsbury, Frank, Tate, Michelle D., Sinclair, Jane ... Young, Paul (2023). Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”. mSphere, 8 (3), e0016523. doi: 10.1128/msphere.00165-23 |
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2023 Journal Article Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”Speck, Peter, Mackenzie, Jason, Bull, Rowena A., Slobedman, Barry, Drummer, Heidi, Fraser, Johanna, Herrero, Lara, Helbig, Karla, Londrigan, Sarah, Moseley, Gregory, Prow, Natalie, Hansman, Grant, Edwards, Robert, Ahlenstiel, Chantelle, Abendroth, Allison, Tscharke, David, Hobson-Peters, Jody, Kriiger-Loterio, Robson, Parry, Rhys, Marsh, Glenn, Harding, Emma, Jacques, David A., Gartner, Matthew J., Lee, Wen Shi, McAuley, Julie, Vaz, Paola, Sainsbury, Frank, Tate, Michelle D., Sinclair, Jane ... Young, Paul (2023). Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”. mBio, 14 (3), e0081523. doi: 10.1128/mbio.00815-23 |
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2023 Other Outputs Chimeric insect-specific flavivirusesHall, Roy, Hobson-Peters, Jody, Khromykh, Alexander, Watterson, Daniel, Setoh, Mn, Piyasena, Thisun, Colmant, Agathe, Harrison, Jessica, Vet, Laura, Newton, N Ata Lee and Bielefeldt-Ohmann, Helle (2023). Chimeric insect-specific flaviviruses. 11572390B2. |
