
Overview
Background
Dr Mitchell Anthony Sullivan is a CJ Martin Early Career Research Fellow, funded by the National Health and Medical Research Council (NHMRC). Mitchell has a postdoctoral position in Professor Josephine Forbes’ Glycation and Diabetes research group at the Translational Research Institute. With a keen interest in the role of the blood-sugar storage molecule glycogen in health and disease, Mitchell has used the techniques he developed in his PhD, supervised by Prof. Robert Gilbert, to examine the important role this molecule has in diseases such as diabetes, Lafora disease and Adult Polyglucosan Body Disease. Currently he is extending this research into the field of diabetic kidney disease, combining the skills and knowledge he obtained in a 2-year postdoctoral position in Toronto with Prof. Berge Minassian, with the kidney expertise of Prof. Forbes. Awards received by Mitchell include the Biochemistry Alumni Prize (2008), awarded to the top ranked student at UQ in 3 biology/biochemistry course and the Chemistry Honours Research Prize (2010), awarded to “the student who, in completing a BSc (Honours) in the field of Chemistry, demonstrated a high level of achievement in the research component of the program and a high potential for independent research.” Mitchell was an organizing committee member for the Annual RACI Polymer Student Symposium (2013) and is currently a member of the Translation Research Institute Mentoring Committee. While less than 3 years from completing his PhD, Mitchell has 23 publication involving collaboration in China, Sweden, Canada, USA and Spain.
Personal statement: “Ever since beginning my research career as an undergraduate, I have thoroughly enjoyed the privilege of being able to pursue research questions I am passionate about. The opportunity to add new information and insights into the shared knowledge pool of the global scientific community is greatly appreciated. I will continue to relish these opportunities and strive to perform research to the best of my ability, with the goal of maximising a beneficial impact. As I advance through my career I will also endeavour to encourage and support my colleagues, helping foster a collaborative and fruitful environment to perform research.”
Availability
- Dr Mitchell Sullivan is:
- Available for supervision
Research impacts
Dr Mitchell Sullivan's PhD developed a number of techniques that allowed him to analyse the key structural features of glycogen, a highly branched macromolecule of ~50,000 glucose units. These techniques enabled his collaborative discovery that the diabetic liver contains fragile glycogen molecules, making them susceptible to uncontrolled degradation into glucose. The award of an NHMRC CJ Martin Fellowship allowed him to further his research in Toronto. The techniques Dr Sullivan developed in his PhD allowed him to analyse glycogen from various glycogen storage diseases (GSDs), leading to key breakthroughs in our understanding on the formation of the pathological glycogen accumulations characteristic of these diseases. In Toronto he continued to acquire and develop new methods that are essential in understanding the malformed glycogen present in these various GSDs. He is now using these skills to analyse the role of glycogen in diabetic kidney disease.
Works
Search Professor Mitchell Sullivan’s works on UQ eSpace
2016
Journal Article
Molecular structure of human-liver glycogen
Deng, Bin, Sullivan, Mitchell A., Chen, Cheng, Li, Jialun, Powell, Prudence O., Hu, Zhenxia and Gilbert, Robert G. (2016). Molecular structure of human-liver glycogen. Plos One, 11 (3) e0150540, e0150540. doi: 10.1371/journal.pone.0150540
2016
Conference Publication
The metabolic and inflammatory challenges of summer in the feedlot
Wijfells, G., Sullivan, M. L., Stockwell, S., Briscoe, S., McCulloch, R., Straube, J., Olm, J., Cawdell-Smith, J., Anderson, S. T., Le Cao, K.-A. and Gaughan, J. B. (2016). The metabolic and inflammatory challenges of summer in the feedlot. Northern Australia Beef Research Update Conference, Rockhampton, QLD Australia, 15 - 18 August 2016. Gympie, QLD, Australia: Queensland North Australia Beef Research Council.
2016
Conference Publication
Glycogen: Higher -Level Molecular Structure and Diabetes
Tan, Xinle, Deng, Bin, Jiang, Xiaoyin, Zhang, Peng, Hu, Zhenxia, Li, Enpeng, Sullivan, Mitchell A., Schulz, Benjamin L. and Gilbert, Robert G. (2016). Glycogen: Higher -Level Molecular Structure and Diabetes. 12th International Conference on Polysaccharides-Glycoscience, Prague Czech Republic, 19-21 October 2016. Prague Czech Republic: Czech Chemical Society.
2015
Journal Article
Correction: Acid hydrolysis and molecular density of phytoglycogen and liver glycogen helps understand the bonding in glycogen a (composite) particles
Powell, Prudence O., Sullivan, Mitchell A., Sheehy, Joshua J., Schulz, Benjamin L., Warren, Frederick J. and Gilbert, Robert G. (2015). Correction: Acid hydrolysis and molecular density of phytoglycogen and liver glycogen helps understand the bonding in glycogen a (composite) particles. PLoS One, 10 (7) e0134065, e0134065. doi: 10.1371/journal.pone.0134065
2015
Journal Article
The mechanism for stopping chain and total-molecule growth in complex branched polymers, exemplified by glycogen
Deng, Bin, Sullivan, Mitchell A., Wu, Alex Chi, Li, Jialun, Chen, Cheng and Gilbert, Robert G. (2015). The mechanism for stopping chain and total-molecule growth in complex branched polymers, exemplified by glycogen. Biomacromolecules, 16 (6), 1870-1872. doi: 10.1021/acs.biomac.5b00459
2015
Journal Article
Molecular structure of glycogen in diabetic liver
Deng, Bin, Sullivan, Mitchell A., Li, Jialun, Tan, Xinle, Zhu, Chengjun, Schulz, Benjamin L. and Gilbert, Robert G. (2015). Molecular structure of glycogen in diabetic liver. Glycoconjugate Journal, 32 (3-4), 113-118. doi: 10.1007/s10719-015-9578-6
2015
Journal Article
A rapid extraction method for glycogen from formalin-fixed liver
Sullivan, Mitchell A., Li, Shihan, Aroney, Samuel T.N., Deng, Bin, Li, Cheng, Roura, Eugeni, Schulz, Benjamin L., Harcourt, Brooke E., Forbes, Josephine M. and Gilbert, Robert G. (2015). A rapid extraction method for glycogen from formalin-fixed liver. Carbohydrate Polymers, 118, 9-15. doi: 10.1016/j.carbpol.2014.11.005
2015
Journal Article
Acid Hydrolysis and Molecular Density of Phytoglycogen and Liver Glycogen Helps Understand the Bonding in Glycogen α (Composite) Particles.
Powell, Prudence O., Sullivan, Mitchell A., Sheehy, Joshua J., Schulz, Benjamin L., Warren, Frederick J. W. and Gilbert, Robert G. (2015). Acid Hydrolysis and Molecular Density of Phytoglycogen and Liver Glycogen Helps Understand the Bonding in Glycogen α (Composite) Particles.. PLoS One, 10 (3) e0121337, e0121337-e0121337. doi: 10.1371/journal.pone.0121337
2015
Journal Article
Impairment of liver glycogen storage in the db/db animal model of type 2 diabetes: a potential target for future therapeutics?
Sullivan, Mitchell A., Harcourt, Brooke E., Xu, Ping, Forbes, Josephine M. and Gilbert, Robert G. (2015). Impairment of liver glycogen storage in the db/db animal model of type 2 diabetes: a potential target for future therapeutics?. Current Drug Targets, 16 (10), 1088-1093. doi: 10.2174/1389450116666150727123115
2014
Other Outputs
Liver-glycogen metabolism: A structural perspective
Sullivan, Mitchell (2014). Liver-glycogen metabolism: A structural perspective. PhD Thesis, Queensland Alliance for Agricultural and Food Innovation, The University of Queensland. doi: 10.14264/uql.2015.75
2014
Journal Article
Improving size-exclusion chromatography separation for glycogen
Sullivan, Mitchell A., Powell, Prudence O., Witt, Torsten, Vilaplana, Francisco, Roura, Eugeni and Gilbert, Robert G. (2014). Improving size-exclusion chromatography separation for glycogen. Journal of Chromatography A, 1332, 21-29. doi: 10.1016/j.chroma.2014.01.053
2014
Journal Article
Changes in glycogen structure over feeding cycle sheds new light on blood-glucose control
Sullivan, Mitchell A., Aroney, Samuel T. N., Li, Shihan, Warren, Frederick J., Joo, Jin Suk, Mak, Ka Sin, Stapleton, David I., Bell-Anderson, Kim S. and Gilbert, Robert G. (2014). Changes in glycogen structure over feeding cycle sheds new light on blood-glucose control. Biomacromolecules, 15 (2), 660-665. doi: 10.1021/bm401714v
2014
Journal Article
Extraction, isolation and characterisation of phytoglycogen from su-1 maize leaves and grain
Powell, Prudence O., Sullivan, Mitchell A., Sweedman, Michael C., Stapleton, David I., Hasjim, Jovin and Gilbert, Robert G. (2014). Extraction, isolation and characterisation of phytoglycogen from su-1 maize leaves and grain. Carbohydrate Polymers, 101 (1), 423-431. doi: 10.1016/j.carbpol.2013.09.061
2014
Conference Publication
The molecular size distribution of glycogen and its relevance to diabetes
Gilbert, Robert G. and Sullivan, Mitchell A. (2014). The molecular size distribution of glycogen and its relevance to diabetes. 34th Australasian Polymer Symposium, Darwin, Australia, 7-10 July 2013. Clayton, VIC, Australia: C S I R O Publishing. doi: 10.1071/CH13573
2012
Journal Article
The structure of cardiac glycogen in healthy mice
Besford, Quinn A., Sullivan, Mitchell A., Zheng, Ling, Gilbert, Robert G., Stapleton, David and Gray-Weale, Angus (2012). The structure of cardiac glycogen in healthy mice. International Journal of Biological Macromolecules, 51 (5), 887-891. doi: 10.1016/j.ijbiomac.2012.06.037
2012
Journal Article
Molecular insights into glycogen alpha-particle formation
Sullivan, Mitchell A., O'Connor, Mitchell J., Umana, Felipe, Roura, Eugeni, Jack, Kevin, Stapleton, David I. and Gilbert, Robert G. (2012). Molecular insights into glycogen alpha-particle formation. Biomacromolecules, 13 (11), 3805-3813. doi: 10.1021/bm3012727
2011
Journal Article
Molecular structural differences between type-2-diabetic and healthy glycogen
Sullivan, Mitchell A., Li, Jiong, Li, Chuanzhou, Vilaplana, Francisco, Stapleton, David, Gray-Weale, Angus A., Bowen, Stirling, Zheng, Ling and Gilbert, Robert G. (2011). Molecular structural differences between type-2-diabetic and healthy glycogen. Biomacromolecules, 12 (6), 1983-1986. doi: 10.1021/bm2006054
2011
Conference Publication
Biosynthesis - structure - property relations for branched polysaccharides as revealed by two-dimensional macromolecular size/branch chain-length distributions
Vilaplana, Francisco, Sullivan, Mitchell A., Hasjim, Jovin and Gilbert, Robert G. (2011). Biosynthesis - structure - property relations for branched polysaccharides as revealed by two-dimensional macromolecular size/branch chain-length distributions. EPF 2011: European Polymer Federation Conference, Granada, Spain, 26 June-1 July 2011. European Polymer Federation; Specialized Group of Polymers (GEP); Institute of Polymer Science and Technology (ICTP-CSIC).
2010
Journal Article
Nature of alpha and beta particles in glycogen using molecular size distributions
Sullivan, Mitchell A., Vilaplana, Francisco, Cave, Richard A., Stapleton, David, Gray-Weale, Angus A. and Gilbert, Robert G. (2010). Nature of alpha and beta particles in glycogen using molecular size distributions. Biomacromolecules, 11 (4), 1094-1100. doi: 10.1021/bm100074p
Funding
Past funding
Supervision
Availability
- Dr Mitchell Sullivan is:
- Available for supervision
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Available projects
-
Unravelling the role of glycogen in diabetic kidney disease
Type 2 diabetes is Australia’s largest healthcare burden, with almost 2 million people suffering from the disease and ˜30% developing diabetic kidney disease. This study will characterise kidney glycogen accumulation, relating it to glycaemic control and kidney function over a time course of type 2 diabetes. This research will provide novel insight into how abnormalities in renal glucose handling and storage may contribute to kidney damage in type 2 diabetes, potentially leading to new therapies that mitigate diabetic kidney disease.
Hypothesis: Renal glycogen accumulation occurs in type 2 diabetes contributing to kidney damage.
Aims:
- To relate changes in renal glycogen accumulation to glycaemic control and kidney damage over a time course of diabetes.
- To analyse the structure of diabetic kidney glycogen and determine if it accumulates into insoluble polyglucosan bodies.
- To determine the effects of glucose and insulin on glycogen accumulation in the kidney, including the effect of the kidney-targeted glucose lowering SGLT2 inhibitor, empagliflozin.
Supervision history
Current supervision
-
Doctor Philosophy
Unravelling the role of abnormal glycogen accumulation in diabetic kidney disease
Principal Advisor
Other advisors: Honorary Professor Josephine Forbes
-
Doctor Philosophy
Unravelling the role of abnormal glycogen accumulation in diabetic kidney disease
Principal Advisor
Other advisors: Honorary Professor Josephine Forbes
-
Doctor Philosophy
Study of the structure of glycogen and potential drug target for diabetes
Associate Advisor
Other advisors: Professor Bob Gilbert
-
Doctor Philosophy
The effect of high-amylose resistant starch on the glycogen structure of diabetic mice
Associate Advisor
Other advisors: Professor Bob Gilbert
-
Doctor Philosophy
Host-directed therapies for treatment against respiratory virus disease
Associate Advisor
Other advisors: Professor Kirsty Short
Completed supervision
-
2023
Doctor Philosophy
The Analysis of Liver Glycogen Structure and its Implication in Various Diseases
Associate Advisor
Other advisors: Professor Bob Gilbert
Media
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