Overview
Background
Dr Mitchell Anthony Sullivan is a CJ Martin Early Career Research Fellow, funded by the National Health and Medical Research Council (NHMRC). Mitchell has a postdoctoral position in Professor Josephine Forbes’ Glycation and Diabetes research group at the Translational Research Institute. With a keen interest in the role of the blood-sugar storage molecule glycogen in health and disease, Mitchell has used the techniques he developed in his PhD, supervised by Prof. Robert Gilbert, to examine the important role this molecule has in diseases such as diabetes, Lafora disease and Adult Polyglucosan Body Disease. Currently he is extending this research into the field of diabetic kidney disease, combining the skills and knowledge he obtained in a 2-year postdoctoral position in Toronto with Prof. Berge Minassian, with the kidney expertise of Prof. Forbes. Awards received by Mitchell include the Biochemistry Alumni Prize (2008), awarded to the top ranked student at UQ in 3 biology/biochemistry course and the Chemistry Honours Research Prize (2010), awarded to “the student who, in completing a BSc (Honours) in the field of Chemistry, demonstrated a high level of achievement in the research component of the program and a high potential for independent research.” Mitchell was an organizing committee member for the Annual RACI Polymer Student Symposium (2013) and is currently a member of the Translation Research Institute Mentoring Committee. While less than 3 years from completing his PhD, Mitchell has 23 publication involving collaboration in China, Sweden, Canada, USA and Spain.
Personal statement: “Ever since beginning my research career as an undergraduate, I have thoroughly enjoyed the privilege of being able to pursue research questions I am passionate about. The opportunity to add new information and insights into the shared knowledge pool of the global scientific community is greatly appreciated. I will continue to relish these opportunities and strive to perform research to the best of my ability, with the goal of maximising a beneficial impact. As I advance through my career I will also endeavour to encourage and support my colleagues, helping foster a collaborative and fruitful environment to perform research.”
Availability
- Dr Mitchell Sullivan is:
- Available for supervision
Research impacts
Dr Mitchell Sullivan's PhD developed a number of techniques that allowed him to analyse the key structural features of glycogen, a highly branched macromolecule of ~50,000 glucose units. These techniques enabled his collaborative discovery that the diabetic liver contains fragile glycogen molecules, making them susceptible to uncontrolled degradation into glucose. The award of an NHMRC CJ Martin Fellowship allowed him to further his research in Toronto. The techniques Dr Sullivan developed in his PhD allowed him to analyse glycogen from various glycogen storage diseases (GSDs), leading to key breakthroughs in our understanding on the formation of the pathological glycogen accumulations characteristic of these diseases. In Toronto he continued to acquire and develop new methods that are essential in understanding the malformed glycogen present in these various GSDs. He is now using these skills to analyse the role of glycogen in diabetic kidney disease.
Works
Search Professor Mitchell Sullivan’s works on UQ eSpace
2019
Journal Article
The preventative effects of procyanidin on binge ethanol-induced lipid accumulation and ROS overproduction via the promotion of hepatic autophagy
Cao, Peng, Zhang, Yu, Huang, Zi, Sullivan, Mitchell A., He, Zihao, Wang, Jinglin, Chen, Zehong, Hu, Huiping and Wang, Kaiping (2019). The preventative effects of procyanidin on binge ethanol-induced lipid accumulation and ROS overproduction via the promotion of hepatic autophagy. Molecular Nutrition and Food Research, 63 (18) 1801255, 1801255. doi: 10.1002/mnfr.201801255
2019
Journal Article
Glycogen structure in type 1 diabetic mice: towards understanding the origin of diabetic glycogen molecular fragility
Hu, Zhenxia, Li, Enpeng, Sullivan, Mitchell A., Tan, Xinle, Deng, Bin, Gilbert, Robert G. and Li, Cheng (2019). Glycogen structure in type 1 diabetic mice: towards understanding the origin of diabetic glycogen molecular fragility. International Journal of Biological Macromolecules, 128, 665-672. doi: 10.1016/j.ijbiomac.2019.01.186
2019
Journal Article
Effects of active ingredients from traditional Chinese medicines on glycogen molecular structure in diabetic mice
Li, Cheng, Gan, Hua, Tan, Xinle, Hu, Zhenxia, Deng, Bin, Sullivan, Mitchell A. and Gilbert, Robert G. (2019). Effects of active ingredients from traditional Chinese medicines on glycogen molecular structure in diabetic mice. European Polymer Journal, 112, 67-72. doi: 10.1016/j.eurpolymj.2018.12.039
2019
Journal Article
Skeletal Muscle Glycogen Chain Length Correlates with Insolubility in Mouse Models of Polyglucosan-Associated Neurodegenerative Diseases
Sullivan, Mitchell A., Nitschke, Silvia, Skwara, Evan P., Wang, Peixiang, Zhao, Xiaochu, Pan, Xiao S., Chown, Erin E., Wang, Travis, Perri, Ami M., Lee, Jennifer P.Y., Vilaplana, Francisco, Minassian, Berge A. and Nitschke, Felix (2019). Skeletal Muscle Glycogen Chain Length Correlates with Insolubility in Mouse Models of Polyglucosan-Associated Neurodegenerative Diseases. Cell Reports, 27 (5), 1334-1344.e6. doi: 10.1016/j.celrep.2019.04.017
2018
Journal Article
Exploring glycogen biosynthesis through Monte Carlo simulation
Zhang, Peng, Nada, Sharif S., Tan, Xinle, Deng, Bin, Sullivan, Mitchell A. and Gilbert, Robert G. (2018). Exploring glycogen biosynthesis through Monte Carlo simulation. International Journal of Biological Macromolecules, 116, 264-271. doi: 10.1016/j.ijbiomac.2018.05.027
2018
Conference Publication
GLYCOGEN IN THE DIABETIC KIDNEY: THE HERO OR THE VILLAIN?
Sullivan, M. A., Wang, Z., Li, I., Milton, L., Mccarthy, D., Harcourt, B. E., Penfold, S. and Forbes, J. M. (2018). GLYCOGEN IN THE DIABETIC KIDNEY: THE HERO OR THE VILLAIN?. HOBOKEN: WILEY.
2018
Journal Article
Corrigendum to “Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro” [Int. J. Biol. Macromol. 111 (May 2018) 1133–1139] (S0141813017336826) (10.1016/j.ijbiomac.2018.01.139))
Cao, Peng, Sun, Jinlu, Sullivan, Mitchell A., Huang, Xiao, Wang, Hanxiang, Zhang, Yu, Wang, Na and Wang, Kaiping (2018). Corrigendum to “Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro” [Int. J. Biol. Macromol. 111 (May 2018) 1133–1139] (S0141813017336826) (10.1016/j.ijbiomac.2018.01.139)). International Journal of Biological Macromolecules, 115, 1269-1269. doi: 10.1016/j.ijbiomac.2018.04.168
2018
Journal Article
Diurnal changes of glycogen molecular structure in healthy and diabetic mice
Hu, Zhenxia, Deng, Bin, Tan, Xinle, Gan, Hua, Li, Cheng, Nada, Sharif S., Sullivan, Mitchell A., Li, Jialun, Jiang, Xiaoyin, Li, Enpeng and Gilbert, Robert G. (2018). Diurnal changes of glycogen molecular structure in healthy and diabetic mice. Carbohydrate Polymers, 185, 145-152. doi: 10.1016/j.carbpol.2018.01.003
2018
Journal Article
Proteomic investigation of the binding agent between liver glycogen beta particles
Tan, Xinle, Sullivan, Mitchell A., Nada, Sharif S., Deng, Bin, Schulz, Benjamin L. and Gilbert, Robert G. (2018). Proteomic investigation of the binding agent between liver glycogen beta particles. ACS Omega, 3 (4), 3640-3645. doi: 10.1021/acsomega.8b00119
2018
Journal Article
Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro
Cao, Peng, Sun, Jinlu, Sullivan, Mitchell A., Huang, Xiao, Wang, Hanxiang, Zhang, Yu, Wang, Na and Wang, Kaiping (2018). Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro. International Journal of Biological Macromolecules, 111, 1133-1139. doi: 10.1016/j.ijbiomac.2018.01.139
2017
Journal Article
Increased liver AGEs induce hepatic injury mediated through an OST48 pathway
Zhuang, Aowen, Yap, Felicia Y. T., Bruce, Clinton, Leung, Chris, Plan, Manuel R., Sullivan, Mitchell A., Herath, Chandana, McCarthy, Domenica, Sourris, Karly C., Kantharidis, Phillip, Coughlan, Melinda T., Febbraio, Mark A. , Hodson, Mark P., Watt, Matthew J., Angus, Peter, Schulz, Benjamin L. and Forbes, Josephine M. (2017). Increased liver AGEs induce hepatic injury mediated through an OST48 pathway. Scientific Reports, 7 (1) 12292, 12292. doi: 10.1038/s41598-017-12548-4
2017
Journal Article
Pathogenesis of Lafora Disease: Transition of Soluble Glycogen to Insoluble Polyglucosan
Sullivan, Mitchell A., Nitschke, Silvia, Steup, Martin, Minassian, Berge A. and Nitschke, Felix (2017). Pathogenesis of Lafora Disease: Transition of Soluble Glycogen to Insoluble Polyglucosan. International Journal of Molecular Sciences, 18 (8) 1743, 1743. doi: 10.3390/ijms18081743
2017
Journal Article
Lack of glycogenin causes glycogen accumulation and muscle function impairment
Testoni, Giorgia, Duran, Jordi, Garcia-Rocha, Mar, Vilaplana, Francisco, Serrano, Antorio L., Sebastian, David, Lopez-Soldado, Iliana, Sullivan, Mitchell A., Slebe, Felipe, Vilaseca, Marta, Munoz-Canoves, Pura and Guinovart, Joan J. (2017). Lack of glycogenin causes glycogen accumulation and muscle function impairment. Cell Metabolism, 26 (1), 256-266. doi: 10.1016/j.cmet.2017.06.008
2017
Journal Article
Abnormal glycogen chain length pattern, not hyperphosphorylation, is critical in Lafora disease
Nitschke, Felix, Sullivan, Mitchell A., Wang, Peixiang, Zhao, Xiaochu, Chown, Erin E., Perri, Ami M., Israelian, Lori, Juana-Lopez, Lucia, Bovolenta, Paola, Rodriguez de Cordoba, Santiago, Steup, Martin and Minassian, Berge A. (2017). Abnormal glycogen chain length pattern, not hyperphosphorylation, is critical in Lafora disease. EMBO Molecular Medicine, 9 (7), 906-917. doi: 10.15252/emmm.201707608
2017
Journal Article
Implications for biological function of lobe dependence of the molecular structure of liver glycogen
Hu, Zhenxia, Tan, Xinle, Deng, Bin, Gan, Hua, Jiang, Xiaoyin, Wang, Kai, Li, Cheng, Li, Enpeng, Gilbert, Robert G. and Sullivan, Mitchell A. (2017). Implications for biological function of lobe dependence of the molecular structure of liver glycogen. European Polymer Journal, 90, 105-113. doi: 10.1016/j.eurpolymj.2017.03.009
2017
Journal Article
Genetic and proteomic characterization of Bile Salt Export Pump (BSEP) in Snake Liver
Tan, Xinle, Gao, Fei, Su, Hexiu, Gong, Yajun, Zhang, Jie, Sullivan, Mitchell A. and Chen, Jiachun (2017). Genetic and proteomic characterization of Bile Salt Export Pump (BSEP) in Snake Liver. Scientific Reports, 7 (1) 43556, 1-6. doi: 10.1038/srep43556
2016
Journal Article
Molecular-size dependence of glycogen enzymatic degradation and its importance for diabetes
Jiang, Xiaoyin, Zhang, Peng, Li, Shihan, Tan, Xinle, Hu, Zhenxia, Deng, Bin, Wang, Kai, Li, Cheng, Sullivan, Mitchell A., Li, Enpeng and Gilbert, Robert G. (2016). Molecular-size dependence of glycogen enzymatic degradation and its importance for diabetes. European Polymer Journal, 82, 175-180. doi: 10.1016/j.eurpolymj.2016.07.017
2016
Journal Article
A new non-degradative method to purify glycogen
Tan, Xinle, Sullivan, Mitchell A., Gao, Fei, Li, Shihan, Schulz, Benjamin L. and Gilbert, Robert G. (2016). A new non-degradative method to purify glycogen. Carbohydrate Polymers, 147, 165-170. doi: 10.1016/j.carbpol.2016.04.009
2016
Journal Article
Molecular structure of human-liver glycogen
Deng, Bin, Sullivan, Mitchell A., Chen, Cheng, Li, Jialun, Powell, Prudence O., Hu, Zhenxia and Gilbert, Robert G. (2016). Molecular structure of human-liver glycogen. Plos One, 11 (3) e0150540, e0150540. doi: 10.1371/journal.pone.0150540
2016
Conference Publication
Glycogen: Higher -Level Molecular Structure and Diabetes
Tan, Xinle, Deng, Bin, Jiang, Xiaoyin, Zhang, Peng, Hu, Zhenxia, Li, Enpeng, Sullivan, Mitchell A., Schulz, Benjamin L. and Gilbert, Robert G. (2016). Glycogen: Higher -Level Molecular Structure and Diabetes. 12th International Conference on Polysaccharides-Glycoscience, Prague Czech Republic, 19-21 October 2016. Prague Czech Republic: Czech Chemical Society.
Funding
Past funding
Supervision
Availability
- Dr Mitchell Sullivan is:
- Available for supervision
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Available projects
-
Unravelling the role of glycogen in diabetic kidney disease
Type 2 diabetes is Australia’s largest healthcare burden, with almost 2 million people suffering from the disease and ˜30% developing diabetic kidney disease. This study will characterise kidney glycogen accumulation, relating it to glycaemic control and kidney function over a time course of type 2 diabetes. This research will provide novel insight into how abnormalities in renal glucose handling and storage may contribute to kidney damage in type 2 diabetes, potentially leading to new therapies that mitigate diabetic kidney disease.
Hypothesis: Renal glycogen accumulation occurs in type 2 diabetes contributing to kidney damage.
Aims:
- To relate changes in renal glycogen accumulation to glycaemic control and kidney damage over a time course of diabetes.
- To analyse the structure of diabetic kidney glycogen and determine if it accumulates into insoluble polyglucosan bodies.
- To determine the effects of glucose and insulin on glycogen accumulation in the kidney, including the effect of the kidney-targeted glucose lowering SGLT2 inhibitor, empagliflozin.
Supervision history
Current supervision
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Doctor Philosophy
Unravelling the role of abnormal glycogen accumulation in diabetic kidney disease
Principal Advisor
Other advisors: Honorary Professor Josephine Forbes
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Doctor Philosophy
Unravelling the role of abnormal glycogen accumulation in diabetic kidney disease
Principal Advisor
Other advisors: Honorary Professor Josephine Forbes
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Doctor Philosophy
Study of the structure of glycogen and potential drug target for diabetes
Associate Advisor
Other advisors: Professor Bob Gilbert
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Doctor Philosophy
The effect of high-amylose resistant starch on the glycogen structure of diabetic mice
Associate Advisor
Other advisors: Professor Bob Gilbert
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Doctor Philosophy
Host-directed therapies for treatment against respiratory virus disease
Associate Advisor
Other advisors: Associate Professor Kirsty Short
Completed supervision
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2023
Doctor Philosophy
The Analysis of Liver Glycogen Structure and its Implication in Various Diseases
Associate Advisor
Other advisors: Professor Bob Gilbert
Media
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