Skip to menu Skip to content Skip to footer
Dr Mitchell Sullivan
Dr

Mitchell Sullivan

Email: 

Overview

Background

Dr Mitchell Anthony Sullivan is a CJ Martin Early Career Research Fellow, funded by the National Health and Medical Research Council (NHMRC). Mitchell has a postdoctoral position in Professor Josephine Forbes’ Glycation and Diabetes research group at the Translational Research Institute. With a keen interest in the role of the blood-sugar storage molecule glycogen in health and disease, Mitchell has used the techniques he developed in his PhD, supervised by Prof. Robert Gilbert, to examine the important role this molecule has in diseases such as diabetes, Lafora disease and Adult Polyglucosan Body Disease. Currently he is extending this research into the field of diabetic kidney disease, combining the skills and knowledge he obtained in a 2-year postdoctoral position in Toronto with Prof. Berge Minassian, with the kidney expertise of Prof. Forbes. Awards received by Mitchell include the Biochemistry Alumni Prize (2008), awarded to the top ranked student at UQ in 3 biology/biochemistry course and the Chemistry Honours Research Prize (2010), awarded to “the student who, in completing a BSc (Honours) in the field of Chemistry, demonstrated a high level of achievement in the research component of the program and a high potential for independent research.” Mitchell was an organizing committee member for the Annual RACI Polymer Student Symposium (2013) and is currently a member of the Translation Research Institute Mentoring Committee. While less than 3 years from completing his PhD, Mitchell has 23 publication involving collaboration in China, Sweden, Canada, USA and Spain.

Personal statement: “Ever since beginning my research career as an undergraduate, I have thoroughly enjoyed the privilege of being able to pursue research questions I am passionate about. The opportunity to add new information and insights into the shared knowledge pool of the global scientific community is greatly appreciated. I will continue to relish these opportunities and strive to perform research to the best of my ability, with the goal of maximising a beneficial impact. As I advance through my career I will also endeavour to encourage and support my colleagues, helping foster a collaborative and fruitful environment to perform research.”

Availability

Dr Mitchell Sullivan is:
Available for supervision

Research impacts

Dr Mitchell Sullivan's PhD developed a number of techniques that allowed him to analyse the key structural features of glycogen, a highly branched macromolecule of ~50,000 glucose units. These techniques enabled his collaborative discovery that the diabetic liver contains fragile glycogen molecules, making them susceptible to uncontrolled degradation into glucose. The award of an NHMRC CJ Martin Fellowship allowed him to further his research in Toronto. The techniques Dr Sullivan developed in his PhD allowed him to analyse glycogen from various glycogen storage diseases (GSDs), leading to key breakthroughs in our understanding on the formation of the pathological glycogen accumulations characteristic of these diseases. In Toronto he continued to acquire and develop new methods that are essential in understanding the malformed glycogen present in these various GSDs. He is now using these skills to analyse the role of glycogen in diabetic kidney disease.

Works

Search Professor Mitchell Sullivan’s works on UQ eSpace

74 works between 2010 and 2024

41 - 60 of 74 works

2019

Journal Article

Skeletal Muscle Glycogen Chain Length Correlates with Insolubility in Mouse Models of Polyglucosan-Associated Neurodegenerative Diseases

Sullivan, Mitchell A., Nitschke, Silvia, Skwara, Evan P., Wang, Peixiang, Zhao, Xiaochu, Pan, Xiao S., Chown, Erin E., Wang, Travis, Perri, Ami M., Lee, Jennifer P.Y., Vilaplana, Francisco, Minassian, Berge A. and Nitschke, Felix (2019). Skeletal Muscle Glycogen Chain Length Correlates with Insolubility in Mouse Models of Polyglucosan-Associated Neurodegenerative Diseases. Cell Reports, 27 (5), 1334-1344.e6. doi: 10.1016/j.celrep.2019.04.017

Skeletal Muscle Glycogen Chain Length Correlates with Insolubility in Mouse Models of Polyglucosan-Associated Neurodegenerative Diseases

2018

Journal Article

Exploring glycogen biosynthesis through Monte Carlo simulation

Zhang, Peng, Nada, Sharif S., Tan, Xinle, Deng, Bin, Sullivan, Mitchell A. and Gilbert, Robert G. (2018). Exploring glycogen biosynthesis through Monte Carlo simulation. International Journal of Biological Macromolecules, 116, 264-271. doi: 10.1016/j.ijbiomac.2018.05.027

Exploring glycogen biosynthesis through Monte Carlo simulation

2018

Conference Publication

GLYCOGEN IN THE DIABETIC KIDNEY: THE HERO OR THE VILLAIN?

Sullivan, M. A., Wang, Z., Li, I., Milton, L., Mccarthy, D., Harcourt, B. E., Penfold, S. and Forbes, J. M. (2018). GLYCOGEN IN THE DIABETIC KIDNEY: THE HERO OR THE VILLAIN?. HOBOKEN: WILEY.

GLYCOGEN IN THE DIABETIC KIDNEY: THE HERO OR THE VILLAIN?

2018

Journal Article

Corrigendum to “Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro” [Int. J. Biol. Macromol. 111 (May 2018) 1133–1139] (S0141813017336826) (10.1016/j.ijbiomac.2018.01.139))

Cao, Peng, Sun, Jinlu, Sullivan, Mitchell A., Huang, Xiao, Wang, Hanxiang, Zhang, Yu, Wang, Na and Wang, Kaiping (2018). Corrigendum to “Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro” [Int. J. Biol. Macromol. 111 (May 2018) 1133–1139] (S0141813017336826) (10.1016/j.ijbiomac.2018.01.139)). International Journal of Biological Macromolecules, 115, 1269-1269. doi: 10.1016/j.ijbiomac.2018.04.168

Corrigendum to “Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro” [Int. J. Biol. Macromol. 111 (May 2018) 1133–1139] (S0141813017336826) (10.1016/j.ijbiomac.2018.01.139))

2018

Journal Article

Diurnal changes of glycogen molecular structure in healthy and diabetic mice

Hu, Zhenxia, Deng, Bin, Tan, Xinle, Gan, Hua, Li, Cheng, Nada, Sharif S., Sullivan, Mitchell A., Li, Jialun, Jiang, Xiaoyin, Li, Enpeng and Gilbert, Robert G. (2018). Diurnal changes of glycogen molecular structure in healthy and diabetic mice. Carbohydrate Polymers, 185, 145-152. doi: 10.1016/j.carbpol.2018.01.003

Diurnal changes of glycogen molecular structure in healthy and diabetic mice

2018

Journal Article

Proteomic investigation of the binding agent between liver glycogen beta particles

Tan, Xinle, Sullivan, Mitchell A., Nada, Sharif S., Deng, Bin, Schulz, Benjamin L. and Gilbert, Robert G. (2018). Proteomic investigation of the binding agent between liver glycogen beta particles. ACS Omega, 3 (4), 3640-3645. doi: 10.1021/acsomega.8b00119

Proteomic investigation of the binding agent between liver glycogen beta particles

2018

Journal Article

Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro

Cao, Peng, Sun, Jinlu, Sullivan, Mitchell A., Huang, Xiao, Wang, Hanxiang, Zhang, Yu, Wang, Na and Wang, Kaiping (2018). Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro. International Journal of Biological Macromolecules, 111, 1133-1139. doi: 10.1016/j.ijbiomac.2018.01.139

Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro

2017

Journal Article

Increased liver AGEs induce hepatic injury mediated through an OST48 pathway

Zhuang, Aowen, Yap, Felicia Y. T., Bruce, Clinton, Leung, Chris, Plan, Manuel R., Sullivan, Mitchell A., Herath, Chandana, McCarthy, Domenica, Sourris, Karly C., Kantharidis, Phillip, Coughlan, Melinda T., Febbraio, Mark A. , Hodson, Mark P., Watt, Matthew J., Angus, Peter, Schulz, Benjamin L. and Forbes, Josephine M. (2017). Increased liver AGEs induce hepatic injury mediated through an OST48 pathway. Scientific Reports, 7 (1) 12292, 12292. doi: 10.1038/s41598-017-12548-4

Increased liver AGEs induce hepatic injury mediated through an OST48 pathway

2017

Journal Article

Pathogenesis of Lafora Disease: Transition of Soluble Glycogen to Insoluble Polyglucosan

Sullivan, Mitchell A., Nitschke, Silvia, Steup, Martin, Minassian, Berge A. and Nitschke, Felix (2017). Pathogenesis of Lafora Disease: Transition of Soluble Glycogen to Insoluble Polyglucosan. International Journal of Molecular Sciences, 18 (8) 1743, 1743. doi: 10.3390/ijms18081743

Pathogenesis of Lafora Disease: Transition of Soluble Glycogen to Insoluble Polyglucosan

2017

Journal Article

Lack of glycogenin causes glycogen accumulation and muscle function impairment

Testoni, Giorgia, Duran, Jordi, Garcia-Rocha, Mar, Vilaplana, Francisco, Serrano, Antorio L., Sebastian, David, Lopez-Soldado, Iliana, Sullivan, Mitchell A., Slebe, Felipe, Vilaseca, Marta, Munoz-Canoves, Pura and Guinovart, Joan J. (2017). Lack of glycogenin causes glycogen accumulation and muscle function impairment. Cell Metabolism, 26 (1), 256-266. doi: 10.1016/j.cmet.2017.06.008

Lack of glycogenin causes glycogen accumulation and muscle function impairment

2017

Journal Article

Abnormal glycogen chain length pattern, not hyperphosphorylation, is critical in Lafora disease

Nitschke, Felix, Sullivan, Mitchell A., Wang, Peixiang, Zhao, Xiaochu, Chown, Erin E., Perri, Ami M., Israelian, Lori, Juana-Lopez, Lucia, Bovolenta, Paola, Rodriguez de Cordoba, Santiago, Steup, Martin and Minassian, Berge A. (2017). Abnormal glycogen chain length pattern, not hyperphosphorylation, is critical in Lafora disease. EMBO Molecular Medicine, 9 (7), 906-917. doi: 10.15252/emmm.201707608

Abnormal glycogen chain length pattern, not hyperphosphorylation, is critical in Lafora disease

2017

Journal Article

Implications for biological function of lobe dependence of the molecular structure of liver glycogen

Hu, Zhenxia, Tan, Xinle, Deng, Bin, Gan, Hua, Jiang, Xiaoyin, Wang, Kai, Li, Cheng, Li, Enpeng, Gilbert, Robert G. and Sullivan, Mitchell A. (2017). Implications for biological function of lobe dependence of the molecular structure of liver glycogen. European Polymer Journal, 90, 105-113. doi: 10.1016/j.eurpolymj.2017.03.009

Implications for biological function of lobe dependence of the molecular structure of liver glycogen

2017

Journal Article

Genetic and proteomic characterization of Bile Salt Export Pump (BSEP) in Snake Liver

Tan, Xinle, Gao, Fei, Su, Hexiu, Gong, Yajun, Zhang, Jie, Sullivan, Mitchell A. and Chen, Jiachun (2017). Genetic and proteomic characterization of Bile Salt Export Pump (BSEP) in Snake Liver. Scientific Reports, 7 (1) 43556, 1-6. doi: 10.1038/srep43556

Genetic and proteomic characterization of Bile Salt Export Pump (BSEP) in Snake Liver

2016

Journal Article

Molecular-size dependence of glycogen enzymatic degradation and its importance for diabetes

Jiang, Xiaoyin, Zhang, Peng, Li, Shihan, Tan, Xinle, Hu, Zhenxia, Deng, Bin, Wang, Kai, Li, Cheng, Sullivan, Mitchell A., Li, Enpeng and Gilbert, Robert G. (2016). Molecular-size dependence of glycogen enzymatic degradation and its importance for diabetes. European Polymer Journal, 82, 175-180. doi: 10.1016/j.eurpolymj.2016.07.017

Molecular-size dependence of glycogen enzymatic degradation and its importance for diabetes

2016

Journal Article

A new non-degradative method to purify glycogen

Tan, Xinle, Sullivan, Mitchell A., Gao, Fei, Li, Shihan, Schulz, Benjamin L. and Gilbert, Robert G. (2016). A new non-degradative method to purify glycogen. Carbohydrate Polymers, 147, 165-170. doi: 10.1016/j.carbpol.2016.04.009

A new non-degradative method to purify glycogen

2016

Journal Article

Molecular structure of human-liver glycogen

Deng, Bin, Sullivan, Mitchell A., Chen, Cheng, Li, Jialun, Powell, Prudence O., Hu, Zhenxia and Gilbert, Robert G. (2016). Molecular structure of human-liver glycogen. Plos One, 11 (3) e0150540, e0150540. doi: 10.1371/journal.pone.0150540

Molecular structure of human-liver glycogen

2016

Conference Publication

Glycogen: Higher -Level Molecular Structure and Diabetes

Tan, Xinle, Deng, Bin, Jiang, Xiaoyin, Zhang, Peng, Hu, Zhenxia, Li, Enpeng, Sullivan, Mitchell A., Schulz, Benjamin L. and Gilbert, Robert G. (2016). Glycogen: Higher -Level Molecular Structure and Diabetes. 12th International Conference on Polysaccharides-Glycoscience, Prague Czech Republic, 19-21 October 2016. Prague Czech Republic: Czech Chemical Society.

Glycogen: Higher -Level Molecular Structure and Diabetes

2016

Conference Publication

The metabolic and inflammatory challenges of summer in the feedlot

Wijfells, G., Sullivan, M. L., Stockwell, S., Briscoe, S., McCulloch, R., Straube, J., Olm, J., Cawdell-Smith, J., Anderson, S. T., Le Cao, K.-A. and Gaughan, J. B. (2016). The metabolic and inflammatory challenges of summer in the feedlot. Northern Australia Beef Research Update Conference, Rockhampton, QLD Australia, 15 - 18 August 2016. Gympie, QLD, Australia: Queensland North Australia Beef Research Council.

The metabolic and inflammatory challenges of summer in the feedlot

2015

Journal Article

Correction: Acid hydrolysis and molecular density of phytoglycogen and liver glycogen helps understand the bonding in glycogen a (composite) particles

Powell, Prudence O., Sullivan, Mitchell A., Sheehy, Joshua J., Schulz, Benjamin L., Warren, Frederick J. and Gilbert, Robert G. (2015). Correction: Acid hydrolysis and molecular density of phytoglycogen and liver glycogen helps understand the bonding in glycogen a (composite) particles. PLoS One, 10 (7) e0134065, e0134065. doi: 10.1371/journal.pone.0134065

Correction: Acid hydrolysis and molecular density of phytoglycogen and liver glycogen helps understand the bonding in glycogen a (composite) particles

2015

Journal Article

The mechanism for stopping chain and total-molecule growth in complex branched polymers, exemplified by glycogen

Deng, Bin, Sullivan, Mitchell A., Wu, Alex Chi, Li, Jialun, Chen, Cheng and Gilbert, Robert G. (2015). The mechanism for stopping chain and total-molecule growth in complex branched polymers, exemplified by glycogen. Biomacromolecules, 16 (6), 1870-1872. doi: 10.1021/acs.biomac.5b00459

The mechanism for stopping chain and total-molecule growth in complex branched polymers, exemplified by glycogen

Funding

Past funding

  • 2021 - 2024
    MitoKhondrion: Decreasing COVID-19 mortality by increasing the functioning of our cell's powerhouses
    Advance Queensland Industry Research Fellowships
    Open grant
  • 2015 - 2019
    Exploring the Role of Glycogen Structure in Type 2 Diabetes
    NHMRC Early Career Fellowships
    Open grant

Supervision

Availability

Dr Mitchell Sullivan is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Unravelling the role of glycogen in diabetic kidney disease

    Type 2 diabetes is Australia’s largest healthcare burden, with almost 2 million people suffering from the disease and ˜30% developing diabetic kidney disease. This study will characterise kidney glycogen accumulation, relating it to glycaemic control and kidney function over a time course of type 2 diabetes. This research will provide novel insight into how abnormalities in renal glucose handling and storage may contribute to kidney damage in type 2 diabetes, potentially leading to new therapies that mitigate diabetic kidney disease.

    Hypothesis: Renal glycogen accumulation occurs in type 2 diabetes contributing to kidney damage.

    Aims:

    1. To relate changes in renal glycogen accumulation to glycaemic control and kidney damage over a time course of diabetes.
    2. To analyse the structure of diabetic kidney glycogen and determine if it accumulates into insoluble polyglucosan bodies.
    3. To determine the effects of glucose and insulin on glycogen accumulation in the kidney, including the effect of the kidney-targeted glucose lowering SGLT2 inhibitor, empagliflozin.

Supervision history

Current supervision

  • Doctor Philosophy

    Unravelling the role of abnormal glycogen accumulation in diabetic kidney disease

    Principal Advisor

    Other advisors: Honorary Professor Josephine Forbes

  • Doctor Philosophy

    A new treatment for viral disease: Modulators of the renin angiotension system

    Associate Advisor

    Other advisors: Associate Professor Kirsty Short

  • Doctor Philosophy

    Study of the structure of glycogen and potential drug target for diabetes

    Associate Advisor

    Other advisors: Professor Bob Gilbert

  • Doctor Philosophy

    The effect of high-amylose resistant starch on the glycogen structure of diabetic mice

    Associate Advisor

    Other advisors: Professor Bob Gilbert

Completed supervision

Media

Enquiries

For media enquiries about Dr Mitchell Sullivan's areas of expertise, story ideas and help finding experts, contact our Media team:

communications@uq.edu.au