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Dr Mitchell Sullivan
Dr

Mitchell Sullivan

Email: 

Overview

Background

Dr Mitchell Anthony Sullivan is a CJ Martin Early Career Research Fellow, funded by the National Health and Medical Research Council (NHMRC). Mitchell has a postdoctoral position in Professor Josephine Forbes’ Glycation and Diabetes research group at the Translational Research Institute. With a keen interest in the role of the blood-sugar storage molecule glycogen in health and disease, Mitchell has used the techniques he developed in his PhD, supervised by Prof. Robert Gilbert, to examine the important role this molecule has in diseases such as diabetes, Lafora disease and Adult Polyglucosan Body Disease. Currently he is extending this research into the field of diabetic kidney disease, combining the skills and knowledge he obtained in a 2-year postdoctoral position in Toronto with Prof. Berge Minassian, with the kidney expertise of Prof. Forbes. Awards received by Mitchell include the Biochemistry Alumni Prize (2008), awarded to the top ranked student at UQ in 3 biology/biochemistry course and the Chemistry Honours Research Prize (2010), awarded to “the student who, in completing a BSc (Honours) in the field of Chemistry, demonstrated a high level of achievement in the research component of the program and a high potential for independent research.” Mitchell was an organizing committee member for the Annual RACI Polymer Student Symposium (2013) and is currently a member of the Translation Research Institute Mentoring Committee. While less than 3 years from completing his PhD, Mitchell has 23 publication involving collaboration in China, Sweden, Canada, USA and Spain.

Personal statement: “Ever since beginning my research career as an undergraduate, I have thoroughly enjoyed the privilege of being able to pursue research questions I am passionate about. The opportunity to add new information and insights into the shared knowledge pool of the global scientific community is greatly appreciated. I will continue to relish these opportunities and strive to perform research to the best of my ability, with the goal of maximising a beneficial impact. As I advance through my career I will also endeavour to encourage and support my colleagues, helping foster a collaborative and fruitful environment to perform research.”

Availability

Dr Mitchell Sullivan is:
Available for supervision

Research impacts

Dr Mitchell Sullivan's PhD developed a number of techniques that allowed him to analyse the key structural features of glycogen, a highly branched macromolecule of ~50,000 glucose units. These techniques enabled his collaborative discovery that the diabetic liver contains fragile glycogen molecules, making them susceptible to uncontrolled degradation into glucose. The award of an NHMRC CJ Martin Fellowship allowed him to further his research in Toronto. The techniques Dr Sullivan developed in his PhD allowed him to analyse glycogen from various glycogen storage diseases (GSDs), leading to key breakthroughs in our understanding on the formation of the pathological glycogen accumulations characteristic of these diseases. In Toronto he continued to acquire and develop new methods that are essential in understanding the malformed glycogen present in these various GSDs. He is now using these skills to analyse the role of glycogen in diabetic kidney disease.

Works

Search Professor Mitchell Sullivan’s works on UQ eSpace

75 works between 2010 and 2024

21 - 40 of 75 works

2021

Journal Article

T cell expression and release of kidney injury molecule-1 in response to glucose variations initiates kidney injury in early diabetes

Forbes, Josephine M., McCarthy, Domenica A., Kassianos, Andrew J., Baskerville, Tracey, Fotheringham, Amelia J., Giuliani, Kurt T. K., Grivei, Anca, Murphy, Andrew J., Flynn, Michelle C., Sullivan, Mitchell A., Chandrashekar, Preeti, Whiddett, Rani, Radford, Kristen J., Flemming, Nicole, Beard, Sam S., D’Silva, Neisha, Nisbet, Janelle, Morton, Adam, Teasdale, Stephanie, Russell, Anthony, Isbel, Nicole, Jones, Timothy, Couper, Jennifer, Healy, Helen, Harris, Mark, Donaghue, Kim, Johnson, David W., Cotterill, Andrew, Barrett, Helen L. and O’Moore-Sullivan, Trisha (2021). T cell expression and release of kidney injury molecule-1 in response to glucose variations initiates kidney injury in early diabetes. Diabetes, 70 (8), 1754-1766. doi: 10.2337/db20-1081

T cell expression and release of kidney injury molecule-1 in response to glucose variations initiates kidney injury in early diabetes

2021

Journal Article

Mechanism of lentinan intestinal absorption: clathrin-mediated endocytosis and macropinocytosis

Zheng, Ziming, Pan, Xianglin, Wang, Haoyu, Wu, Zhijing, Sullivan, Mitchell A., Liu, Yuxuan, Liu, Junxi, Wang, Kaiping and Zhang, Yu (2021). Mechanism of lentinan intestinal absorption: clathrin-mediated endocytosis and macropinocytosis. Journal of Agricultural and Food Chemistry, 69 (26) acs.jafc.1c00349, 7344-7352. doi: 10.1021/acs.jafc.1c00349

Mechanism of lentinan intestinal absorption: clathrin-mediated endocytosis and macropinocytosis

2021

Journal Article

Optimization of liver glycogen extraction when considering the fine molecular structure

Wang, Ziyi, Liu, Qinghua, Wang, Liang, Gilbert, Robert G. and Sullivan, Mitchell A. (2021). Optimization of liver glycogen extraction when considering the fine molecular structure. Carbohydrate Polymers, 261 117887, 1-11. doi: 10.1016/j.carbpol.2021.117887

Optimization of liver glycogen extraction when considering the fine molecular structure

2021

Book Chapter

The Pathologies of a Dysfunctional Glycogen Metabolism

Sullivan, Mitchell A., Minassian, Berge A. and Nitschke, Felix (2021). The Pathologies of a Dysfunctional Glycogen Metabolism. Enzymology of Complex Alpha-Glucans. (pp. 138-162) Boca Raton, FL United States: CRC Press. doi: 10.1201/b22412-6

The Pathologies of a Dysfunctional Glycogen Metabolism

2021

Journal Article

Comprehensive landscape of heparin therapy for COVID-19

Shi, Chen, Tingting, Wu, Li, Jin-Ping, Sullivan, Mitchell A., Wang, Cong, Wang, Hanxiang, Deng, Bin and Zhang, Yu (2021). Comprehensive landscape of heparin therapy for COVID-19. Carbohydrate Polymers, 254 117232, 117232. doi: 10.1016/j.carbpol.2020.117232

Comprehensive landscape of heparin therapy for COVID-19

2021

Journal Article

The importance of glycogen molecular structure for blood glucose control

Nawaz, Asad, Zhang, Peng, Li, Enpeng, Gilbert, Robert G. and Sullivan, Mitchell A. (2021). The importance of glycogen molecular structure for blood glucose control. iScience, 24 (1) 101953, 101953. doi: 10.1016/j.isci.2020.101953

The importance of glycogen molecular structure for blood glucose control

2021

Journal Article

Impact of dietary carbohydrate type and protein–carbohydrate interaction on metabolic health

Wali, Jibran A., Milner, Annabelle J., Luk, Alison W. S., Pulpitel, Tamara J., Dodgson, Tim, Facey, Harrison J. W., Wahl, Devin, Kebede, Melkam A., Senior, Alistair M., Sullivan, Mitchell A., Brandon, Amanda E., Yau, Belinda, Lockwood, Glen P., Koay, Yen Chin, Ribeiro, Rosilene, Solon-Biet, Samantha M., Bell-Anderson, Kim S., O’Sullivan, John F., Macia, Laurence, Forbes, Josephine M., Cooney, Gregory J., Cogger, Victoria C., Holmes, Andrew, Raubenheimer, David, Le Couteur, David G. and Simpson, Stephen J. (2021). Impact of dietary carbohydrate type and protein–carbohydrate interaction on metabolic health. Nature Metabolism, 3 (6), 810-828. doi: 10.1038/s42255-021-00393-9

Impact of dietary carbohydrate type and protein–carbohydrate interaction on metabolic health

2021

Journal Article

Protective effect of Yi Shen Pai du formula against diabetic kidney injury via inhibition of oxidative stress, inflammation, and epithelial-to-mesenchymal transition in db/db mice

Zhang, Qilin, Liu, Xiaocui, Sullivan, Mitchell A., Shi, Chen and Deng, Bin (2021). Protective effect of Yi Shen Pai du formula against diabetic kidney injury via inhibition of oxidative stress, inflammation, and epithelial-to-mesenchymal transition in db/db mice. Oxidative Medicine and Cellular Longevity, 2021 (1) 7958021, 1-15. doi: 10.1155/2021/7958021

Protective effect of Yi Shen Pai du formula against diabetic kidney injury via inhibition of oxidative stress, inflammation, and epithelial-to-mesenchymal transition in db/db mice

2020

Journal Article

Mutation of regulatory phosphorylation sites in PFKFB2 worsens renal fibrosis

Lee, Mardiana, Harley, Geoff, Katerelos, Marina, Gleich, Kurt, Sullivan, Mitchell A., Laskowski, Adrienne, Coughlan, Melinda, Fraser, Scott A., Mount, Peter F. and Power, David A. (2020). Mutation of regulatory phosphorylation sites in PFKFB2 worsens renal fibrosis. Scientific Reports, 10 (1) 14531. doi: 10.1038/s41598-020-71475-z

Mutation of regulatory phosphorylation sites in PFKFB2 worsens renal fibrosis

2020

Journal Article

Revisiting Glycogen in Cancer: A Conspicuous and Targetable Enabler of Malignant Transformation

Khan, Tashbib, Sullivan, Mitchell A., Gunter, Jennifer H., Kryza, Thomas, Lyons, Nicholas, He, Yaowu and Hooper, John D. (2020). Revisiting Glycogen in Cancer: A Conspicuous and Targetable Enabler of Malignant Transformation. Frontiers in Oncology, 10 592455, 592455. doi: 10.3389/fonc.2020.592455

Revisiting Glycogen in Cancer: A Conspicuous and Targetable Enabler of Malignant Transformation

2020

Journal Article

Metformin and Berberine suppress glycogenolysis by inhibiting glycogen phosphorylase and stabilizing the molecular structure of glycogen in db/db mice

Liu, Xiaocui, Wang, Kaiping, Zhou, Jing, Sullivan, Mitchell A., Liu, Yage, Gilbert, Robert G. and Deng, Bin (2020). Metformin and Berberine suppress glycogenolysis by inhibiting glycogen phosphorylase and stabilizing the molecular structure of glycogen in db/db mice. Carbohydrate Polymers, 243 116435, 116435. doi: 10.1016/j.carbpol.2020.116435

Metformin and Berberine suppress glycogenolysis by inhibiting glycogen phosphorylase and stabilizing the molecular structure of glycogen in db/db mice

2020

Journal Article

Polyglucosan body structure in Lafora disease

Brewer, M. Kathryn, Putaux, Jean-Luc, Rondon, Alberto, Uittenbogaard, Annette, Sullivan, Mitchell A. and Gentry, Matthew S. (2020). Polyglucosan body structure in Lafora disease. Carbohydrate Polymers, 240 116260, 1-14. doi: 10.1016/j.carbpol.2020.116260

Polyglucosan body structure in Lafora disease

2020

Journal Article

Disruption of glycogen utilization markedly improves the efficacy of carboplatin against preclinical models of clear cell ovarian carcinoma

Khan, Tashbib, He, Yaowu, Kryza, Thomas, Harrington, Brittney S., Gunter, Jennifer H., Sullivan, Mitchell A., Cuda, Tahleesa, Rogers, Rebecca, Davies, Claire M., Broomfield, Amy, Gough, Madeline, Wu, Andy C., McGann, Thomas, Weroha, S. John, Haluska, Paul, Forbes, Josephine M., Armes, Jane E., Barry, Sinead C., Coward, Jermaine I., Jagasia, Nisha, Chetty, Naven, Snell, Cameron E., Lourie, Rohan, Perrin, Lewis C. and Hooper, John D. (2020). Disruption of glycogen utilization markedly improves the efficacy of carboplatin against preclinical models of clear cell ovarian carcinoma. Cancers, 12 (4) 869, 869. doi: 10.3390/cancers12040869

Disruption of glycogen utilization markedly improves the efficacy of carboplatin against preclinical models of clear cell ovarian carcinoma

2020

Journal Article

Erratum to “Exploring glycogen biosynthesis through Monte Carlo simulation”

Zhang, Peng, Nada, Sharif S., Tan, Xinle, Deng, Bin, Sullivan, Mitchell A. and Gilbert, Robert G. (2020). Erratum to “Exploring glycogen biosynthesis through Monte Carlo simulation”. International Journal of Biological Macromolecules, 144, 1043-1044. doi: 10.1016/j.ijbiomac.2019.05.183

Erratum to “Exploring glycogen biosynthesis through Monte Carlo simulation”

2020

Journal Article

Corrigendum to: “Exploring glycogen biosynthesis through Monte Carlo simulation” (International Journal of Biological Macromolecules (2018) 116 (264–271), (S0141813018312923), (10.1016/j.ijbiomac.2018.05.027))

Zhang, Peng, Nada, Sharif S., Tan, Xinle, Deng, Bin, Sullivan, Mitchell A. and Gilbert, Robert G. (2020). Corrigendum to: “Exploring glycogen biosynthesis through Monte Carlo simulation” (International Journal of Biological Macromolecules (2018) 116 (264–271), (S0141813018312923), (10.1016/j.ijbiomac.2018.05.027)). International Journal of Biological Macromolecules, 142, 889-890. doi: 10.1016/j.ijbiomac.2019.11.160

Corrigendum to: “Exploring glycogen biosynthesis through Monte Carlo simulation” (International Journal of Biological Macromolecules (2018) 116 (264–271), (S0141813018312923), (10.1016/j.ijbiomac.2018.05.027))

2020

Journal Article

GYS1 or PPP1R3C deficiency rescues murine adult polyglucosan body disease

Chown, Erin E., Wang, Peixiang, Zhao, Xiaochu, Crowder, Justin J., Strober, Jordan W., Sullivan, Mitchell A., Xue, Yunlin, Bennett, Cody S., Perri, Ami M., Evers, Bret M., Roach, Peter J., Depaoli-Roach, Anna A., Akman, H. Orhan, Pederson, Bartholomew A. and Minassian, Berge A. (2020). GYS1 or PPP1R3C deficiency rescues murine adult polyglucosan body disease. Annals of Clinical and Translational Neurology, 7 (11) acn3.51211, 2186-2198. doi: 10.1002/acn3.51211

GYS1 or PPP1R3C deficiency rescues murine adult polyglucosan body disease

2019

Journal Article

Some molecular structural features of glycogen in the kidneys of diabetic rats

Wang, Ziyi, Liu, Qinghua, Wang, Liang, Tan, Xinle, Deng, Bin, Li, Enpeng, Gilbert, Robert G. and Sullivan, Mitchell A. (2019). Some molecular structural features of glycogen in the kidneys of diabetic rats. Carbohydrate Polymers, 229 115526, 115526. doi: 10.1016/j.carbpol.2019.115526

Some molecular structural features of glycogen in the kidneys of diabetic rats

2019

Journal Article

Glucose and glycogen in the diabetic kidney: heroes or villains?

Sullivan, Mitchell A. and Forbes, Josephine M. (2019). Glucose and glycogen in the diabetic kidney: heroes or villains?. EBioMedicine, 47, 590-597. doi: 10.1016/j.ebiom.2019.07.067

Glucose and glycogen in the diabetic kidney: heroes or villains?

2019

Journal Article

The preventative effects of procyanidin on binge ethanol-induced lipid accumulation and ROS overproduction via the promotion of hepatic autophagy

Cao, Peng, Zhang, Yu, Huang, Zi, Sullivan, Mitchell A., He, Zihao, Wang, Jinglin, Chen, Zehong, Hu, Huiping and Wang, Kaiping (2019). The preventative effects of procyanidin on binge ethanol-induced lipid accumulation and ROS overproduction via the promotion of hepatic autophagy. Molecular Nutrition and Food Research, 63 (18) 1801255, 1801255. doi: 10.1002/mnfr.201801255

The preventative effects of procyanidin on binge ethanol-induced lipid accumulation and ROS overproduction via the promotion of hepatic autophagy

2019

Journal Article

Glycogen structure in type 1 diabetic mice: towards understanding the origin of diabetic glycogen molecular fragility

Hu, Zhenxia, Li, Enpeng, Sullivan, Mitchell A., Tan, Xinle, Deng, Bin, Gilbert, Robert G. and Li, Cheng (2019). Glycogen structure in type 1 diabetic mice: towards understanding the origin of diabetic glycogen molecular fragility. International Journal of Biological Macromolecules, 128, 665-672. doi: 10.1016/j.ijbiomac.2019.01.186

Glycogen structure in type 1 diabetic mice: towards understanding the origin of diabetic glycogen molecular fragility

Funding

Past funding

  • 2021 - 2024
    MitoKhondrion: Decreasing COVID-19 mortality by increasing the functioning of our cell's powerhouses
    Advance Queensland Industry Research Fellowships
    Open grant
  • 2015 - 2019
    Exploring the Role of Glycogen Structure in Type 2 Diabetes
    NHMRC Early Career Fellowships
    Open grant

Supervision

Availability

Dr Mitchell Sullivan is:
Available for supervision

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Available projects

  • Unravelling the role of glycogen in diabetic kidney disease

    Type 2 diabetes is Australia’s largest healthcare burden, with almost 2 million people suffering from the disease and ˜30% developing diabetic kidney disease. This study will characterise kidney glycogen accumulation, relating it to glycaemic control and kidney function over a time course of type 2 diabetes. This research will provide novel insight into how abnormalities in renal glucose handling and storage may contribute to kidney damage in type 2 diabetes, potentially leading to new therapies that mitigate diabetic kidney disease.

    Hypothesis: Renal glycogen accumulation occurs in type 2 diabetes contributing to kidney damage.

    Aims:

    1. To relate changes in renal glycogen accumulation to glycaemic control and kidney damage over a time course of diabetes.
    2. To analyse the structure of diabetic kidney glycogen and determine if it accumulates into insoluble polyglucosan bodies.
    3. To determine the effects of glucose and insulin on glycogen accumulation in the kidney, including the effect of the kidney-targeted glucose lowering SGLT2 inhibitor, empagliflozin.

Supervision history

Current supervision

  • Doctor Philosophy

    Unravelling the role of abnormal glycogen accumulation in diabetic kidney disease

    Principal Advisor

    Other advisors: Honorary Professor Josephine Forbes

  • Doctor Philosophy

    A new treatment for viral disease: Modulators of the renin angiotension system

    Associate Advisor

    Other advisors: Associate Professor Kirsty Short

  • Doctor Philosophy

    The effect of high-amylose resistant starch on the glycogen structure of diabetic mice

    Associate Advisor

    Other advisors: Professor Bob Gilbert

  • Doctor Philosophy

    Study of the structure of glycogen and potential drug target for diabetes

    Associate Advisor

    Other advisors: Professor Bob Gilbert

Completed supervision

Media

Enquiries

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communications@uq.edu.au