
Overview
Background
Dr Mitchell Anthony Sullivan is a CJ Martin Early Career Research Fellow, funded by the National Health and Medical Research Council (NHMRC). Mitchell has a postdoctoral position in Professor Josephine Forbes’ Glycation and Diabetes research group at the Translational Research Institute. With a keen interest in the role of the blood-sugar storage molecule glycogen in health and disease, Mitchell has used the techniques he developed in his PhD, supervised by Prof. Robert Gilbert, to examine the important role this molecule has in diseases such as diabetes, Lafora disease and Adult Polyglucosan Body Disease. Currently he is extending this research into the field of diabetic kidney disease, combining the skills and knowledge he obtained in a 2-year postdoctoral position in Toronto with Prof. Berge Minassian, with the kidney expertise of Prof. Forbes. Awards received by Mitchell include the Biochemistry Alumni Prize (2008), awarded to the top ranked student at UQ in 3 biology/biochemistry course and the Chemistry Honours Research Prize (2010), awarded to “the student who, in completing a BSc (Honours) in the field of Chemistry, demonstrated a high level of achievement in the research component of the program and a high potential for independent research.” Mitchell was an organizing committee member for the Annual RACI Polymer Student Symposium (2013) and is currently a member of the Translation Research Institute Mentoring Committee. While less than 3 years from completing his PhD, Mitchell has 23 publication involving collaboration in China, Sweden, Canada, USA and Spain.
Personal statement: “Ever since beginning my research career as an undergraduate, I have thoroughly enjoyed the privilege of being able to pursue research questions I am passionate about. The opportunity to add new information and insights into the shared knowledge pool of the global scientific community is greatly appreciated. I will continue to relish these opportunities and strive to perform research to the best of my ability, with the goal of maximising a beneficial impact. As I advance through my career I will also endeavour to encourage and support my colleagues, helping foster a collaborative and fruitful environment to perform research.”
Availability
- Dr Mitchell Sullivan is:
- Available for supervision
Research impacts
Dr Mitchell Sullivan's PhD developed a number of techniques that allowed him to analyse the key structural features of glycogen, a highly branched macromolecule of ~50,000 glucose units. These techniques enabled his collaborative discovery that the diabetic liver contains fragile glycogen molecules, making them susceptible to uncontrolled degradation into glucose. The award of an NHMRC CJ Martin Fellowship allowed him to further his research in Toronto. The techniques Dr Sullivan developed in his PhD allowed him to analyse glycogen from various glycogen storage diseases (GSDs), leading to key breakthroughs in our understanding on the formation of the pathological glycogen accumulations characteristic of these diseases. In Toronto he continued to acquire and develop new methods that are essential in understanding the malformed glycogen present in these various GSDs. He is now using these skills to analyse the role of glycogen in diabetic kidney disease.
Works
Search Professor Mitchell Sullivan’s works on UQ eSpace
2022
Journal Article
Efficacy and safety of thalidomide as a pre-medication of Chemotherapy-Induced Nausea and Vomiting (CINV) following Highly Emetogenic Chemotherapy (HEC): a systematic review and meta-analysis
Xie, Jiyi, Zhang, Cong, Li, Shijun, Dai, Rong, Sullivan, Mitchell A., Deng, Bin, Xu, Qiling, Wang, Jinglin, Shi, Chen and Zhang, Yu (2022). Efficacy and safety of thalidomide as a pre-medication of Chemotherapy-Induced Nausea and Vomiting (CINV) following Highly Emetogenic Chemotherapy (HEC): a systematic review and meta-analysis. Frontiers in Oncology, 11 818839. doi: 10.3389/fonc.2021.818839
2021
Journal Article
A review on the structure and anti-diabetic (type 2) functions of β-glucans
Wan, Yujun, Xu, Xiaojuan, Gilbert, Robert G. and Sullivan, Mitchell A. (2021). A review on the structure and anti-diabetic (type 2) functions of β-glucans. Foods, 11 (1) 57, 57. doi: 10.3390/foods11010057
2021
Journal Article
Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure
Fotheringham, Amelia K., Solon-Biet, Samantha M., Bielefeldt-Ohmann, Helle, McCarthy, Domenica A., McMahon, Aisling C., Ruohonen, Kari, Li, Isaac, Sullivan, Mitchell A., Whiddett, Rani O., Borg, Danielle J., Cogger, Victoria C., Ballard, William O., Turner, Nigel, Melvin, Richard G., Raubenheimer, David, Le Couteur, David G., Simpson, Stephen J. and Forbes, Josephine M. (2021). Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure. iScience, 24 (11) 103308, 103308. doi: 10.1016/j.isci.2021.103308
2021
Journal Article
Maternal choline supplementation in a rat model of periconceptional alcohol exposure: Impacts on the fetus and placenta
Steane, Sarah E., Fielding, Arree M., Kent, Nykola L., Andersen, Isabella, Browne, Daniel J., Tejo, Ellen N., Gårdebjer, Emelie M., Kalisch‐Smith, Jacinta I., Sullivan, Mitchell A., Moritz, Karen M. and Akison, Lisa K. (2021). Maternal choline supplementation in a rat model of periconceptional alcohol exposure: Impacts on the fetus and placenta. Alcoholism: Clinical and Experimental Research, 45 (10) acer.14685, 2130-2146. doi: 10.1111/acer.14685
2021
Journal Article
T cell expression and release of kidney injury molecule-1 in response to glucose variations initiates kidney injury in early diabetes
Forbes, Josephine M., McCarthy, Domenica A., Kassianos, Andrew J., Baskerville, Tracey, Fotheringham, Amelia J., Giuliani, Kurt T. K., Grivei, Anca, Murphy, Andrew J., Flynn, Michelle C., Sullivan, Mitchell A., Chandrashekar, Preeti, Whiddett, Rani, Radford, Kristen J., Flemming, Nicole, Beard, Sam S., D’Silva, Neisha, Nisbet, Janelle, Morton, Adam, Teasdale, Stephanie, Russell, Anthony, Isbel, Nicole, Jones, Timothy, Couper, Jennifer, Healy, Helen, Harris, Mark, Donaghue, Kim, Johnson, David W., Cotterill, Andrew, Barrett, Helen L. and O’Moore-Sullivan, Trisha (2021). T cell expression and release of kidney injury molecule-1 in response to glucose variations initiates kidney injury in early diabetes. Diabetes, 70 (8), 1754-1766. doi: 10.2337/db20-1081
2021
Journal Article
Mechanism of lentinan intestinal absorption: clathrin-mediated endocytosis and macropinocytosis
Zheng, Ziming, Pan, Xianglin, Wang, Haoyu, Wu, Zhijing, Sullivan, Mitchell A., Liu, Yuxuan, Liu, Junxi, Wang, Kaiping and Zhang, Yu (2021). Mechanism of lentinan intestinal absorption: clathrin-mediated endocytosis and macropinocytosis. Journal of Agricultural and Food Chemistry, 69 (26) acs.jafc.1c00349, 7344-7352. doi: 10.1021/acs.jafc.1c00349
2021
Journal Article
Optimization of liver glycogen extraction when considering the fine molecular structure
Wang, Ziyi, Liu, Qinghua, Wang, Liang, Gilbert, Robert G. and Sullivan, Mitchell A. (2021). Optimization of liver glycogen extraction when considering the fine molecular structure. Carbohydrate Polymers, 261 117887, 1-11. doi: 10.1016/j.carbpol.2021.117887
2021
Book Chapter
The Pathologies of a Dysfunctional Glycogen Metabolism
Sullivan, Mitchell A., Minassian, Berge A. and Nitschke, Felix (2021). The Pathologies of a Dysfunctional Glycogen Metabolism. Enzymology of Complex Alpha-Glucans. (pp. 138-162) Boca Raton, FL United States: CRC Press. doi: 10.1201/b22412-6
2021
Journal Article
Comprehensive landscape of heparin therapy for COVID-19
Shi, Chen, Tingting, Wu, Li, Jin-Ping, Sullivan, Mitchell A., Wang, Cong, Wang, Hanxiang, Deng, Bin and Zhang, Yu (2021). Comprehensive landscape of heparin therapy for COVID-19. Carbohydrate Polymers, 254 117232, 117232. doi: 10.1016/j.carbpol.2020.117232
2021
Journal Article
The importance of glycogen molecular structure for blood glucose control
Nawaz, Asad, Zhang, Peng, Li, Enpeng, Gilbert, Robert G. and Sullivan, Mitchell A. (2021). The importance of glycogen molecular structure for blood glucose control. iScience, 24 (1) 101953, 101953. doi: 10.1016/j.isci.2020.101953
2021
Journal Article
Impact of dietary carbohydrate type and protein–carbohydrate interaction on metabolic health
Wali, Jibran A., Milner, Annabelle J., Luk, Alison W. S., Pulpitel, Tamara J., Dodgson, Tim, Facey, Harrison J. W., Wahl, Devin, Kebede, Melkam A., Senior, Alistair M., Sullivan, Mitchell A., Brandon, Amanda E., Yau, Belinda, Lockwood, Glen P., Koay, Yen Chin, Ribeiro, Rosilene, Solon-Biet, Samantha M., Bell-Anderson, Kim S., O’Sullivan, John F., Macia, Laurence, Forbes, Josephine M., Cooney, Gregory J., Cogger, Victoria C., Holmes, Andrew, Raubenheimer, David, Le Couteur, David G. and Simpson, Stephen J. (2021). Impact of dietary carbohydrate type and protein–carbohydrate interaction on metabolic health. Nature Metabolism, 3 (6), 810-828. doi: 10.1038/s42255-021-00393-9
2021
Journal Article
Protective effect of Yi Shen Pai du formula against diabetic kidney injury via inhibition of oxidative stress, inflammation, and epithelial-to-mesenchymal transition in db/db mice
Zhang, Qilin, Liu, Xiaocui, Sullivan, Mitchell A., Shi, Chen and Deng, Bin (2021). Protective effect of Yi Shen Pai du formula against diabetic kidney injury via inhibition of oxidative stress, inflammation, and epithelial-to-mesenchymal transition in db/db mice. Oxidative Medicine and Cellular Longevity, 2021 (1) 7958021, 1-15. doi: 10.1155/2021/7958021
2020
Journal Article
Mutation of regulatory phosphorylation sites in PFKFB2 worsens renal fibrosis
Lee, Mardiana, Harley, Geoff, Katerelos, Marina, Gleich, Kurt, Sullivan, Mitchell A., Laskowski, Adrienne, Coughlan, Melinda, Fraser, Scott A., Mount, Peter F. and Power, David A. (2020). Mutation of regulatory phosphorylation sites in PFKFB2 worsens renal fibrosis. Scientific Reports, 10 (1) 14531. doi: 10.1038/s41598-020-71475-z
2020
Journal Article
Revisiting Glycogen in Cancer: A Conspicuous and Targetable Enabler of Malignant Transformation
Khan, Tashbib, Sullivan, Mitchell A., Gunter, Jennifer H., Kryza, Thomas, Lyons, Nicholas, He, Yaowu and Hooper, John D. (2020). Revisiting Glycogen in Cancer: A Conspicuous and Targetable Enabler of Malignant Transformation. Frontiers in Oncology, 10 592455, 592455. doi: 10.3389/fonc.2020.592455
2020
Journal Article
Metformin and Berberine suppress glycogenolysis by inhibiting glycogen phosphorylase and stabilizing the molecular structure of glycogen in db/db mice
Liu, Xiaocui, Wang, Kaiping, Zhou, Jing, Sullivan, Mitchell A., Liu, Yage, Gilbert, Robert G. and Deng, Bin (2020). Metformin and Berberine suppress glycogenolysis by inhibiting glycogen phosphorylase and stabilizing the molecular structure of glycogen in db/db mice. Carbohydrate Polymers, 243 116435, 116435. doi: 10.1016/j.carbpol.2020.116435
2020
Journal Article
Polyglucosan body structure in Lafora disease
Brewer, M. Kathryn, Putaux, Jean-Luc, Rondon, Alberto, Uittenbogaard, Annette, Sullivan, Mitchell A. and Gentry, Matthew S. (2020). Polyglucosan body structure in Lafora disease. Carbohydrate Polymers, 240 116260, 1-14. doi: 10.1016/j.carbpol.2020.116260
2020
Journal Article
Disruption of glycogen utilization markedly improves the efficacy of carboplatin against preclinical models of clear cell ovarian carcinoma
Khan, Tashbib, He, Yaowu, Kryza, Thomas, Harrington, Brittney S., Gunter, Jennifer H., Sullivan, Mitchell A., Cuda, Tahleesa, Rogers, Rebecca, Davies, Claire M., Broomfield, Amy, Gough, Madeline, Wu, Andy C., McGann, Thomas, Weroha, S. John, Haluska, Paul, Forbes, Josephine M., Armes, Jane E., Barry, Sinead C., Coward, Jermaine I., Jagasia, Nisha, Chetty, Naven, Snell, Cameron E., Lourie, Rohan, Perrin, Lewis C. and Hooper, John D. (2020). Disruption of glycogen utilization markedly improves the efficacy of carboplatin against preclinical models of clear cell ovarian carcinoma. Cancers, 12 (4) 869, 869. doi: 10.3390/cancers12040869
2020
Journal Article
Erratum to “Exploring glycogen biosynthesis through Monte Carlo simulation”
Zhang, Peng, Nada, Sharif S., Tan, Xinle, Deng, Bin, Sullivan, Mitchell A. and Gilbert, Robert G. (2020). Erratum to “Exploring glycogen biosynthesis through Monte Carlo simulation”. International Journal of Biological Macromolecules, 144, 1043-1044. doi: 10.1016/j.ijbiomac.2019.05.183
2020
Journal Article
Corrigendum to: “Exploring glycogen biosynthesis through Monte Carlo simulation” (International Journal of Biological Macromolecules (2018) 116 (264–271), (S0141813018312923), (10.1016/j.ijbiomac.2018.05.027))
Zhang, Peng, Nada, Sharif S., Tan, Xinle, Deng, Bin, Sullivan, Mitchell A. and Gilbert, Robert G. (2020). Corrigendum to: “Exploring glycogen biosynthesis through Monte Carlo simulation” (International Journal of Biological Macromolecules (2018) 116 (264–271), (S0141813018312923), (10.1016/j.ijbiomac.2018.05.027)). International Journal of Biological Macromolecules, 142, 889-890. doi: 10.1016/j.ijbiomac.2019.11.160
2020
Journal Article
GYS1 or PPP1R3C deficiency rescues murine adult polyglucosan body disease
Chown, Erin E., Wang, Peixiang, Zhao, Xiaochu, Crowder, Justin J., Strober, Jordan W., Sullivan, Mitchell A., Xue, Yunlin, Bennett, Cody S., Perri, Ami M., Evers, Bret M., Roach, Peter J., Depaoli-Roach, Anna A., Akman, H. Orhan, Pederson, Bartholomew A. and Minassian, Berge A. (2020). GYS1 or PPP1R3C deficiency rescues murine adult polyglucosan body disease. Annals of Clinical and Translational Neurology, 7 (11) acn3.51211, 2186-2198. doi: 10.1002/acn3.51211
Funding
Past funding
Supervision
Availability
- Dr Mitchell Sullivan is:
- Available for supervision
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Available projects
-
Unravelling the role of glycogen in diabetic kidney disease
Type 2 diabetes is Australia’s largest healthcare burden, with almost 2 million people suffering from the disease and ˜30% developing diabetic kidney disease. This study will characterise kidney glycogen accumulation, relating it to glycaemic control and kidney function over a time course of type 2 diabetes. This research will provide novel insight into how abnormalities in renal glucose handling and storage may contribute to kidney damage in type 2 diabetes, potentially leading to new therapies that mitigate diabetic kidney disease.
Hypothesis: Renal glycogen accumulation occurs in type 2 diabetes contributing to kidney damage.
Aims:
- To relate changes in renal glycogen accumulation to glycaemic control and kidney damage over a time course of diabetes.
- To analyse the structure of diabetic kidney glycogen and determine if it accumulates into insoluble polyglucosan bodies.
- To determine the effects of glucose and insulin on glycogen accumulation in the kidney, including the effect of the kidney-targeted glucose lowering SGLT2 inhibitor, empagliflozin.
Supervision history
Current supervision
-
Doctor Philosophy
Unravelling the role of abnormal glycogen accumulation in diabetic kidney disease
Principal Advisor
Other advisors: Honorary Professor Josephine Forbes
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Doctor Philosophy
Unravelling the role of abnormal glycogen accumulation in diabetic kidney disease
Principal Advisor
Other advisors: Honorary Professor Josephine Forbes
-
Doctor Philosophy
Study of the structure of glycogen and potential drug target for diabetes
Associate Advisor
Other advisors: Professor Bob Gilbert
-
Doctor Philosophy
The effect of high-amylose resistant starch on the glycogen structure of diabetic mice
Associate Advisor
Other advisors: Professor Bob Gilbert
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Doctor Philosophy
Host-directed therapies for treatment against respiratory virus disease
Associate Advisor
Other advisors: Professor Kirsty Short
Completed supervision
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2023
Doctor Philosophy
The Analysis of Liver Glycogen Structure and its Implication in Various Diseases
Associate Advisor
Other advisors: Professor Bob Gilbert
Media
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