
Overview
Background
Dr Kai-Hsiang Chuang received his Ph.D. degree in electrical and biomedical engineering from the National Taiwan University, Taiwan, in 2001. During his graduate study, he developed methods for improving the detection of brain activity using functional magnetic resonance imaging (fMRI). He undertook postdoctoral research at the National Institutes of Health, USA, from 2003 to 2007, where he focused on understanding brain connectivity using novel functional and molecular imaging. He developed manganese-enhanced MRI for high-resolution imaging functional neural pathways in the rodent brain and cerebral blood flow imaging for mapping the resting-state network of the human brain. He joined the Agency for Science Technology and Research (A*STAR), Singapore, in 2008 as the head of MRI Group in the Singapore Bioimaging Consortium (a national research institute). He established the first preclinical imaging facility in Singapore and facilitated research collaboration across academia, clinic and industry. His lab pioneered functional connectivity imaging of the rodent brain to understand the neural basis and function of resting-state brain network, and the development and application of MRI biomarkers for treatment development. In late 2015, he moved to the University of Queensland, Australia, as an Associate Professor with the Queensland Brain Institute and the Centre for Advanced Imaging. His current research focuses on understanding the structure and function of brain network that underlies cognition and behavior, such as learning, memory and dementia. He is developing multimodal techniques, including fMRI, calcium recording, electrophysiology and optogenetic/chemogenetic neuromodulation, to test hypothesis in transgenic mouse models and then translating to humans to improve the diagnosis and intervention of disorders. The imaging and analysis techniques he developed have been widely used in the research community and some in clinical trials. He is serving on the editorial boards of Frontiers in Neuroscience: Brain Imaging Methods, Imaging Neuroscience and Scientific Reports.
Availability
- Associate Professor Kai-Hsiang Chuang is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, National Taiwan University
Research interests
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Functional brain mapping
Develop in vivo imaging techniques, including functional MRI and multimodality integration (optogenetics, calcium imaging, electrophysiology), in humans and animal models to improve the understanding and intervention of brain function, disease process and treatment effects.
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Brain network in learning, memory and dementia
Brain network wiring and activity underpin our cognition and behaviour. However the brain-behaviour relationship of cognitive functions, such as memory, is unclear. We are developing techniques to understand the causal relationship between brain network activity and memory formation, and how to modulate behaviour by manipulating brain network activity.
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Brain waste clearance
The brain is a highly metabolic active organ. Maintaining optimal brain function relies on efficient disposal of metabolic wastes. We are studying a brain fluid drainage system that clear waste and toxic molecules, such as amyloid plaques, from the brain. We're developing imaging techniques to track its function and to understand its regulatory mechanism, treatment target and pathogenic role in dementia.
Works
Search Professor Kai-Hsiang Chuang’s works on UQ eSpace
2016
Journal Article
Synthesis of ferromagnetic Fe0.6Mn0.4O nanoflowers as a new class of magnetic theranostic platform for in vivo T1-T2 dual-mode magnetic resonance imaging and magnetic hyperthermia therapy
Liu, Xiao Li, Ng, Cheng Teng, Chandrasekharan, Prashant, Yang, Hai Tao, Zhao, Ling Yun, Peng, Erwin, Lv, Yun Bo, Xiao, Wen, Fang, Jie, Yi, Jia Bao, Zhang, Huan, Chuang, Kai-Hsiang, Bay, Boon Huat, Ding, Jun and Fan, Hai Ming (2016). Synthesis of ferromagnetic Fe0.6Mn0.4O nanoflowers as a new class of magnetic theranostic platform for in vivo T1-T2 dual-mode magnetic resonance imaging and magnetic hyperthermia therapy. Advanced Healthcare Materials, 5 (16), 2092-2104. doi: 10.1002/adhm.201600357
2016
Journal Article
Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease
Teo, Roy Tang Yi, Hong, Xin, Yu-Taeger, Libo, Huang, Yihui, Tan, Liang Juin, Xie, Yuanyun, To, Xuan Vinh, Guo, Ling, Rajendran, Reshmi, Novati, Arianna, Calaminus, Carsten, Riess, Olaf, Hayden, Michael R., Nguyen, Huu P., Chuang, Kai-Hsiang and Pouladi, Mahmoud A. (2016). Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease. Human Molecular Genetics, 25 (13), 2621-2632. doi: 10.1093/hmg/ddw122
2016
Journal Article
Multispectral optoacoustic and MRI coregistration for molecular imaging of orthotopic model of human glioblastoma
Attia, Amalina Binte Ebrahim, Ho, Chris Jun Hui, Chandrasekharan, Prashant, Balasundaram, Ghayathri, Tay, Hui Chien, Burton, Neal C., Chuang, Kai-Hsiang, Ntziachristos, Vasilis and Olivo, Malini (2016). Multispectral optoacoustic and MRI coregistration for molecular imaging of orthotopic model of human glioblastoma. Journal of Biophotonics, 9 (7) JBIO201670070, 701-708. doi: 10.1002/jbio.201500321
2016
Journal Article
Resting state functional connectivity data supports detection of cognition in the rodent brain
Nasrallah, Fatima A., To, Xuan Vinh, Chen, Der-Yow, Routtenberg, Aryeh and Chuang, Kai-Hsiang (2016). Resting state functional connectivity data supports detection of cognition in the rodent brain. Data in Brief, 7, 1156-1164. doi: 10.1016/j.dib.2016.03.041
2016
Journal Article
Modality specificity in the cerebro-cerebellar neurocircuitry during working memory
Ng, H. B. Tommy, Kao, K.-L. Cathy, Chan, Y. C., Chew, Effie, Chuang, K. H. and Chen, S. H. Annabel (2016). Modality specificity in the cerebro-cerebellar neurocircuitry during working memory. Behavioural Brain Research, 305, 164-173. doi: 10.1016/j.bbr.2016.02.027
2016
Journal Article
A method for the automatic segmentation of brown adipose tissue
Prakash, K. N. Bhanu, Srour, Hussein, Velan, Sendhil S. and Chuang, Kai-Hsiang (2016). A method for the automatic segmentation of brown adipose tissue. Magnetic Resonance Materials in Physics, Biology and Medicine, 29 (2), 287-299. doi: 10.1007/s10334-015-0517-0
2016
Journal Article
Spatial memory training induces morphological changes detected by manganese-enhanced MRI in the hippocampal CA3 mossy fiber terminal zone
Zhang, Binbin, Chuang, Kai-Hsiang, Tjio, Ci'en, Chen, Way Cherng, Sheu, Fwu-Shan and Routtenberg, Aryeh (2016). Spatial memory training induces morphological changes detected by manganese-enhanced MRI in the hippocampal CA3 mossy fiber terminal zone. NeuroImage, 128 (3), 227-237. doi: 10.1016/j.neuroimage.2015.07.084
2016
Journal Article
Functional connectivity MRI tracks memory networks after maze learning in rodents
Nasrallah, Fatima A., To, Xuan Vinh, Chen, Der-Yow, Routtenberg, Aryeh and Chuang, Kai-Hsiang (2016). Functional connectivity MRI tracks memory networks after maze learning in rodents. NeuroImage, 127, 196-202. doi: 10.1016/j.neuroimage.2015.08.013
2016
Journal Article
Temporal dynamics of visual working memory
Sobczak-Edmans, M., Ng, T. H. B., Chan, Y. C., Chew, E., Chuang, K. H. and Chen, S. H. A. (2016). Temporal dynamics of visual working memory. NeuroImage, 124 (Pt A), 1021-1030. doi: 10.1016/j.neuroimage.2015.09.038
2015
Journal Article
Intravoxel incoherent imaging of renal fibrosis induced in a murine model of unilateral ureteral obstruction
Hennedige, Tiffany, koh, Tong San, Hartono, Septian, Yan, Yet Yen, Song, In Chin, Zheng, Lin, Lee, Wing Sum, Rumpel, Helmut, Martarello, Laurent, Khoo, James B., Koh, Dow-Mu, Chuang, Kai Hsiang and Thng, Choon Hua (2015). Intravoxel incoherent imaging of renal fibrosis induced in a murine model of unilateral ureteral obstruction. Magnetic Resonance Imaging, 33 (10), 1324-1328. doi: 10.1016/j.mri.2015.07.012
2015
Journal Article
Evaluation of EPI distortion correction methods for quantitative MRI of the brain at high magnetic field
Hong, Xin, To, Xuan Vinh, Teh, Irvin, Soh, Jian Rui and Chuang, Kai-Hsiang (2015). Evaluation of EPI distortion correction methods for quantitative MRI of the brain at high magnetic field. Magnetic Resonance Imaging, 33 (9) 8392, 1098-1105. doi: 10.1016/j.mri.2015.06.010
2015
Journal Article
Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation
Li, Yinghui, Zhou, Qi-Ling, Sun, Wenjie, Chandrasekharan, Prashant, Cheng, Hui Shan, Ying, Zhe, Lakshmanan, Manikandan, Raju, Anandhkumar, Tenen, Daniel G., Cheng, Shi-Yuan, Chuang, Kai-Hsiang, Li, Jun, Prabhakar, Shyam, Li, Mengfeng and Tergaonkar, Vinay (2015). Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation. Nature Cell Biology, 17 (10), 1327-1338. doi: 10.1038/ncb3240
2015
Journal Article
Dependence of BOLD signal fluctuation on arterial blood CO2 and O2: Implication for resting-state functional connectivity
Nasrallah, Fatima A., Yeow, Ling Yun, Biswal, Bharat and Chuang, Kai-Hsiang (2015). Dependence of BOLD signal fluctuation on arterial blood CO2 and O2: Implication for resting-state functional connectivity. NeuroImage, 117, 29-39. doi: 10.1016/j.neuroimage.2015.05.035
2015
Journal Article
Optimization of arterial spin labeling MRI for quantitative tumor perfusion in a mouse xenograft model
Rajendran, Rajendran, Liang, Jieming, Tang, M. Y .A., Henry, Brian and Chuang, Kai-Hsiang (2015). Optimization of arterial spin labeling MRI for quantitative tumor perfusion in a mouse xenograft model. NMR in Biomedicine, 28 (8), 988-997. doi: 10.1002/nbm.3330
2015
Journal Article
Pharmacokinetics of Gd(DO3A-Lys) and MR imaging studies in an orthotopic U87MG glioma tumor model
Chandrasekharan, Prashant, Yang, Chang-Tong, Nasrallah, Fatima Ali, Tay, Hui Chien, Chuang, Kai-Hsiang and Robins, Edward G. (2015). Pharmacokinetics of Gd(DO3A-Lys) and MR imaging studies in an orthotopic U87MG glioma tumor model. Contrast Media and Molecular Imaging, 10 (3), 237-244. doi: 10.1002/cmmi.1634
2015
Journal Article
Selective delivery of PEGylated compounds to tumor cells by anti-PEG hybrid antibodies
Tung, H.-Y., Su, Y.-C., Chen, B.-M., Burnouf, P.-A., Huang, W.-C., Chuang, K.-H., Yan, Y.-T., Cheng, T.-L. and Roffler, S. R. (2015). Selective delivery of PEGylated compounds to tumor cells by anti-PEG hybrid antibodies. Molecular Cancer Therapeutics, 14 (6), 1317-1326. doi: 10.1158/1535-7163.mct-15-0151
2015
Journal Article
Evaluation of thermo-triggered drug release in intramuscular-transplanted tumors using thermosensitive polymer-modified liposomes and MRI
Kokuryo, Daisuke, Nakashima, Seiji, Ozaki, Fuminori, Yuba, Eiji, Chuang, Kai-Hsiang, Aoshima, Sadahito, Ishizaka, Yukihito, Saga, Tsuneo, Kono, Kenji and Aoki, Ichio (2015). Evaluation of thermo-triggered drug release in intramuscular-transplanted tumors using thermosensitive polymer-modified liposomes and MRI. Nanomedicine: Nanotechnology, Biology and Medicine, 11 (1), 229-238. doi: 10.1016/j.nano.2014.09.001
2015
Conference Publication
Molecular photoacoustic imaging of orthotopic glioblastoma
Attia, Amalina Binte Ebrahim, Ho, Chris Jun Hui, Chandrasekharan, Prashant, Balasundaram, Ghayathri, Chuang, Kai-Hsiang and Olivo, Malini (2015). Molecular photoacoustic imaging of orthotopic glioblastoma. Optical Molecular Probes, Imaging and Drug Delivery 2015, Vancouver, Canada, 12–15 April 2015. Washington, D.C.: OSA. doi: 10.1364/omp.2015.ow3d.3
2015
Journal Article
Dynamic contrast-enhanced MRI of mouse liver: A feasibility study using a dual-input two-compartment tracer kinetic model
Hartono, Septian, Thng, Choon Hua, Chuang, Kai Hsiang, Hung, Huynh and Koh, Tong San (2015). Dynamic contrast-enhanced MRI of mouse liver: A feasibility study using a dual-input two-compartment tracer kinetic model. Journal of Biomedical Science and Engineering, 08 (02), 90-97. doi: 10.4236/jbise.2015.82009
2015
Conference Publication
Combining EPI and motion correction for fMRI human brain images with big motion
Lu, Zhongkang, Phua, Kok Soon, Huang, Weimin, Hong, Xin, Nasrallah, Fatima Ali, Chuang, Kai-Hsiang and Guan, Cuntai (2015). Combining EPI and motion correction for fMRI human brain images with big motion. 3Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Milan, Italy, 25-29 August 2015. Piscataway, NJ, United States: IEEE. doi: 10.1109/EMBC.2015.7319624
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Kai-Hsiang Chuang is:
- Available for supervision
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Available projects
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Understanding mechanisms of glymphatic dysfunction in Alzheimer’s disease.
Glymphatic and brain network deficits have been associated with neuropathology of Alzheimer’s disease. However, the mechanism is still unclear. This project aims to test a new hypothesis that leads to accelerated amyloid and tau pathology in brain networks, such as the default mode network. The study will combine structural and functional MRI and genetic tools to test the hypothesis in animal model of AD.
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Develop techniques for improving cognition via modulating brain network
The brain is a complex neural network that supports our cognition, such as learning and memory. We have recently identified brain network hubs that causally involved in memory formation. This project will develop new techniques to detect and selectively modulate the functional connectivity of the causal hubs in order to improve memory.
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Develop novel imaging technique for brain waste clearance
The glymphatic system is a newly discovered waste clearance pathway that removes toxic proteins, such as amyloid plaques, from the brain. Its dysfunction is suggested to lead to Alzheimer's disease. However, there is still no non-invasive imaging technique for measuring its function. This project aims to develop novel non-invasive MRI techniques for tracking the structure and function of the glymphatic system. These techniques will be used to understand how glymphatic function maintain brain health and network function, and for the diagnosis of its impairment in aging and disorders.
Supervision history
Current supervision
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Doctor Philosophy
Understanding neural Basis of Resting-State Network Using Simultaneous Calcium Recording and Functional Magnetic Resonance Imaging
Principal Advisor
Other advisors: Professor Pankaj Sah
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Doctor Philosophy
Developing imaging and neuro-technologies for decoding memory formation
Principal Advisor
Other advisors: Professor Elizabeth Coulson
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Doctor Philosophy
Improving Artificial Intelligence And Deep Learning Algorithms In Super-Resolution Imaging
Associate Advisor
Other advisors: Professor Feng Liu
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Doctor Philosophy
Improving Artificial Intelligence And Deep Learning Algorithms In Super-Resolution Imaging
Associate Advisor
Other advisors: Professor Feng Liu
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Doctor Philosophy
The Role of Basal Forebrain Cholinergic Neurons in Glymphatic Function - Insights and Neuroimaging Perspectives
Associate Advisor
Other advisors: Professor Elizabeth Coulson
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Doctor Philosophy
MRI biomarker of glymphatic dysfunction in dementia
Associate Advisor
Other advisors: Professor Elizabeth Coulson
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Master Philosophy
The Role of Basal Forebrain Cholinergic Neurons in Glymphatic Function - Insights and Neuroimaging Perspectives
Associate Advisor
Other advisors: Professor Elizabeth Coulson
Completed supervision
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2024
Doctor Philosophy
Understanding neural Basis of Resting-State Network Using Simultaneous Calcium Recording and Functional Magnetic Resonance Imaging
Principal Advisor
Other advisors: Professor Pankaj Sah
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2022
Doctor Philosophy
Determining large-scale brain networks involved in memory consolidation
Principal Advisor
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2023
Doctor Philosophy
Improving functional MRI through Modelling and Imaging Microvascular Dynamics
Associate Advisor
Other advisors: Dr Saskia Bollmann, Professor Markus Barth
Media
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