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Associate Professor Kai-Hsiang Chuang
Associate Professor

Kai-Hsiang Chuang

Email: 
Phone: 
+61 7 344 33811

Overview

Background

Dr Kai-Hsiang Chuang received his Ph.D. degree in electrical and biomedical engineering from the National Taiwan University, Taiwan, in 2001. During his graduate study, he developed methods for improving the detection of brain activity using functional magnetic resonance imaging (fMRI). He undertook postdoctoral research at the National Institutes of Health, USA, from 2003 to 2007, where he focused on understanding brain connectivity using novel functional and molecular imaging. He developed manganese-enhanced MRI for high-resolution imaging functional neural pathways in the rodent brain and cerebral blood flow imaging for mapping the resting-state network of the human brain. He joined the Agency for Science Technology and Research (A*STAR), Singapore, in 2008 as the head of MRI Group in the Singapore Bioimaging Consortium (a national research institute). He established the first preclinical imaging facility in Singapore and facilitated research collaboration across academia, clinic and industry. His lab pioneered functional connectivity imaging of the rodent brain to understand the neural basis and function of resting-state brain network, and the development and application of MRI biomarkers for treatment development. In late 2015, he moved to the University of Queensland, Australia, as an Associate Professor with the Queensland Brain Institute and the Centre for Advanced Imaging. His current research focuses on understanding the structure and function of brain network that underlies cognition and behavior, such as learning, memory and dementia. He is developing multimodal techniques, including fMRI, calcium recording, electrophysiology and optogenetic/chemogenetic neuromodulation, to test hypothesis in transgenic mouse models and then translating to humans to improve the diagnosis and intervention of disorders. The imaging and analysis techniques he developed have been widely used in the research community and some in clinical trials. He is serving on the editorial boards of Frontiers in Neuroscience: Brain Imaging Methods, Imaging Neuroscience and Scientific Reports.

Availability

Associate Professor Kai-Hsiang Chuang is:
Available for supervision

Qualifications

  • Doctor of Philosophy, National Taiwan University

Research interests

  • Functional brain mapping

    Develop in vivo imaging techniques, including functional MRI and multimodality integration (optogenetics, calcium imaging, electrophysiology), in humans and animal models to improve the understanding and intervention of brain function, disease process and treatment effects.

  • Brain network in learning, memory and dementia

    Brain network wiring and activity underpin our cognition and behaviour. However the brain-behaviour relationship of cognitive functions, such as memory, is unclear. We are developing techniques to understand the causal relationship between brain network activity and memory formation, and how to modulate behaviour by manipulating brain network activity.

  • Brain waste clearance

    The brain is a highly metabolic active organ. Maintaining optimal brain function relies on efficient disposal of metabolic wastes. We are studying a brain fluid drainage system that clear waste and toxic molecules, such as amyloid plaques, from the brain. We're developing imaging techniques to track its function and to understand its regulatory mechanism, treatment target and pathogenic role in dementia.

Works

Search Professor Kai-Hsiang Chuang’s works on UQ eSpace

126 works between 1998 and 2025

41 - 60 of 126 works

2016

Journal Article

Synthesis of ferromagnetic Fe0.6Mn0.4O nanoflowers as a new class of magnetic theranostic platform for in vivo T1-T2 dual-mode magnetic resonance imaging and magnetic hyperthermia therapy

Liu, Xiao Li, Ng, Cheng Teng, Chandrasekharan, Prashant, Yang, Hai Tao, Zhao, Ling Yun, Peng, Erwin, Lv, Yun Bo, Xiao, Wen, Fang, Jie, Yi, Jia Bao, Zhang, Huan, Chuang, Kai-Hsiang, Bay, Boon Huat, Ding, Jun and Fan, Hai Ming (2016). Synthesis of ferromagnetic Fe0.6Mn0.4O nanoflowers as a new class of magnetic theranostic platform for in vivo T1-T2 dual-mode magnetic resonance imaging and magnetic hyperthermia therapy. Advanced Healthcare Materials, 5 (16), 2092-2104. doi: 10.1002/adhm.201600357

Synthesis of ferromagnetic Fe0.6Mn0.4O nanoflowers as a new class of magnetic theranostic platform for in vivo T1-T2 dual-mode magnetic resonance imaging and magnetic hyperthermia therapy

2016

Journal Article

Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease

Teo, Roy Tang Yi, Hong, Xin, Yu-Taeger, Libo, Huang, Yihui, Tan, Liang Juin, Xie, Yuanyun, To, Xuan Vinh, Guo, Ling, Rajendran, Reshmi, Novati, Arianna, Calaminus, Carsten, Riess, Olaf, Hayden, Michael R., Nguyen, Huu P., Chuang, Kai-Hsiang and Pouladi, Mahmoud A. (2016). Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease. Human Molecular Genetics, 25 (13), 2621-2632. doi: 10.1093/hmg/ddw122

Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease

2016

Journal Article

Multispectral optoacoustic and MRI coregistration for molecular imaging of orthotopic model of human glioblastoma

Attia, Amalina Binte Ebrahim, Ho, Chris Jun Hui, Chandrasekharan, Prashant, Balasundaram, Ghayathri, Tay, Hui Chien, Burton, Neal C., Chuang, Kai-Hsiang, Ntziachristos, Vasilis and Olivo, Malini (2016). Multispectral optoacoustic and MRI coregistration for molecular imaging of orthotopic model of human glioblastoma. Journal of Biophotonics, 9 (7) JBIO201670070, 701-708. doi: 10.1002/jbio.201500321

Multispectral optoacoustic and MRI coregistration for molecular imaging of orthotopic model of human glioblastoma

2016

Journal Article

Resting state functional connectivity data supports detection of cognition in the rodent brain

Nasrallah, Fatima A., To, Xuan Vinh, Chen, Der-Yow, Routtenberg, Aryeh and Chuang, Kai-Hsiang (2016). Resting state functional connectivity data supports detection of cognition in the rodent brain. Data in Brief, 7, 1156-1164. doi: 10.1016/j.dib.2016.03.041

Resting state functional connectivity data supports detection of cognition in the rodent brain

2016

Journal Article

Modality specificity in the cerebro-cerebellar neurocircuitry during working memory

Ng, H. B. Tommy, Kao, K.-L. Cathy, Chan, Y. C., Chew, Effie, Chuang, K. H. and Chen, S. H. Annabel (2016). Modality specificity in the cerebro-cerebellar neurocircuitry during working memory. Behavioural Brain Research, 305, 164-173. doi: 10.1016/j.bbr.2016.02.027

Modality specificity in the cerebro-cerebellar neurocircuitry during working memory

2016

Journal Article

A method for the automatic segmentation of brown adipose tissue

Prakash, K. N. Bhanu, Srour, Hussein, Velan, Sendhil S. and Chuang, Kai-Hsiang (2016). A method for the automatic segmentation of brown adipose tissue. Magnetic Resonance Materials in Physics, Biology and Medicine, 29 (2), 287-299. doi: 10.1007/s10334-015-0517-0

A method for the automatic segmentation of brown adipose tissue

2016

Journal Article

Spatial memory training induces morphological changes detected by manganese-enhanced MRI in the hippocampal CA3 mossy fiber terminal zone

Zhang, Binbin, Chuang, Kai-Hsiang, Tjio, Ci'en, Chen, Way Cherng, Sheu, Fwu-Shan and Routtenberg, Aryeh (2016). Spatial memory training induces morphological changes detected by manganese-enhanced MRI in the hippocampal CA3 mossy fiber terminal zone. NeuroImage, 128 (3), 227-237. doi: 10.1016/j.neuroimage.2015.07.084

Spatial memory training induces morphological changes detected by manganese-enhanced MRI in the hippocampal CA3 mossy fiber terminal zone

2016

Journal Article

Functional connectivity MRI tracks memory networks after maze learning in rodents

Nasrallah, Fatima A., To, Xuan Vinh, Chen, Der-Yow, Routtenberg, Aryeh and Chuang, Kai-Hsiang (2016). Functional connectivity MRI tracks memory networks after maze learning in rodents. NeuroImage, 127, 196-202. doi: 10.1016/j.neuroimage.2015.08.013

Functional connectivity MRI tracks memory networks after maze learning in rodents

2016

Journal Article

Temporal dynamics of visual working memory

Sobczak-Edmans, M., Ng, T. H. B., Chan, Y. C., Chew, E., Chuang, K. H. and Chen, S. H. A. (2016). Temporal dynamics of visual working memory. NeuroImage, 124 (Pt A), 1021-1030. doi: 10.1016/j.neuroimage.2015.09.038

Temporal dynamics of visual working memory

2015

Journal Article

Intravoxel incoherent imaging of renal fibrosis induced in a murine model of unilateral ureteral obstruction

Hennedige, Tiffany, koh, Tong San, Hartono, Septian, Yan, Yet Yen, Song, In Chin, Zheng, Lin, Lee, Wing Sum, Rumpel, Helmut, Martarello, Laurent, Khoo, James B., Koh, Dow-Mu, Chuang, Kai Hsiang and Thng, Choon Hua (2015). Intravoxel incoherent imaging of renal fibrosis induced in a murine model of unilateral ureteral obstruction. Magnetic Resonance Imaging, 33 (10), 1324-1328. doi: 10.1016/j.mri.2015.07.012

Intravoxel incoherent imaging of renal fibrosis induced in a murine model of unilateral ureteral obstruction

2015

Journal Article

Evaluation of EPI distortion correction methods for quantitative MRI of the brain at high magnetic field

Hong, Xin, To, Xuan Vinh, Teh, Irvin, Soh, Jian Rui and Chuang, Kai-Hsiang (2015). Evaluation of EPI distortion correction methods for quantitative MRI of the brain at high magnetic field. Magnetic Resonance Imaging, 33 (9) 8392, 1098-1105. doi: 10.1016/j.mri.2015.06.010

Evaluation of EPI distortion correction methods for quantitative MRI of the brain at high magnetic field

2015

Journal Article

Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation

Li, Yinghui, Zhou, Qi-Ling, Sun, Wenjie, Chandrasekharan, Prashant, Cheng, Hui Shan, Ying, Zhe, Lakshmanan, Manikandan, Raju, Anandhkumar, Tenen, Daniel G., Cheng, Shi-Yuan, Chuang, Kai-Hsiang, Li, Jun, Prabhakar, Shyam, Li, Mengfeng and Tergaonkar, Vinay (2015). Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation. Nature Cell Biology, 17 (10), 1327-1338. doi: 10.1038/ncb3240

Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation

2015

Journal Article

Dependence of BOLD signal fluctuation on arterial blood CO2 and O2: Implication for resting-state functional connectivity

Nasrallah, Fatima A., Yeow, Ling Yun, Biswal, Bharat and Chuang, Kai-Hsiang (2015). Dependence of BOLD signal fluctuation on arterial blood CO2 and O2: Implication for resting-state functional connectivity. NeuroImage, 117, 29-39. doi: 10.1016/j.neuroimage.2015.05.035

Dependence of BOLD signal fluctuation on arterial blood CO2 and O2: Implication for resting-state functional connectivity

2015

Journal Article

Optimization of arterial spin labeling MRI for quantitative tumor perfusion in a mouse xenograft model

Rajendran, Rajendran, Liang, Jieming, Tang, M. Y .A., Henry, Brian and Chuang, Kai-Hsiang (2015). Optimization of arterial spin labeling MRI for quantitative tumor perfusion in a mouse xenograft model. NMR in Biomedicine, 28 (8), 988-997. doi: 10.1002/nbm.3330

Optimization of arterial spin labeling MRI for quantitative tumor perfusion in a mouse xenograft model

2015

Journal Article

Pharmacokinetics of Gd(DO3A-Lys) and MR imaging studies in an orthotopic U87MG glioma tumor model

Chandrasekharan, Prashant, Yang, Chang-Tong, Nasrallah, Fatima Ali, Tay, Hui Chien, Chuang, Kai-Hsiang and Robins, Edward G. (2015). Pharmacokinetics of Gd(DO3A-Lys) and MR imaging studies in an orthotopic U87MG glioma tumor model. Contrast Media and Molecular Imaging, 10 (3), 237-244. doi: 10.1002/cmmi.1634

Pharmacokinetics of Gd(DO3A-Lys) and MR imaging studies in an orthotopic U87MG glioma tumor model

2015

Journal Article

Selective delivery of PEGylated compounds to tumor cells by anti-PEG hybrid antibodies

Tung, H.-Y., Su, Y.-C., Chen, B.-M., Burnouf, P.-A., Huang, W.-C., Chuang, K.-H., Yan, Y.-T., Cheng, T.-L. and Roffler, S. R. (2015). Selective delivery of PEGylated compounds to tumor cells by anti-PEG hybrid antibodies. Molecular Cancer Therapeutics, 14 (6), 1317-1326. doi: 10.1158/1535-7163.mct-15-0151

Selective delivery of PEGylated compounds to tumor cells by anti-PEG hybrid antibodies

2015

Journal Article

Evaluation of thermo-triggered drug release in intramuscular-transplanted tumors using thermosensitive polymer-modified liposomes and MRI

Kokuryo, Daisuke, Nakashima, Seiji, Ozaki, Fuminori, Yuba, Eiji, Chuang, Kai-Hsiang, Aoshima, Sadahito, Ishizaka, Yukihito, Saga, Tsuneo, Kono, Kenji and Aoki, Ichio (2015). Evaluation of thermo-triggered drug release in intramuscular-transplanted tumors using thermosensitive polymer-modified liposomes and MRI. Nanomedicine: Nanotechnology, Biology and Medicine, 11 (1), 229-238. doi: 10.1016/j.nano.2014.09.001

Evaluation of thermo-triggered drug release in intramuscular-transplanted tumors using thermosensitive polymer-modified liposomes and MRI

2015

Conference Publication

Molecular photoacoustic imaging of orthotopic glioblastoma

Attia, Amalina Binte Ebrahim, Ho, Chris Jun Hui, Chandrasekharan, Prashant, Balasundaram, Ghayathri, Chuang, Kai-Hsiang and Olivo, Malini (2015). Molecular photoacoustic imaging of orthotopic glioblastoma. Optical Molecular Probes, Imaging and Drug Delivery 2015, Vancouver, Canada, 12–15 April 2015. Washington, D.C.: OSA. doi: 10.1364/omp.2015.ow3d.3

Molecular photoacoustic imaging of orthotopic glioblastoma

2015

Journal Article

Dynamic contrast-enhanced MRI of mouse liver: A feasibility study using a dual-input two-compartment tracer kinetic model

Hartono, Septian, Thng, Choon Hua, Chuang, Kai Hsiang, Hung, Huynh and Koh, Tong San (2015). Dynamic contrast-enhanced MRI of mouse liver: A feasibility study using a dual-input two-compartment tracer kinetic model. Journal of Biomedical Science and Engineering, 08 (02), 90-97. doi: 10.4236/jbise.2015.82009

Dynamic contrast-enhanced MRI of mouse liver: A feasibility study using a dual-input two-compartment tracer kinetic model

2015

Conference Publication

Combining EPI and motion correction for fMRI human brain images with big motion

Lu, Zhongkang, Phua, Kok Soon, Huang, Weimin, Hong, Xin, Nasrallah, Fatima Ali, Chuang, Kai-Hsiang and Guan, Cuntai (2015). Combining EPI and motion correction for fMRI human brain images with big motion. 3Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Milan, Italy, 25-29 August 2015. Piscataway, NJ, United States: IEEE. doi: 10.1109/EMBC.2015.7319624

Combining EPI and motion correction for fMRI human brain images with big motion

Funding

Current funding

  • 2024 - 2028
    Decoding the brain network of memory formation
    ARC Discovery Projects
    Open grant

Past funding

  • 2019
    Dissolution DNP Hyperpolariser
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2019 - 2021
    Mechanisms and consequences of cholinergic neuron degeneration in sleep apnea
    NHMRC Project Grant
    Open grant
  • 2018
    A specialised surgical and behavioural facility for longitudinal, multimodal examination of the rodent brain
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2019
    Reduced cerebral blood flow in Alzheimer's disease and cholinergic neuron dysfunction
    The Mason Foundation National Medical Program
    Open grant
  • 2017 - 2024
    ARC Training Centre for Innovation in Biomedical Imaging Technology
    ARC Industrial Transformation Training Centres
    Open grant
  • 2017 - 2020
    A randomised-control validation trial of Mindfulness-based cognitive therapy (MBCT): an eight week mindfulness program for youth living with Inflammatory Bowel Disease and co-morbid depression
    Mater Medical Research Institute Limited
    Open grant
  • 2017 - 2018
    Understanding functional and metabolic brain connectivity in mice
    Universities Australia - Germany Joint Research Co-operation Scheme
    Open grant
  • 2016 - 2023
    Improving human fMRI through modeling and imaging microvascular dynamics (NHMRC component of an NHMRC-NIH BRAIN Initiative Collaborative Research Grant)
    NHMRC-NIH BRAIN Initiative Collaborative Research Grants
    Open grant

Supervision

Availability

Associate Professor Kai-Hsiang Chuang is:
Available for supervision

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Available projects

  • Understanding mechanisms of glymphatic dysfunction in Alzheimer’s disease.

    Glymphatic and brain network deficits have been associated with neuropathology of Alzheimer’s disease. However, the mechanism is still unclear. This project aims to test a new hypothesis that leads to accelerated amyloid and tau pathology in brain networks, such as the default mode network. The study will combine structural and functional MRI and genetic tools to test the hypothesis in animal model of AD.

  • Develop techniques for improving cognition via modulating brain network

    The brain is a complex neural network that supports our cognition, such as learning and memory. We have recently identified brain network hubs that causally involved in memory formation. This project will develop new techniques to detect and selectively modulate the functional connectivity of the causal hubs in order to improve memory.

  • Develop novel imaging technique for brain waste clearance

    The glymphatic system is a newly discovered waste clearance pathway that removes toxic proteins, such as amyloid plaques, from the brain. Its dysfunction is suggested to lead to Alzheimer's disease. However, there is still no non-invasive imaging technique for measuring its function. This project aims to develop novel non-invasive MRI techniques for tracking the structure and function of the glymphatic system. These techniques will be used to understand how glymphatic function maintain brain health and network function, and for the diagnosis of its impairment in aging and disorders.

Supervision history

Current supervision

  • Doctor Philosophy

    Understanding neural Basis of Resting-State Network Using Simultaneous Calcium Recording and Functional Magnetic Resonance Imaging

    Principal Advisor

    Other advisors: Professor Pankaj Sah

  • Doctor Philosophy

    Developing imaging and neuro-technologies for decoding memory formation

    Principal Advisor

    Other advisors: Professor Elizabeth Coulson

  • Doctor Philosophy

    Improving Artificial Intelligence And Deep Learning Algorithms In Super-Resolution Imaging

    Associate Advisor

    Other advisors: Professor Feng Liu

  • Doctor Philosophy

    Improving Artificial Intelligence And Deep Learning Algorithms In Super-Resolution Imaging

    Associate Advisor

    Other advisors: Professor Feng Liu

  • Doctor Philosophy

    The Role of Basal Forebrain Cholinergic Neurons in Glymphatic Function - Insights and Neuroimaging Perspectives

    Associate Advisor

    Other advisors: Professor Elizabeth Coulson

  • Doctor Philosophy

    MRI biomarker of glymphatic dysfunction in dementia

    Associate Advisor

    Other advisors: Professor Elizabeth Coulson

  • Master Philosophy

    The Role of Basal Forebrain Cholinergic Neurons in Glymphatic Function - Insights and Neuroimaging Perspectives

    Associate Advisor

    Other advisors: Professor Elizabeth Coulson

Completed supervision

Media

Enquiries

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