
Overview
Background
Dr Kai-Hsiang Chuang received his Ph.D. degree in electrical and biomedical engineering from the National Taiwan University, Taiwan, in 2001. During his graduate study, he developed methods for improving the detection of brain activity using functional magnetic resonance imaging (fMRI). He undertook postdoctoral research at the National Institutes of Health, USA, from 2003 to 2007, where he focused on understanding brain connectivity using novel functional and molecular imaging. He developed manganese-enhanced MRI for high-resolution imaging functional neural pathways in the rodent brain and cerebral blood flow imaging for mapping the resting-state network of the human brain. He joined the Agency for Science Technology and Research (A*STAR), Singapore, in 2008 as the head of MRI Group in the Singapore Bioimaging Consortium (a national research institute). He established the first preclinical imaging facility in Singapore and facilitated research collaboration across academia, clinic and industry. His lab pioneered functional connectivity imaging of the rodent brain to understand the neural basis and function of resting-state brain network, and the development and application of MRI biomarkers for treatment development. In late 2015, he moved to the University of Queensland, Australia, as an Associate Professor with the Queensland Brain Institute and the Centre for Advanced Imaging. His current research focuses on understanding the structure and function of brain network that underlies cognition and behavior, such as learning, memory and dementia. He is developing multimodal techniques, including fMRI, calcium recording, electrophysiology and optogenetic/chemogenetic neuromodulation, to test hypothesis in transgenic mouse models and then translating to humans to improve the diagnosis and intervention of disorders. The imaging and analysis techniques he developed have been widely used in the research community and some in clinical trials. He is serving on the editorial boards of Frontiers in Neuroscience: Brain Imaging Methods, Imaging Neuroscience and Scientific Reports.
Availability
- Associate Professor Kai-Hsiang Chuang is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, National Taiwan University
Research interests
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Functional brain mapping
Develop in vivo imaging techniques, including functional MRI and multimodality integration (optogenetics, calcium imaging, electrophysiology), in humans and animal models to improve the understanding and intervention of brain function, disease process and treatment effects.
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Brain network in learning, memory and dementia
Brain network wiring and activity underpin our cognition and behaviour. However the brain-behaviour relationship of cognitive functions, such as memory, is unclear. We are developing techniques to understand the causal relationship between brain network activity and memory formation, and how to modulate behaviour by manipulating brain network activity.
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Brain waste clearance
The brain is a highly metabolic active organ. Maintaining optimal brain function relies on efficient disposal of metabolic wastes. We are studying a brain fluid drainage system that clear waste and toxic molecules, such as amyloid plaques, from the brain. We're developing imaging techniques to track its function and to understand its regulatory mechanism, treatment target and pathogenic role in dementia.
Works
Search Professor Kai-Hsiang Chuang’s works on UQ eSpace
2010
Journal Article
Imaging metabolic syndrome
Han, Weiping, Chuang, Kai-Hsiang, Chang, Young-Tae, Olivo, Malini, Velan, S. Sendhil, Bhakoo, Kishore, Townsend, David and Radda, George K. (2010). Imaging metabolic syndrome. EMBO Molecular Medicine, 2 (6), 196-210. doi: 10.1002/emmm.201000074
2010
Journal Article
In vivo detection of individual glomeruli in the rodent olfactory bulb using manganese enhanced MRI
Chuang, Kai-Hsiang, Belluscio, Leonardo and Koretsky, Alan P. (2010). In vivo detection of individual glomeruli in the rodent olfactory bulb using manganese enhanced MRI. NeuroImage, 49 (2), 1350-1356. doi: 10.1016/j.neuroimage.2009.09.060
2009
Journal Article
Ipsilateral cortical fMRI responses after peripheral nerve damage in rats reflect increased interneuron activity
Pelled, Galit, Bergstrom, Debra A., Tierney, Patrick L., Conroy, Richard S., Chuang, Kai-Hsiang, Yu, David, Leopold, David A., Walters, Judith R. and Koretsky, Alan P. (2009). Ipsilateral cortical fMRI responses after peripheral nerve damage in rats reflect increased interneuron activity. Proceedings of the National Academy of Sciences of the United States of America, 106 (33), 14114-14119. doi: 10.1073/pnas.0903153106
2009
Journal Article
Accounting for nonspecific enhancement in neuronal tract tracing using manganese enhanced magnetic resonance imaging
Chuang, Kai-Hsiang and Koretsky, Alan P. (2009). Accounting for nonspecific enhancement in neuronal tract tracing using manganese enhanced magnetic resonance imaging. Magnetic Resonance Imaging, 27 (5), 594-600. doi: 10.1016/j.mri.2008.10.006
2009
Journal Article
Temporal changes in the T1 and T2 relaxation rates (ΔR1 and ΔR2) in the rat brain are consistent with the tissue-clearance rates of elemental manganese
Chuang, Kai-Hsiang, Koretsky, Alan P. and Sotak, Christopher H. (2009). Temporal changes in the T1 and T2 relaxation rates (ΔR1 and ΔR2) in the rat brain are consistent with the tissue-clearance rates of elemental manganese. Magnetic Resonance in Medicine, 61 (6), 1528-1532. doi: 10.1002/mrm.21962
2009
Journal Article
Layer specific tracing of corticocortical and thalamocortical connectivity in the rodent using manganese enhanced MRI
Tucciarone, Jason, Chuang, Kai-Hsiang, Dodd, Steven J., Silva, Afonso, Pelled, Galit and Koretsky, Alan P. (2009). Layer specific tracing of corticocortical and thalamocortical connectivity in the rodent using manganese enhanced MRI. NeuroImage, 44 (3), 923-931. doi: 10.1016/j.neuroimage.2008.07.036
2009
Journal Article
Manganese enhanced MRI reveals functional circuitry in response to odorant stimuli
Chuang, Kai-Hsiang, Lee, Jung Hee, Silva, Afonso C., Belluscio, Leonardo and Koretsky, Alan P. (2009). Manganese enhanced MRI reveals functional circuitry in response to odorant stimuli. NeuroImage, 44 (2), 363-372. doi: 10.1016/j.neuroimage.2008.08.046
2008
Journal Article
Absence of gender effect on children with attention-deficit/hyperactivity disorder as assessed by optimized voxel-based morphometry
Yang, Pinchen, Wang, Pei-Ning, Chuang, Kai-Hsiang, Jong, Yuh-Jyh, Chao, Tzu-Cheng and Wu, Ming-Ting (2008). Absence of gender effect on children with attention-deficit/hyperactivity disorder as assessed by optimized voxel-based morphometry. Psychiatry Research - Neuroimaging, 164 (3), 245-253. doi: 10.1016/j.pscychresns.2007.12.013
2008
Journal Article
Monitoring dynamic alterations in calcium homeostasis by T1-weighted and T1-mapping cardiac manganese-enhanced MRI in a murine myocardial infarction model
Waghorn, Ben, Edwards, Tiffany, Yang, Yuhui, Chuang, Kai-Hsiang, Yanasak, Nathan and Hu, Tom C.-C. (2008). Monitoring dynamic alterations in calcium homeostasis by T1-weighted and T1-mapping cardiac manganese-enhanced MRI in a murine myocardial infarction model. NMR in Biomedicine, 21 (10), 1102-1111. doi: 10.1002/nbm.1287
2008
Journal Article
Vascular space occupancy-dependent functional MRI by tissue suppression
Wu, Changwei W., Chuang, Kai-Hsiang, Wai, Yau-Yau, Wan, Yung-Liang, Chen, Jyh-Horng and Liu, Ho-Ling (2008). Vascular space occupancy-dependent functional MRI by tissue suppression. Journal of Magnetic Resonance Imaging, 28 (1), 219-226. doi: 10.1002/jmri.21410
2008
Journal Article
Brain redox imaging using blood-brain barrier-permeable nitroxide MRI contrast agent
Hyodo, Fuminori, Chuang, Kai-Hsiang, Goloshevsky, Artem G., Sulima, Agnieszka, Griffiths, Gary L., Mitchell, James B., Koretsky, Alan P. and Krishna, Murali C. (2008). Brain redox imaging using blood-brain barrier-permeable nitroxide MRI contrast agent. Journal of Cerebral Blood Flow and Metabolism, 28 (6), 1165-1174. doi: 10.1038/jcbfm.2008.5
2008
Journal Article
Mapping resting-state functional connectivity using perfusion MRI
Chuang, Kai-Hsiang, van Gelderen, Peter, Merkle, Hellmut, Bodurka, Jerzy, Ikonomidou, Vasiliki N., Koretsky, Alan P., Duyn, Jeff H. and Talagala, S. Lalith (2008). Mapping resting-state functional connectivity using perfusion MRI. NeuroImage, 40 (4), 1595-1605. doi: 10.1016/j.neuroimage.2008.01.006
2007
Journal Article
Functional MRI detection of bilateral cortical reorganization in the rodent brain following peripheral nerve deafferentation
Pelled, Galit, Chuang, Kai-Hsiang, Dodd, Stephen J. and Koretsky, Alan P. (2007). Functional MRI detection of bilateral cortical reorganization in the rodent brain following peripheral nerve deafferentation. NeuroImage, 37 (1), 262-273. doi: 10.1016/j.neuroimage.2007.03.069
2007
Conference Publication
Improved cardiac manganese-enhanced MRI (MEMRI) with T1 mapping in rodent
Hu, Tom C.-C., Kai-Hsiang Chuang,, Yanasak, Nathan and Koretsky, Alan P. (2007). Improved cardiac manganese-enhanced MRI (MEMRI) with T1 mapping in rodent. 2007 IEEE 33rd Annual Northeast Bioengineering Conference, Long Island, NY, United States, 10-11 March 2007. IEEE. doi: 10.1109/nebc.2007.4413285
2007
Conference Publication
RF power duty cycle restrictions of continuous arterial spin labeling coil for 7.0 tesla perfusion magnetic resonance imaging
Wang, Shumin , Chuang, Kai-Hsiang and Talagala, Lalith (2007). RF power duty cycle restrictions of continuous arterial spin labeling coil for 7.0 tesla perfusion magnetic resonance imaging. 2007 IEEE Antennas and Propagation Society International Symposium, Honolulu, HI, United States, 9-15 June 2007. Piscataway, NJ, United States: IEEE. doi: 10.1109/aps.2007.4396498
2006
Journal Article
Dissociated roles of the middle frontal gyri in the processing of Chinese characters
Liu, Chia-Li, Hue, Chih-Wei, Chen, Chien-Chung, Chuang, Kai-Hsiang, Liang, Keng-Chen, Wang, Yao-Hung, Wu, Chang-Wei and Chen, Jyh-Horng (2006). Dissociated roles of the middle frontal gyri in the processing of Chinese characters. NeuroReport, 17 (13), 1397-1401. doi: 10.1097/01.wnr.0000233090.00463.35
2006
Journal Article
Improved neuronal tract tracing using manganese enhanced magnetic resonance imaging with fast T1 mapping
Chuang, Kai-Hsiang and Koretsky, Alan (2006). Improved neuronal tract tracing using manganese enhanced magnetic resonance imaging with fast T1 mapping. Magnetic Resonance in Medicine, 55 (3), 604-611. doi: 10.1002/mrm.20797
2006
Journal Article
Cell labeling for magnetic resonance imaging with the T1 agent manganese chloride
Aoki, Ichio, Takahashi, Yoshiyuki, Chuang, Kai-Hsiang, Silva, Afonso C., Igarashi, Takehito, Tanaka, Chuzo, Childs, Richard W. and Koretsky, Alan P. (2006). Cell labeling for magnetic resonance imaging with the T1 agent manganese chloride. NMR in Biomedicine, 19 (1), 50-59. doi: 10.1002/nbm.1000
2005
Journal Article
Application of model-free analysis in the MR assessment of pulmonary perfusion dynamics
Chuang, Kai-Hsiang, Wu, Ming-Ting, Lin, Yi-Ru, Hsieh, Kai-Sheng, Wu, Ming-Long, Tsai, Shang-Yueh, Ko, Cheng-Wen and Chung, Hsiao-Wen (2005). Application of model-free analysis in the MR assessment of pulmonary perfusion dynamics. Magnetic Resonance in Medicine, 54 (2), 299-308. doi: 10.1002/mrm.20551
2002
Journal Article
Neuronal specificity of acupuncture response: A fMRI study with electroacupuncture
Wu, M.T., Sheen, J.M., Chuang, K.H.S., Yang, P.C., Chin, S.L., Tsai, C.Y., Chen, C.J., Liao,, Lai, P,H., Chu, K.A., Pan, H.B. and Yang, C.F. (2002). Neuronal specificity of acupuncture response: A fMRI study with electroacupuncture. Neuroimage, 16 (4), 1028-1037. doi: 10.1006/nimg.2002.1145
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Kai-Hsiang Chuang is:
- Available for supervision
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Available projects
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Understanding mechanisms of glymphatic dysfunction in Alzheimer’s disease.
Glymphatic and brain network deficits have been associated with neuropathology of Alzheimer’s disease. However, the mechanism is still unclear. This project aims to test a new hypothesis that leads to accelerated amyloid and tau pathology in brain networks, such as the default mode network. The study will combine structural and functional MRI and genetic tools to test the hypothesis in animal model of AD.
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Develop techniques for improving cognition via modulating brain network
The brain is a complex neural network that supports our cognition, such as learning and memory. We have recently identified brain network hubs that causally involved in memory formation. This project will develop new techniques to detect and selectively modulate the functional connectivity of the causal hubs in order to improve memory.
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Develop novel imaging technique for brain waste clearance
The glymphatic system is a newly discovered waste clearance pathway that removes toxic proteins, such as amyloid plaques, from the brain. Its dysfunction is suggested to lead to Alzheimer's disease. However, there is still no non-invasive imaging technique for measuring its function. This project aims to develop novel non-invasive MRI techniques for tracking the structure and function of the glymphatic system. These techniques will be used to understand how glymphatic function maintain brain health and network function, and for the diagnosis of its impairment in aging and disorders.
Supervision history
Current supervision
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Doctor Philosophy
Understanding neural Basis of Resting-State Network Using Simultaneous Calcium Recording and Functional Magnetic Resonance Imaging
Principal Advisor
Other advisors: Professor Pankaj Sah
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Doctor Philosophy
Developing imaging and neuro-technologies for decoding memory formation
Principal Advisor
Other advisors: Professor Elizabeth Coulson
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Master Philosophy
The Role of Basal Forebrain Cholinergic Neurons in Glymphatic Function - Insights and Neuroimaging Perspectives
Associate Advisor
Other advisors: Professor Elizabeth Coulson
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Doctor Philosophy
Improving Artificial Intelligence And Deep Learning Algorithms In Super-Resolution Imaging
Associate Advisor
Other advisors: Professor Feng Liu
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Doctor Philosophy
Improving Artificial Intelligence And Deep Learning Algorithms In Super-Resolution Imaging
Associate Advisor
Other advisors: Professor Feng Liu
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Doctor Philosophy
The Role of Basal Forebrain Cholinergic Neurons in Glymphatic Function - Insights and Neuroimaging Perspectives
Associate Advisor
Other advisors: Professor Elizabeth Coulson
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Doctor Philosophy
MRI biomarker of glymphatic dysfunction in dementia
Associate Advisor
Other advisors: Professor Elizabeth Coulson
Completed supervision
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2024
Doctor Philosophy
Understanding neural Basis of Resting-State Network Using Simultaneous Calcium Recording and Functional Magnetic Resonance Imaging
Principal Advisor
Other advisors: Professor Pankaj Sah
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2022
Doctor Philosophy
Determining large-scale brain networks involved in memory consolidation
Principal Advisor
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2023
Doctor Philosophy
Improving functional MRI through Modelling and Imaging Microvascular Dynamics
Associate Advisor
Other advisors: Dr Saskia Bollmann, Professor Markus Barth
Media
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