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Associate Professor Kai-Hsiang Chuang
Associate Professor

Kai-Hsiang Chuang

Email: 
Phone: 
+61 7 344 33811

Overview

Background

Dr Kai-Hsiang Chuang received his Ph.D. degree in electrical and biomedical engineering from the National Taiwan University, Taiwan, in 2001. During his graduate study, he developed methods for improving the detection of brain activity using functional magnetic resonance imaging (fMRI). He undertook postdoctoral research at the National Institutes of Health, USA, from 2003 to 2007, where he focused on understanding brain connectivity using novel functional and molecular imaging. He developed manganese-enhanced MRI for high-resolution imaging functional neural pathways in the rodent brain and cerebral blood flow imaging for mapping the resting-state network of the human brain. He joined the Agency for Science Technology and Research (A*STAR), Singapore, in 2008 as the head of MRI Group in the Singapore Bioimaging Consortium (a national research institute). He established the first preclinical imaging facility in Singapore and facilitated research collaboration across academia, clinic and industry. His lab pioneered functional connectivity imaging of the rodent brain to understand the neural basis and function of resting-state brain network, and the development and application of MRI biomarkers for treatment development. In late 2015, he moved to the University of Queensland, Australia, as an Associate Professor with the Queensland Brain Institute and the Centre for Advanced Imaging. His current research focuses on understanding the structure and function of brain network that underlies cognition and behavior, such as learning, memory and dementia. He is developing multimodal techniques, including fMRI, calcium recording, electrophysiology and optogenetic/chemogenetic neuromodulation, to test hypothesis in transgenic mouse models and then translating to humans to improve the diagnosis and intervention of disorders. The imaging and analysis techniques he developed have been widely used in the research community and some in clinical trials. He is serving on the editorial boards of Frontiers in Neuroscience: Brain Imaging Methods, Imaging Neuroscience and Scientific Reports.

Availability

Associate Professor Kai-Hsiang Chuang is:
Available for supervision

Qualifications

  • Doctor of Philosophy, National Taiwan University

Research interests

  • Functional brain mapping

    Develop in vivo imaging techniques, including functional MRI and multimodality integration (optogenetics, calcium imaging, electrophysiology), in humans and animal models to improve the understanding and intervention of brain function, disease process and treatment effects.

  • Brain network in learning, memory and dementia

    Brain network wiring and activity underpin our cognition and behaviour. However the brain-behaviour relationship of cognitive functions, such as memory, is unclear. We are developing techniques to understand the causal relationship between brain network activity and memory formation, and how to modulate behaviour by manipulating brain network activity.

  • Brain waste clearance

    The brain is a highly metabolic active organ. Maintaining optimal brain function relies on efficient disposal of metabolic wastes. We are studying a brain fluid drainage system that clear waste and toxic molecules, such as amyloid plaques, from the brain. We're developing imaging techniques to track its function and to understand its regulatory mechanism, treatment target and pathogenic role in dementia.

Works

Search Professor Kai-Hsiang Chuang’s works on UQ eSpace

126 works between 1998 and 2025

101 - 120 of 126 works

2010

Journal Article

Imaging metabolic syndrome

Han, Weiping, Chuang, Kai-Hsiang, Chang, Young-Tae, Olivo, Malini, Velan, S. Sendhil, Bhakoo, Kishore, Townsend, David and Radda, George K. (2010). Imaging metabolic syndrome. EMBO Molecular Medicine, 2 (6), 196-210. doi: 10.1002/emmm.201000074

Imaging metabolic syndrome

2010

Journal Article

In vivo detection of individual glomeruli in the rodent olfactory bulb using manganese enhanced MRI

Chuang, Kai-Hsiang, Belluscio, Leonardo and Koretsky, Alan P. (2010). In vivo detection of individual glomeruli in the rodent olfactory bulb using manganese enhanced MRI. NeuroImage, 49 (2), 1350-1356. doi: 10.1016/j.neuroimage.2009.09.060

In vivo detection of individual glomeruli in the rodent olfactory bulb using manganese enhanced MRI

2009

Journal Article

Ipsilateral cortical fMRI responses after peripheral nerve damage in rats reflect increased interneuron activity

Pelled, Galit, Bergstrom, Debra A., Tierney, Patrick L., Conroy, Richard S., Chuang, Kai-Hsiang, Yu, David, Leopold, David A., Walters, Judith R. and Koretsky, Alan P. (2009). Ipsilateral cortical fMRI responses after peripheral nerve damage in rats reflect increased interneuron activity. Proceedings of the National Academy of Sciences of the United States of America, 106 (33), 14114-14119. doi: 10.1073/pnas.0903153106

Ipsilateral cortical fMRI responses after peripheral nerve damage in rats reflect increased interneuron activity

2009

Journal Article

Accounting for nonspecific enhancement in neuronal tract tracing using manganese enhanced magnetic resonance imaging

Chuang, Kai-Hsiang and Koretsky, Alan P. (2009). Accounting for nonspecific enhancement in neuronal tract tracing using manganese enhanced magnetic resonance imaging. Magnetic Resonance Imaging, 27 (5), 594-600. doi: 10.1016/j.mri.2008.10.006

Accounting for nonspecific enhancement in neuronal tract tracing using manganese enhanced magnetic resonance imaging

2009

Journal Article

Temporal changes in the T1 and T2 relaxation rates (ΔR1 and ΔR2) in the rat brain are consistent with the tissue-clearance rates of elemental manganese

Chuang, Kai-Hsiang, Koretsky, Alan P. and Sotak, Christopher H. (2009). Temporal changes in the T1 and T2 relaxation rates (ΔR1 and ΔR2) in the rat brain are consistent with the tissue-clearance rates of elemental manganese. Magnetic Resonance in Medicine, 61 (6), 1528-1532. doi: 10.1002/mrm.21962

Temporal changes in the T1 and T2 relaxation rates (ΔR1 and ΔR2) in the rat brain are consistent with the tissue-clearance rates of elemental manganese

2009

Journal Article

Layer specific tracing of corticocortical and thalamocortical connectivity in the rodent using manganese enhanced MRI

Tucciarone, Jason, Chuang, Kai-Hsiang, Dodd, Steven J., Silva, Afonso, Pelled, Galit and Koretsky, Alan P. (2009). Layer specific tracing of corticocortical and thalamocortical connectivity in the rodent using manganese enhanced MRI. NeuroImage, 44 (3), 923-931. doi: 10.1016/j.neuroimage.2008.07.036

Layer specific tracing of corticocortical and thalamocortical connectivity in the rodent using manganese enhanced MRI

2009

Journal Article

Manganese enhanced MRI reveals functional circuitry in response to odorant stimuli

Chuang, Kai-Hsiang, Lee, Jung Hee, Silva, Afonso C., Belluscio, Leonardo and Koretsky, Alan P. (2009). Manganese enhanced MRI reveals functional circuitry in response to odorant stimuli. NeuroImage, 44 (2), 363-372. doi: 10.1016/j.neuroimage.2008.08.046

Manganese enhanced MRI reveals functional circuitry in response to odorant stimuli

2008

Journal Article

Absence of gender effect on children with attention-deficit/hyperactivity disorder as assessed by optimized voxel-based morphometry

Yang, Pinchen, Wang, Pei-Ning, Chuang, Kai-Hsiang, Jong, Yuh-Jyh, Chao, Tzu-Cheng and Wu, Ming-Ting (2008). Absence of gender effect on children with attention-deficit/hyperactivity disorder as assessed by optimized voxel-based morphometry. Psychiatry Research - Neuroimaging, 164 (3), 245-253. doi: 10.1016/j.pscychresns.2007.12.013

Absence of gender effect on children with attention-deficit/hyperactivity disorder as assessed by optimized voxel-based morphometry

2008

Journal Article

Monitoring dynamic alterations in calcium homeostasis by T1-weighted and T1-mapping cardiac manganese-enhanced MRI in a murine myocardial infarction model

Waghorn, Ben, Edwards, Tiffany, Yang, Yuhui, Chuang, Kai-Hsiang, Yanasak, Nathan and Hu, Tom C.-C. (2008). Monitoring dynamic alterations in calcium homeostasis by T1-weighted and T1-mapping cardiac manganese-enhanced MRI in a murine myocardial infarction model. NMR in Biomedicine, 21 (10), 1102-1111. doi: 10.1002/nbm.1287

Monitoring dynamic alterations in calcium homeostasis by T1-weighted and T1-mapping cardiac manganese-enhanced MRI in a murine myocardial infarction model

2008

Journal Article

Vascular space occupancy-dependent functional MRI by tissue suppression

Wu, Changwei W., Chuang, Kai-Hsiang, Wai, Yau-Yau, Wan, Yung-Liang, Chen, Jyh-Horng and Liu, Ho-Ling (2008). Vascular space occupancy-dependent functional MRI by tissue suppression. Journal of Magnetic Resonance Imaging, 28 (1), 219-226. doi: 10.1002/jmri.21410

Vascular space occupancy-dependent functional MRI by tissue suppression

2008

Journal Article

Brain redox imaging using blood-brain barrier-permeable nitroxide MRI contrast agent

Hyodo, Fuminori, Chuang, Kai-Hsiang, Goloshevsky, Artem G., Sulima, Agnieszka, Griffiths, Gary L., Mitchell, James B., Koretsky, Alan P. and Krishna, Murali C. (2008). Brain redox imaging using blood-brain barrier-permeable nitroxide MRI contrast agent. Journal of Cerebral Blood Flow and Metabolism, 28 (6), 1165-1174. doi: 10.1038/jcbfm.2008.5

Brain redox imaging using blood-brain barrier-permeable nitroxide MRI contrast agent

2008

Journal Article

Mapping resting-state functional connectivity using perfusion MRI

Chuang, Kai-Hsiang, van Gelderen, Peter, Merkle, Hellmut, Bodurka, Jerzy, Ikonomidou, Vasiliki N., Koretsky, Alan P., Duyn, Jeff H. and Talagala, S. Lalith (2008). Mapping resting-state functional connectivity using perfusion MRI. NeuroImage, 40 (4), 1595-1605. doi: 10.1016/j.neuroimage.2008.01.006

Mapping resting-state functional connectivity using perfusion MRI

2007

Journal Article

Functional MRI detection of bilateral cortical reorganization in the rodent brain following peripheral nerve deafferentation

Pelled, Galit, Chuang, Kai-Hsiang, Dodd, Stephen J. and Koretsky, Alan P. (2007). Functional MRI detection of bilateral cortical reorganization in the rodent brain following peripheral nerve deafferentation. NeuroImage, 37 (1), 262-273. doi: 10.1016/j.neuroimage.2007.03.069

Functional MRI detection of bilateral cortical reorganization in the rodent brain following peripheral nerve deafferentation

2007

Conference Publication

Improved cardiac manganese-enhanced MRI (MEMRI) with T1 mapping in rodent

Hu, Tom C.-C., Kai-Hsiang Chuang,, Yanasak, Nathan and Koretsky, Alan P. (2007). Improved cardiac manganese-enhanced MRI (MEMRI) with T1 mapping in rodent. 2007 IEEE 33rd Annual Northeast Bioengineering Conference, Long Island, NY, United States, 10-11 March 2007. IEEE. doi: 10.1109/nebc.2007.4413285

Improved cardiac manganese-enhanced MRI (MEMRI) with T1 mapping in rodent

2007

Conference Publication

RF power duty cycle restrictions of continuous arterial spin labeling coil for 7.0 tesla perfusion magnetic resonance imaging

Wang, Shumin , Chuang, Kai-Hsiang and Talagala, Lalith (2007). RF power duty cycle restrictions of continuous arterial spin labeling coil for 7.0 tesla perfusion magnetic resonance imaging. 2007 IEEE Antennas and Propagation Society International Symposium, Honolulu, HI, United States, 9-15 June 2007. Piscataway, NJ, United States: IEEE. doi: 10.1109/aps.2007.4396498

RF power duty cycle restrictions of continuous arterial spin labeling coil for 7.0 tesla perfusion magnetic resonance imaging

2006

Journal Article

Dissociated roles of the middle frontal gyri in the processing of Chinese characters

Liu, Chia-Li, Hue, Chih-Wei, Chen, Chien-Chung, Chuang, Kai-Hsiang, Liang, Keng-Chen, Wang, Yao-Hung, Wu, Chang-Wei and Chen, Jyh-Horng (2006). Dissociated roles of the middle frontal gyri in the processing of Chinese characters. NeuroReport, 17 (13), 1397-1401. doi: 10.1097/01.wnr.0000233090.00463.35

Dissociated roles of the middle frontal gyri in the processing of Chinese characters

2006

Journal Article

Improved neuronal tract tracing using manganese enhanced magnetic resonance imaging with fast T1 mapping

Chuang, Kai-Hsiang and Koretsky, Alan (2006). Improved neuronal tract tracing using manganese enhanced magnetic resonance imaging with fast T1 mapping. Magnetic Resonance in Medicine, 55 (3), 604-611. doi: 10.1002/mrm.20797

Improved neuronal tract tracing using manganese enhanced magnetic resonance imaging with fast T1 mapping

2006

Journal Article

Cell labeling for magnetic resonance imaging with the T1 agent manganese chloride

Aoki, Ichio, Takahashi, Yoshiyuki, Chuang, Kai-Hsiang, Silva, Afonso C., Igarashi, Takehito, Tanaka, Chuzo, Childs, Richard W. and Koretsky, Alan P. (2006). Cell labeling for magnetic resonance imaging with the T1 agent manganese chloride. NMR in Biomedicine, 19 (1), 50-59. doi: 10.1002/nbm.1000

Cell labeling for magnetic resonance imaging with the T1 agent manganese chloride

2005

Journal Article

Application of model-free analysis in the MR assessment of pulmonary perfusion dynamics

Chuang, Kai-Hsiang, Wu, Ming-Ting, Lin, Yi-Ru, Hsieh, Kai-Sheng, Wu, Ming-Long, Tsai, Shang-Yueh, Ko, Cheng-Wen and Chung, Hsiao-Wen (2005). Application of model-free analysis in the MR assessment of pulmonary perfusion dynamics. Magnetic Resonance in Medicine, 54 (2), 299-308. doi: 10.1002/mrm.20551

Application of model-free analysis in the MR assessment of pulmonary perfusion dynamics

2002

Journal Article

Neuronal specificity of acupuncture response: A fMRI study with electroacupuncture

Wu, M.T., Sheen, J.M., Chuang, K.H.S., Yang, P.C., Chin, S.L., Tsai, C.Y., Chen, C.J., Liao,, Lai, P,H., Chu, K.A., Pan, H.B. and Yang, C.F. (2002). Neuronal specificity of acupuncture response: A fMRI study with electroacupuncture. Neuroimage, 16 (4), 1028-1037. doi: 10.1006/nimg.2002.1145

Neuronal specificity of acupuncture response: A fMRI study with electroacupuncture

Funding

Current funding

  • 2024 - 2028
    Decoding the brain network of memory formation
    ARC Discovery Projects
    Open grant

Past funding

  • 2019
    Dissolution DNP Hyperpolariser
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2019 - 2021
    Mechanisms and consequences of cholinergic neuron degeneration in sleep apnea
    NHMRC Project Grant
    Open grant
  • 2018
    A specialised surgical and behavioural facility for longitudinal, multimodal examination of the rodent brain
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2019
    Reduced cerebral blood flow in Alzheimer's disease and cholinergic neuron dysfunction
    The Mason Foundation National Medical Program
    Open grant
  • 2017 - 2024
    ARC Training Centre for Innovation in Biomedical Imaging Technology
    ARC Industrial Transformation Training Centres
    Open grant
  • 2017 - 2020
    A randomised-control validation trial of Mindfulness-based cognitive therapy (MBCT): an eight week mindfulness program for youth living with Inflammatory Bowel Disease and co-morbid depression
    Mater Medical Research Institute Limited
    Open grant
  • 2017 - 2018
    Understanding functional and metabolic brain connectivity in mice
    Universities Australia - Germany Joint Research Co-operation Scheme
    Open grant
  • 2016 - 2023
    Improving human fMRI through modeling and imaging microvascular dynamics (NHMRC component of an NHMRC-NIH BRAIN Initiative Collaborative Research Grant)
    NHMRC-NIH BRAIN Initiative Collaborative Research Grants
    Open grant

Supervision

Availability

Associate Professor Kai-Hsiang Chuang is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Understanding mechanisms of glymphatic dysfunction in Alzheimer’s disease.

    Glymphatic and brain network deficits have been associated with neuropathology of Alzheimer’s disease. However, the mechanism is still unclear. This project aims to test a new hypothesis that leads to accelerated amyloid and tau pathology in brain networks, such as the default mode network. The study will combine structural and functional MRI and genetic tools to test the hypothesis in animal model of AD.

  • Develop techniques for improving cognition via modulating brain network

    The brain is a complex neural network that supports our cognition, such as learning and memory. We have recently identified brain network hubs that causally involved in memory formation. This project will develop new techniques to detect and selectively modulate the functional connectivity of the causal hubs in order to improve memory.

  • Develop novel imaging technique for brain waste clearance

    The glymphatic system is a newly discovered waste clearance pathway that removes toxic proteins, such as amyloid plaques, from the brain. Its dysfunction is suggested to lead to Alzheimer's disease. However, there is still no non-invasive imaging technique for measuring its function. This project aims to develop novel non-invasive MRI techniques for tracking the structure and function of the glymphatic system. These techniques will be used to understand how glymphatic function maintain brain health and network function, and for the diagnosis of its impairment in aging and disorders.

Supervision history

Current supervision

  • Doctor Philosophy

    Understanding neural Basis of Resting-State Network Using Simultaneous Calcium Recording and Functional Magnetic Resonance Imaging

    Principal Advisor

    Other advisors: Professor Pankaj Sah

  • Doctor Philosophy

    Developing imaging and neuro-technologies for decoding memory formation

    Principal Advisor

    Other advisors: Professor Elizabeth Coulson

  • Master Philosophy

    The Role of Basal Forebrain Cholinergic Neurons in Glymphatic Function - Insights and Neuroimaging Perspectives

    Associate Advisor

    Other advisors: Professor Elizabeth Coulson

  • Doctor Philosophy

    Improving Artificial Intelligence And Deep Learning Algorithms In Super-Resolution Imaging

    Associate Advisor

    Other advisors: Professor Feng Liu

  • Doctor Philosophy

    Improving Artificial Intelligence And Deep Learning Algorithms In Super-Resolution Imaging

    Associate Advisor

    Other advisors: Professor Feng Liu

  • Doctor Philosophy

    The Role of Basal Forebrain Cholinergic Neurons in Glymphatic Function - Insights and Neuroimaging Perspectives

    Associate Advisor

    Other advisors: Professor Elizabeth Coulson

  • Doctor Philosophy

    MRI biomarker of glymphatic dysfunction in dementia

    Associate Advisor

    Other advisors: Professor Elizabeth Coulson

Completed supervision

Media

Enquiries

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