Elizabeth Coulson
- Email:
- e.coulson@uq.edu.au
- Phone:
- +61 7 336 52905
- Phone:
- +61 7 336 59022
Overview
Background
Professor Elizabeth (Lizzie) Coulson did her undergraduate Honours degree at the University of Melbourne, majoring in Genetics and Biochemistry. Her PhD (1997) in the Department of Pathology, University of Melbourne, with Professor Colin Masters, was on the normal function of the amyloid precursor protein of Alzheimer’s disease. Following a year at the ZMBH, University of Heidelberg, Germany, she pursued postdoctoral work studying neuronal cell death in neurodegeneration and development at the Walter and Eliza Hall Institute with Professor Perry Bartlett before being recruited in 2003 to the University of Queensland as a founding member of the Queensland Brain Institute. She was appointed Professor in 2015, joining the School of Biomedical Sciences and becoming Deputy Head of School in 2016/7 and 2019 and Head of School in 2020. She maintains a 20% Queensland Brain Institutes appointment and is a member of the Clem Jones Centre for Ageing Dementia Research.
Her Lab webpage is: Coulson Lab - Neurotrophin - School of Biomedical Sciences ...
Availability
- Professor Elizabeth Coulson is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), University of Melbourne
- Doctor of Philosophy, University of Melbourne
Research interests
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Role of p75NTR in neurodegenerative disease.
The laboratory recently reported that p75NTR death signalling can be promoted by amyloid-ß peptide that characteristically accumulates in Alzheimer’s disease. We are investigating the regulation and activation of p75NTR death signalling in cholinergic neurons in this condition, and testing whether disrupting p75NTR function can prevent cholinergic degeneration, and cognitive decline, in animal models. As an extension of this work we are developing methods to assess cholinergic degeneration and amyloid plaque deposition in animal models of Alzheimer’s disease by magnetic resonance imaging (MRI).
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How neurotransmitter- and neurotrophin-mediated signals determine cell survival.
We are investigating the basic molecular mechanisms by which neurotransmitter receptor activation and receptor trafficking affect p75NTR activation and subsequent death signalling using molecular and biochemical techniques in in vitro and in vivo models. We are also investigating the role of p75NTR cleavage in promoting death signalling, using confocal microscopy techniques to image live cells and cell membranes in real time. This project will lead to a greater understanding of p75NTR biology, and will also provide knowledge of the kinetics of p75NTR-mediated death signals and the time frame within which they can be inhibited.
Works
Search Professor Elizabeth Coulson’s works on UQ eSpace
2024
Journal Article
Association of Basal Forebrain Atrophy With Cognitive Decline in Early Alzheimer Disease
Xia, Ying, Dore, Vincent, Fripp, Jurgen, Bourgeat, Pierrick, Laws, Simon M., Fowler, Christopher J., Rainey-Smith, Stephanie R., Martins, Ralph N., Rowe, Christopher, Masters, Colin L., Coulson, Elizabeth J. and Maruff, Paul (2024). Association of Basal Forebrain Atrophy With Cognitive Decline in Early Alzheimer Disease. Neurology, 103 (2) ARTN e209626. doi: 10.1212/WNL.0000000000209626
2024
Journal Article
Stimulation of the muscarinic receptor M4 regulates neural precursor cell proliferation and promotes adult hippocampal neurogenesis
Madrid, Lidia I., Hafey, Katelyn, Bandhavkar, Saurabh, Bodea, Gabriela O., Jimenez-Martin, Javier, Milne, Michael, Walker, Tara L., Faulkner, Geoffrey J., Coulson, Elizabeth J. and Jhaveri, Dhanisha J. (2024). Stimulation of the muscarinic receptor M4 regulates neural precursor cell proliferation and promotes adult hippocampal neurogenesis. Development, 151 (1) dev201835, 1-13. doi: 10.1242/dev.201835
2023
Journal Article
Longitudinal trajectories of basal forebrain volume in normal aging and Alzheimer's disease
Xia, Ying, Maruff, Paul, Doré, Vincent, Bourgeat, Pierrick, Laws, Simon M., Fowler, Christopher, Rainey-Smith, Stephanie R., Martins, Ralph N., Villemagne, Victor L., Rowe, Christopher C., Masters, Colin L., Coulson, Elizabeth J. and Fripp, Jurgen (2023). Longitudinal trajectories of basal forebrain volume in normal aging and Alzheimer's disease. Neurobiology of Aging, 132, 120-130. doi: 10.1016/j.neurobiolaging.2023.09.002
2023
Conference Publication
The effect of basal forebrain atrophy on the rate of cognitive decline in older adults without dementia
Xia, Ying, Maruff, Paul, Dore, Vincent, Bourgeat, Pierrick, Villemagne, Victor L., Rowe, Christopher C., Coulson, Elizabeth J. and Fripp, Jurgen (2023). The effect of basal forebrain atrophy on the rate of cognitive decline in older adults without dementia. Alzheimer’s Association International Conference AAIC 2023, Amsterdam, Netherlands, 16-20 July 2023. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1002/alz.079648
2023
Journal Article
Hericerin derivatives activates a pan‐neurotrophic pathway in central hippocampal neurons converging to ERK1 /2 signaling enhancing spatial memory
Martínez‐Mármol, Ramón, Chai, YeJin, Conroy, Jacinta N., Khan, Zahra, Hong, Seong‐Min, Kim, Seon Beom, Gormal, Rachel S., Lee, Dae Hee, Lee, Jae Kang, Coulson, Elizabeth J., Lee, Mi Kyeong, Kim, Sun Yeou and Meunier, Frédéric A. (2023). Hericerin derivatives activates a pan‐neurotrophic pathway in central hippocampal neurons converging to ERK1 /2 signaling enhancing spatial memory. Journal of Neurochemistry, 165 (6), 791-808. doi: 10.1111/jnc.15767
2023
Conference Publication
Longitudinal basal forebrain atrophy in association with amyloid‐β positivity and dementia severity
Xia, Ying, Maruff, Paul, Bourgeat, Pierrick, Dore, Vincent, Villemagne, Victor L., Rowe, Christopher C., Coulson, Elizabeth J. and Fripp, Jurgen (2023). Longitudinal basal forebrain atrophy in association with amyloid‐β positivity and dementia severity. Alzheimer's Association International Conference (AAIC) 2022, San Diego, CA United States, 31 July - 4 August 2022. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1002/alz.064027
2023
Conference Publication
Reduced cortical cholinergic innervation correlates with cognitive decline in mild cognitive impairment
Xia, Ying, Eeles, Eamonn, Fripp, Jurgen, Pinsker, Donna, Thomas, Paul, Latter, Melissa, Dore, Vincent, Fazlollahi, Amir, Bourgeat, Pierrick, Villemagne, Victor L., Coulson, Elizabeth J. and Rose, Stephen (2023). Reduced cortical cholinergic innervation correlates with cognitive decline in mild cognitive impairment. Alzheimer's Association International Conference (AAIC) 2022, San Diego, CA United States, 31 July - 4 August 2022. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1002/alz.063527
2023
Book Chapter
Signaling and function of death receptors of the tumor necrosis factor receptor superfamily
Skeldal, S. and Coulson, E.J. (2023). Signaling and function of death receptors of the tumor necrosis factor receptor superfamily. Encyclopedia of cell biology. (pp. 85-94) Amsterdam, Netherlands: Elsevier. doi: 10.1016/b978-0-12-821618-7.30011-6
2022
Journal Article
Cholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer’s disease
Qian, Lei, Rawashdeh, Oliver, Kasas, Leda, Milne, Michael R., Garner, Nicholas, Sankorrakul, Kornraviya, Marks, Nicola, Dean, Matthew W., Kim, Pu Reum, Sharma, Aanchal, Bellingham, Mark C. and Coulson, Elizabeth J. (2022). Cholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer’s disease. Nature Communications, 13 (1) 6543, 1-18. doi: 10.1038/s41467-022-33624-y
2022
Conference Publication
CPAP therapy compliance and changes in cognitive function in patients with obstructive sleep apnoea
Adams, R., Georgeson, T., Szollosi, I. and Coulson, E. (2022). CPAP therapy compliance and changes in cognitive function in patients with obstructive sleep apnoea. 33rd annual scientific meeting of Australasian Sleep Association (ASA) & Australian and New Zealand Sleep Science Association (ANZSSA), Brisbane, QLD, Australia, 8-11 November 2022. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/sleepadvances/zpac029.075
2022
Journal Article
Frailty and Treatment-Resistant Schizophrenia: A Retrospective Cohort Study
Pearson, Ella, Siskind, Dan, Hubbard, Ruth, Gordon, Emily, Coulson, Elizabeth, Arnautovska, Urska and Warren, Nicola (2022). Frailty and Treatment-Resistant Schizophrenia: A Retrospective Cohort Study. Community Mental Health Journal, 59 (1), 1-5. doi: 10.1007/s10597-022-00998-8
2022
Journal Article
The basal forebrain volume reduction detected by MRI does not necessarily link with the cholinergic neuronal loss in the Alzheimer's Disease mouse model
Zhou, Xiaoqing Alice, Ngiam, Grace, Qian, Lei, Sankorrakul, Kornraviya, Coulson, Elizabeth J. and Chuang, Kai-Hsiang (2022). The basal forebrain volume reduction detected by MRI does not necessarily link with the cholinergic neuronal loss in the Alzheimer's Disease mouse model. Neurobiology of Aging, 117, 24-32. doi: 10.1016/j.neurobiolaging.2022.03.017
2022
Journal Article
Reduced cortical cholinergic innervation measured using [18F]-FEOBV PET imaging correlates with cognitive decline in mild cognitive impairment
Xia, Ying, Eeles, Eamonn, Fripp, Jurgen, Pinsker, Donna, Thomas, Paul, Latter, Melissa, Doré, Vincent, Fazlollahi, Amir, Bourgeat, Pierrick, Villemagne, Victor L., Coulson, Elizabeth J. and Rose, Stephen (2022). Reduced cortical cholinergic innervation measured using [18F]-FEOBV PET imaging correlates with cognitive decline in mild cognitive impairment. NeuroImage: Clinical, 34 102992, 102992. doi: 10.1016/j.nicl.2022.102992
2022
Journal Article
Up-regulation of proBDNF/p75NTR signaling in antibody-secreting cells drives systemic lupus erythematosus
Shen, Wei-Yun, Luo, Cong, Hurtado, Plinio Reinaldo, Liu, Xiao-Jing, Luo, Ru-Yi, Li, Hui, Hu, Zhao-Lan, Xu, Jun-Mei, Coulson, Elizabeth J., Zhao, Ming, Zhou, Xin-Fu and Dai, Ru-Ping (2022). Up-regulation of proBDNF/p75NTR signaling in antibody-secreting cells drives systemic lupus erythematosus. Science Advances, 8 (3) eabj2797, eabj2797. doi: 10.1126/sciadv.abj2797
2022
Journal Article
Sleep and circadian rhythms in Parkinson’s disease and preclinical models
Hunt, Jeremy, Coulson, Elizabeth J., Rajnarayanan, Rajendram, Oster, Henrik, Videnovic, Aleksandar and Rawashdeh, Oliver (2022). Sleep and circadian rhythms in Parkinson’s disease and preclinical models. Molecular Neurodegeneration, 17 (1) 2, 2. doi: 10.1186/s13024-021-00504-w
2022
Journal Article
Frailty and severe mental illness: A systematic review and narrative synthesis
Pearson, Ella, Siskind, Dan, Hubbard, Ruth E., Gordon, Emily H., Coulson, Elizabeth and Warren, Nicola (2022). Frailty and severe mental illness: A systematic review and narrative synthesis. Journal of Psychiatric Research, 147, 166-175. doi: 10.1016/j.jpsychires.2022.01.014
2022
Journal Article
High-affinity TrkA and p75 neurotrophin receptor complexes: a twisted affair
Conroy, Jacinta N. and Coulson, Elizabeth J. (2022). High-affinity TrkA and p75 neurotrophin receptor complexes: a twisted affair. Journal of Biological Chemistry, 298 (3) 101568, 101568. doi: 10.1016/j.jbc.2022.101568
2022
Other Outputs
Cholinergic basal forebrain degeneration due to sleep-disordered breathing project source data
Coulson, Elizabeth, Qian, Lei, Bellingham, Mark, Georgeson, Thomas, Garner, Nicholas and Dean, Matthew (2022). Cholinergic basal forebrain degeneration due to sleep-disordered breathing project source data. The University of Queensland. (Dataset) doi: 10.48610/81462a6
2021
Journal Article
Is there a role for the p75 neurotrophin receptor in mediating degeneration during oxidative stress and after hypoxia?
Sankorrakul, Kornraviya, Qian, Lei, Thangnipon, Wipawan and Coulson, Elizabeth J (2021). Is there a role for the p75 neurotrophin receptor in mediating degeneration during oxidative stress and after hypoxia?. Journal of Neurochemistry, 158 (6) jnc.15451, 1-15. doi: 10.1111/jnc.15451
2021
Journal Article
Fast-Trk(B)ing the mechanism of antidepressants
Conroy, Jacinta N., Jhaveri, Dhanisha J. and Coulson, Elizabeth J. (2021). Fast-Trk(B)ing the mechanism of antidepressants. Neuron, 109 (10), 1593-1595. doi: 10.1016/j.neuron.2021.04.027
Funding
Current funding
Past funding
Supervision
Availability
- Professor Elizabeth Coulson is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Dissection of the Role of Active Dendritic Integration in Neuronal Computation
Principal Advisor
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Doctor Philosophy
Detecting risk of dementia in people with sleep apnoea
Principal Advisor
Other advisors: Associate Professor Philip Terrill
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Doctor Philosophy
MRI biomarker of glymphatic dysfunction in dementia
Principal Advisor
Other advisors: Associate Professor Kai-Hsiang Chuang
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Doctor Philosophy
Dissection of the Role of Active Dendritic Integration in Neuronal Computation
Principal Advisor
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Master Philosophy
Efficacy of Non-Invasive Ventilation for the treatment of sleep hypoventilation in Myotonic Dystrophy
Associate Advisor
Other advisors: Professor Kwun Fong
Completed supervision
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2020
Doctor Philosophy
p75 neurotrophin receptor function in brain development
Principal Advisor
Other advisors: Professor Michael Piper
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2017
Master Philosophy
An investigation of risk factors for Alzheimer's disease in obstructive sleep apnoea patients
Principal Advisor
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2016
Doctor Philosophy
Role of p75 neurotrophin receptor in normal cholinergic basal forebrain function in adults
Principal Advisor
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2016
Doctor Philosophy
Neurotrophin Regulation of Alzheimer's Disease Pathology
Principal Advisor
Other advisors: Professor Jürgen Götz
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2014
Master Philosophy
Efficacy of a novel neuronal death inhibitor in Alzheimer¿s disease models
Principal Advisor
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2012
Doctor Philosophy
Characterisation of a novel p75 neurotrophin receptor death signalling pathway
Principal Advisor
Other advisors: Professor Pankaj Sah
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2008
Doctor Philosophy
Role of p75NTR in BDNF - Stimulated Neurogenesis in the Adult Hippocampus
Principal Advisor
Other advisors: Professor Helen Cooper
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2007
Doctor Philosophy
REGULATION OF P75 NEUROTROPHIN RECEPTOR-MEDIATED NEURONAL DEATH THROUGH POST-TRANSLATIONAL MODIFICATIONS
Principal Advisor
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2006
Doctor Philosophy
CELL DEATH AND PROLIFERATION IN PSYCHIATRIC DISORDERS
Principal Advisor
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2024
Doctor Philosophy
Stimulating the counter-regulatory renin-angiotensin system: a novel approach to prevent Alzheimer's disease
Associate Advisor
Other advisors: Dr Niwanthi Rajapakse
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2021
Master Philosophy
Cholinergic regulation of hippocampal neural precursor cell activity and neurogenesis
Associate Advisor
Other advisors: Dr Dhanisha Jhaveri
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2014
Doctor Philosophy
The regulation of membrane trafficking pathways at the presynaptic nerve terminal
Associate Advisor
Other advisors: Professor Frederic Meunier
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2012
Doctor Philosophy
Role of Munc18-1 in regulating neuroexocytosis
Associate Advisor
Other advisors: Professor Frederic Meunier, Professor Brett Collins
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2011
Doctor Philosophy
Post-synaptic scaffolding protein changes in Alzheimer's disease.
Associate Advisor
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2007
Master Philosophy
Neurogenesis in the adult hippocampus: quantification, identification of neural subtypes, andregulation by the immune system
Associate Advisor
Media
Enquiries
Contact Professor Elizabeth Coulson directly for media enquiries about:
- Alzheimer's disease
- Biochemistry
- Cell biology
- Disease - Alzheimer's
- Disease - Motor Neuron
- Molecular mechanisms
- Motor Neuron disease
- Research models
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