![Professor Elizabeth Coulson](/sites/default/files/profiles/1188.jpeg)
Elizabeth Coulson
- Email:
- e.coulson@uq.edu.au
- Phone:
- +61 7 336 52905
- Phone:
- +61 7 336 59022
Overview
Background
Professor Elizabeth (Lizzie) Coulson did her undergraduate Honours degree at the University of Melbourne, majoring in Genetics and Biochemistry. Her PhD (1997) in the Department of Pathology, University of Melbourne, with Professor Colin Masters, was on the normal function of the amyloid precursor protein of Alzheimer’s disease. Following a year at the ZMBH, University of Heidelberg, Germany, she pursued postdoctoral work studying neuronal cell death in neurodegeneration and development at the Walter and Eliza Hall Institute with Professor Perry Bartlett before being recruited in 2003 to the University of Queensland as a founding member of the Queensland Brain Institute. She was appointed Professor in 2015, joining the School of Biomedical Sciences and becoming Deputy Head of School in 2016/7 and 2019 and Head of School in 2020. She maintains a 20% Queensland Brain Institutes appointment and is a member of the Clem Jones Centre for Ageing Dementia Research.
Her Lab webpage is: Coulson Lab - Neurotrophin - School of Biomedical Sciences ...
Availability
- Professor Elizabeth Coulson is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), University of Melbourne
- Doctor of Philosophy, University of Melbourne
Research interests
-
Role of p75NTR in neurodegenerative disease.
The laboratory recently reported that p75NTR death signalling can be promoted by amyloid-ß peptide that characteristically accumulates in Alzheimer’s disease. We are investigating the regulation and activation of p75NTR death signalling in cholinergic neurons in this condition, and testing whether disrupting p75NTR function can prevent cholinergic degeneration, and cognitive decline, in animal models. As an extension of this work we are developing methods to assess cholinergic degeneration and amyloid plaque deposition in animal models of Alzheimer’s disease by magnetic resonance imaging (MRI).
-
How neurotransmitter- and neurotrophin-mediated signals determine cell survival.
We are investigating the basic molecular mechanisms by which neurotransmitter receptor activation and receptor trafficking affect p75NTR activation and subsequent death signalling using molecular and biochemical techniques in in vitro and in vivo models. We are also investigating the role of p75NTR cleavage in promoting death signalling, using confocal microscopy techniques to image live cells and cell membranes in real time. This project will lead to a greater understanding of p75NTR biology, and will also provide knowledge of the kinetics of p75NTR-mediated death signals and the time frame within which they can be inhibited.
Works
Search Professor Elizabeth Coulson’s works on UQ eSpace
2021
Journal Article
Cholinergic regulation of adult hippocampal neurogenesis and hippocampus-dependent functions
Madrid, Lidia I., Jimenez-Martin, Javier, Coulson, Elizabeth J. and Jhaveri, Dhanisha J. (2021). Cholinergic regulation of adult hippocampal neurogenesis and hippocampus-dependent functions. The International Journal of Biochemistry & Cell Biology, 134 105969, 1-6. doi: 10.1016/j.biocel.2021.105969
2021
Journal Article
Identification of 14-3-3 epsilon as a regulator of the neural apoptotic pathway for chronic-stress-induced depression
Zhao, Yan, Coulson, Elizabeth J., Su, Xingli, Zhang, Junfeng, Sha, Baoyong, Xu, Hao, Deng, Yating, Chen, Yulong, Cao, Jian, Wang, Yunpeng and Wang, Shuang (2021). Identification of 14-3-3 epsilon as a regulator of the neural apoptotic pathway for chronic-stress-induced depression. iScience, 24 (2) 102043, 1-16. doi: 10.1016/j.isci.2021.102043
2020
Journal Article
A validated quantitative method for the assessment of neuroprotective barrier impairment in neurodegenerative disease models
Kumar, Vinod, Lee, John D., Coulson, Elizabeth J. and Woodruff, Trent M. (2020). A validated quantitative method for the assessment of neuroprotective barrier impairment in neurodegenerative disease models. Journal of Neurochemistry, 158 (3) jnc.15119, 807-817. doi: 10.1111/jnc.15119
2020
Journal Article
Comparative studies of glial fibrillary acidic protein and brain‐derived neurotrophic factor expression in two transgenic mouse models of Alzheimer’s disease
Edwards, Stephen R., Khan, Nemat, Coulson, Elizabeth J. and Smith, Maree T. (2020). Comparative studies of glial fibrillary acidic protein and brain‐derived neurotrophic factor expression in two transgenic mouse models of Alzheimer’s disease. Clinical and Experimental Pharmacology and Physiology, 47 (10) 1440-1681.13363, 1740-1750. doi: 10.1111/1440-1681.13363
2020
Journal Article
Partial deletion of p75NTR in large-diameter DRG neurons exerts no influence upon the survival of peripheral sensory neurons in vivo
Qin, Zuoheng, Gonsalvez, David G., Wood, Rhiannon J., Daemi, Fatemeh, Yoo, Sangwon, Ivanusic, Jason J., Coulson, Elizabeth J., Murray, Simon S. and Xiao, Junhua (2020). Partial deletion of p75NTR in large-diameter DRG neurons exerts no influence upon the survival of peripheral sensory neurons in vivo. Journal of Neuroscience Research, 98 (10) jnr.24665, 1987-1998. doi: 10.1002/jnr.24665
2020
Journal Article
Blockade of TrkB but not p75 NTR activates a subpopulation of quiescent neural precursor cells and enhances neurogenesis in the adult mouse hippocampus
Groves, Natalie, O’Keeffe, Imogen, Lee, Wendy, Toft, Alexandra, Blackmore, Daniel, Bandhavkar, Saurabh, Coulson, Elizabeth J., Bartlett, Perry F. and Jhaveri, Dhanisha J. (2020). Blockade of TrkB but not p75 NTR activates a subpopulation of quiescent neural precursor cells and enhances neurogenesis in the adult mouse hippocampus. Developmental Neurobiology, 79 (9-10) dneu.22729, 868-879. doi: 10.1002/dneu.22729
2019
Journal Article
The p75 neurotrophin receptor is required for the survival of neuronal progenitors and normal formation of the basal forebrain, striatum, thalamus and neocortex
Meier, Sonja, Alfonsi, Fabienne, Kurniawan, Nyoman D., Milne, Michael R., Kasherman, Maria A., Delogu, Alessio, Piper, Michael and Coulson, Elizabeth J. (2019). The p75 neurotrophin receptor is required for the survival of neuronal progenitors and normal formation of the basal forebrain, striatum, thalamus and neocortex. Development, 146 (18) dev181933, dev.181933. doi: 10.1242/dev.181933
2019
Journal Article
p110δ PI 3-kinase inhibition perturbs APP and TNFα trafficking, reduces plaque burden, dampens neuroinflammation and prevents cognitive decline in an Alzheimer's disease mouse model
Martínez-Mármol, Ramón, Mohannak, Nika, Qian, Lei, Wang, Tong, Gormal, Rachel S, Ruitenberg, Marc J, Vanhaesebroeck, Bart, Coulson, Elizabeth J and Meunier, Frédéric A (2019). p110δ PI 3-kinase inhibition perturbs APP and TNFα trafficking, reduces plaque burden, dampens neuroinflammation and prevents cognitive decline in an Alzheimer's disease mouse model. Journal of Neuroscience, 39 (40), 7976-7991. doi: 10.1523/JNEUROSCI.0674-19.2019
2019
Journal Article
Ultrafast fMRI of the rodent brain using simultaneous multi-slice EPI
Lee, Hsu-Lei, Li, Zengmin, Coulson, Elizabeth J. and Chuang, Kai-Hsiang (2019). Ultrafast fMRI of the rodent brain using simultaneous multi-slice EPI. NeuroImage, 195, 48-58. doi: 10.1016/j.neuroimage.2019.03.045
2019
Journal Article
Peripheral Nerve Regeneration Is Independent From Schwann Cell p75(NTR) Expression
Goncalves, Nadia P., Mohseni, Simin, El Soury, Marwa, Ulrichsen, Maj, Richner, Mette, Xiao, Junhua, Wood, Rhiannon J., Andersen, Olav M., Coulson, Elizabeth J., Raimondo, Stefania, Murray, Simon S. and Vaegter, Christian B. (2019). Peripheral Nerve Regeneration Is Independent From Schwann Cell p75(NTR) Expression. Frontiers in Cellular Neuroscience, 13 235, 235. doi: 10.3389/fncel.2019.00235
2019
Journal Article
Downregulation of SNX27 expression does not exacerbate amyloidogenesis in the APP/PS1 Alzheimer's disease mouse model
Milne, Michael R., Qian, Lei, Turnbull, Marion T., Kinna, Genevieve, Collins, Brett M., Teasdale, Rohan D. and Coulson, Elizabeth J. (2019). Downregulation of SNX27 expression does not exacerbate amyloidogenesis in the APP/PS1 Alzheimer's disease mouse model. Neurobiology of Aging, 77, 144-153. doi: 10.1016/j.neurobiolaging.2019.01.011
2019
Journal Article
Regulation of cholinergic basal forebrain development, connectivity, and function by neurotrophin receptors
Boskovic, Zoran, Meier, Sonja, Wang, Yunpeng, Milne, Michael R., Onraet, Tessa, Tedoldi, Angelo and Coulson, Elizabeth J. (2019). Regulation of cholinergic basal forebrain development, connectivity, and function by neurotrophin receptors. Neuronal Signaling, 3 (1), NS20180066. doi: 10.1042/ns20180066
2018
Journal Article
Cholinergic basal forebrain neurons regulate fear extinction consolidation through p75 neurotrophin receptor signaling
Boskovic, Zoran, Milne, Michael R., Qian, Lei, Clifton, Hamish D., McGovern, Alice E., Turnbull, Marion T., Mazzone, Stuart B. and Coulson, Elizabeth J. (2018). Cholinergic basal forebrain neurons regulate fear extinction consolidation through p75 neurotrophin receptor signaling. Translational Psychiatry, 8 (1) 199, 199. doi: 10.1038/s41398-018-0248-x
2018
Journal Article
Removal of p75 neurotrophin receptor expression from cholinergic basal forebrain neurons reduces amyloid-β plaque deposition and cognitive impairment in aged APP/PS1 mice
Qian, Lei, Milne, Michael R., Shepheard, Stephanie, Rogers, Mary-Louise, Medeiros, Rodrigo and Coulson, Elizabeth J. (2018). Removal of p75 neurotrophin receptor expression from cholinergic basal forebrain neurons reduces amyloid-β plaque deposition and cognitive impairment in aged APP/PS1 mice. Molecular Neurobiology, 56 (7), 4639-4652. doi: 10.1007/s12035-018-1404-2
2018
Journal Article
Acute Down-regulation of BDNF Signaling Does Not Replicate Exacerbated Amyloid-beta Levels and Cognitive Impairment Induced by Cholinergic Basal Forebrain Lesion
Turnbull, Marion T., Boskovic, Zoran and Coulson, Elizabeth J. (2018). Acute Down-regulation of BDNF Signaling Does Not Replicate Exacerbated Amyloid-beta Levels and Cognitive Impairment Induced by Cholinergic Basal Forebrain Lesion. Frontiers in Molecular Neuroscience, 11 51, 1-13. doi: 10.3389/fnmol.2018.00051
2018
Conference Publication
Impairment of basal forebrain projections contributes to hippocampal atrophy in subjects at risk of Alzheimer's disease
Lerch, O., Pannek, K., Laczo, J., Nedelska, Z., Fripp, J., Hort, J. and Coulson, E. (2018). Impairment of basal forebrain projections contributes to hippocampal atrophy in subjects at risk of Alzheimer's disease. 4th Congress of the European Academy of Neurology, Lisbon, Portugal, 16-19 June 2018. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/ene.13700
2017
Journal Article
G-protein-coupled inwardly rectifying potassium (GIRK) channel activation by the p75 neurotrophin receptor is required for amyloid beta toxicity
May, Linda M., Anggono, Victor, Gooch, Helen M., Jang, Se E., Matusica, Dusan, Kerbler, Georg M., Meunier, Frederic A., Sah, Pankaj and Coulson, Elizabeth J. (2017). G-protein-coupled inwardly rectifying potassium (GIRK) channel activation by the p75 neurotrophin receptor is required for amyloid beta toxicity. Frontiers in Neuroscience, 11 (455) 455. doi: 10.3389/fnins.2017.00455
2017
Journal Article
An exercise path to preventing Alzheimer's disease : An Editorial Highlight on 'Exercise and BDNF reduce Ab production by enhancing alpha-secretase processing of APP'
Coulson, Elizabeth J. and Bartlett, Perry F. (2017). An exercise path to preventing Alzheimer's disease : An Editorial Highlight on 'Exercise and BDNF reduce Ab production by enhancing alpha-secretase processing of APP'. Journal of Neurochemistry, 142 (2), 191-193. doi: 10.1111/jnc.14038
2017
Journal Article
Cholinergic basal forebrain lesion decreases neurotrophin signaling without affecting tau hyperphosphorylation in genetically susceptible mice
Turnbull, Marion T. and Coulson, Elizabeth J. (2017). Cholinergic basal forebrain lesion decreases neurotrophin signaling without affecting tau hyperphosphorylation in genetically susceptible mice. Journal of Alzheimer's Disease, 55 (3), 1141-1154. doi: 10.3233/JAD-160805
2017
Conference Publication
Cholinergic dysfunction may explain the link between obstructive sleep apnea and sporadic Alzheimer's disease
Coulson, E. (2017). Cholinergic dysfunction may explain the link between obstructive sleep apnea and sporadic Alzheimer's disease. ISN-ESN Meeting 2017, Paris, France, 20-24 August 2017. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.14089
Funding
Current funding
Past funding
Supervision
Availability
- Professor Elizabeth Coulson is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Detecting risk of dementia in people with sleep apnoea
Principal Advisor
Other advisors: Associate Professor Philip Terrill
-
Doctor Philosophy
MRI biomarker of glymphatic dysfunction in dementia
Principal Advisor
Other advisors: Associate Professor Kai-Hsiang Chuang
-
Doctor Philosophy
Dissection of the Role of Active Dendritic Integration in Neuronal Computation
Principal Advisor
-
Master Philosophy
Efficacy of Non-Invasive Ventilation for the treatment of sleep hypoventilation in Myotonic Dystrophy
Associate Advisor
Other advisors: Professor Kwun Fong
Completed supervision
-
2020
Doctor Philosophy
p75 neurotrophin receptor function in brain development
Principal Advisor
Other advisors: Professor Michael Piper
-
2017
Master Philosophy
An investigation of risk factors for Alzheimer's disease in obstructive sleep apnoea patients
Principal Advisor
-
2016
Doctor Philosophy
Role of p75 neurotrophin receptor in normal cholinergic basal forebrain function in adults
Principal Advisor
-
2016
Doctor Philosophy
Neurotrophin Regulation of Alzheimer's Disease Pathology
Principal Advisor
Other advisors: Professor Jürgen Götz
-
-
2014
Master Philosophy
Efficacy of a novel neuronal death inhibitor in Alzheimer¿s disease models
Principal Advisor
-
2012
Doctor Philosophy
Characterisation of a novel p75 neurotrophin receptor death signalling pathway
Principal Advisor
Other advisors: Professor Pankaj Sah
-
2008
Doctor Philosophy
Role of p75NTR in BDNF - Stimulated Neurogenesis in the Adult Hippocampus
Principal Advisor
Other advisors: Professor Helen Cooper
-
2007
Doctor Philosophy
REGULATION OF P75 NEUROTROPHIN RECEPTOR-MEDIATED NEURONAL DEATH THROUGH POST-TRANSLATIONAL MODIFICATIONS
Principal Advisor
-
2006
Doctor Philosophy
CELL DEATH AND PROLIFERATION IN PSYCHIATRIC DISORDERS
Principal Advisor
-
2024
Doctor Philosophy
Stimulating the counter-regulatory renin-angiotensin system: a novel approach to prevent Alzheimer's disease
Associate Advisor
Other advisors: Dr Niwanthi Rajapakse
-
2021
Master Philosophy
Cholinergic regulation of hippocampal neural precursor cell activity and neurogenesis
Associate Advisor
Other advisors: Dr Dhanisha Jhaveri
-
2014
Doctor Philosophy
The regulation of membrane trafficking pathways at the presynaptic nerve terminal
Associate Advisor
Other advisors: Professor Frederic Meunier
-
2012
Doctor Philosophy
Role of Munc18-1 in regulating neuroexocytosis
Associate Advisor
Other advisors: Professor Frederic Meunier, Professor Brett Collins
-
2011
Doctor Philosophy
Post-synaptic scaffolding protein changes in Alzheimer's disease.
Associate Advisor
-
2007
Master Philosophy
Neurogenesis in the adult hippocampus: quantification, identification of neural subtypes, andregulation by the immune system
Associate Advisor
Media
Enquiries
Contact Professor Elizabeth Coulson directly for media enquiries about:
- Alzheimer's disease
- Biochemistry
- Cell biology
- Disease - Alzheimer's
- Disease - Motor Neuron
- Molecular mechanisms
- Motor Neuron disease
- Research models
Need help?
For help with finding experts, story ideas and media enquiries, contact our Media team: