
Overview
Background
Dr Kai-Hsiang Chuang received his Ph.D. degree in electrical and biomedical engineering from the National Taiwan University, Taiwan, in 2001. During his graduate study, he developed methods for improving the detection of brain activity using functional magnetic resonance imaging (fMRI). He undertook postdoctoral research at the National Institutes of Health, USA, from 2003 to 2007, where he focused on understanding brain connectivity using novel functional and molecular imaging. He developed manganese-enhanced MRI for high-resolution imaging functional neural pathways in the rodent brain and cerebral blood flow imaging for mapping the resting-state network of the human brain. He joined the Agency for Science Technology and Research (A*STAR), Singapore, in 2008 as the head of MRI Group in the Singapore Bioimaging Consortium (a national research institute). He established the first preclinical imaging facility in Singapore and facilitated research collaboration across academia, clinic and industry. His lab pioneered functional connectivity imaging of the rodent brain to understand the neural basis and function of resting-state brain network, and the development and application of MRI biomarkers for treatment development. In late 2015, he moved to the University of Queensland, Australia, as an Associate Professor with the Queensland Brain Institute and the Centre for Advanced Imaging. His current research focuses on understanding the structure and function of brain network that underlies cognition and behavior, such as learning, memory and dementia. He is developing multimodal techniques, including fMRI, calcium recording, electrophysiology and optogenetic/chemogenetic neuromodulation, to test hypothesis in transgenic mouse models and then translating to humans to improve the diagnosis and intervention of disorders. The imaging and analysis techniques he developed have been widely used in the research community and some in clinical trials. He is serving on the editorial boards of Frontiers in Neuroscience: Brain Imaging Methods, Imaging Neuroscience and Scientific Reports.
Availability
- Associate Professor Kai-Hsiang Chuang is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, National Taiwan University
Research interests
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Functional brain mapping
Develop in vivo imaging techniques, including functional MRI and multimodality integration (optogenetics, calcium imaging, electrophysiology), in humans and animal models to improve the understanding and intervention of brain function, disease process and treatment effects.
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Brain network in learning, memory and dementia
Brain network wiring and activity underpin our cognition and behaviour. However the brain-behaviour relationship of cognitive functions, such as memory, is unclear. We are developing techniques to understand the causal relationship between brain network activity and memory formation, and how to modulate behaviour by manipulating brain network activity.
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Brain waste clearance
The brain is a highly metabolic active organ. Maintaining optimal brain function relies on efficient disposal of metabolic wastes. We are studying a brain fluid drainage system that clear waste and toxic molecules, such as amyloid plaques, from the brain. We're developing imaging techniques to track its function and to understand its regulatory mechanism, treatment target and pathogenic role in dementia.
Works
Search Professor Kai-Hsiang Chuang’s works on UQ eSpace
2014
Journal Article
Pharmacological insight into neurotransmission origins of resting-state functional connectivity: α2-adrenergic agonist vs antagonist
Nasrallah, Fatima A., Low, Si-Min, Lew, Si Kang, Chen, Kaina and Chuang, Kai-Hsiang (2014). Pharmacological insight into neurotransmission origins of resting-state functional connectivity: α2-adrenergic agonist vs antagonist. NeuroImage, 103, 364-373. doi: 10.1016/j.neuroimage.2014.09.004
2014
Journal Article
A facile synthetic approach to a biodegradable polydisulfide MRI contrast agent
Cheng, Weiren, Rajendran, Reshmi, Ren, Wei, Gu, Liuqun, Zhang, Yong, Chuang, Kai-Hsiang and Liu, Ye (2014). A facile synthetic approach to a biodegradable polydisulfide MRI contrast agent. Journal of Materials Chemistry B, 2 (32), 5295-5301. doi: 10.1039/c4tb00413b
2014
Journal Article
Functional networks in parallel with cortical development associate with executive functions in children
Zhong, Jidan, Rifkin-Graboi, Anne, Ta, Anh Tuan, Yap, Kar Lai, Chuang, Kai-Hsiang, Meaney, Michael J. and Qiu, Anqi (2014). Functional networks in parallel with cortical development associate with executive functions in children. Cerebral Cortex, 24 (7), 1937-1947. doi: 10.1093/cercor/bht051
2014
Journal Article
Detection of functional connectivity in the resting mouse brain
Nasrallah, Fatima A., Tay, Hui-Chien and Chuang, Kai-Hsiang (2014). Detection of functional connectivity in the resting mouse brain. NeuroImage, 86, 417-424. doi: 10.1016/j.neuroimage.2013.10.025
2014
Journal Article
Early detection of antiangiogenic treatment responses in a mouse xenograft tumor model using quantitative perfusion MRI
Rajendran, Reshmi, Huang, Wei, Tang, Annie Mei Yee, Liang, Jie Ming, Choo, Stephanie, Reese, Torsten, Hentze, Hannes, van Boxtel, Susan, Cliffe, Adam, Rogers, Keith, Henry, Brian and Chuang, Kai Hsiang (2014). Early detection of antiangiogenic treatment responses in a mouse xenograft tumor model using quantitative perfusion MRI. Cancer Medicine, 3 (1), 47-60. doi: 10.1002/cam4.177
2014
Journal Article
An intravascular MRI contrast agent based on Gd(DO3A-Lys) for tumor angiography
Yang, Chang-Tong, Chandrasekharan, Prashant, He, Tao, Poh, Zihan, Raju, Anandhkumar, Chuang, Kai-Hsiang and Robins, Edward G. (2014). An intravascular MRI contrast agent based on Gd(DO3A-Lys) for tumor angiography. Biomaterials, 35 (1), 327-336. doi: 10.1016/j.biomaterials.2013.10.006
2014
Book Chapter
Vitamin E (D-Alpha-Tocopheryl-co-Poly (Ethylene Glycol) 1000 Succinate) Micelles-Superparamagnetic Iron Oxide Nanoparticles for Enhanced Thermotherapy and MRI
Chandrasekharan, Prashant, Maity, Dipak, Yong, Cai, Chuang, Kai-Hsiang, Ding, Jun and Feng, Si-Shen (2014). Vitamin E (D-Alpha-Tocopheryl-co-Poly (Ethylene Glycol) 1000 Succinate) Micelles-Superparamagnetic Iron Oxide Nanoparticles for Enhanced Thermotherapy and MRI. Chemotherapeutic engineering: collected papers of Si-Shen Feng a tribute to Shu Chien on his 82nd birthday. (pp. 841-861) edited by Feng Si-shen, Stanford Chong and Jenny Rompas. Boca Raton, FL, United States: Pan Stanford Publishing. doi: 10.1201/b15645-52
2014
Journal Article
Neural correlate of resting-state functional connectivity under α2 adrenergic receptor agonist, medetomidine
Nasrallah, Fatima A., Lew, Si Kang, Low, Amanda Si-Min and Chuang, Kai-Hsiang (2014). Neural correlate of resting-state functional connectivity under α2 adrenergic receptor agonist, medetomidine. NeuroImage, 84, 27-34. doi: 10.1016/j.neuroimage.2013.08.004
2014
Book Chapter
Superparamagnetic iron oxide—loaded poly(lactic acid)-D-_-tocopherol polyethylene glycol 1000 succinate copolymer nanoparticles as MRI contrast agent
Prashant, Chandrasekharan, Dipak, Maity, Yang, Chang-Tong, Chuang, Kai-Hsiang, Jun, Ding and Feng, Si-Shen (2014). Superparamagnetic iron oxide—loaded poly(lactic acid)-D-_-tocopherol polyethylene glycol 1000 succinate copolymer nanoparticles as MRI contrast agent. Chemotherapeutic engineering: collected papers of Si-Shen Feng a tribute to Shu Chien on his 82nd birthday. (pp. 863-885) edited by Si-Shen Feng, Stanford Chong and Jenny Rompas. Boca Raton, FL, United States: Pan Stanford Publishing. doi: 10.1201/b15645-53
2013
Book Chapter
Multimodal tumor imaging by iron oxides and quantum dots formulated in poly(lactic acid)-D-alpha-tocopheryl polyethylene glycol 1000 succinate nanoparticles
Tan, Yang Fei, Chandrasekharan, Prashant, Maity, Dipak, Yong, Cai Xian, Chuang, Kai-Hsiang, Zhao, Ying, Wang, Shu, Ding, Jun and Feng, Si-Shen (2013). Multimodal tumor imaging by iron oxides and quantum dots formulated in poly(lactic acid)-D-alpha-tocopheryl polyethylene glycol 1000 succinate nanoparticles. Chemotherapeutic Engineering: Collected Papers of Si-Shen Feng - A Tribute to Shu Chien on His 82nd Birthday. (pp. 819-840) Pan Stanford Publishing Pte. Ltd.. doi: 10.4032/9789814463157
2013
Journal Article
Quantitative mouse renal perfusion using arterial spin labeling
Rajendran, Reshmi, Lew, Si Kang, Yong, Cai Xian, Tan, Jolena, Wang, Danny J. J. and Chuang, Kai-Hsiang (2013). Quantitative mouse renal perfusion using arterial spin labeling. NMR in Biomedicine, 26 (10), 1225-1232. doi: 10.1002/nbm.2939
2013
Journal Article
Imaging brain deoxyglucose uptake and metabolism by glucoCEST MRI
Nasrallah, Fatima A., Pages, Guilhem, Kuchel, Philip W., Golay, Xavier and Chuang, Kai-Hsiang (2013). Imaging brain deoxyglucose uptake and metabolism by glucoCEST MRI. Journal of Cerebral Blood Flow and Metabolism, 33 (8), 1270-1278. doi: 10.1038/jcbfm.2013.79
2013
Journal Article
A variational surface deformation and subdivision-based modeling framework for noisy and small n-furcated tube-like structures
Yuan, Feiniu, Chuang, Kai-Hsiang and Liu, Jimin (2013). A variational surface deformation and subdivision-based modeling framework for noisy and small n-furcated tube-like structures. IEEE Transactions on Biomedical Engineering, 60 (6) 6409425, 1589-1598. doi: 10.1109/TBME.2013.2238936
2013
Journal Article
Magnetic resonance imaging (MRI) contrast agents for tumor diagnosis
Cheng, Weiren, Ping, Yuan, Zhang, Yong, Chuang, Kai-Hsiang and Liu, Ye (2013). Magnetic resonance imaging (MRI) contrast agents for tumor diagnosis. Journal of Healthcare Engineering, 4 (1), 23-46. doi: 10.1260/2040-2295.4.1.23
2013
Journal Article
Superparamagnetic nanostructures for off-resonance magnetic resonance spectroscopic imaging
Choo, Eugene Shi Guang, Peng, Erwin, Rajendran, Reshmi, Chandrasekharan, Prashant, Yang, Chang-Tong, Ding, Jun, Chuang, Kai-Hsiang and Xue, Junmin (2013). Superparamagnetic nanostructures for off-resonance magnetic resonance spectroscopic imaging. Advanced Functional Materials, 23 (4), 496-505. doi: 10.1002/adfm.201200275
2013
Conference Publication
ASL and DSC MRI for the evaluation of intracranial large artery stenosis
Srour, Hussein, Sung, Suz-Chieh, Sharma, Vijay K., Teoh, Hock Luen, Seet, Raymond C. S., Chen, Christopher L. H., Wong, Peter T. H., Chan, Bernard P. L. and Chuang, Kai-Hsiang (2013). ASL and DSC MRI for the evaluation of intracranial large artery stenosis. Annual Conference of the Asia Pacific Stroke Organization (APSO), Hong Kong, 30 August –1 September 2013. Basel, Switzerland: S. Karger. doi: 10.1159/000353795
2013
Journal Article
Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo
Sundaram, Jeyapriya Raja, Poore, Charlene Priscilla, Bin Sulaimee, Noor Hazim, Pareek, Tej, Asad, A. B. M. A., Rajkumar, Ramamoorthy, Cheong, Wei Fun, Wenk, Markus R., Dawe, Gavin Stewart, Chuang, Kai-Hsiang, Pant, Harish C. and Kesavapany, Sashi (2013). Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo. Journal of Neuroscience, 33 (1), 334-343. doi: 10.1523/JNEUROSCI.3593-12.2013
2013
Book Chapter
Imaging in Metabolic Medicine
Lu, J., Bhakoo, K., Chuang, K.-H., Radda, G. K., Kuchel, P. W. and Han, W. (2013). Imaging in Metabolic Medicine. Imaging in Cellular and Tissue Engineering. (pp. 191-211) edited by Yu, H. and Rahim, N. A. A.. Boca Raton: CRC Press (Taylor and Francis). doi: 10.1201/b14868
2012
Journal Article
Synthesis of manganese ferrite/graphene oxide nanocomposites for biomedical applications
Peng, Erwin, Choo, Eugene Shi Guang, Chandrasekharan, Prashant, Yang, Chang-Tong, Ding, Jun, Chuang, Kai-Hsiang and Xue, Jun Min (2012). Synthesis of manganese ferrite/graphene oxide nanocomposites for biomedical applications. Small, 8 (23), 3620-3630. doi: 10.1002/smll.201201427
2012
Journal Article
Optimization of flow-sensitive alternating inversion recovery (FAIR) for perfusion functional MRI of rodent brain
Nasrallah, Fatima A., Lee, Eugene L. Q. and Chuang, Kai-Hsiang (2012). Optimization of flow-sensitive alternating inversion recovery (FAIR) for perfusion functional MRI of rodent brain. NMR in Biomedicine, 25 (11), 1209-1216. doi: 10.1002/nbm.2790
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Kai-Hsiang Chuang is:
- Available for supervision
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Available projects
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Understanding mechanisms of glymphatic dysfunction in Alzheimer’s disease.
Glymphatic and brain network deficits have been associated with neuropathology of Alzheimer’s disease. However, the mechanism is still unclear. This project aims to test a new hypothesis that leads to accelerated amyloid and tau pathology in brain networks, such as the default mode network. The study will combine structural and functional MRI and genetic tools to test the hypothesis in animal model of AD.
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Develop techniques for improving cognition via modulating brain network
The brain is a complex neural network that supports our cognition, such as learning and memory. We have recently identified brain network hubs that causally involved in memory formation. This project will develop new techniques to detect and selectively modulate the functional connectivity of the causal hubs in order to improve memory.
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Develop novel imaging technique for brain waste clearance
The glymphatic system is a newly discovered waste clearance pathway that removes toxic proteins, such as amyloid plaques, from the brain. Its dysfunction is suggested to lead to Alzheimer's disease. However, there is still no non-invasive imaging technique for measuring its function. This project aims to develop novel non-invasive MRI techniques for tracking the structure and function of the glymphatic system. These techniques will be used to understand how glymphatic function maintain brain health and network function, and for the diagnosis of its impairment in aging and disorders.
Supervision history
Current supervision
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Doctor Philosophy
Developing imaging and neuro-technologies for decoding memory formation
Principal Advisor
Other advisors: Professor Elizabeth Coulson
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Doctor Philosophy
Understanding neural Basis of Resting-State Network Using Simultaneous Calcium Recording and Functional Magnetic Resonance Imaging
Principal Advisor
Other advisors: Professor Pankaj Sah
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Doctor Philosophy
The Role of Basal Forebrain Cholinergic Neurons in Glymphatic Function - Insights and Neuroimaging Perspectives
Associate Advisor
Other advisors: Professor Elizabeth Coulson
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Doctor Philosophy
MRI biomarker of glymphatic dysfunction in dementia
Associate Advisor
Other advisors: Professor Elizabeth Coulson
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Master Philosophy
The Role of Basal Forebrain Cholinergic Neurons in Glymphatic Function - Insights and Neuroimaging Perspectives
Associate Advisor
Other advisors: Professor Elizabeth Coulson
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Doctor Philosophy
Improving Artificial Intelligence And Deep Learning Algorithms In Super-Resolution Imaging
Associate Advisor
Other advisors: Professor Feng Liu
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Doctor Philosophy
Improving Artificial Intelligence And Deep Learning Algorithms In Super-Resolution Imaging
Associate Advisor
Other advisors: Professor Feng Liu
Completed supervision
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2024
Doctor Philosophy
Understanding neural Basis of Resting-State Network Using Simultaneous Calcium Recording and Functional Magnetic Resonance Imaging
Principal Advisor
Other advisors: Professor Pankaj Sah
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2022
Doctor Philosophy
Determining large-scale brain networks involved in memory consolidation
Principal Advisor
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2023
Doctor Philosophy
Improving functional MRI through Modelling and Imaging Microvascular Dynamics
Associate Advisor
Other advisors: Dr Saskia Bollmann, Professor Markus Barth
Media
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