Skip to menu Skip to content Skip to footer
Associate Professor Kai-Hsiang Chuang
Associate Professor

Kai-Hsiang Chuang

Email: 
Phone: 
+61 7 344 33811

Overview

Background

Dr Kai-Hsiang Chuang received his Ph.D. degree in electrical and biomedical engineering from the National Taiwan University, Taiwan, in 2001. During his graduate study, he developed methods for improving the detection of brain activity using functional magnetic resonance imaging (fMRI). He undertook postdoctoral research at the National Institutes of Health, USA, from 2003 to 2007, where he focused on understanding brain connectivity using novel functional and molecular imaging. He developed manganese-enhanced MRI for high-resolution imaging functional neural pathways in the rodent brain and cerebral blood flow imaging for mapping the resting-state network of the human brain. He joined the Agency for Science Technology and Research (A*STAR), Singapore, in 2008 as the head of MRI Group in the Singapore Bioimaging Consortium (a national research institute). He established the first preclinical imaging facility in Singapore and facilitated research collaboration across academia, clinic and industry. His lab pioneered functional connectivity imaging of the rodent brain to understand the neural basis and function of resting-state brain network, and the development and application of MRI biomarkers for treatment development. In late 2015, he moved to the University of Queensland, Australia, as an Associate Professor with the Queensland Brain Institute and the Centre for Advanced Imaging. His current research focuses on understanding the structure and function of brain network that underlies cognition and behavior, such as learning, memory and dementia. He is developing multimodal techniques, including fMRI, calcium recording, electrophysiology and optogenetic/chemogenetic neuromodulation, to test hypothesis in transgenic mouse models and then translating to humans to improve the diagnosis and intervention of disorders. The imaging and analysis techniques he developed have been widely used in the research community and some in clinical trials. He is serving on the editorial boards of Frontiers in Neuroscience: Brain Imaging Methods, Imaging Neuroscience and Scientific Reports.

Availability

Associate Professor Kai-Hsiang Chuang is:
Available for supervision

Qualifications

  • Doctor of Philosophy, National Taiwan University

Research interests

  • Functional brain mapping

    Develop in vivo imaging techniques, including functional MRI and multimodality integration (optogenetics, calcium imaging, electrophysiology), in humans and animal models to improve the understanding and intervention of brain function, disease process and treatment effects.

  • Brain network in learning, memory and dementia

    Brain network wiring and activity underpin our cognition and behaviour. However the brain-behaviour relationship of cognitive functions, such as memory, is unclear. We are developing techniques to understand the causal relationship between brain network activity and memory formation, and how to modulate behaviour by manipulating brain network activity.

  • Brain waste clearance

    The brain is a highly metabolic active organ. Maintaining optimal brain function relies on efficient disposal of metabolic wastes. We are studying a brain fluid drainage system that clear waste and toxic molecules, such as amyloid plaques, from the brain. We're developing imaging techniques to track its function and to understand its regulatory mechanism, treatment target and pathogenic role in dementia.

Works

Search Professor Kai-Hsiang Chuang’s works on UQ eSpace

126 works between 1998 and 2025

61 - 80 of 126 works

2014

Journal Article

Pharmacological insight into neurotransmission origins of resting-state functional connectivity: α2-adrenergic agonist vs antagonist

Nasrallah, Fatima A., Low, Si-Min, Lew, Si Kang, Chen, Kaina and Chuang, Kai-Hsiang (2014). Pharmacological insight into neurotransmission origins of resting-state functional connectivity: α2-adrenergic agonist vs antagonist. NeuroImage, 103, 364-373. doi: 10.1016/j.neuroimage.2014.09.004

Pharmacological insight into neurotransmission origins of resting-state functional connectivity: α2-adrenergic agonist vs antagonist

2014

Journal Article

A facile synthetic approach to a biodegradable polydisulfide MRI contrast agent

Cheng, Weiren, Rajendran, Reshmi, Ren, Wei, Gu, Liuqun, Zhang, Yong, Chuang, Kai-Hsiang and Liu, Ye (2014). A facile synthetic approach to a biodegradable polydisulfide MRI contrast agent. Journal of Materials Chemistry B, 2 (32), 5295-5301. doi: 10.1039/c4tb00413b

A facile synthetic approach to a biodegradable polydisulfide MRI contrast agent

2014

Journal Article

Functional networks in parallel with cortical development associate with executive functions in children

Zhong, Jidan, Rifkin-Graboi, Anne, Ta, Anh Tuan, Yap, Kar Lai, Chuang, Kai-Hsiang, Meaney, Michael J. and Qiu, Anqi (2014). Functional networks in parallel with cortical development associate with executive functions in children. Cerebral Cortex, 24 (7), 1937-1947. doi: 10.1093/cercor/bht051

Functional networks in parallel with cortical development associate with executive functions in children

2014

Journal Article

Detection of functional connectivity in the resting mouse brain

Nasrallah, Fatima A., Tay, Hui-Chien and Chuang, Kai-Hsiang (2014). Detection of functional connectivity in the resting mouse brain. NeuroImage, 86, 417-424. doi: 10.1016/j.neuroimage.2013.10.025

Detection of functional connectivity in the resting mouse brain

2014

Journal Article

Early detection of antiangiogenic treatment responses in a mouse xenograft tumor model using quantitative perfusion MRI

Rajendran, Reshmi, Huang, Wei, Tang, Annie Mei Yee, Liang, Jie Ming, Choo, Stephanie, Reese, Torsten, Hentze, Hannes, van Boxtel, Susan, Cliffe, Adam, Rogers, Keith, Henry, Brian and Chuang, Kai Hsiang (2014). Early detection of antiangiogenic treatment responses in a mouse xenograft tumor model using quantitative perfusion MRI. Cancer Medicine, 3 (1), 47-60. doi: 10.1002/cam4.177

Early detection of antiangiogenic treatment responses in a mouse xenograft tumor model using quantitative perfusion MRI

2014

Journal Article

An intravascular MRI contrast agent based on Gd(DO3A-Lys) for tumor angiography

Yang, Chang-Tong, Chandrasekharan, Prashant, He, Tao, Poh, Zihan, Raju, Anandhkumar, Chuang, Kai-Hsiang and Robins, Edward G. (2014). An intravascular MRI contrast agent based on Gd(DO3A-Lys) for tumor angiography. Biomaterials, 35 (1), 327-336. doi: 10.1016/j.biomaterials.2013.10.006

An intravascular MRI contrast agent based on Gd(DO3A-Lys) for tumor angiography

2014

Book Chapter

Vitamin E (D-Alpha-Tocopheryl-co-Poly (Ethylene Glycol) 1000 Succinate) Micelles-Superparamagnetic Iron Oxide Nanoparticles for Enhanced Thermotherapy and MRI

Chandrasekharan, Prashant, Maity, Dipak, Yong, Cai, Chuang, Kai-Hsiang, Ding, Jun and Feng, Si-Shen (2014). Vitamin E (D-Alpha-Tocopheryl-co-Poly (Ethylene Glycol) 1000 Succinate) Micelles-Superparamagnetic Iron Oxide Nanoparticles for Enhanced Thermotherapy and MRI. Chemotherapeutic engineering: collected papers of Si-Shen Feng a tribute to Shu Chien on his 82nd birthday. (pp. 841-861) edited by Feng Si-shen, Stanford Chong and Jenny Rompas. Boca Raton, FL, United States: Pan Stanford Publishing. doi: 10.1201/b15645-52

Vitamin E (D-Alpha-Tocopheryl-co-Poly (Ethylene Glycol) 1000 Succinate) Micelles-Superparamagnetic Iron Oxide Nanoparticles for Enhanced Thermotherapy and MRI

2014

Journal Article

Neural correlate of resting-state functional connectivity under α2 adrenergic receptor agonist, medetomidine

Nasrallah, Fatima A., Lew, Si Kang, Low, Amanda Si-Min and Chuang, Kai-Hsiang (2014). Neural correlate of resting-state functional connectivity under α2 adrenergic receptor agonist, medetomidine. NeuroImage, 84, 27-34. doi: 10.1016/j.neuroimage.2013.08.004

Neural correlate of resting-state functional connectivity under α2 adrenergic receptor agonist, medetomidine

2014

Book Chapter

Superparamagnetic iron oxide—loaded poly(lactic acid)-D-_-tocopherol polyethylene glycol 1000 succinate copolymer nanoparticles as MRI contrast agent

Prashant, Chandrasekharan, Dipak, Maity, Yang, Chang-Tong, Chuang, Kai-Hsiang, Jun, Ding and Feng, Si-Shen (2014). Superparamagnetic iron oxide—loaded poly(lactic acid)-D-_-tocopherol polyethylene glycol 1000 succinate copolymer nanoparticles as MRI contrast agent. Chemotherapeutic engineering: collected papers of Si-Shen Feng a tribute to Shu Chien on his 82nd birthday. (pp. 863-885) edited by Si-Shen Feng, Stanford Chong and Jenny Rompas. Boca Raton, FL, United States: Pan Stanford Publishing. doi: 10.1201/b15645-53

Superparamagnetic iron oxide—loaded poly(lactic acid)-D-_-tocopherol polyethylene glycol 1000 succinate copolymer nanoparticles as MRI contrast agent

2013

Book Chapter

Multimodal tumor imaging by iron oxides and quantum dots formulated in poly(lactic acid)-D-alpha-tocopheryl polyethylene glycol 1000 succinate nanoparticles

Tan, Yang Fei, Chandrasekharan, Prashant, Maity, Dipak, Yong, Cai Xian, Chuang, Kai-Hsiang, Zhao, Ying, Wang, Shu, Ding, Jun and Feng, Si-Shen (2013). Multimodal tumor imaging by iron oxides and quantum dots formulated in poly(lactic acid)-D-alpha-tocopheryl polyethylene glycol 1000 succinate nanoparticles. Chemotherapeutic Engineering: Collected Papers of Si-Shen Feng - A Tribute to Shu Chien on His 82nd Birthday. (pp. 819-840) Pan Stanford Publishing Pte. Ltd.. doi: 10.4032/9789814463157

Multimodal tumor imaging by iron oxides and quantum dots formulated in poly(lactic acid)-D-alpha-tocopheryl polyethylene glycol 1000 succinate nanoparticles

2013

Journal Article

Quantitative mouse renal perfusion using arterial spin labeling

Rajendran, Reshmi, Lew, Si Kang, Yong, Cai Xian, Tan, Jolena, Wang, Danny J. J. and Chuang, Kai-Hsiang (2013). Quantitative mouse renal perfusion using arterial spin labeling. NMR in Biomedicine, 26 (10), 1225-1232. doi: 10.1002/nbm.2939

Quantitative mouse renal perfusion using arterial spin labeling

2013

Journal Article

Imaging brain deoxyglucose uptake and metabolism by glucoCEST MRI

Nasrallah, Fatima A., Pages, Guilhem, Kuchel, Philip W., Golay, Xavier and Chuang, Kai-Hsiang (2013). Imaging brain deoxyglucose uptake and metabolism by glucoCEST MRI. Journal of Cerebral Blood Flow and Metabolism, 33 (8), 1270-1278. doi: 10.1038/jcbfm.2013.79

Imaging brain deoxyglucose uptake and metabolism by glucoCEST MRI

2013

Journal Article

A variational surface deformation and subdivision-based modeling framework for noisy and small n-furcated tube-like structures

Yuan, Feiniu, Chuang, Kai-Hsiang and Liu, Jimin (2013). A variational surface deformation and subdivision-based modeling framework for noisy and small n-furcated tube-like structures. IEEE Transactions on Biomedical Engineering, 60 (6) 6409425, 1589-1598. doi: 10.1109/TBME.2013.2238936

A variational surface deformation and subdivision-based modeling framework for noisy and small n-furcated tube-like structures

2013

Journal Article

Magnetic resonance imaging (MRI) contrast agents for tumor diagnosis

Cheng, Weiren, Ping, Yuan, Zhang, Yong, Chuang, Kai-Hsiang and Liu, Ye (2013). Magnetic resonance imaging (MRI) contrast agents for tumor diagnosis. Journal of Healthcare Engineering, 4 (1), 23-46. doi: 10.1260/2040-2295.4.1.23

Magnetic resonance imaging (MRI) contrast agents for tumor diagnosis

2013

Journal Article

Superparamagnetic nanostructures for off-resonance magnetic resonance spectroscopic imaging

Choo, Eugene Shi Guang, Peng, Erwin, Rajendran, Reshmi, Chandrasekharan, Prashant, Yang, Chang-Tong, Ding, Jun, Chuang, Kai-Hsiang and Xue, Junmin (2013). Superparamagnetic nanostructures for off-resonance magnetic resonance spectroscopic imaging. Advanced Functional Materials, 23 (4), 496-505. doi: 10.1002/adfm.201200275

Superparamagnetic nanostructures for off-resonance magnetic resonance spectroscopic imaging

2013

Conference Publication

ASL and DSC MRI for the evaluation of intracranial large artery stenosis

Srour, Hussein, Sung, Suz-Chieh, Sharma, Vijay K., Teoh, Hock Luen, Seet, Raymond C. S., Chen, Christopher L. H., Wong, Peter T. H., Chan, Bernard P. L. and Chuang, Kai-Hsiang (2013). ASL and DSC MRI for the evaluation of intracranial large artery stenosis. Annual Conference of the Asia Pacific Stroke Organization (APSO), Hong Kong, 30 August –1 September 2013. Basel, Switzerland: S. Karger. doi: 10.1159/000353795

ASL and DSC MRI for the evaluation of intracranial large artery stenosis

2013

Journal Article

Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo

Sundaram, Jeyapriya Raja, Poore, Charlene Priscilla, Bin Sulaimee, Noor Hazim, Pareek, Tej, Asad, A. B. M. A., Rajkumar, Ramamoorthy, Cheong, Wei Fun, Wenk, Markus R., Dawe, Gavin Stewart, Chuang, Kai-Hsiang, Pant, Harish C. and Kesavapany, Sashi (2013). Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo. Journal of Neuroscience, 33 (1), 334-343. doi: 10.1523/JNEUROSCI.3593-12.2013

Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo

2013

Book Chapter

Imaging in Metabolic Medicine

Lu, J., Bhakoo, K., Chuang, K.-H., Radda, G. K., Kuchel, P. W. and Han, W. (2013). Imaging in Metabolic Medicine. Imaging in Cellular and Tissue Engineering. (pp. 191-211) edited by Yu, H. and Rahim, N. A. A.. Boca Raton: CRC Press (Taylor and Francis). doi: 10.1201/b14868

Imaging in Metabolic Medicine

2012

Journal Article

Synthesis of manganese ferrite/graphene oxide nanocomposites for biomedical applications

Peng, Erwin, Choo, Eugene Shi Guang, Chandrasekharan, Prashant, Yang, Chang-Tong, Ding, Jun, Chuang, Kai-Hsiang and Xue, Jun Min (2012). Synthesis of manganese ferrite/graphene oxide nanocomposites for biomedical applications. Small, 8 (23), 3620-3630. doi: 10.1002/smll.201201427

Synthesis of manganese ferrite/graphene oxide nanocomposites for biomedical applications

2012

Journal Article

Optimization of flow-sensitive alternating inversion recovery (FAIR) for perfusion functional MRI of rodent brain

Nasrallah, Fatima A., Lee, Eugene L. Q. and Chuang, Kai-Hsiang (2012). Optimization of flow-sensitive alternating inversion recovery (FAIR) for perfusion functional MRI of rodent brain. NMR in Biomedicine, 25 (11), 1209-1216. doi: 10.1002/nbm.2790

Optimization of flow-sensitive alternating inversion recovery (FAIR) for perfusion functional MRI of rodent brain

Funding

Current funding

  • 2024 - 2028
    Decoding the brain network of memory formation
    ARC Discovery Projects
    Open grant

Past funding

  • 2019
    Dissolution DNP Hyperpolariser
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2019 - 2021
    Mechanisms and consequences of cholinergic neuron degeneration in sleep apnea
    NHMRC Project Grant
    Open grant
  • 2018
    A specialised surgical and behavioural facility for longitudinal, multimodal examination of the rodent brain
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2019
    Reduced cerebral blood flow in Alzheimer's disease and cholinergic neuron dysfunction
    The Mason Foundation National Medical Program
    Open grant
  • 2017 - 2024
    ARC Training Centre for Innovation in Biomedical Imaging Technology
    ARC Industrial Transformation Training Centres
    Open grant
  • 2017 - 2020
    A randomised-control validation trial of Mindfulness-based cognitive therapy (MBCT): an eight week mindfulness program for youth living with Inflammatory Bowel Disease and co-morbid depression
    Mater Medical Research Institute Limited
    Open grant
  • 2017 - 2018
    Understanding functional and metabolic brain connectivity in mice
    Universities Australia - Germany Joint Research Co-operation Scheme
    Open grant
  • 2016 - 2023
    Improving human fMRI through modeling and imaging microvascular dynamics (NHMRC component of an NHMRC-NIH BRAIN Initiative Collaborative Research Grant)
    NHMRC-NIH BRAIN Initiative Collaborative Research Grants
    Open grant

Supervision

Availability

Associate Professor Kai-Hsiang Chuang is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Understanding mechanisms of glymphatic dysfunction in Alzheimer’s disease.

    Glymphatic and brain network deficits have been associated with neuropathology of Alzheimer’s disease. However, the mechanism is still unclear. This project aims to test a new hypothesis that leads to accelerated amyloid and tau pathology in brain networks, such as the default mode network. The study will combine structural and functional MRI and genetic tools to test the hypothesis in animal model of AD.

  • Develop techniques for improving cognition via modulating brain network

    The brain is a complex neural network that supports our cognition, such as learning and memory. We have recently identified brain network hubs that causally involved in memory formation. This project will develop new techniques to detect and selectively modulate the functional connectivity of the causal hubs in order to improve memory.

  • Develop novel imaging technique for brain waste clearance

    The glymphatic system is a newly discovered waste clearance pathway that removes toxic proteins, such as amyloid plaques, from the brain. Its dysfunction is suggested to lead to Alzheimer's disease. However, there is still no non-invasive imaging technique for measuring its function. This project aims to develop novel non-invasive MRI techniques for tracking the structure and function of the glymphatic system. These techniques will be used to understand how glymphatic function maintain brain health and network function, and for the diagnosis of its impairment in aging and disorders.

Supervision history

Current supervision

  • Doctor Philosophy

    Developing imaging and neuro-technologies for decoding memory formation

    Principal Advisor

    Other advisors: Professor Elizabeth Coulson

  • Doctor Philosophy

    Understanding neural Basis of Resting-State Network Using Simultaneous Calcium Recording and Functional Magnetic Resonance Imaging

    Principal Advisor

    Other advisors: Professor Pankaj Sah

  • Doctor Philosophy

    The Role of Basal Forebrain Cholinergic Neurons in Glymphatic Function - Insights and Neuroimaging Perspectives

    Associate Advisor

    Other advisors: Professor Elizabeth Coulson

  • Doctor Philosophy

    MRI biomarker of glymphatic dysfunction in dementia

    Associate Advisor

    Other advisors: Professor Elizabeth Coulson

  • Master Philosophy

    The Role of Basal Forebrain Cholinergic Neurons in Glymphatic Function - Insights and Neuroimaging Perspectives

    Associate Advisor

    Other advisors: Professor Elizabeth Coulson

  • Doctor Philosophy

    Improving Artificial Intelligence And Deep Learning Algorithms In Super-Resolution Imaging

    Associate Advisor

    Other advisors: Professor Feng Liu

  • Doctor Philosophy

    Improving Artificial Intelligence And Deep Learning Algorithms In Super-Resolution Imaging

    Associate Advisor

    Other advisors: Professor Feng Liu

Completed supervision

Media

Enquiries

For media enquiries about Associate Professor Kai-Hsiang Chuang's areas of expertise, story ideas and help finding experts, contact our Media team:

communications@uq.edu.au