Overview
Background
Kindly visit my laboratory's webpage for more information
Availability
- Dr Christian Nefzger is:
- Available for supervision
Qualifications
- Doctor of Philosophy, Monash University
Research impacts
Kindly visit my laboratory's webpage for more information
Works
Search Professor Christian Nefzger’s works on UQ eSpace
2020
Book Chapter
Aging of intestinal stem cells and associated niche
Jardé, Thierry, Nefzger, Christian M., Polo, Jose M. and Abud, Helen E. (2020). Aging of intestinal stem cells and associated niche. The Stem Cell Niche during Ageing. (pp. 25-40) edited by Susie Nilsson. Cambridge, MA, United States: Academic Press. doi: 10.1016/bs.asn.2020.05.001
2019
Journal Article
Class-switch recombination occurs infrequently in germinal centers
Roco, Jonathan A., Mesin, Luka, Binder, Sebastian C., Nefzger, Christian, Gonzalez-Figueroa, Paula, Canete, Pablo F., Ellyard, Julia, Shen, Qian, Robert, Philippe A., Cappello, Jean, Vohra, Harpreet, Zhang, Yang, Nowosad, Carla R., Schiepers, Arien, Corcoran, Lynn M., Toellner, Kai-Michael, Polo, Jose M., Meyer-Hermann, Michael, Victora, Gabriel D. and Vinuesa, Carola G. (2019). Class-switch recombination occurs infrequently in germinal centers. Immunity, 51 (2), 337-350.e7. doi: 10.1016/j.immuni.2019.07.001
2019
Journal Article
TAF5L and TAF6L maintain self-renewal of embryonic stem cells via the MYC regulatory network
Seruggia, Davide, Oti, Martin, Tripathi, Pratibha, Canver, Matthew C., LeBlanc, Lucy, Di Giammartino, Dafne C., Bullen, Michael J., Nefzger, Christian M., Sun, Yu Bo Yang, Farouni, Rick, Polo, Jose M., Pinello, Luca, Apostolou, Effie, Kim, Jonghwan, Orkin, Stuart H. and Das, Partha Pratim (2019). TAF5L and TAF6L maintain self-renewal of embryonic stem cells via the MYC regulatory network. Molecular Cell, 74 (6), 1148-+. doi: 10.1016/j.molcel.2019.03.025
2019
Journal Article
Generation of mouse-induced pluripotent stem cells by lentiviral transduction
Liu, Xiaodong, Chen, Joseph, Firas, Jaber, Paynter, Jacob M., Nefzger, Christian M. and Polo, Jose M. (2019). Generation of mouse-induced pluripotent stem cells by lentiviral transduction. Methods in Molecular Biology, 1940, 63-76. doi: 10.1007/978-1-4939-9086-3_5
2019
Journal Article
Propagation and maintenance of mouse embryonic stem cells
Paynter, Jacob M., Chen, Joseph, Liu, Xiaodong and Nefzger, Christian M. (2019). Propagation and maintenance of mouse embryonic stem cells. Methods in Molecular Biology, 1940, 33-45. doi: 10.1007/978-1-4939-9086-3_3
2019
Book Chapter
Production of high-titer lentiviral particles for stable genetic modification of mammalian cells
Larcombe, Michael R., Manent, Jan, Chen, Joseph, Mishra, Ketan, Liu, Xiaodong and Nefzger, Christian M. (2019). Production of high-titer lentiviral particles for stable genetic modification of mammalian cells. Mouse cell culture. (pp. 47-61) edited by Ivan Bertoncello. New York, NY, United States: Humana Press. doi: 10.1007/978-1-4939-9086-3_4
2019
Journal Article
Generation of four iPSC lines from peripheral blood mononuclear cells (PBMCs) of an attention deficit hyperactivity disorder (ADHD) individual and a healthy sibling in an Australia-Caucasian family
Tong, Janette, Lee, Kyung Min, Liu, Xiaodong, Nefzger, Christian M., Vijayakumar, Prasidhee, Hawi, Ziarih, Pang, Ken C., Parish, Clare L., Polo, Jose M. and Bellgrove, Mark A. (2019). Generation of four iPSC lines from peripheral blood mononuclear cells (PBMCs) of an attention deficit hyperactivity disorder (ADHD) individual and a healthy sibling in an Australia-Caucasian family. Stem Cell Research, 34 101353. doi: 10.1016/j.scr.2018.11.014
2018
Journal Article
A modular dCas9-SunTag DNMT3A epigenome editing system overcomes pervasive off-target activity of direct fusion dCas9-DNMT3A constructs
Pflueger, Christian, Tan, Dennis, Swain, Tessa, Trung Nguyen,, Pflueger, Jahnvi, Nefzger, Christian, Polo, Jose M., Ford, Ethan and Lister, Ryan (2018). A modular dCas9-SunTag DNMT3A epigenome editing system overcomes pervasive off-target activity of direct fusion dCas9-DNMT3A constructs. Genome Research, 28 (8), 1193-1206. doi: 10.1101/gr.233049.117
2018
Journal Article
Identification of dynamic undifferentiated cell states within the male germline
La, Hue M., Makela, Juho-Antti, Chan, Ai-Leen, Rossello, Fernando J., Nefzger, Christian M., Legrand, Julien M. D., De Seram, Mia, Polo, Jose M. and Hobbs, Robin M. (2018). Identification of dynamic undifferentiated cell states within the male germline. Nature Communications, 9 (1) 2819. doi: 10.1038/s41467-018-04827-z
2018
Journal Article
Fine tuning of canonical Wnt stimulation enhances differentiation of pluripotent stem cells independent of beta-catenin-mediated T-cell factor signaling
Chen, Joseph, Nefzger, Christian M., Rossello, Fernando J., Sun, Yu B. Y., Lim, Sue Mei, Liu, Xiaodong, de Boer, Suzan, Knaupp, Anja S., Li, Jinhua, Davidson, Kathryn C., Polo, Jose M. and Barberi, Tiziano (2018). Fine tuning of canonical Wnt stimulation enhances differentiation of pluripotent stem cells independent of beta-catenin-mediated T-cell factor signaling. Stem Cells, 36 (6), 822-833. doi: 10.1002/stem.2794
2018
Journal Article
SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program
Ratnadiwakara, Madara, Archer, Stuart K., Dent, Craig I., De Los Mozos, Igor Ruiz, Beilharz, Traude H., Knaupp, Anja S., Nefzger, Christian M., Polo, Jose M. and Anko, Minna-Liisa (2018). SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program. Elife, 7 ARTN e37419. doi: 10.7554/eLife.37419
2018
Journal Article
Method of derivation and differentiation of mouse embryonic stem cells generating synchronous neuronal networks
Gazina, Elena V., Morrisroe, Emma, Mendis, Gunarathna D. C., Michalska, Anna E., Chen, Joseph, Nefzger, Christian M., Rollo, Benjamin N., Reid, Christopher A., Pera, Martin F. and Petrou, Steven (2018). Method of derivation and differentiation of mouse embryonic stem cells generating synchronous neuronal networks. Journal of Neuroscience Methods, 293, 53-58. doi: 10.1016/j.jneumeth.2017.08.018
2017
Journal Article
Transient and permanent reconfiguration of chromatin and transcription factor occupancy drive reprogramming
Knaupp, Anja S., Buckberry, Sam, Pflueger, Jahnvi, Lim, Sue Mei, Ford, Ethan, Larcombe, Michael R., Rossello, Fernando J., de Mendoza, Alex, Alaei, Sara, Firas, Jaber, Holmes, Melissa L., Nair, Shalima S., Clark, Susan J., Nefzger, Christian M., Lister, Ryan and Polo, Jose M. (2017). Transient and permanent reconfiguration of chromatin and transcription factor occupancy drive reprogramming. Cell Stem Cell, 21 (6), 834-845+. doi: 10.1016/j.stem.2017.11.007
2017
Journal Article
Cell type of origin dictates the route to pluripotency
Nefzger, Christian M., Rossello, Fernando J., Chen, Joseph, Liu, Xiaodong, Knaupp, Anja S., Firas, Jaber, Paynter, Jacob M., Pflueger, Jahnvi, Buckberry, Sam, Lim, Sue Mei, Williams, Brenda, Alaei, Sara, Faye-Chauhan, Keshav, Petretto, Enrico, Nilsson, Susan K., Lister, Ryan, Ramialison, Mirana, Powell, David R., Rackham, Owen J. L. and Polo, Jose M. (2017). Cell type of origin dictates the route to pluripotency. Cell Reports, 21 (10), 2649-2660. doi: 10.1016/j.celrep.2017.11.029
2017
Journal Article
Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes (vol 18, pg 552, 2017)
Marino, Eliana, Richards, James L., McLeod, Keiran H., Stanley, Dragana, Yap, Yu Anne, Knight, Jacinta, McKenzie, Craig, Kranich, Jan, Oliveira, Ana Carolina, Rossello, Fernando J., Krishnamurthy, Balasubramanian, Nefzger, Christian M., Macia, Laurence, Thorburn, Alison, Baxter, Alan G., Morahan, Grant, Wong, Lee H., Polo, Jose M., Moore, Robert J., Lockett, Trevor J., Clarke, Julie M., Topping, David L., Harrison, Leonard C. and Mackay, Charles R. (2017). Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes (vol 18, pg 552, 2017). Nature Immunology, 18 (11), 1271-1271. doi: 10.1038/ni1117-1271c
2017
Journal Article
Comprehensive characterization of distinct states of human naive pluripotency generated by reprogramming
Liu, Xiaodong, Nefzger, Christian M., Rossello, Fernando J., Chen, Joseph, Knaupp, Anja S., Firas, Jaber, Ford, Ethan, Pflueger, Jahnvi, Paynter, Jacob M., Chy, Hun S., O'Brien, Carmel M., Huang, Cheng, Mishra, Ketan, Hodgson-Garms, Margeaux, Jansz, Natasha, Williams, Sarah M., Blewitt, Marnie E., Nilsson, Susan K., Schittenhelm, Ralf B., Laslett, Andrew L., Lister, Ryan and Polo, Jose M. (2017). Comprehensive characterization of distinct states of human naive pluripotency generated by reprogramming. Nature Methods, 14 (11), 1055-1062+. doi: 10.1038/NMETH.4436
2017
Journal Article
Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes (vol 18, pg 552, 2017)
Marino, Eliana, Richards, James L., McLeod, Keiran H., Stanley, Dragana, Yap, Yu Anne, Knight, Jacinta, McKenzie, Craig, Kranich, Jan, Oliveira, Ana Carolina, Rossello, Fernando J., Krishnamurthy, Balasubramanian, Nefzger, Christian M., Macia, Laurence, Thorburn, Alison, Baxter, Alan G., Morahan, Grant, Wong, Lee H., Polo, Jose M., Moore, Robert J., Lockett, Trevor J., Clarke, Julie M., Topping, David L., Harrison, Leonard C. and Mackay, Charles R. (2017). Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes (vol 18, pg 552, 2017). Nature Immunology, 18 (8), 951-951. doi: 10.1038/ni0817-951c
2017
Journal Article
Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes
Marino, Eliana, Richards, James L., McLeod, Keiran H., Stanley, Dragana, Yap, Yu Anne, Knight, Jacinta, McKenzie, Craig, Kranich, Jan, Oliveira, Ana Carolina, Rossello, Fernando J., Krishnamurthy, Balasubramanian, Nefzger, Christian M., Macia, Laurence, Thorburn, Alison, Baxter, Alan G., Morahan, Grant, Wong, Lee H., Polo, Jose M., Moore, Robert J., Lockett, Trevor J., Clarke, Julie M., Topping, David L., Harrison, Leonard C. and Mackay, Charles R. (2017). Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nature Immunology, 18 (5), 552-562. doi: 10.1038/ni.3713
2017
Journal Article
DEAD-box RNA binding protein DDX5: not a black-box during reprogramming
Nefzger, Christian M. and Polo, Jose M. (2017). DEAD-box RNA binding protein DDX5: not a black-box during reprogramming. Cell Stem Cell, 20 (4), 419-420. doi: 10.1016/j.stem.2017.03.006
2017
Journal Article
New monoclonal antibodies to defined cell surface proteins on human pluripotent stem cells
O'Brien, Carmel M., Chy, Hun S., Zhou, Qi, Blumenfeld, Shiri, Lambshead, Jack W., Liu, Xiaodong, Kie, Joshua, Capaldo, Bianca D., Chung, Tung-Liang, Adams, Timothy E., Tram Phan,, Bentley, John D., McKinstry, William J., Oliva, Karen, McMurrick, Paul J., Wang, Yu-Chieh, Rossello, Fernando J., Lindeman, Geoffrey J., Chen, Di, Jarde, Thierry, Clark, Amander T., Abud, Helen E., Visvader, Jane E., Nefzger, Christian M., Polo, Jose M., Loring, Jeanne F. and Laslett, Andrew L. (2017). New monoclonal antibodies to defined cell surface proteins on human pluripotent stem cells. Stem Cells, 35 (3), 626-640. doi: 10.1002/stem.2558
Funding
Current funding
Past funding
Supervision
Availability
- Dr Christian Nefzger is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Leveraging integrative multiomic data to enable controlled cell state transition
Principal Advisor
Other advisors: Professor Matt Sweet
-
Doctor Philosophy
Network reinforcement to improve the function of aged cells
Principal Advisor
-
Doctor Philosophy
Deciphering the age-altered transcription factor network and its control over regenerative potential
Principal Advisor
Other advisors: Dr Quan Nguyen
-
Doctor Philosophy
Understanding and controlling the age-stage of somatic cells
Principal Advisor
Other advisors: Professor Di Yu
Completed supervision
-
2024
Doctor Philosophy
Imaging and Sequencing Analysis of Cellular Regulation and Communication within Spatial Context in Cancer Tissue
Associate Advisor
Other advisors: Dr Quan Nguyen
-
2024
Doctor Philosophy
Genetic regulation of Wnt-dependent mesendoderm differentiation from pluripotency
Associate Advisor
Other advisors: Associate Professor Nathan Palpant
Media
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