
Overview
Background
Dr. Marina Naval-Sanchez is a NHMRC Research Fellow at the Institute for Molecular Bioscience at The University of Queensland (Australia). She pursued postdoctoral studies in 2019-2024 in the Institute for Molecular Bioscience, The University of Queensland (Australia) and as an Office Chief Executive (OCE) Fellow in 2015-2019 at the Commonwealth Scientific and Industrial Research Organisation (CSIRO) (Australia). She received her PhD in Molecular Biosciences in 2014 from KULeuven (Belgium). She received her MSc in Applied Bioinformatics in 2009 from Cranfield University (UK) and MSc in Agriculture Engineering in 2008 from the Universitat de Lleida (Spain).
Marina’s research program applies state-of-the-art bioinformatic, machine learning, and genetic and genomic tools to unearth the master regulators and enhancer grammar governing development and ageing across species (mouse and human) and to decipher the genomic (regulatory) impact of evolution, domestication and human selection in farm species (sheep, cattle, salmon). Her research outcomes have been published in high-impact journals such as Cell Metabolism, Nature Communications, Genome Biology, Nucleic Acids Research, Genome Research and Molecular Biology and Evolution.
Her research efforts have been supported by domestic and international fellowships and grants, including the Australian National Health and Medical Research Council (NHMRC, EL1 2024 Recipient), Advance Queensland, UQ Innovation Connections, CSIRO Scientific Investment Projects, CSIRO OCE Fellowships, and Flanders Wetesnchappelijk Onderzoek (FWO) PhD Fellowship.
Availability
- Dr Marina Naval Sanchez is:
- Available for supervision
Qualifications
- Doctor of Philosophy, Catholic University of Leuven
Works
Search Professor Marina Naval Sanchez’s works on UQ eSpace
2024
Journal Article
Endothelial c-Src Mediates Neovascular Tuft Formation in Oxygen-Induced Retinopathy
Frampton, Emmanuelle, Som, Priyanka, Hill, Brittany, Yu, Alexander, Naval-Sanchez, Marina, Nefzger, Chistian M., Noordstra, Ivar, Gordon, Emma and Schimmel, Lilian (2024). Endothelial c-Src Mediates Neovascular Tuft Formation in Oxygen-Induced Retinopathy. The American Journal of Pathology, 194 (12), 2239-2251. doi: 10.1016/j.ajpath.2024.09.003
2024
Journal Article
The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening
Patrick, Ralph, Naval-Sanchez, Marina, Deshpande, Nikita, Huang, Yifei, Zhang, Jingyu, Chen, Xiaoli, Yang, Ying, Tiwari, Kanupriya, Esmaeili, Mohammadhossein, Tran, Minh, Mohamed, Amin R., Wang, Binxu, Xia, Di, Ma, Jun, Bayliss, Jacqueline, Wong, Kahlia, Hun, Michael L., Sun, Xuan, Cao, Benjamin, Cottle, Denny L., Catterall, Tara, Barzilai-Tutsch, Hila, Troskie, Robin-Lee, Chen, Zhian, Wise, Andrea F., Saini, Sheetal, Soe, Ye Mon, Kumari, Snehlata, Sweet, Matthew J. ... Nefzger, Christian M. (2024). The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening. Cell Metabolism, 36 (8), 1858-1881.e23. doi: 10.1016/j.cmet.2024.06.006
2024
Journal Article
Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm
Wu, Zhixuan, Shen, Sophie, Mizikovsky, Dalia, Cao, Yuanzhao, Naval-Sanchez, Marina, Tan, Siew Zhuan, Alvarez, Yanina D., Sun, Yuliangzi, Chen, Xiaoli, Zhao, Qiongyi, Kim, Daniel, Yang, Pengyi, Hill, Timothy A., Jones, Alun, Fairlie, David P., Pébay, Alice, Hewitt, Alex W., Tam, Patrick P.L., White, Melanie D., Nefzger, Christian M. and Palpant, Nathan J. (2024). Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm. Developmental Cell, 59 (6), 705-722.e8. doi: 10.1016/j.devcel.2024.01.019
2023
Journal Article
Micrococcal nuclease sequencing of porcine sperm suggests enriched co-location between retained histones and genomic regions related to semen quality and early embryo development
Gòdia, Marta, Lian, Yu, Naval-Sanchez, Marina, Ponte, Inma, Rodríguez-Gil, Joan Enric, Sanchez, Armand and Clop, Alex (2023). Micrococcal nuclease sequencing of porcine sperm suggests enriched co-location between retained histones and genomic regions related to semen quality and early embryo development. PeerJ, 11 e15520, 1-25. doi: 10.7717/peerj.15520
2022
Journal Article
Leveraging transcriptome and epigenome landscapes to infer regulatory networks during the onset of sexual maturation
Mohamed, Amin R., Naval-Sanchez, Marina, Menzies, Moira, Evans, Bradley, King, Harry, Reverter, Antonio and Kijas, James W. (2022). Leveraging transcriptome and epigenome landscapes to infer regulatory networks during the onset of sexual maturation. BMC Genomics, 23 (1) 413, 1-19. doi: 10.1186/s12864-022-08514-8
2022
Journal Article
Organization of gene programs revealed by unsupervised analysis of diverse gene–trait associations
Mizikovsky, Dalia, Naval Sanchez, Marina, Nefzger, Christian M, Cuellar Partida, Gabriel and Palpant, Nathan J (2022). Organization of gene programs revealed by unsupervised analysis of diverse gene–trait associations. Nucleic Acids Research, 50 (15) e87, 1-12. doi: 10.1093/nar/gkac413
2022
Journal Article
Benchmarking of ATAC Sequencing Data From BGI’s Low-Cost DNBSEQ-G400 Instrument for Identification of Open and Occupied Chromatin Regions
Naval-Sanchez, Marina, Deshpande, Nikita, Tran, Minh, Zhang, Jingyu, Alhomrani, Majid, Alsanie, Walaa, Nguyen, Quan and Nefzger, Christian M. (2022). Benchmarking of ATAC Sequencing Data From BGI’s Low-Cost DNBSEQ-G400 Instrument for Identification of Open and Occupied Chromatin Regions. Frontiers in Molecular Biosciences, 9 900323, 1-15. doi: 10.3389/fmolb.2022.900323
2022
Journal Article
Temporal perturbation of histone deacetylase activity reveals a requirement for HDAC1–3 in mesendoderm cell differentiation
Sinniah, Enakshi, Wu, Zhixuan, Shen, Sophie, Naval-Sanchez, Marina, Chen, Xiaoli, Lim, Junxian, Helfer, Abbigail, Iyer, Abishek, Tng, Jiahui, Lucke, Andrew J., Reid, Robert C., Redd, Meredith A., Nefzger, Christian M., Fairlie, David P. and Palpant, Nathan J. (2022). Temporal perturbation of histone deacetylase activity reveals a requirement for HDAC1–3 in mesendoderm cell differentiation. Cell Reports, 39 (7) 110818, 1-21. doi: 10.1016/j.celrep.2022.110818
2021
Journal Article
Chromatin accessibility and regulatory vocabulary across indicine cattle tissues
Alexandre, Pâmela A., Naval-Sánchez, Marina, Menzies, Moira, Nguyen, Loan T., Porto-Neto, Laercio R., Fortes, Marina R. S. and Reverter, Antonio (2021). Chromatin accessibility and regulatory vocabulary across indicine cattle tissues. Genome Biology, 22 (1) 273, 273. doi: 10.1186/s13059-021-02489-7
2021
Conference Publication
Chromatin accessibility and regulatory vocabulary in indicine cattle
Alexandre, Pâmela A., Naval-Sánchez, Marina, Menzies, Moira, Nguyen, Loan T., Porto-Neto, Laercio, Fortes, Marina R.S. and Reverter, Antonio (2021). Chromatin accessibility and regulatory vocabulary in indicine cattle. 38th International Society of Animal Genetics (ISAG), Virtual, 26-30 July 2021. Champaign, IL United States: ISAG.
2021
Journal Article
A conserved haplotype in Wagyu cattle contains RAB4A whose encoded protein regulates glucose trafficking in muscle and fat cells
Hudson, N. J., Porto-Neto, L., Naval-Sanchez, M., Lyons, R. E. and Reverter, Antonio (2021). A conserved haplotype in Wagyu cattle contains RAB4A whose encoded protein regulates glucose trafficking in muscle and fat cells. Animal Genetics, 52 (3), 275-283. doi: 10.1111/age.13054
2021
Journal Article
Analysis of polycerate mutants reveals the evolutionary co-option of HOXD1 for horn patterning in Bovidae
Allais-Bonnet, Aurélie, Hintermann, Aurélie, Deloche, Marie-Christine, Cornette, Raphaël, Bardou, Philippe, Naval-Sanchez, Marina, Pinton, Alain, Haruda, Ashleigh, Grohs, Cécile, Zakany, Jozsef, Bigi, Daniele, Medugorac, Ivica, Putelat, Olivier, Greyvenstein, Ockert, Hadfield, Tracy, Jemaa, Slim Ben, Bunevski, Gjoko, Menzi, Fiona, Hirter, Nathalie, Paris, Julia M., Hedges, John, Palhiere, Isabelle, Rupp, Rachel, Lenstra, Johannes A., Gidney, Louisa, Lesur, Joséphine, Schafberg, Renate, Stache, Michael, Wandhammer, Marie-Dominique ... Capitan, Aurélien (2021). Analysis of polycerate mutants reveals the evolutionary co-option of HOXD1 for horn patterning in Bovidae. Molecular Biology and Evolution, 38 (6), 2260-2272. doi: 10.1093/molbev/msab021
2021
Journal Article
Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells
Sun, Xuan, Cao, Benjamin, Naval-Sanchez, Marina, Pham, Tony, Sun, Yu Bo Yang, Williams, Brenda, Heazlewood, Shen Y, Deshpande, Nikita, Li, Jinhua, Kraus, Felix, Rae, James, Nguyen, Quan, Yari, Hamed, Schröder, Jan, Heazlewood, Chad K, Fulton, Madeline, Hatwell-Humble, Jessica, Das Gupta, Kaustav, Kapetanovic, Ronan, Chen, Xiaoli, Sweet, Matthew J, Parton, Robert G, Ryan, Michael T, Polo, Jose M, Nefzger, Christian M and Nilsson, Susan K (2021). Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells. Nature Communications, 12 (1) 2665, 1-17. doi: 10.1038/s41467-021-22863-0
2020
Journal Article
Genome-wide co-expression distributions as a metric to prioritize genes of functional importance
Alexandre, Pâmela A., Hudson, Nicholas J., Lehnert, Sigrid A., Fortes, Marina R. S., Naval-Sánchez, Marina, Nguyen, Loan T., Porto-Neto, Laercio R. and Reverter, Antonio (2020). Genome-wide co-expression distributions as a metric to prioritize genes of functional importance. Genes, 11 (10) 1231, 1231-13. doi: 10.3390/genes11101231
2020
Journal Article
Selection signatures in tropical cattle are enriched for promoter and coding regions and reveal missense mutations in the damage response gene HELB
Naval-Sánchez, Marina, Porto-Neto, Laercio R., Cardoso, Diercles F., Hayes, Ben J., Daetwyler, Hans D., Kijas, James and Reverter, Antonio (2020). Selection signatures in tropical cattle are enriched for promoter and coding regions and reveal missense mutations in the damage response gene HELB. Genetics Selection Evolution, 52 (1) 27, 27. doi: 10.1186/s12711-020-00546-6
2020
Journal Article
Dynamics of gene co-expression networks in time-series data: a case study in Drosophila melanogaster embryogenesis
Lau, Li Yieng, Reverter, Antonio, Hudson, Nicholas J., Naval-Sanchez, Marina, Fortes, Marina R. S. and Alexandre, Pâmela A. (2020). Dynamics of gene co-expression networks in time-series data: a case study in Drosophila melanogaster embryogenesis. Frontiers in Genetics, 11 517, 517. doi: 10.3389/fgene.2020.00517
2020
Journal Article
Changed Patterns of Genomic Variation Following Recent Domestication: Selection Sweeps in Farmed Atlantic Salmon
Naval-Sanchez, Marina, McWilliam, Sean, Evans, Bradley, Yáñez, José M., Houston, Ross D. and Kijas, James W. (2020). Changed Patterns of Genomic Variation Following Recent Domestication: Selection Sweeps in Farmed Atlantic Salmon. Frontiers in Genetics, 11 264. doi: 10.3389/fgene.2020.00264
2020
Journal Article
Association analysis of loci implied in 'buffering' epistasis
Reverter, Antonio, Vitezica, Zulma G., Naval-Sánchez, Marina, Henshall, John, Raidan, Fernanda, Li, Yutao, Meyer, Karin, Hudson, Nicholas J., Porto-Neto, Laercio R. and Legarra, Andrés (2020). Association analysis of loci implied in 'buffering' epistasis. Journal of Animal Science, 98 (3) skaa045. doi: 10.1093/jas/skaa045
2019
Journal Article
Systems biology reveals NR2F6 and TGFB1 as key regulators of feed efficiency in beef cattle
Alexandre, Pâmela A., Naval-Sanchez, Marina, Porto-Neto, Laercio R., Ferraz, José Bento S., Reverter, Antonio and Fukumasu, Heidge (2019). Systems biology reveals NR2F6 and TGFB1 as key regulators of feed efficiency in beef cattle. Frontiers in Genetics, 10 (MAR) 230. doi: 10.3389/fgene.2019.00230
2018
Journal Article
Correction: Amniotic ectoderm expansion in mouse occurs via distinct modes and requires SMAD5-mediated signalling (vol 145, dev157222, 2018)
Dobreva, Mariya P., Escalona, Vanesa Abon, Lawson, Kirstie A., Sanchez, Marina N., Ponomarev, Ljuba C., Pereira, Paulo N. G., Stryjewska, Agata, Criem, Nathan, Huylebroeck, Danny, Lopes, Susana M. Chuva de Sousa, Aerts, Stein and Zwijsen, An (2018). Correction: Amniotic ectoderm expansion in mouse occurs via distinct modes and requires SMAD5-mediated signalling (vol 145, dev157222, 2018). Development, 145 (15). doi: 10.1242/dev.169722
Supervision
Availability
- Dr Marina Naval Sanchez is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Deciphering the gene regulatory code of ageing to set the stage for therapeutic interventions
Decipher the gene regulatory code and epigenetic mechanisms governing developmental processes and aging, and their links to disease.
Supervision history
Current supervision
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Doctor Philosophy
Development of a multimodal single-cell assay reveals somatic NFI transcription factors as dose-dependent pluripotency mediators
Associate Advisor
Other advisors: Professor Matt Sweet, Dr Christian Nefzger
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Doctor Philosophy
Deciphering the age-altered transcription factor network and its control over regenerative potential
Associate Advisor
Other advisors: Dr Quan Nguyen, Dr Christian Nefzger
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Doctor Philosophy
Leveraging integrative multiomic data to enable controlled cell state transition
Associate Advisor
Other advisors: Professor Matt Sweet, Dr Christian Nefzger
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Doctor Philosophy
Leveraging integrative multiomic data to enable controlled cell state transition
Associate Advisor
Other advisors: Professor Matt Sweet, Dr Christian Nefzger
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Doctor Philosophy
Network reinforcement to improve the function of aged cells
Associate Advisor
Other advisors: Dr Christian Nefzger
Media
Enquiries
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